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Items: 1 to 50 of 142

1.

The dynamical interplay between a megadalton peptide nanocage and solutes probed by microsecond atomistic MD; implications for design.

Shoemark DK, Avila Ibarra A, Ross JF, Beesley JL, Bray HEV, Mosayebi M, Linden N, Liverpool TB, McIntosh-Smith SN, Woolfson DN, Sessions RB.

Phys Chem Chem Phys. 2018 Dec 19;21(1):137-147. doi: 10.1039/c8cp06282j.

PMID:
30515500
2.

De novo coiled-coil peptides as scaffolds for disrupting protein-protein interactions.

Fletcher JM, Horner KA, Bartlett GJ, Rhys GG, Wilson AJ, Woolfson DN.

Chem Sci. 2018 Aug 7;9(39):7656-7665. doi: 10.1039/c8sc02643b. eCollection 2018 Oct 21.

3.

Maintaining and breaking symmetry in homomeric coiled-coil assemblies.

Rhys GG, Wood CW, Lang EJM, Mulholland AJ, Brady RL, Thomson AR, Woolfson DN.

Nat Commun. 2018 Oct 8;9(1):4132. doi: 10.1038/s41467-018-06391-y.

4.

De novo targeting to the cytoplasmic and luminal side of bacterial microcompartments.

Lee MJ, Mantell J, Brown IR, Fletcher JM, Verkade P, Pickersgill RW, Woolfson DN, Frank S, Warren MJ.

Nat Commun. 2018 Aug 24;9(1):3413. doi: 10.1038/s41467-018-05922-x.

5.

Modifying Self-Assembled Peptide Cages To Control Internalization into Mammalian Cells.

Beesley JL, Baum HE, Hodgson LR, Verkade P, Banting GS, Woolfson DN.

Nano Lett. 2018 Aug 8. doi: 10.1021/acs.nanolett.8b02633. [Epub ahead of print]

PMID:
30084257
6.

Hydra Mesoglea Proteome Identifies Thrombospondin as a Conserved Component Active in Head Organizer Restriction.

Lommel M, Strompen J, Hellewell AL, Balasubramanian GP, Christofidou ED, Thomson AR, Boyle AL, Woolfson DN, Puglisi K, Hartl M, Holstein TW, Adams JC, Özbek S.

Sci Rep. 2018 Aug 6;8(1):11753. doi: 10.1038/s41598-018-30035-2.

7.

De Novo-Designed α-Helical Barrels as Receptors for Small Molecules.

Thomas F, Dawson WM, Lang EJM, Burton AJ, Bartlett GJ, Rhys GG, Mulholland AJ, Woolfson DN.

ACS Synth Biol. 2018 Jul 20;7(7):1808-1816. doi: 10.1021/acssynbio.8b00225. Epub 2018 Jul 10.

PMID:
29944338
8.

Applying graph theory to protein structures: an Atlas of coiled coils.

Heal JW, Bartlett GJ, Wood CW, Thomson AR, Woolfson DN.

Bioinformatics. 2018 Oct 1;34(19):3316-3323. doi: 10.1093/bioinformatics/bty347.

9.

Bioinspired Silicification Reveals Structural Detail in Self-Assembled Peptide Cages.

Galloway JM, Senior L, Fletcher JM, Beesley JL, Hodgson LR, Harniman RL, Mantell JM, Coombs J, Rhys GG, Xue WF, Mosayebi M, Linden N, Liverpool TB, Curnow P, Verkade P, Woolfson DN.

ACS Nano. 2018 Feb 27;12(2):1420-1432. doi: 10.1021/acsnano.7b07785. Epub 2018 Jan 22.

10.

Engineered synthetic scaffolds for organizing proteins within the bacterial cytoplasm.

Lee MJ, Mantell J, Hodgson L, Alibhai D, Fletcher JM, Brown IR, Frank S, Xue WF, Verkade P, Woolfson DN, Warren MJ.

Nat Chem Biol. 2018 Feb;14(2):142-147. doi: 10.1038/nchembio.2535. Epub 2017 Dec 11.

PMID:
29227472
11.

Conformational Dynamics of Asparagine at Coiled-Coil Interfaces.

Thomas F, Niitsu A, Oregioni A, Bartlett GJ, Woolfson DN.

Biochemistry. 2017 Dec 19;56(50):6544-6554. doi: 10.1021/acs.biochem.7b00848. Epub 2017 Dec 5.

12.

Toward a Soluble Model System for the Amyloid State.

Thomas NC, Bartlett GJ, Woolfson DN, Gellman SH.

J Am Chem Soc. 2017 Nov 22;139(46):16434-16437. doi: 10.1021/jacs.7b07225. Epub 2017 Nov 8.

13.

CCBuilder 2.0: Powerful and accessible coiled-coil modeling.

Wood CW, Woolfson DN.

Protein Sci. 2018 Jan;27(1):103-111. doi: 10.1002/pro.3279. Epub 2017 Sep 15.

14.

Miniprotein Design: Past, Present, and Prospects.

Baker EG, Bartlett GJ, Porter Goff KL, Woolfson DN.

Acc Chem Res. 2017 Sep 19;50(9):2085-2092. doi: 10.1021/acs.accounts.7b00186. Epub 2017 Aug 23.

PMID:
28832117
15.

Beyond icosahedral symmetry in packings of proteins in spherical shells.

Mosayebi M, Shoemark DK, Fletcher JM, Sessions RB, Linden N, Woolfson DN, Liverpool TB.

Proc Natl Acad Sci U S A. 2017 Aug 22;114(34):9014-9019. doi: 10.1073/pnas.1706825114. Epub 2017 Aug 8.

16.

How do miniproteins fold?

Woolfson DN, Baker EG, Bartlett GJ.

Science. 2017 Jul 14;357(6347):133-134. doi: 10.1126/science.aan6864. No abstract available.

PMID:
28706028
17.

Decorating Self-Assembled Peptide Cages with Proteins.

Ross JF, Bridges A, Fletcher JM, Shoemark D, Alibhai D, Bray HEV, Beesley JL, Dawson WM, Hodgson LR, Mantell J, Verkade P, Edge CM, Sessions RB, Tew D, Woolfson DN.

ACS Nano. 2017 Aug 22;11(8):7901-7914. doi: 10.1021/acsnano.7b02368. Epub 2017 Jul 11.

PMID:
28686416
18.

Membrane-spanning α-helical barrels as tractable protein-design targets.

Niitsu A, Heal JW, Fauland K, Thomson AR, Woolfson DN.

Philos Trans R Soc Lond B Biol Sci. 2017 Aug 5;372(1726). pii: 20160213. doi: 10.1098/rstb.2016.0213. Review.

19.

ISAMBARD: an open-source computational environment for biomolecular analysis, modelling and design.

Wood CW, Heal JW, Thomson AR, Bartlett GJ, Ibarra AÁ, Brady RL, Sessions RB, Woolfson DN.

Bioinformatics. 2017 Oct 1;33(19):3043-3050. doi: 10.1093/bioinformatics/btx352.

20.

Engineering protein stability with atomic precision in a monomeric miniprotein.

Baker EG, Williams C, Hudson KL, Bartlett GJ, Heal JW, Porter Goff KL, Sessions RB, Crump MP, Woolfson DN.

Nat Chem Biol. 2017 Jul;13(7):764-770. doi: 10.1038/nchembio.2380. Epub 2017 May 22.

21.

A monodisperse transmembrane α-helical peptide barrel.

Mahendran KR, Niitsu A, Kong L, Thomson AR, Sessions RB, Woolfson DN, Bayley H.

Nat Chem. 2017 May;9(5):411-419. doi: 10.1038/nchem.2647. Epub 2016 Nov 14.

PMID:
28430192
22.

Characterization of long and stable de novo single alpha-helix domains provides novel insight into their stability.

Wolny M, Batchelor M, Bartlett GJ, Baker EG, Kurzawa M, Knight PJ, Dougan L, Woolfson DN, Paci E, Peckham M.

Sci Rep. 2017 Mar 13;7:44341. doi: 10.1038/srep44341.

23.

Construction of a Chassis for a Tripartite Protein-Based Molecular Motor.

Small LSR, Bruning M, Thomson AR, Boyle AL, Davies RB, Curmi PMG, Forde NR, Linke H, Woolfson DN, Bromley EHC.

ACS Synth Biol. 2017 Jun 16;6(6):1096-1102. doi: 10.1021/acssynbio.7b00037. Epub 2017 Mar 14.

24.

Coiled-Coil Design: Updated and Upgraded.

Woolfson DN.

Subcell Biochem. 2017;82:35-61. doi: 10.1007/978-3-319-49674-0_2. Review.

PMID:
28101858
25.

N@a and N@d: Oligomer and Partner Specification by Asparagine in Coiled-Coil Interfaces.

Fletcher JM, Bartlett GJ, Boyle AL, Danon JJ, Rush LE, Lupas AN, Woolfson DN.

ACS Chem Biol. 2017 Feb 17;12(2):528-538. doi: 10.1021/acschembio.6b00935. Epub 2017 Jan 9.

PMID:
28026921
26.

Installing hydrolytic activity into a completely de novo protein framework.

Burton AJ, Thomson AR, Dawson WM, Brady RL, Woolfson DN.

Nat Chem. 2016 Sep;8(9):837-44. doi: 10.1038/nchem.2555. Epub 2016 Jul 4.

PMID:
27554410
27.

BrisSynBio: a BBSRC/EPSRC-funded Synthetic Biology Research Centre.

Sedgley KR, Race PR, Woolfson DN.

Biochem Soc Trans. 2016 Jun 15;44(3):689-91. doi: 10.1042/BST20160004.

28.

On the satisfaction of backbone-carbonyl lone pairs of electrons in protein structures.

Bartlett GJ, Woolfson DN.

Protein Sci. 2016 Apr;25(4):887-97. doi: 10.1002/pro.2896. Epub 2016 Feb 25.

29.

Controlling the Assembly of Coiled-Coil Peptide Nanotubes.

Thomas F, Burgess NC, Thomson AR, Woolfson DN.

Angew Chem Int Ed Engl. 2016 Jan 18;55(3):987-91. doi: 10.1002/anie.201509304. Epub 2015 Dec 14.

30.

Carbohydrate-Aromatic Interactions in Proteins.

Hudson KL, Bartlett GJ, Diehl RC, Agirre J, Gallagher T, Kiessling LL, Woolfson DN.

J Am Chem Soc. 2015 Dec 9;137(48):15152-60. doi: 10.1021/jacs.5b08424. Epub 2015 Nov 30.

31.

Corrigendum: Local and macroscopic electrostatic interactions in single α-helices.

Baker EG, Bartlett GJ, Crump MP, Sessions RB, Linden N, Faul CF, Woolfson DN.

Nat Chem Biol. 2015 Sep;11(9):741. doi: 10.1038/nchembio0915-741e. No abstract available.

PMID:
26284676
32.

Functionalized α-Helical Peptide Hydrogels for Neural Tissue Engineering.

Mehrban N, Zhu B, Tamagnini F, Young FI, Wasmuth A, Hudson KL, Thomson AR, Birchall MA, Randall AD, Song B, Woolfson DN.

ACS Biomater Sci Eng. 2015 Jun 8;1(6):431-439. Epub 2015 Apr 28.

33.

Modular Design of Self-Assembling Peptide-Based Nanotubes.

Burgess NC, Sharp TH, Thomas F, Wood CW, Thomson AR, Zaccai NR, Brady RL, Serpell LC, Woolfson DN.

J Am Chem Soc. 2015 Aug 26;137(33):10554-62. doi: 10.1021/jacs.5b03973. Epub 2015 Aug 12.

PMID:
26219086
34.

De novo protein design: how do we expand into the universe of possible protein structures?

Woolfson DN, Bartlett GJ, Burton AJ, Heal JW, Niitsu A, Thomson AR, Wood CW.

Curr Opin Struct Biol. 2015 Aug;33:16-26. doi: 10.1016/j.sbi.2015.05.009. Epub 2015 Jun 18. Review.

35.

Local and macroscopic electrostatic interactions in single α-helices.

Baker EG, Bartlett GJ, Crump MP, Sessions RB, Linden N, Faul CF, Woolfson DN.

Nat Chem Biol. 2015 Mar;11(3):221-8. doi: 10.1038/nchembio.1739. Epub 2015 Feb 9. Erratum in: Nat Chem Biol. 2015 Sep;11(9):741.

36.

Computational design of water-soluble α-helical barrels.

Thomson AR, Wood CW, Burton AJ, Bartlett GJ, Sessions RB, Brady RL, Woolfson DN.

Science. 2014 Oct 24;346(6208):485-8. doi: 10.1126/science.1257452.

37.

Construction and characterization of kilobasepair densely labeled peptide-DNA.

Kovacic S, Samii L, Lamour G, Li H, Linke H, Bromley EH, Woolfson DN, Curmi PM, Forde NR.

Biomacromolecules. 2014 Nov 10;15(11):4065-72. doi: 10.1021/bm501109p. Epub 2014 Oct 7.

PMID:
25233124
38.

CCBuilder: an interactive web-based tool for building, designing and assessing coiled-coil protein assemblies.

Wood CW, Bruning M, Ibarra AÁ, Bartlett GJ, Thomson AR, Sessions RB, Brady RL, Woolfson DN.

Bioinformatics. 2014 Nov 1;30(21):3029-35. doi: 10.1093/bioinformatics/btu502. Epub 2014 Jul 26.

39.

Assessing cellular response to functionalized α-helical peptide hydrogels.

Mehrban N, Abelardo E, Wasmuth A, Hudson KL, Mullen LM, Thomson AR, Birchall MA, Woolfson DN.

Adv Healthc Mater. 2014 Sep;3(9):1387-91. doi: 10.1002/adhm.201400065. Epub 2014 Mar 24.

40.

Signatures of n→π* interactions in proteins.

Newberry RW, Bartlett GJ, VanVeller B, Woolfson DN, Raines RT.

Protein Sci. 2014 Mar;23(3):284-8. doi: 10.1002/pro.2413.

41.

Interplay of hydrogen bonds and n→π* interactions in proteins.

Bartlett GJ, Newberry RW, VanVeller B, Raines RT, Woolfson DN.

J Am Chem Soc. 2013 Dec 11;135(49):18682-8. doi: 10.1021/ja4106122. Epub 2013 Dec 3.

42.

Accessibility, reactivity, and selectivity of side chains within a channel of de novo peptide assembly.

Burton AJ, Thomas F, Agnew C, Hudson KL, Halford SE, Brady RL, Woolfson DN.

J Am Chem Soc. 2013 Aug 28;135(34):12524-7. doi: 10.1021/ja4053027. Epub 2013 Aug 13.

PMID:
23924058
43.

Prediction and analysis of higher-order coiled-coils: insights from proteins of the extracellular matrix, tenascins and thrombospondins.

Vincent TL, Woolfson DN, Adams JC.

Int J Biochem Cell Biol. 2013 Nov;45(11):2392-401. doi: 10.1016/j.biocel.2013.07.011. Epub 2013 Jul 24.

PMID:
23891848
44.

Controlled microfluidic switching in arbitrary time-sequences with low drag.

Niman CS, Beech JP, Tegenfeldt JO, Curmi PM, Woolfson DN, Forde NR, Linke H.

Lab Chip. 2013 Jun 21;13(12):2389-96. doi: 10.1039/c3lc50194a. Epub 2013 May 8.

PMID:
23657706
45.

A basis set of de novo coiled-coil peptide oligomers for rational protein design and synthetic biology.

Fletcher JM, Boyle AL, Bruning M, Bartlett GJ, Vincent TL, Zaccai NR, Armstrong CT, Bromley EH, Booth PJ, Brady RL, Thomson AR, Woolfson DN.

ACS Synth Biol. 2012 Jun 15;1(6):240-50. doi: 10.1021/sb300028q. Epub 2012 May 14.

PMID:
23651206
46.

Self-assembling cages from coiled-coil peptide modules.

Fletcher JM, Harniman RL, Barnes FR, Boyle AL, Collins A, Mantell J, Sharp TH, Antognozzi M, Booth PJ, Linden N, Miles MJ, Sessions RB, Verkade P, Woolfson DN.

Science. 2013 May 3;340(6132):595-9. doi: 10.1126/science.1233936. Epub 2013 Apr 11.

47.

A set of de novo designed parallel heterodimeric coiled coils with quantified dissociation constants in the micromolar to sub-nanomolar regime.

Thomas F, Boyle AL, Burton AJ, Woolfson DN.

J Am Chem Soc. 2013 Apr 3;135(13):5161-6. doi: 10.1021/ja312310g. Epub 2013 Mar 19.

PMID:
23477407
48.

LOGICOIL--multi-state prediction of coiled-coil oligomeric state.

Vincent TL, Green PJ, Woolfson DN.

Bioinformatics. 2013 Jan 1;29(1):69-76. doi: 10.1093/bioinformatics/bts648. Epub 2012 Nov 4.

PMID:
23129295
49.

Strong contributions from vertical triads to helix-partner preferences in parallel coiled coils.

Steinkruger JD, Bartlett GJ, Woolfson DN, Gellman SH.

J Am Chem Soc. 2012 Sep 26;134(38):15652-5. Epub 2012 Sep 13.

50.

Squaring the circle in peptide assembly: from fibers to discrete nanostructures by de novo design.

Boyle AL, Bromley EH, Bartlett GJ, Sessions RB, Sharp TH, Williams CL, Curmi PM, Forde NR, Linke H, Woolfson DN.

J Am Chem Soc. 2012 Sep 19;134(37):15457-67. Epub 2012 Sep 6.

PMID:
22917063

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