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Items: 1 to 50 of 120

1.

New tricks for an ancient system: Physiological and pathological roles of complement in the CNS.

Tenner AJ, Stevens B, Woodruff TM.

Mol Immunol. 2018 Jun 27. pii: S0161-5890(18)30466-8. doi: 10.1016/j.molimm.2018.06.264. [Epub ahead of print]

PMID:
29958698
2.

Complement components are upregulated and correlate with disease progression in the TDP-43Q331K mouse model of amyotrophic lateral sclerosis.

Lee JD, Levin SC, Willis EF, Li R, Woodruff TM, Noakes PG.

J Neuroinflammation. 2018 Jun 1;15(1):171. doi: 10.1186/s12974-018-1217-2.

3.

Development and validation of a LC-MS/MS assay for pharmacokinetic studies of complement C5a receptor antagonists PMX53 and PMX205 in mice.

Kumar V, Lee JD, Clark RJ, Woodruff TM.

Sci Rep. 2018 May 25;8(1):8101. doi: 10.1038/s41598-018-26387-4.

4.

Systemic inhibition of the membrane attack complex impedes neuroinflammation in chronic relapsing experimental autoimmune encephalomyelitis.

Michailidou I, Jongejan A, Vreijling JP, Georgakopoulou T, de Wissel MB, Wolterman RA, Ruizendaal P, Klar-Mohamad N, Grootemaat AE, Picavet DI, Kumar V, van Kooten C, Woodruff TM, Morgan BP, van der Wel NN, Ramaglia V, Fluiter K, Baas F.

Acta Neuropathol Commun. 2018 May 3;6(1):36. doi: 10.1186/s40478-018-0536-y.

5.

Complement: The Emerging Architect of the Developing Brain.

Coulthard LG, Hawksworth OA, Woodruff TM.

Trends Neurosci. 2018 Jun;41(6):373-384. doi: 10.1016/j.tins.2018.03.009. Epub 2018 Mar 29. Review.

PMID:
29606485
6.

Complement in stem cells and development.

Hawksworth OA, Coulthard LG, Mantovani S, Woodruff TM.

Semin Immunol. 2018 Jun;37:74-84. doi: 10.1016/j.smim.2018.02.009. Epub 2018 Mar 8. Review.

PMID:
29525104
7.

Chronic helminth infection perturbs the gut-brain axis, promotes neuropathology and alters behaviour.

Giacomin PR, Kraeuter AK, Albornoz EA, Jin S, Bengtsson M, Gordon R, Woodruff TM, Urich T, Sarnyai Z, Soares Magalhães RJ.

J Infect Dis. 2018 Feb 15. doi: 10.1093/infdis/jiy092. [Epub ahead of print]

PMID:
29462492
8.

Staphylococcus aureus-induced complement activation promotes tissue factor-mediated coagulation.

Skjeflo EW, Christiansen D, Fure H, Ludviksen JK, Woodruff TM, Espevik T, Nielsen EW, Brekke OL, Mollnes TE.

J Thromb Haemost. 2018 May;16(5):905-918. doi: 10.1111/jth.13979. Epub 2018 Mar 23.

PMID:
29437288
9.

T Cell Expression of C5a Receptor 2 Augments Murine Regulatory T Cell (TREG) Generation and TREG-Dependent Cardiac Allograft Survival.

A Verghese D, Demir M, Chun N, Fribourg M, Cravedi P, Llaudo I, Woodruff TM, Yadav P, Lira SA, Medof ME, Heeger PS.

J Immunol. 2018 Mar 15;200(6):2186-2198. doi: 10.4049/jimmunol.1701638. Epub 2018 Feb 7.

PMID:
29436411
10.

Complement C5a Receptor 1 Exacerbates the Pathophysiology of N. meningitidis Sepsis and Is a Potential Target for Disease Treatment.

Herrmann JB, Muenstermann M, Strobel L, Schubert-Unkmeir A, Woodruff TM, Gray-Owen SD, Klos A, Johswich KO.

MBio. 2018 Jan 23;9(1). pii: e01755-17. doi: 10.1128/mBio.01755-17.

11.

Role of complement anaphylatoxin receptors in a mouse model of acute burn-induced pain.

Morgan M, Deuis JR, Woodruff TM, Lewis RJ, Vetter I.

Mol Immunol. 2018 Feb;94:68-74. doi: 10.1016/j.molimm.2017.12.016. Epub 2017 Dec 21.

PMID:
29274925
12.

C5a receptor 1 promotes autoimmunity, neutrophil dysfunction and injury in experimental anti-myeloperoxidase glomerulonephritis.

Dick J, Gan PY, Ford SL, Odobasic D, Alikhan MA, Loosen SH, Hall P, Westhorpe CL, Li A, Ooi JD, Woodruff TM, Mackay CR, Kitching AR, Hickey MJ, Holdsworth SR.

Kidney Int. 2018 Mar;93(3):615-625. doi: 10.1016/j.kint.2017.09.018. Epub 2017 Dec 12.

PMID:
29241626
13.

Monitoring C5aR2 Expression Using a Floxed tdTomato-C5aR2 Knock-In Mouse.

Karsten CM, Wiese AV, Mey F, Figge J, Woodruff TM, Reuter T, Scurtu O, Kordowski A, Almeida LN, Briukhovetska D, Quell KM, Sun J, Ender F, Schmudde I, Vollbrandt T, Laumonnier Y, Köhl J.

J Immunol. 2017 Nov 1;199(9):3234-3248. doi: 10.4049/jimmunol.1700710. Epub 2017 Sep 1.

PMID:
28864475
14.

Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation.

Chen W, Foo SS, Zaid A, Teng TS, Herrero LJ, Wolf S, Tharmarajah K, Vu LD, van Vreden C, Taylor A, Freitas JR, Li RW, Woodruff TM, Gordon R, Ojcius DM, Nakaya HI, Kanneganti TD, O'Neill LAJ, Robertson AAB, King NJ, Suhrbier A, Cooper MA, Ng LFP, Mahalingam S.

Nat Microbiol. 2017 Oct;2(10):1435-1445. doi: 10.1038/s41564-017-0015-4. Epub 2017 Aug 28.

PMID:
28848230
15.

The Ketone Body β-Hydroxybutyrate Does Not Inhibit Synuclein Mediated Inflammasome Activation in Microglia.

Deora V, Albornoz EA, Zhu K, Woodruff TM, Gordon R.

J Neuroimmune Pharmacol. 2017 Dec;12(4):568-574. doi: 10.1007/s11481-017-9754-5. Epub 2017 Aug 23.

PMID:
28836226
16.

Serping1/C1 Inhibitor Affects Cortical Development in a Cell Autonomous and Non-cell Autonomous Manner.

Gorelik A, Sapir T, Woodruff TM, Reiner O.

Front Cell Neurosci. 2017 Jun 16;11:169. doi: 10.3389/fncel.2017.00169. eCollection 2017.

17.

New concepts on the therapeutic control of complement anaphylatoxin receptors.

Hawksworth OA, Li XX, Coulthard LG, Wolvetang EJ, Woodruff TM.

Mol Immunol. 2017 Sep;89:36-43. doi: 10.1016/j.molimm.2017.05.015. Epub 2017 May 30. Review.

PMID:
28576324
18.

Complement C5a-C5aR1 signalling drives skeletal muscle macrophage recruitment in the hSOD1G93A mouse model of amyotrophic lateral sclerosis.

Wang HA, Lee JD, Lee KM, Woodruff TM, Noakes PG.

Skelet Muscle. 2017 Jun 1;7(1):10. doi: 10.1186/s13395-017-0128-8.

19.

Developmental activities of the complement pathway in migrating neurons.

Gorelik A, Sapir T, Haffner-Krausz R, Olender T, Woodruff TM, Reiner O.

Nat Commun. 2017 May 2;8:15096. doi: 10.1038/ncomms15096.

20.

Complement C5aR1 Signaling Promotes Polarization and Proliferation of Embryonic Neural Progenitor Cells through PKCζ.

Coulthard LG, Hawksworth OA, Li R, Balachandran A, Lee JD, Sepehrband F, Kurniawan N, Jeanes A, Simmons DG, Wolvetang E, Woodruff TM.

J Neurosci. 2017 May 31;37(22):5395-5407. doi: 10.1523/JNEUROSCI.0525-17.2017. Epub 2017 Apr 28.

21.

The Alternative Receptor for Complement Component 5a, C5aR2, Conveys Neuroprotection in Traumatic Spinal Cord Injury.

Biggins PJC, Brennan FH, Taylor SM, Woodruff TM, Ruitenberg MJ.

J Neurotrauma. 2017 Jun 15;34(12):2075-2085. doi: 10.1089/neu.2016.4701. Epub 2017 Apr 26.

PMID:
28173736
22.

Pharmacological inhibition of complement C5a-C5a1 receptor signalling ameliorates disease pathology in the hSOD1G93A mouse model of amyotrophic lateral sclerosis.

Lee JD, Kumar V, Fung JN, Ruitenberg MJ, Noakes PG, Woodruff TM.

Br J Pharmacol. 2017 Apr;174(8):689-699. doi: 10.1111/bph.13730. Epub 2017 Mar 3.

23.

Properdin deficiency protects from 5-fluorouracil-induced small intestinal mucositis in a complement activation-independent, interleukin-10-dependent mechanism.

Jain U, Midgen CA, Woodruff TM, Schwaeble WJ, Stover CM, Stadnyk AW.

Clin Exp Immunol. 2017 Apr;188(1):36-44. doi: 10.1111/cei.12922. Epub 2017 Jan 31.

24.

Noninvasive assessment of altered activity following restraint in mice using an automated physiological monitoring system.

Spiers JG, Chen HC, Steyn FJ, Lavidis NA, Woodruff TM, Lee JD.

Stress. 2017 Jan;20(1):59-67. doi: 10.1080/10253890.2016.1276898. Epub 2017 Jan 17.

PMID:
28027673
25.

Complement in the fundamental processes of the cell.

Hawksworth OA, Coulthard LG, Woodruff TM.

Mol Immunol. 2017 Apr;84:17-25. doi: 10.1016/j.molimm.2016.11.010. Epub 2016 Nov 25. Review.

PMID:
27894513
26.

Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration.

Gordon R, Neal ML, Luo J, Langley MR, Harischandra DS, Panicker N, Charli A, Jin H, Anantharam V, Woodruff TM, Zhou QY, Kanthasamy AG, Kanthasamy A.

Nat Commun. 2016 Oct 5;7:12932. doi: 10.1038/ncomms12932.

27.

T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4⁺ T cells.

Arbore G, West EE, Spolski R, Robertson AAB, Klos A, Rheinheimer C, Dutow P, Woodruff TM, Yu ZX, O'Neill LA, Coll RC, Sher A, Leonard WJ, Köhl J, Monk P, Cooper MA, Arno M, Afzali B, Lachmann HJ, Cope AP, Mayer-Barber KD, Kemper C.

Science. 2016 Jun 17;352(6292):aad1210. doi: 10.1126/science.aad1210.

28.

Release of bioactive peptides from polyurethane films in vitro and in vivo: Effect of polymer composition.

Zhang J, Woodruff TM, Clark RJ, Martin DJ, Minchin RF.

Acta Biomater. 2016 Sep 1;41:264-72. doi: 10.1016/j.actbio.2016.05.034. Epub 2016 May 28.

PMID:
27245428
29.

C5a induces caspase-dependent apoptosis in brain vascular endothelial cells in experimental lupus.

Mahajan SD, Tutino VM, Redae Y, Meng H, Siddiqui A, Woodruff TM, Jarvis JN, Hennon T, Schwartz S, Quigg RJ, Alexander JJ.

Immunology. 2016 Aug;148(4):407-19. doi: 10.1111/imm.12619. Epub 2016 Jul 11.

30.

Comparison of Measured to Predicted Estimations of Nonpoint Source Contaminants Using Conservation Practices in an Agriculturally-Dominated Watershed in Northeast Arkansas, USA.

Frasher SK, Woodruff TM, Bouldin JL.

Bull Environ Contam Toxicol. 2016 Jun;96(6):762-6. doi: 10.1007/s00128-016-1823-6. Epub 2016 May 19.

PMID:
27194420
31.

The Complement C3a Receptor Contributes to Melanoma Tumorigenesis by Inhibiting Neutrophil and CD4+ T Cell Responses.

Nabizadeh JA, Manthey HD, Steyn FJ, Chen W, Widiapradja A, Md Akhir FN, Boyle GM, Taylor SM, Woodruff TM, Rolfe BE.

J Immunol. 2016 Jun 1;196(11):4783-92. doi: 10.4049/jimmunol.1600210. Epub 2016 Apr 20.

32.

The Complement System Component C5a Produces Thermal Hyperalgesia via Macrophage-to-Nociceptor Signaling That Requires NGF and TRPV1.

Shutov LP, Warwick CA, Shi X, Gnanasekaran A, Shepherd AJ, Mohapatra DP, Woodruff TM, Clark JD, Usachev YM.

J Neurosci. 2016 May 4;36(18):5055-70. doi: 10.1523/JNEUROSCI.3249-15.2016.

33.

Discovery of functionally selective C5aR2 ligands: novel modulators of C5a signalling.

Croker DE, Monk PN, Halai R, Kaeslin G, Schofield Z, Wu MC, Clark RJ, Blaskovich MA, Morikis D, Floudas CA, Cooper MA, Woodruff TM.

Immunol Cell Biol. 2016 Sep;94(8):787-95. doi: 10.1038/icb.2016.43. Epub 2016 Apr 25.

34.

Therapeutic targeting of complement to modify disease course and improve outcomes in neurological conditions.

Brennan FH, Lee JD, Ruitenberg MJ, Woodruff TM.

Semin Immunol. 2016 Jun;28(3):292-308. doi: 10.1016/j.smim.2016.03.015. Epub 2016 Apr 3. Review.

PMID:
27049459
35.

Contribution of the anaphylatoxin receptors, C3aR and C5aR, to the pathogenesis of pulmonary fibrosis.

Gu H, Fisher AJ, Mickler EA, Duerson F 3rd, Cummings OW, Peters-Golden M, Twigg HL 3rd, Woodruff TM, Wilkes DS, Vittal R.

FASEB J. 2016 Jun;30(6):2336-50. doi: 10.1096/fj.201500044. Epub 2016 Mar 8.

36.

Motor deficits associated with Huntington's disease occur in the absence of striatal degeneration in BACHD transgenic mice.

Mantovani S, Gordon R, Li R, Christie DC, Kumar V, Woodruff TM.

Hum Mol Genet. 2016 May 1;25(9):1780-91. doi: 10.1093/hmg/ddw050. Epub 2016 Feb 21.

PMID:
26908618
37.

Autoantibodies against homocysteinylated protein in a mouse model of folate deficiency-induced neural tube defects.

Denny KJ, Kelly CF, Kumar V, Witham KL, Cabrera RM, Finnell RH, Taylor SM, Jeanes A, Woodruff TM.

Birth Defects Res A Clin Mol Teratol. 2016 Mar;106(3):201-7. doi: 10.1002/bdra.23483. Epub 2016 Feb 22.

38.

EPHA4-FC TREATMENT REDUCES ISCHEMIA/REPERFUSION-INDUCED INTESTINAL INJURY BY INHIBITING VASCULAR PERMEABILITY.

Woodruff TM, Wu MC, Morgan M, Bain NT, Jeanes A, Lipman J, Ting MJ, Boyd AW, Taylor SM, Coulthard MG.

Shock. 2016 Feb;45(2):184-91. doi: 10.1097/SHK.0000000000000494.

PMID:
26771935
39.

The Receptor for Advanced Glycation Endproducts Does Not Contribute to Pathology in a Mouse Mesenteric Ischemia/Reperfusion-Induced Injury Model.

Wu MC, Gilmour TD, Mantovani S, Woodruff TM.

Front Immunol. 2015 Dec 7;6:614. doi: 10.3389/fimmu.2015.00614. eCollection 2015.

40.

Co-ordinated expression of innate immune molecules during mouse neurulation.

Jeanes A, Coulthard LG, Mantovani S, Markham K, Woodruff TM.

Mol Immunol. 2015 Dec;68(2 Pt A):253-60. doi: 10.1016/j.molimm.2015.09.004. Epub 2015 Sep 14.

PMID:
26383831
41.

Placental lipase expression in pregnancies complicated by preeclampsia: a case-control study.

Barrett HL, Kubala MH, Scholz Romero K, Denny KJ, Woodruff TM, McIntyre HD, Callaway LK, Dekker Nitert M.

Reprod Biol Endocrinol. 2015 Sep 4;13:100. doi: 10.1186/s12958-015-0098-9.

42.

Altered expression of metabolic proteins and adipokines in patients with amyotrophic lateral sclerosis.

Ngo ST, Steyn FJ, Huang L, Mantovani S, Pfluger CM, Woodruff TM, O'Sullivan JD, Henderson RD, McCombe PA.

J Neurol Sci. 2015 Oct 15;357(1-2):22-7. doi: 10.1016/j.jns.2015.06.053. Epub 2015 Jul 6.

43.
44.

C5a alters blood-brain barrier integrity in a human in vitro model of systemic lupus erythematosus.

Mahajan SD, Parikh NU, Woodruff TM, Jarvis JN, Lopez M, Hennon T, Cunningham P, Quigg RJ, Schwartz SA, Alexander JJ.

Immunology. 2015 Sep;146(1):130-43. doi: 10.1111/imm.12489. Epub 2015 Jul 15.

45.
46.

Absence of toll-like receptor 4 (TLR4) extends survival in the hSOD1 G93A mouse model of amyotrophic lateral sclerosis.

Lee JY, Lee JD, Phipps S, Noakes PG, Woodruff TM.

J Neuroinflammation. 2015 May 13;12:90. doi: 10.1186/s12974-015-0310-z.

47.

The Complement Receptor C5aR Controls Acute Inflammation and Astrogliosis following Spinal Cord Injury.

Brennan FH, Gordon R, Lao HW, Biggins PJ, Taylor SM, Franklin RJ, Woodruff TM, Ruitenberg MJ.

J Neurosci. 2015 Apr 22;35(16):6517-31. doi: 10.1523/JNEUROSCI.5218-14.2015.

48.

Is the complement activation product C3a a proinflammatory molecule? Re-evaluating the evidence and the myth.

Coulthard LG, Woodruff TM.

J Immunol. 2015 Apr 15;194(8):3542-8. doi: 10.4049/jimmunol.1403068. Review.

49.

The Role of C5a Receptor Signaling in Endotoxin-Induced Miscarriage and Preterm Birth.

Denny KJ, Coulthard LG, Mantovani S, Simmons D, Taylor SM, Woodruff TM.

Am J Reprod Immunol. 2015 Aug;74(2):148-55. doi: 10.1111/aji.12386. Epub 2015 Apr 6.

PMID:
25846074
50.

Properdin provides protection from Citrobacter rodentium-induced intestinal inflammation in a C5a/IL-6-dependent manner.

Jain U, Cao Q, Thomas NA, Woodruff TM, Schwaeble WJ, Stover CM, Stadnyk AW.

J Immunol. 2015 Apr 1;194(7):3414-21. doi: 10.4049/jimmunol.1401814. Epub 2015 Feb 27.

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