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Items: 1 to 50 of 135

1.

Complement alone drives efficacy of a chimeric antigonococcal monoclonal antibody.

Gulati S, Beurskens FJ, de Kreuk BJ, Roza M, Zheng B, DeOliveira RB, Shaughnessy J, Nowak NA, Taylor RP, Botto M, He X, Ingalls RR, Woodruff TM, Song WC, Schuurman J, Rice PA, Ram S.

PLoS Biol. 2019 Jun 19;17(6):e3000323. doi: 10.1371/journal.pbio.3000323. [Epub ahead of print]

2.

The Complement Receptor C5aR2: A Powerful Modulator of Innate and Adaptive Immunity.

Li XX, Lee JD, Kemper C, Woodruff TM.

J Immunol. 2019 Jun 15;202(12):3339-3348. doi: 10.4049/jimmunol.1900371. Review.

PMID:
31160390
3.

Gut microbiota in ALS: possible role in pathogenesis?

McCombe PA, Henderson RD, Lee A, Lee JD, Woodruff TM, Restuadi R, McRae A, Wray NR, Ngo S, Steyn FJ.

Expert Rev Neurother. 2019 May 29:1-21. doi: 10.1080/14737175.2019.1623026. [Epub ahead of print]

PMID:
31122082
4.

Phagocytosis of live and dead Escherichia coli and Staphylococcus aureus in human whole blood is markedly reduced by combined inhibition of C5aR1 and CD14.

Skjeflo EW, Christiansen D, Landsem A, Stenvik J, Woodruff TM, Espevik T, Nielsen EW, Mollnes TE.

Mol Immunol. 2019 May 15;112:131-139. doi: 10.1016/j.molimm.2019.03.014. [Epub ahead of print]

5.

Complement receptor C3aR1 controls neutrophil mobilization following spinal cord injury through physiological antagonism of CXCR2.

Brennan FH, Jogia T, Gillespie ER, Blomster LV, Li XX, Nowlan B, Williams GM, Jacobson E, Osborne GW, Meunier FA, Taylor SM, Campbell KE, MacDonald KP, Levesque JP, Woodruff TM, Ruitenberg MJ.

JCI Insight. 2019 May 2;4(9). pii: 98254. doi: 10.1172/jci.insight.98254. eCollection 2019 May 2.

6.

Partial ligand-receptor engagement yields functional bias at the human complement receptor, C5aR1.

Pandey S, Li XX, Srivastava A, Baidya M, Kumari P, Dwivedi H, Chaturvedi M, Ghosh E, Woodruff TM, Shukla AK.

J Biol Chem. 2019 Jun 14;294(24):9416-9429. doi: 10.1074/jbc.RA119.007485. Epub 2019 Apr 29.

PMID:
31036565
7.

Deletion of Biliverdin Reductase A in Myeloid Cells Promotes Chemokine Expression and Chemotaxis in Part via a Complement C5a--C5aR1 Pathway.

Bisht K, Canesin G, Cheytan T, Li M, Nemeth Z, Csizmadia E, Woodruff TM, Stec DE, Bulmer AC, Otterbein LE, Wegiel B.

J Immunol. 2019 May 15;202(10):2982-2990. doi: 10.4049/jimmunol.1701443. Epub 2019 Apr 5.

PMID:
30952817
8.

Revisiting the role of the innate immune complement system in ALS.

Parker SE, Hanton AM, Stefanou SN, Noakes PG, Woodruff TM, Lee JD.

Neurobiol Dis. 2019 Jul;127:223-232. doi: 10.1016/j.nbd.2019.03.003. Epub 2019 Mar 6. Review.

PMID:
30849511
9.

Therapeutic blockade of HMGB1 reduces early motor deficits, but not survival in the SOD1G93A mouse model of amyotrophic lateral sclerosis.

Lee JD, Liu N, Levin SC, Ottosson L, Andersson U, Harris HE, Woodruff TM.

J Neuroinflammation. 2019 Feb 19;16(1):45. doi: 10.1186/s12974-019-1435-2.

10.

C5aR1 regulates T follicular helper differentiation and chronic graft-versus-host disease bronchiolitis obliterans.

Verghese DA, Chun N, Paz K, Fribourg M, Woodruff TM, Flynn R, Hu Y, Xiong H, Zhang W, Yi Z, Du J, Blazar BR, Heeger PS.

JCI Insight. 2018 Dec 20;3(24). pii: 124646. doi: 10.1172/jci.insight.124646.

11.

Characterisation of small molecule ligands 4CMTB and 2CTAP as modulators of human FFA2 receptor signalling.

Schofield ZV, Croker D, Robertson AAB, Massey NL, Donovan C, Tee E, Edwards D, Woodruff TM, Halai R, Hansbro PM, Cooper MA.

Sci Rep. 2018 Dec 13;8(1):17819. doi: 10.1038/s41598-018-36242-1.

12.

Inflammasomes in CNS Diseases.

Albornoz EA, Woodruff TM, Gordon R.

Exp Suppl. 2018;108:41-60. doi: 10.1007/978-3-319-89390-7_3.

PMID:
30536167
13.

Complement C3a receptor modulates embryonic neural progenitor cell proliferation and cognitive performance.

Coulthard LG, Hawksworth OA, Conroy J, Lee JD, Woodruff TM.

Mol Immunol. 2018 Sep;101:176-181. doi: 10.1016/j.molimm.2018.06.271. Epub 2018 Jun 27.

PMID:
30449309
14.

Complement component 5 does not interfere with physiological hemostasis but is essential for Escherichia coli-induced coagulation accompanied by Toll-like receptor 4.

Landsem A, Fure H, Krey Ludviksen J, Christiansen D, Lau C, Mathisen M, Bergseth G, Nymo S, Lappegård KT, Woodruff TM, Espevik T, Mollnes TE, Brekke OL.

Clin Exp Immunol. 2019 Apr;196(1):97-110. doi: 10.1111/cei.13240. Epub 2018 Dec 19.

15.

Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice.

Gordon R, Albornoz EA, Christie DC, Langley MR, Kumar V, Mantovani S, Robertson AAB, Butler MS, Rowe DB, O'Neill LA, Kanthasamy AG, Schroder K, Cooper MA, Woodruff TM.

Sci Transl Med. 2018 Oct 31;10(465). pii: eaah4066. doi: 10.1126/scitranslmed.aah4066.

PMID:
30381407
16.

New tricks for an ancient system: Physiological and pathological roles of complement in the CNS.

Tenner AJ, Stevens B, Woodruff TM.

Mol Immunol. 2018 Oct;102:3-13. doi: 10.1016/j.molimm.2018.06.264. Epub 2018 Jun 27. Review.

PMID:
29958698
17.

Complement components are upregulated and correlate with disease progression in the TDP-43Q331K mouse model of amyotrophic lateral sclerosis.

Lee JD, Levin SC, Willis EF, Li R, Woodruff TM, Noakes PG.

J Neuroinflammation. 2018 Jun 1;15(1):171. doi: 10.1186/s12974-018-1217-2.

18.

Development and validation of a LC-MS/MS assay for pharmacokinetic studies of complement C5a receptor antagonists PMX53 and PMX205 in mice.

Kumar V, Lee JD, Clark RJ, Woodruff TM.

Sci Rep. 2018 May 25;8(1):8101. doi: 10.1038/s41598-018-26387-4.

19.

Systemic inhibition of the membrane attack complex impedes neuroinflammation in chronic relapsing experimental autoimmune encephalomyelitis.

Michailidou I, Jongejan A, Vreijling JP, Georgakopoulou T, de Wissel MB, Wolterman RA, Ruizendaal P, Klar-Mohamad N, Grootemaat AE, Picavet DI, Kumar V, van Kooten C, Woodruff TM, Morgan BP, van der Wel NN, Ramaglia V, Fluiter K, Baas F.

Acta Neuropathol Commun. 2018 May 3;6(1):36. doi: 10.1186/s40478-018-0536-y.

20.

Complement: The Emerging Architect of the Developing Brain.

Coulthard LG, Hawksworth OA, Woodruff TM.

Trends Neurosci. 2018 Jun;41(6):373-384. doi: 10.1016/j.tins.2018.03.009. Epub 2018 Mar 29. Review.

PMID:
29606485
21.

Complement in stem cells and development.

Hawksworth OA, Coulthard LG, Mantovani S, Woodruff TM.

Semin Immunol. 2018 Jun;37:74-84. doi: 10.1016/j.smim.2018.02.009. Epub 2018 Mar 8. Review.

PMID:
29525104
22.

Chronic Helminth Infection Perturbs the Gut-Brain Axis, Promotes Neuropathology, and Alters Behavior.

Giacomin PR, Kraeuter AK, Albornoz EA, Jin S, Bengtsson M, Gordon R, Woodruff TM, Urich T, Sarnyai Z, Soares Magalhães RJ.

J Infect Dis. 2018 Sep 22;218(9):1511-1516. doi: 10.1093/infdis/jiy092.

PMID:
29462492
23.

Staphylococcus aureus-induced complement activation promotes tissue factor-mediated coagulation.

Skjeflo EW, Christiansen D, Fure H, Ludviksen JK, Woodruff TM, Espevik T, Nielsen EW, Brekke OL, Mollnes TE.

J Thromb Haemost. 2018 May;16(5):905-918. doi: 10.1111/jth.13979. Epub 2018 Mar 23.

PMID:
29437288
24.

T Cell Expression of C5a Receptor 2 Augments Murine Regulatory T Cell (TREG) Generation and TREG-Dependent Cardiac Allograft Survival.

A Verghese D, Demir M, Chun N, Fribourg M, Cravedi P, Llaudo I, Woodruff TM, Yadav P, Lira SA, Medof ME, Heeger PS.

J Immunol. 2018 Mar 15;200(6):2186-2198. doi: 10.4049/jimmunol.1701638. Epub 2018 Feb 7.

25.

Complement C5a Receptor 1 Exacerbates the Pathophysiology of N. meningitidis Sepsis and Is a Potential Target for Disease Treatment.

Herrmann JB, Muenstermann M, Strobel L, Schubert-Unkmeir A, Woodruff TM, Gray-Owen SD, Klos A, Johswich KO.

MBio. 2018 Jan 23;9(1). pii: e01755-17. doi: 10.1128/mBio.01755-17.

26.

Role of complement anaphylatoxin receptors in a mouse model of acute burn-induced pain.

Morgan M, Deuis JR, Woodruff TM, Lewis RJ, Vetter I.

Mol Immunol. 2018 Feb;94:68-74. doi: 10.1016/j.molimm.2017.12.016. Epub 2017 Dec 21.

PMID:
29274925
27.

C5a receptor 1 promotes autoimmunity, neutrophil dysfunction and injury in experimental anti-myeloperoxidase glomerulonephritis.

Dick J, Gan PY, Ford SL, Odobasic D, Alikhan MA, Loosen SH, Hall P, Westhorpe CL, Li A, Ooi JD, Woodruff TM, Mackay CR, Kitching AR, Hickey MJ, Holdsworth SR.

Kidney Int. 2018 Mar;93(3):615-625. doi: 10.1016/j.kint.2017.09.018. Epub 2017 Dec 12.

PMID:
29241626
28.

Monitoring C5aR2 Expression Using a Floxed tdTomato-C5aR2 Knock-In Mouse.

Karsten CM, Wiese AV, Mey F, Figge J, Woodruff TM, Reuter T, Scurtu O, Kordowski A, Almeida LN, Briukhovetska D, Quell KM, Sun J, Ender F, Schmudde I, Vollbrandt T, Laumonnier Y, Köhl J.

J Immunol. 2017 Nov 1;199(9):3234-3248. doi: 10.4049/jimmunol.1700710. Epub 2017 Sep 1.

29.

Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation.

Chen W, Foo SS, Zaid A, Teng TS, Herrero LJ, Wolf S, Tharmarajah K, Vu LD, van Vreden C, Taylor A, Freitas JR, Li RW, Woodruff TM, Gordon R, Ojcius DM, Nakaya HI, Kanneganti TD, O'Neill LAJ, Robertson AAB, King NJ, Suhrbier A, Cooper MA, Ng LFP, Mahalingam S.

Nat Microbiol. 2017 Oct;2(10):1435-1445. doi: 10.1038/s41564-017-0015-4. Epub 2017 Aug 28.

PMID:
28848230
30.

The Ketone Body β-Hydroxybutyrate Does Not Inhibit Synuclein Mediated Inflammasome Activation in Microglia.

Deora V, Albornoz EA, Zhu K, Woodruff TM, Gordon R.

J Neuroimmune Pharmacol. 2017 Dec;12(4):568-574. doi: 10.1007/s11481-017-9754-5. Epub 2017 Aug 23.

PMID:
28836226
31.

Serping1/C1 Inhibitor Affects Cortical Development in a Cell Autonomous and Non-cell Autonomous Manner.

Gorelik A, Sapir T, Woodruff TM, Reiner O.

Front Cell Neurosci. 2017 Jun 16;11:169. doi: 10.3389/fncel.2017.00169. eCollection 2017.

32.

New concepts on the therapeutic control of complement anaphylatoxin receptors.

Hawksworth OA, Li XX, Coulthard LG, Wolvetang EJ, Woodruff TM.

Mol Immunol. 2017 Sep;89:36-43. doi: 10.1016/j.molimm.2017.05.015. Epub 2017 May 30. Review.

PMID:
28576324
33.

Complement C5a-C5aR1 signalling drives skeletal muscle macrophage recruitment in the hSOD1G93A mouse model of amyotrophic lateral sclerosis.

Wang HA, Lee JD, Lee KM, Woodruff TM, Noakes PG.

Skelet Muscle. 2017 Jun 1;7(1):10. doi: 10.1186/s13395-017-0128-8.

34.

Developmental activities of the complement pathway in migrating neurons.

Gorelik A, Sapir T, Haffner-Krausz R, Olender T, Woodruff TM, Reiner O.

Nat Commun. 2017 May 2;8:15096. doi: 10.1038/ncomms15096.

35.

Complement C5aR1 Signaling Promotes Polarization and Proliferation of Embryonic Neural Progenitor Cells through PKCζ.

Coulthard LG, Hawksworth OA, Li R, Balachandran A, Lee JD, Sepehrband F, Kurniawan N, Jeanes A, Simmons DG, Wolvetang E, Woodruff TM.

J Neurosci. 2017 May 31;37(22):5395-5407. doi: 10.1523/JNEUROSCI.0525-17.2017. Epub 2017 Apr 28.

36.

The Alternative Receptor for Complement Component 5a, C5aR2, Conveys Neuroprotection in Traumatic Spinal Cord Injury.

Biggins PJC, Brennan FH, Taylor SM, Woodruff TM, Ruitenberg MJ.

J Neurotrauma. 2017 Jun 15;34(12):2075-2085. doi: 10.1089/neu.2016.4701. Epub 2017 Apr 26.

PMID:
28173736
37.

Pharmacological inhibition of complement C5a-C5a1 receptor signalling ameliorates disease pathology in the hSOD1G93A mouse model of amyotrophic lateral sclerosis.

Lee JD, Kumar V, Fung JN, Ruitenberg MJ, Noakes PG, Woodruff TM.

Br J Pharmacol. 2017 Apr;174(8):689-699. doi: 10.1111/bph.13730. Epub 2017 Mar 3.

38.

Properdin deficiency protects from 5-fluorouracil-induced small intestinal mucositis in a complement activation-independent, interleukin-10-dependent mechanism.

Jain U, Midgen CA, Woodruff TM, Schwaeble WJ, Stover CM, Stadnyk AW.

Clin Exp Immunol. 2017 Apr;188(1):36-44. doi: 10.1111/cei.12922. Epub 2017 Jan 31.

39.

Noninvasive assessment of altered activity following restraint in mice using an automated physiological monitoring system.

Spiers JG, Chen HC, Steyn FJ, Lavidis NA, Woodruff TM, Lee JD.

Stress. 2017 Jan;20(1):59-67. doi: 10.1080/10253890.2016.1276898. Epub 2017 Jan 17.

PMID:
28027673
40.

Complement in the fundamental processes of the cell.

Hawksworth OA, Coulthard LG, Woodruff TM.

Mol Immunol. 2017 Apr;84:17-25. doi: 10.1016/j.molimm.2016.11.010. Epub 2016 Nov 25. Review.

PMID:
27894513
41.

Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration.

Gordon R, Neal ML, Luo J, Langley MR, Harischandra DS, Panicker N, Charli A, Jin H, Anantharam V, Woodruff TM, Zhou QY, Kanthasamy AG, Kanthasamy A.

Nat Commun. 2016 Oct 5;7:12932. doi: 10.1038/ncomms12932.

42.

T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4⁺ T cells.

Arbore G, West EE, Spolski R, Robertson AAB, Klos A, Rheinheimer C, Dutow P, Woodruff TM, Yu ZX, O'Neill LA, Coll RC, Sher A, Leonard WJ, Köhl J, Monk P, Cooper MA, Arno M, Afzali B, Lachmann HJ, Cope AP, Mayer-Barber KD, Kemper C.

Science. 2016 Jun 17;352(6292):aad1210. doi: 10.1126/science.aad1210.

43.

Release of bioactive peptides from polyurethane films in vitro and in vivo: Effect of polymer composition.

Zhang J, Woodruff TM, Clark RJ, Martin DJ, Minchin RF.

Acta Biomater. 2016 Sep 1;41:264-72. doi: 10.1016/j.actbio.2016.05.034. Epub 2016 May 28.

PMID:
27245428
44.

C5a induces caspase-dependent apoptosis in brain vascular endothelial cells in experimental lupus.

Mahajan SD, Tutino VM, Redae Y, Meng H, Siddiqui A, Woodruff TM, Jarvis JN, Hennon T, Schwartz S, Quigg RJ, Alexander JJ.

Immunology. 2016 Aug;148(4):407-19. doi: 10.1111/imm.12619. Epub 2016 Jul 11.

45.

Comparison of Measured to Predicted Estimations of Nonpoint Source Contaminants Using Conservation Practices in an Agriculturally-Dominated Watershed in Northeast Arkansas, USA.

Frasher SK, Woodruff TM, Bouldin JL.

Bull Environ Contam Toxicol. 2016 Jun;96(6):762-6. doi: 10.1007/s00128-016-1823-6. Epub 2016 May 19.

PMID:
27194420
46.

The Complement C3a Receptor Contributes to Melanoma Tumorigenesis by Inhibiting Neutrophil and CD4+ T Cell Responses.

Nabizadeh JA, Manthey HD, Steyn FJ, Chen W, Widiapradja A, Md Akhir FN, Boyle GM, Taylor SM, Woodruff TM, Rolfe BE.

J Immunol. 2016 Jun 1;196(11):4783-92. doi: 10.4049/jimmunol.1600210. Epub 2016 Apr 20.

47.

The Complement System Component C5a Produces Thermal Hyperalgesia via Macrophage-to-Nociceptor Signaling That Requires NGF and TRPV1.

Shutov LP, Warwick CA, Shi X, Gnanasekaran A, Shepherd AJ, Mohapatra DP, Woodruff TM, Clark JD, Usachev YM.

J Neurosci. 2016 May 4;36(18):5055-70. doi: 10.1523/JNEUROSCI.3249-15.2016.

48.

Discovery of functionally selective C5aR2 ligands: novel modulators of C5a signalling.

Croker DE, Monk PN, Halai R, Kaeslin G, Schofield Z, Wu MC, Clark RJ, Blaskovich MA, Morikis D, Floudas CA, Cooper MA, Woodruff TM.

Immunol Cell Biol. 2016 Sep;94(8):787-95. doi: 10.1038/icb.2016.43. Epub 2016 Apr 25.

49.

Therapeutic targeting of complement to modify disease course and improve outcomes in neurological conditions.

Brennan FH, Lee JD, Ruitenberg MJ, Woodruff TM.

Semin Immunol. 2016 Jun;28(3):292-308. doi: 10.1016/j.smim.2016.03.015. Epub 2016 Apr 3. Review.

PMID:
27049459
50.

Contribution of the anaphylatoxin receptors, C3aR and C5aR, to the pathogenesis of pulmonary fibrosis.

Gu H, Fisher AJ, Mickler EA, Duerson F 3rd, Cummings OW, Peters-Golden M, Twigg HL 3rd, Woodruff TM, Wilkes DS, Vittal R.

FASEB J. 2016 Jun;30(6):2336-50. doi: 10.1096/fj.201500044. Epub 2016 Mar 8.

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