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Items: 1 to 50 of 214

1.

HNF1B Mutations Are Associated With a Gitelman-like Tubulopathy That Develops During Childhood.

Adalat S, Hayes WN, Bryant WA, Booth J, Woolf AS, Kleta R, Subtil S, Clissold R, Colclough K, Ellard S, Bockenhauer D.

Kidney Int Rep. 2019 May 29;4(9):1304-1311. doi: 10.1016/j.ekir.2019.05.019. eCollection 2019 Sep.

2.

Loss-of-function variants in myocardin cause congenital megabladder in humans and mice.

Houweling AC, Beaman GM, Postma AV, Gainous TB, Lichtenbelt KD, Brancati F, Lopes FM, van der Made I, Polstra AM, Robinson ML, Wright KD, Ellingford JM, Jackson AR, Overwater E, Genesio R, Romano S, Camerota L, D'Angelo E, Meijers-Heijboer EJ, Christoffels VM, McHugh KM, Black BL, Newman WG, Woolf AS, Creemers EE.

J Clin Invest. 2019 Sep 12. pii: 128545. doi: 10.1172/JCI128545. [Epub ahead of print]

3.

A homozygous missense variant in CHRM3 associated with familial urinary bladder disease.

Beaman GM, Galatà G, Teik KW, Urquhart JE, Aishah A, O'Sullivan J, Bhaskar SS, Wood KA, Thomas HB, O'Keefe RT, Woolf AS, Stuart HM, Newman WG.

Clin Genet. 2019 Aug 23. doi: 10.1111/cge.13631. [Epub ahead of print]

PMID:
31441039
4.

Overactivity or blockade of transforming growth factor-β each generate a specific ureter malformation.

Lopes FM, Roberts NA, Zeef LA, Gardiner NJ, Woolf AS.

J Pathol. 2019 Aug 10. doi: 10.1002/path.5335. [Epub ahead of print]

PMID:
31400222
5.

Growing a new human kidney.

Woolf AS.

Kidney Int. 2019 Oct;96(4):871-882. doi: 10.1016/j.kint.2019.04.040. Epub 2019 May 25. Review.

6.

Rare Variants in BNC2 Are Implicated in Autosomal-Dominant Congenital Lower Urinary-Tract Obstruction.

Kolvenbach CM, Dworschak GC, Frese S, Japp AS, Schuster P, Wenzlitschke N, Yilmaz Ö, Lopes FM, Pryalukhin A, Schierbaum L, van der Zanden LFM, Kause F, Schneider R, Taranta-Janusz K, Szczepańska M, Pawlaczyk K, Newman WG, Beaman GM, Stuart HM, Cervellione RM, Feitz WFJ, van Rooij IALM, Schreuder MF, Steffens M, Weber S, Merz WM, Feldkötter M, Hoppe B, Thiele H, Altmüller J, Berg C, Kristiansen G, Ludwig M, Reutter H, Woolf AS, Hildebrandt F, Grote P, Zaniew M, Odermatt B, Hilger AC.

Am J Hum Genet. 2019 May 2;104(5):994-1006. doi: 10.1016/j.ajhg.2019.03.023.

7.

Congenital Disorders of the Human Urinary Tract: Recent Insights From Genetic and Molecular Studies.

Woolf AS, Lopes FM, Ranjzad P, Roberts NA.

Front Pediatr. 2019 Apr 11;7:136. doi: 10.3389/fped.2019.00136. eCollection 2019. Review.

8.

Lrig2 and Hpse2, mutated in urofacial syndrome, pattern nerves in the urinary bladder.

Roberts NA, Hilton EN, Lopes FM, Singh S, Randles MJ, Gardiner NJ, Chopra K, Coletta R, Bajwa Z, Hall RJ, Yue WW, Schaefer F, Weber S, Henriksson R, Stuart HM, Hedman H, Newman WG, Woolf AS.

Kidney Int. 2019 May;95(5):1138-1152. doi: 10.1016/j.kint.2018.11.040. Epub 2019 Mar 8.

9.

Uncovering genetic mechanisms of kidney aging through transcriptomics, genomics, and epigenomics.

Rowland J, Akbarov A, Eales J, Xu X, Dormer JP, Guo H, Denniff M, Jiang X, Ranjzad P, Nazgiewicz A, Prestes PR, Antczak A, Szulinska M, Wise IA, Zukowska-Szczechowska E, Bogdanski P, Woolf AS, Samani NJ, Charchar FJ, Tomaszewski M.

Kidney Int. 2019 Mar;95(3):624-635. doi: 10.1016/j.kint.2018.10.029.

10.

Serum-Free Organ Culture of the Embryonic Mouse Ureter.

Lopes FM, Woolf AS.

Methods Mol Biol. 2019;1926:31-38. doi: 10.1007/978-1-4939-9021-4_3.

PMID:
30742260
11.

22q11.2 duplications in a UK cohort with bladder exstrophy-epispadias complex.

Beaman GM, Woolf AS, Cervellione RM, Keene D, Mushtaq I, Urquhart JE, Stuart HM, Newman WG.

Am J Med Genet A. 2019 Mar;179(3):404-409. doi: 10.1002/ajmg.a.61032. Epub 2019 Jan 9.

PMID:
30628148
12.

Molecular insights into genome-wide association studies of chronic kidney disease-defining traits.

Xu X, Eales JM, Akbarov A, Guo H, Becker L, Talavera D, Ashraf F, Nawaz J, Pramanik S, Bowes J, Jiang X, Dormer J, Denniff M, Antczak A, Szulinska M, Wise I, Prestes PR, Glyda M, Bogdanski P, Zukowska-Szczechowska E, Berzuini C, Woolf AS, Samani NJ, Charchar FJ, Tomaszewski M.

Nat Commun. 2018 Nov 22;9(1):4800. doi: 10.1038/s41467-018-07260-4.

13.

From human pluripotent stem cells to functional kidney organoids and models of renal disease.

Kimber SJ, Woolf AS.

Stem Cell Investig. 2018 Jul 21;5:20. doi: 10.21037/sci.2018.07.02. eCollection 2018. No abstract available.

14.

Vangl2, a planar cell polarity molecule, is implicated in irreversible and reversible kidney glomerular injury.

Papakrivopoulou E, Vasilopoulou E, Lindenmeyer MT, Pacheco S, Brzóska HŁ, Price KL, Kolatsi-Joannou M, White KE, Henderson DJ, Dean CH, Cohen CD, Salama AD, Woolf AS, Long DA.

J Pathol. 2018 Dec;246(4):485-496. doi: 10.1002/path.5158.

15.

Urofacial Syndrome.

Newman WG, Woolf AS.

In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2019.
2013 Aug 22 [updated 2018 Jun 7].

16.

Functional molecules in mesothelial-to-mesenchymal transition revealed by transcriptome analyses.

Namvar S, Woolf AS, Zeef LA, Wilm T, Wilm B, Herrick SE.

J Pathol. 2018 Aug;245(4):491-501. doi: 10.1002/path.5101. Epub 2018 Jul 4.

17.

Generation of Functioning Nephrons by Implanting Human Pluripotent Stem Cell-Derived Kidney Progenitors.

Bantounas I, Ranjzad P, Tengku F, Silajdžić E, Forster D, Asselin MC, Lewis P, Lennon R, Plagge A, Wang Q, Woolf AS, Kimber SJ.

Stem Cell Reports. 2018 Mar 13;10(3):766-779. doi: 10.1016/j.stemcr.2018.01.008. Epub 2018 Feb 8.

18.

Publisher Correction: Genome-wide linkage and association study implicates the 10q26 region as a major genetic contributor to primary nonsyndromic vesicoureteric reflux.

Darlow JM, Darlay R, Dobson MG, Stewart A, Charoen P, Southgate J, Baker SC, Xu Y, Hunziker M, Lambert HJ, Green AJ, Santibanez-Koref M, Sayer JA, Goodship THJ, Puri P, Woolf AS, Kenda RB, Barton DE, Cordell HJ.

Sci Rep. 2018 Jan 8;8(1):459. doi: 10.1038/s41598-017-17992-w.

19.

ACTB Loss-of-Function Mutations Result in a Pleiotropic Developmental Disorder.

Cuvertino S, Stuart HM, Chandler KE, Roberts NA, Armstrong R, Bernardini L, Bhaskar S, Callewaert B, Clayton-Smith J, Davalillo CH, Deshpande C, Devriendt K, Digilio MC, Dixit A, Edwards M, Friedman JM, Gonzalez-Meneses A, Joss S, Kerr B, Lampe AK, Langlois S, Lennon R, Loget P, Ma DYT, McGowan R, Des Medt M, O'Sullivan J, Odent S, Parker MJ, Pebrel-Richard C, Petit F, Stark Z, Stockler-Ipsiroglu S, Tinschert S, Vasudevan P, Villa O, White SM, Zahir FR; DDD Study, Woolf AS, Banka S.

Am J Hum Genet. 2017 Dec 7;101(6):1021-1033. doi: 10.1016/j.ajhg.2017.11.006.

20.

Genome-wide linkage and association study implicates the 10q26 region as a major genetic contributor to primary nonsyndromic vesicoureteric reflux.

Darlow JM, Darlay R, Dobson MG, Stewart A, Charoen P, Southgate J, Baker SC, Xu Y, Hunziker M, Lambert HJ, Green AJ, Santibanez-Koref M, Sayer JA, Goodship THJ, Puri P, Woolf AS, Kenda RB, Barton DE, Cordell HJ.

Sci Rep. 2017 Nov 6;7(1):14595. doi: 10.1038/s41598-017-15062-9. Erratum in: Sci Rep. 2018 Jan 8;8(1):459.

21.

International multi-centre study of pregnancy outcomes with interleukin-1 inhibitors.

Youngstein T, Hoffmann P, Gül A, Lane T, Williams R, Rowczenio DM, Ozdogan H, Ugurlu S, Ryan J, Harty L, Riminton S, Headley AP, Roesler J, Blank N, Kuemmerle-Deschner JB, Simon A, Woolf AS, Hawkins PN, Lachmann HJ.

Rheumatology (Oxford). 2017 Dec 1;56(12):2102-2108. doi: 10.1093/rheumatology/kex305.

22.

A questionnaire survey of radiological diagnosis and management of renal dysplasia in children.

Montini G, Busutti M, Yalcinkaya F, Woolf AS, Weber S; European Society for Paediatric Nephrology Working Group on Congenital Anomalies of the Kidney and Urinary Tract.

J Nephrol. 2018 Feb;31(1):95-102. doi: 10.1007/s40620-017-0417-7. Epub 2017 Jun 24.

23.

ISL1 is a major susceptibility gene for classic bladder exstrophy and a regulator of urinary tract development.

Zhang R, Knapp M, Suzuki K, Kajioka D, Schmidt JM, Winkler J, Yilmaz Ö, Pleschka M, Cao J, Kockum CC, Barker G, Holmdahl G, Beaman G, Keene D, Woolf AS, Cervellione RM, Cheng W, Wilkins S, Gearhart JP, Sirchia F, Di Grazia M, Ebert AK, Rösch W, Ellinger J, Jenetzky E, Zwink N, Feitz WF, Marcelis C, Schumacher J, Martinón-Torres F, Hibberd ML, Khor CC, Heilmann-Heimbach S, Barth S, Boyadjiev SA, Brusco A, Ludwig M, Newman W, Nordenskjöld A, Yamada G, Odermatt B, Reutter H.

Sci Rep. 2017 Feb 8;7:42170. doi: 10.1038/srep42170.

24.

Exogenous transforming growth factor-β1 enhances smooth muscle differentiation in embryonic mouse jejunal explants.

Coletta R, Roberts NA, Randles MJ, Morabito A, Woolf AS.

J Tissue Eng Regen Med. 2018 Jan;12(1):252-264. doi: 10.1002/term.2409. Epub 2017 Apr 27.

25.

TSHZ3 deletion causes an autism syndrome and defects in cortical projection neurons.

Caubit X, Gubellini P, Andrieux J, Roubertoux PL, Metwaly M, Jacq B, Fatmi A, Had-Aissouni L, Kwan KY, Salin P, Carlier M, Liedén A, Rudd E, Shinawi M, Vincent-Delorme C, Cuisset JM, Lemaitre MP, Abderrehamane F, Duban B, Lemaitre JF, Woolf AS, Bockenhauer D, Severac D, Dubois E, Zhu Y, Sestan N, Garratt AN, Lydia Kerkerian-Le Goff, Fasano L.

Nat Genet. 2016 Nov;48(11):1359-1369. doi: 10.1038/ng.3681. Epub 2016 Sep 26.

26.

Planar cell polarity genes Celsr1 and Vangl2 are necessary for kidney growth, differentiation, and rostrocaudal patterning.

Brzóska HŁ, d'Esposito AM, Kolatsi-Joannou M, Patel V, Igarashi P, Lei Y, Finnell RH, Lythgoe MF, Woolf AS, Papakrivopoulou E, Long DA.

Kidney Int. 2016 Dec;90(6):1274-1284. doi: 10.1016/j.kint.2016.07.011. Epub 2016 Sep 2.

27.

Vascular growth factors play critical roles in kidney glomeruli.

Gnudi L, Benedetti S, Woolf AS, Long DA.

Clin Sci (Lond). 2015 Dec;129(12):1225-36. doi: 10.1042/CS20150403. Review.

PMID:
26561594
28.

Measures of kidney function by minimally invasive techniques correlate with histological glomerular damage in SCID mice with adriamycin-induced nephropathy.

Scarfe L, Rak-Raszewska A, Geraci S, Darssan D, Sharkey J, Huang J, Burton NC, Mason D, Ranjzad P, Kenny S, Gretz N, Lévy R, Kevin Park B, García-Fiñana M, Woolf AS, Murray P, Wilm B.

Sci Rep. 2015 Sep 2;5:13601. doi: 10.1038/srep13601.

29.

From gene discovery to new biological mechanisms: heparanases and congenital urinary bladder disease.

Roberts NA, Hilton EN, Woolf AS.

Nephrol Dial Transplant. 2016 Apr;31(4):534-40. doi: 10.1093/ndt/gfv309. Epub 2015 Aug 27. Review.

30.

Mutations in TBX18 Cause Dominant Urinary Tract Malformations via Transcriptional Dysregulation of Ureter Development.

Vivante A, Kleppa MJ, Schulz J, Kohl S, Sharma A, Chen J, Shril S, Hwang DY, Weiss AC, Kaminski MM, Shukrun R, Kemper MJ, Lehnhardt A, Beetz R, Sanna-Cherchi S, Verbitsky M, Gharavi AG, Stuart HM, Feather SA, Goodship JA, Goodship TH, Woolf AS, Westra SJ, Doody DP, Bauer SB, Lee RS, Adam RM, Lu W, Reutter HM, Kehinde EO, Mancini EJ, Lifton RP, Tasic V, Lienkamp SS, Jüppner H, Kispert A, Hildebrandt F.

Am J Hum Genet. 2015 Aug 6;97(2):291-301. doi: 10.1016/j.ajhg.2015.07.001. Epub 2015 Jul 30.

31.

Bridging the gap: functional healing of embryonic small intestine ex vivo.

Coletta R, Roberts NA, Oltrabella F, Khalil BA, Morabito A, Woolf AS.

J Tissue Eng Regen Med. 2016 Feb;10(2):178-82. doi: 10.1002/term.2073. Epub 2015 Aug 3.

32.

Vascular Endothelial Growth Factor C for Polycystic Kidney Diseases.

Huang JL, Woolf AS, Kolatsi-Joannou M, Baluk P, Sandford RN, Peters DJ, McDonald DM, Price KL, Winyard PJ, Long DA.

J Am Soc Nephrol. 2016 Jan;27(1):69-77. doi: 10.1681/ASN.2014090856. Epub 2015 Jun 2.

33.

Pinpointing clinical diagnosis through whole exome sequencing to direct patient care: a case of Senior-Loken syndrome.

Ellingford JM, Sergouniotis PI, Lennon R, Bhaskar S, Williams SG, Hillman KA, O'Sullivan J, Hall G, Ramsden SC, Lloyd IC, Woolf AS, Black GC.

Lancet. 2015 May 9;385(9980):1916. doi: 10.1016/S0140-6736(15)60496-2. No abstract available.

PMID:
25987160
34.

Genetic Background is a Key Determinant of Glomerular Extracellular Matrix Composition and Organization.

Randles MJ, Woolf AS, Huang JL, Byron A, Humphries JD, Price KL, Kolatsi-Joannou M, Collinson S, Denny T, Knight D, Mironov A, Starborg T, Korstanje R, Humphries MJ, Long DA, Lennon R.

J Am Soc Nephrol. 2015 Dec;26(12):3021-34. doi: 10.1681/ASN.2014040419. Epub 2015 Apr 20.

35.

Coinheritance of COL4A5 and MYO1E mutations accentuate the severity of kidney disease.

Lennon R, Stuart HM, Bierzynska A, Randles MJ, Kerr B, Hillman KA, Batra G, Campbell J, Storey H, Flinter FA, Koziell A, Welsh GI, Saleem MA, Webb NJ, Woolf AS.

Pediatr Nephrol. 2015 Sep;30(9):1459-65. doi: 10.1007/s00467-015-3067-9. Epub 2015 Mar 5.

36.

Urinary tract effects of HPSE2 mutations.

Stuart HM, Roberts NA, Hilton EN, McKenzie EA, Daly SB, Hadfield KD, Rahal JS, Gardiner NJ, Tanley SW, Lewis MA, Sites E, Angle B, Alves C, Lourenço T, Rodrigues M, Calado A, Amado M, Guerreiro N, Serras I, Beetz C, Varga RE, Silay MS, Darlow JM, Dobson MG, Barton DE, Hunziker M, Puri P, Feather SA, Goodship JA, Goodship TH, Lambert HJ, Cordell HJ; UK VUR Study Group, Saggar A, Kinali M; 4C Study Group, Lorenz C, Moeller K, Schaefer F, Bayazit AK, Weber S, Newman WG, Woolf AS.

J Am Soc Nephrol. 2015 Apr;26(4):797-804. doi: 10.1681/ASN.2013090961. Epub 2014 Aug 21.

37.

Representing kidney development using the gene ontology.

Alam-Faruque Y, Hill DP, Dimmer EC, Harris MA, Foulger RE, Tweedie S, Attrill H, Howe DG, Thomas SR, Davidson D, Woolf AS, Blake JA, Mungall CJ, O'Donovan C, Apweiler R, Huntley RP.

PLoS One. 2014 Jun 18;9(6):e99864. doi: 10.1371/journal.pone.0099864. eCollection 2014.

38.

Heparanase 2, mutated in urofacial syndrome, mediates peripheral neural development in Xenopus.

Roberts NA, Woolf AS, Stuart HM, Thuret R, McKenzie EA, Newman WG, Hilton EN.

Hum Mol Genet. 2014 Aug 15;23(16):4302-14. doi: 10.1093/hmg/ddu147. Epub 2014 Apr 1.

39.

Using stem and progenitor cells to recapitulate kidney development and restore renal function.

Murray PA, Woolf AS.

Curr Opin Organ Transplant. 2014 Apr;19(2):140-4. doi: 10.1097/MOT.0000000000000052. Review.

PMID:
24480967
40.

Cytokeratin 15 marks basal epithelia in developing ureters and is upregulated in a subset of urothelial cell carcinomas.

Tai G, Ranjzad P, Marriage F, Rehman S, Denley H, Dixon J, Mitchell K, Day PJ, Woolf AS.

PLoS One. 2013 Nov 18;8(11):e81167. doi: 10.1371/journal.pone.0081167. eCollection 2013.

41.

Targeted glomerular angiopoietin-1 therapy for early diabetic kidney disease.

Dessapt-Baradez C, Woolf AS, White KE, Pan J, Huang JL, Hayward AA, Price KL, Kolatsi-Joannou M, Locatelli M, Diennet M, Webster Z, Smillie SJ, Nair V, Kretzler M, Cohen CD, Long DA, Gnudi L.

J Am Soc Nephrol. 2014 Jan;25(1):33-42. doi: 10.1681/ASN.2012121218. Epub 2013 Sep 5.

42.

Urofacial syndrome: a genetic and congenital disease of aberrant urinary bladder innervation.

Woolf AS, Stuart HM, Roberts NA, McKenzie EA, Hilton EN, Newman WG.

Pediatr Nephrol. 2014 Apr;29(4):513-8. doi: 10.1007/s00467-013-2552-2. Epub 2013 Jul 9. Review.

PMID:
23832138
43.

Genetics of human congenital urinary bladder disease.

Woolf AS, Stuart HM, Newman WG.

Pediatr Nephrol. 2014 Mar;29(3):353-60. doi: 10.1007/s00467-013-2472-1. Epub 2013 Apr 13. Review.

PMID:
23584850
44.

Ex vivo modeling of chemical synergy in prenatal kidney cystogenesis.

Anders C, Ashton N, Ranjzad P, Dilworth MR, Woolf AS.

PLoS One. 2013;8(3):e57797. doi: 10.1371/journal.pone.0057797. Epub 2013 Mar 12.

45.

Albuminuria is associated with too few glomeruli and too much testosterone.

Long DA, Kolatsi-Joannou M, Price KL, Dessapt-Baradez C, Huang JL, Papakrivopoulou E, Hubank M, Korstanje R, Gnudi L, Woolf AS.

Kidney Int. 2013 Jun;83(6):1118-29. doi: 10.1038/ki.2013.45. Epub 2013 Feb 27.

46.

Circulating angiopoietin-2 is a marker for early cardiovascular disease in children on chronic dialysis.

Shroff RC, Price KL, Kolatsi-Joannou M, Todd AF, Wells D, Deanfield J, Johnson RJ, Rees L, Woolf AS, Long DA.

PLoS One. 2013;8(2):e56273. doi: 10.1371/journal.pone.0056273. Epub 2013 Feb 8.

47.

LRIG2 mutations cause urofacial syndrome.

Stuart HM, Roberts NA, Burgu B, Daly SB, Urquhart JE, Bhaskar S, Dickerson JE, Mermerkaya M, Silay MS, Lewis MA, Olondriz MB, Gener B, Beetz C, Varga RE, Gülpınar O, Süer E, Soygür T, Ozçakar ZB, Yalçınkaya F, Kavaz A, Bulum B, Gücük A, Yue WW, Erdogan F, Berry A, Hanley NA, McKenzie EA, Hilton EN, Woolf AS, Newman WG.

Am J Hum Genet. 2013 Feb 7;92(2):259-64. doi: 10.1016/j.ajhg.2012.12.002. Epub 2013 Jan 11.

48.

Cell biology of ureter development.

Woolf AS, Davies JA.

J Am Soc Nephrol. 2013 Jan;24(1):19-25. doi: 10.1681/ASN.2012020127. Epub 2012 Nov 2. Review.

49.

Development of embryonic stem cells in recombinant kidneys.

Rak-Raszewska A, Wilm B, Edgar D, Kenny S, Woolf AS, Murray P.

Organogenesis. 2012 Oct-Dec;8(4):125-36. doi: 10.4161/org.22597. Epub 2012 Oct 1.

50.

Sprouty1 haploinsufficiency prevents renal agenesis in a model of Fraser syndrome.

Pitera JE, Woolf AS, Basson MA, Scambler PJ.

J Am Soc Nephrol. 2012 Nov;23(11):1790-6. doi: 10.1681/ASN.2012020146. Epub 2012 Oct 11.

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