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Items: 14


CD97 is a critical regulator of acute myeloid leukemia stem cell function.

Martin GH, Roy N, Chakraborty S, Desrichard A, Chung SS, Woolthuis CM, Hu W, Berezniuk I, Garrett-Bakelman FE, Hamann J, Devlin SM, Chan TA, Park CY.

J Exp Med. 2019 Oct 7;216(10):2362-2377. doi: 10.1084/jem.20190598. Epub 2019 Aug 1.


Prospective Isolation and Characterization of Genetically and Functionally Distinct AML Subclones.

de Boer B, Prick J, Pruis MG, Keane P, Imperato MR, Jaques J, Brouwers-Vos AZ, Hogeling SM, Woolthuis CM, Nijk MT, Diepstra A, Wandinger S, Versele M, Attar RM, Cockerill PN, Huls G, Vellenga E, Mulder AB, Bonifer C, Schuringa JJ.

Cancer Cell. 2018 Oct 8;34(4):674-689.e8. doi: 10.1016/j.ccell.2018.08.014. Epub 2018 Sep 20.


miR-99 regulates normal and malignant hematopoietic stem cell self-renewal.

Khalaj M, Woolthuis CM, Hu W, Durham BH, Chu SH, Qamar S, Armstrong SA, Park CY.

J Exp Med. 2017 Aug 7;214(8):2453-2470. doi: 10.1084/jem.20161595.


Histone acetyltransferase activity of MOF is required for adult but not early fetal hematopoiesis in mice.

Valerio DG, Xu H, Eisold ME, Woolthuis CM, Pandita TK, Armstrong SA.

Blood. 2017 Jan 5;129(1):48-59. doi: 10.1182/blood-2016-05-714568. Epub 2016 Nov 8.


Leukemic Stem Cells Evade Chemotherapy by Metabolic Adaptation to an Adipose Tissue Niche.

Ye H, Adane B, Khan N, Sullivan T, Minhajuddin M, Gasparetto M, Stevens B, Pei S, Balys M, Ashton JM, Klemm DJ, Woolthuis CM, Stranahan AW, Park CY, Jordan CT.

Cell Stem Cell. 2016 Jul 7;19(1):23-37. doi: 10.1016/j.stem.2016.06.001. Epub 2016 Jun 30.


Hematopoietic stem/progenitor cell commitment to the megakaryocyte lineage.

Woolthuis CM, Park CY.

Blood. 2016 Mar 10;127(10):1242-8. doi: 10.1182/blood-2015-07-607945. Epub 2016 Jan 19. Review.


Aging impairs long-term hematopoietic regeneration after autologous stem cell transplantation.

Woolthuis CM, Mariani N, Verkaik-Schakel RN, Brouwers-Vos AZ, Schuringa JJ, Vellenga E, de Wolf JT, Huls G.

Biol Blood Marrow Transplant. 2014 Jun;20(6):865-71. doi: 10.1016/j.bbmt.2014.03.001. Epub 2014 Mar 7.


Loss of quiescence and impaired function of CD34(+)/CD38(low) cells one year following autologous stem cell transplantation.

Woolthuis CM, Brouwers-Vos AZ, Huls G, de Wolf JT, Schuringa JJ, Vellenga E.

Haematologica. 2013 Dec;98(12):1964-71. doi: 10.3324/haematol.2013.086744. Epub 2013 Sep 13.


A single center analysis of nucleophosmin in acute myeloid leukemia: value of combining immunohistochemistry with molecular mutation analysis.

Woolthuis CM, Mulder AB, Verkaik-Schakel RN, Rosati S, Diepstra A, van den Berg E, Schuringa JJ, Vellenga E, Kluin PM, Huls G.

Haematologica. 2013 Oct;98(10):1532-8. doi: 10.3324/haematol.2012.079806. Epub 2013 May 28.


Downregulation of MEIS1 impairs long-term expansion of CD34+ NPM1-mutated acute myeloid leukemia cells.

Woolthuis CM, Han L, Verkaik-Schakel RN, van Gosliga D, Kluin PM, Vellenga E, Schuringa JJ, Huls G.

Leukemia. 2012 Apr;26(4):848-53. doi: 10.1038/leu.2011.277. Epub 2011 Oct 11. No abstract available.


Gene expression profiling in the leukemic stem cell-enriched CD34+ fraction identifies target genes that predict prognosis in normal karyotype AML.

de Jonge HJ, Woolthuis CM, Vos AZ, Mulder A, van den Berg E, Kluin PM, van der Weide K, de Bont ES, Huls G, Vellenga E, Schuringa JJ.

Leukemia. 2011 Dec;25(12):1825-33. doi: 10.1038/leu.2011.172. Epub 2011 Jul 15.


Aging of hematopoietic stem cells: Intrinsic changes or micro-environmental effects?

Woolthuis CM, de Haan G, Huls G.

Curr Opin Immunol. 2011 Aug;23(4):512-7. doi: 10.1016/j.coi.2011.05.006. Epub 2011 Jun 12. Review.


Paradoxical down-regulation of p16 mRNA with advancing age in acute myeloid leukemia.

de Jonge HJ, Woolthuis CM, de Bont ES, Huls G.

Aging (Albany NY). 2009 Oct 23;1(11):949-53.


AML at older age: age-related gene expression profiles reveal a paradoxical down-regulation of p16INK4A mRNA with prognostic significance.

de Jonge HJ, de Bont ES, Valk PJ, Schuringa JJ, Kies M, Woolthuis CM, Delwel R, Veeger NJ, Vellenga E, Löwenberg B, Huls G.

Blood. 2009 Oct 1;114(14):2869-77. doi: 10.1182/blood-2009-03-212688. Epub 2009 Aug 10.


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