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Items: 1 to 50 of 127

1.

Shear stress sensitizes TRPV4 in endothelium-dependent vasodilatation.

Darby WG, Potocnik S, Ramachandran R, Hollenberg MD, Woodman OL, McIntyre P.

Pharmacol Res. 2018 May 19;133:152-159. doi: 10.1016/j.phrs.2018.05.009. [Epub ahead of print]

PMID:
29787869
2.

Flavonols and flavones - protecting against myocardial ischemia/reperfusion injury by targeting protein kinases.

Woodman OL, Chin KY, Thomas CJ, Ng DCH, May CN.

Curr Med Chem. 2018 Mar 26. doi: 10.2174/0929867325666180326161730. [Epub ahead of print]

PMID:
29589528
3.

Protection against reperfusion injury by 3',4'-dihydroxyflavonol in rat isolated hearts involves inhibition of phospholamban and JNK2.

Chin KY, Silva LS, Darby IA, Ng DCH, Woodman OL.

Int J Cardiol. 2018 Mar 1;254:265-271. doi: 10.1016/j.ijcard.2017.11.101. Epub 2018 Jan 28.

PMID:
29407107
4.

3',4'-dihydroxyflavonol ameliorates endoplasmic reticulum stress-induced apoptosis and endothelial dysfunction in mice.

Lau YS, Mustafa MR, Choy KW, Chan SMH, Potocnik S, Herbert TP, Woodman OL.

Sci Rep. 2018 Jan 29;8(1):1818. doi: 10.1038/s41598-018-19584-8.

5.

A Functional Kinase Short Interfering Ribonucleic Acid Screen Using Protease-Activated Receptor 2-Dependent Opening of Transient Receptor Potential Vanilloid-4.

Darby WG, Grace MS, Simpson KJ, Woodman OL, McIntyre P.

Assay Drug Dev Technol. 2018 Jan;16(1):15-26. doi: 10.1089/adt.2017.799. Epub 2017 Nov 17.

PMID:
29148820
6.

Angiotensin II Causes β-Cell Dysfunction Through an ER Stress-Induced Proinflammatory Response.

Chan SMH, Lau YS, Miller AA, Ku JM, Potocnik S, Ye JM, Woodman OL, Herbert TP.

Endocrinology. 2017 Oct 1;158(10):3162-3173. doi: 10.1210/en.2016-1879.

PMID:
28938442
7.

Molecular Sensors of Blood Flow in Endothelial Cells.

Baratchi S, Khoshmanesh K, Woodman OL, Potocnik S, Peter K, McIntyre P.

Trends Mol Med. 2017 Sep;23(9):850-868. doi: 10.1016/j.molmed.2017.07.007. Epub 2017 Aug 12. Review.

PMID:
28811171
8.

Chronic NaHS treatment decreases oxidative stress and improves endothelial function in diabetic mice.

Ng HH, Yildiz GS, Ku JM, Miller AA, Woodman OL, Hart JL.

Diab Vasc Dis Res. 2017 May;14(3):246-253. doi: 10.1177/1479164117692766. Epub 2017 Feb 1.

PMID:
28467198
9.

Western Diet Chow Consumption in Rats Induces Striatal Neuronal Activation While Reducing Dopamine Levels without Affecting Spatial Memory in the Radial Arm Maze.

Nguyen JC, Ali SF, Kosari S, Woodman OL, Spencer SJ, Killcross AS, Jenkins TA.

Front Behav Neurosci. 2017 Feb 9;11:22. doi: 10.3389/fnbeh.2017.00022. eCollection 2017.

10.
11.

The HNO donor Angeli's salt offers potential haemodynamic advantages over NO or dobutamine in ischaemia-reperfusion injury in the rat heart ex vivo.

Chin KY, Michel L, Qin CX, Cao N, Woodman OL, Ritchie RH.

Pharmacol Res. 2016 Feb;104:165-75. doi: 10.1016/j.phrs.2015.12.006. Epub 2015 Dec 30.

PMID:
26747404
12.

The Dipeptidyl Peptidase-4 Inhibitor Linagliptin Preserves Endothelial Function in Mesenteric Arteries from Type 1 Diabetic Rats without Decreasing Plasma Glucose.

Salheen SM, Panchapakesan U, Pollock CA, Woodman OL.

PLoS One. 2015 Nov 30;10(11):e0143941. doi: 10.1371/journal.pone.0143941. eCollection 2015.

13.

New Pharmacological Approaches to the Prevention of Myocardial Ischemia- Reperfusion Injury.

Chin KY, Qin C, May L, Ritchie RH, Woodman OL.

Curr Drug Targets. 2017;18(15):1689-1711. doi: 10.2174/1389450116666151001112020. Review.

PMID:
26424394
14.
15.

Evidence that the MEK/ERK but not the PI3K/Akt pathway is required for protection from myocardial ischemia-reperfusion injury by 3',4'-dihydroxyflavonol.

Thomas CJ, Lim NR, Kedikaetswe A, Yeap YY, Woodman OL, Ng DC, May CN.

Eur J Pharmacol. 2015 Jul 5;758:53-9. doi: 10.1016/j.ejphar.2015.03.054. Epub 2015 Mar 25.

PMID:
25820159
16.

The DPP-4 inhibitor linagliptin and the GLP-1 receptor agonist exendin-4 improve endothelium-dependent relaxation of rat mesenteric arteries in the presence of high glucose.

Salheen SM, Panchapakesan U, Pollock CA, Woodman OL.

Pharmacol Res. 2015 Apr;94:26-33. doi: 10.1016/j.phrs.2015.02.003. Epub 2015 Feb 16.

PMID:
25697548
17.

Cardioprotective potential of annexin-A1 mimetics in myocardial infarction.

Qin C, Yang YH, May L, Gao X, Stewart AG, Tu Y, Woodman OL, Ritchie RH.

Pharmacol Ther. 2015 Apr;148:47-65. doi: 10.1016/j.pharmthera.2014.11.012. Epub 2014 Nov 25. Review.

PMID:
25460034
18.

Flavonols in the Prevention of Diabetes-induced Vascular Dysfunction.

Leo CH, Woodman OL.

J Cardiovasc Pharmacol. 2015 Jun;65(6):532-44. doi: 10.1097/FJC.0000000000000180. Review.

19.

Microglia are selectively activated in endocrine and cardiovascular control centres in streptozotocin-induced diabetic rats.

Rana I, Badoer E, Alahmadi E, Leo CH, Woodman OL, Stebbing MJ.

J Neuroendocrinol. 2014 Jul;26(7):413-25. doi: 10.1111/jne.12161.

PMID:
24762326
20.

The flavonols quercetin and 3',4'-dihydroxyflavonol reduce platelet function and delay thrombus formation in a model of type 1 diabetes.

Mosawy S, Jackson DE, Woodman OL, Linden MD.

Diab Vasc Dis Res. 2014 May;11(3):174-81. doi: 10.1177/1479164114524234. Epub 2014 Mar 12.

PMID:
24623318
21.

The cardioprotectant 3',4'-dihydroxyflavonol inhibits opening of the mitochondrial permeability transition pore after myocardial ischemia and reperfusion in rats.

Woodman OL, Long R, Pons S, Eychenne N, Berdeaux A, Morin D.

Pharmacol Res. 2014 Mar;81:26-33. doi: 10.1016/j.phrs.2014.01.004. Epub 2014 Feb 9.

PMID:
24521796
22.
23.

Effect of type 1 diabetes on the production and vasoactivity of hydrogen sulfide in rat middle cerebral arteries.

Streeter EY, Badoer E, Woodman OL, Hart JL.

Physiol Rep. 2013 Oct;1(5):e00111. doi: 10.1002/phy2.111. Epub 2013 Oct 20.

24.

Cardioprotective 3',4'-dihydroxyflavonol attenuation of JNK and p38(MAPK) signalling involves CaMKII inhibition.

Lim NR, Thomas CJ, Silva LS, Yeap YY, Yap S, Bell JR, Delbridge LM, Bogoyevitch MA, Woodman OL, Williams SJ, May CN, Ng DC.

Biochem J. 2013 Dec 1;456(2):149-61. doi: 10.1042/BJ20121538.

PMID:
24032640
25.

Low intrinsic exercise capacity in rats predisposes to age-dependent cardiac remodeling independent of macrovascular function.

Ritchie RH, Leo CH, Qin C, Stephenson EJ, Bowden MA, Buxton KD, Lessard SJ, Rivas DA, Koch LG, Britton SL, Hawley JA, Woodman OL.

Am J Physiol Heart Circ Physiol. 2013 Mar 1;304(5):H729-39. doi: 10.1152/ajpheart.00638.2012. Epub 2012 Dec 21.

26.

Inhibition of platelet-mediated arterial thrombosis and platelet granule exocytosis by 3',4'-dihydroxyflavonol and quercetin.

Mosawy S, Jackson DE, Woodman OL, Linden MD.

Platelets. 2013;24(8):594-604. doi: 10.3109/09537104.2012.749396. Epub 2012 Dec 18.

PMID:
23249183
27.

Treatment with quercetin and 3',4'-dihydroxyflavonol inhibits platelet function and reduces thrombus formation in vivo.

Mosawy S, Jackson DE, Woodman OL, Linden MD.

J Thromb Thrombolysis. 2013 Jul;36(1):50-7. doi: 10.1007/s11239-012-0827-2.

PMID:
23070586
28.

Increased nitric oxide activity compensates for increased oxidative stress to maintain endothelial function in rat aorta in early type 1 diabetes.

Joshi A, Woodman OL.

Naunyn Schmiedebergs Arch Pharmacol. 2012 Nov;385(11):1083-94. doi: 10.1007/s00210-012-0794-3. Epub 2012 Sep 11.

PMID:
22965470
29.

Endothelium-dependent nitroxyl-mediated relaxation is resistant to superoxide anion scavenging and preserved in diabetic rat aorta.

Leo CH, Joshi A, Hart JL, Woodman OL.

Pharmacol Res. 2012 Nov;66(5):383-91. doi: 10.1016/j.phrs.2012.07.010. Epub 2012 Aug 9.

PMID:
22898326
30.

2-Morpholinoisoflav-3-enes as flexible intermediates in the synthesis of phenoxodiol, isophenoxodiol, equol and analogues: vasorelaxant properties, estrogen receptor binding and Rho/RhoA kinase pathway inhibition.

Tilley AJ, Zanatta SD, Qin CX, Kim IK, Seok YM, Stewart A, Woodman OL, Williams SJ.

Bioorg Med Chem. 2012 Apr 1;20(7):2353-61. doi: 10.1016/j.bmc.2012.02.008. Epub 2012 Feb 11.

PMID:
22377671
31.

3',4'-Dihydroxyflavonol reduces vascular contraction through Ca²⁺ desensitization in permeabilized rat mesenteric artery.

Kim HY, Seok YM, Woodman OL, Williams SJ, Kim IK.

Naunyn Schmiedebergs Arch Pharmacol. 2012 Feb;385(2):191-202. doi: 10.1007/s00210-011-0697-8. Epub 2011 Oct 14.

PMID:
21993847
32.

3',4'-Dihydroxyflavonol antioxidant attenuates diastolic dysfunction and cardiac remodeling in streptozotocin-induced diabetic m(Ren2)27 rats.

Khong FL, Zhang Y, Edgley AJ, Qi W, Connelly KA, Woodman OL, Krum H, Kelly DJ.

PLoS One. 2011;6(7):e22777. doi: 10.1371/journal.pone.0022777. Epub 2011 Jul 28.

33.

Antioxidant activity contributes to flavonol cardioprotection during reperfusion of rat hearts.

Qin CX, Williams SJ, Woodman OL.

Free Radic Biol Med. 2011 Oct 1;51(7):1437-44. doi: 10.1016/j.freeradbiomed.2011.07.003. Epub 2011 Jul 18.

PMID:
21801832
34.

3',4'-Dihydroxyflavonol reduces superoxide and improves nitric oxide function in diabetic rat mesenteric arteries.

Leo CH, Hart JL, Woodman OL.

PLoS One. 2011;6(6):e20813. doi: 10.1371/journal.pone.0020813. Epub 2011 Jun 6.

35.

The ethanolic extract of Kaempferia parviflora reduces ischaemic injury in rat isolated hearts.

Malakul W, Ingkaninan K, Sawasdee P, Woodman OL.

J Ethnopharmacol. 2011 Sep 1;137(1):184-91. doi: 10.1016/j.jep.2011.05.004. Epub 2011 May 10.

PMID:
21600275
36.

Synthesis of a hypoxia-targeted conjugate of the cardioprotective agent 3',4'-dihydroxyflavonol and evaluation of its ability to reduce ischaemia/reperfusion injury.

Yap S, Woodman OL, Crack PJ, Williams SJ.

Bioorg Med Chem Lett. 2011 Sep 1;21(17):5102-6. doi: 10.1016/j.bmcl.2011.03.040. Epub 2011 Mar 17.

PMID:
21470863
37.

3',4'-Dihydroxyflavonol restores endothelium-dependent relaxation in small mesenteric artery from rats with type 1 and type 2 diabetes.

Leo CH, Hart JL, Woodman OL.

Eur J Pharmacol. 2011 Jun 1;659(2-3):193-8. doi: 10.1016/j.ejphar.2011.03.018. Epub 2011 Mar 29.

PMID:
21453697
38.

Cardioprotection from ischaemia-reperfusion injury by a novel flavonol that reduces activation of p38 MAPK.

Thomas CJ, Ng DC, Patsikatheodorou N, Limengka Y, Lee MW, Darby IA, Woodman OL, May CN.

Eur J Pharmacol. 2011 May 11;658(2-3):160-7. doi: 10.1016/j.ejphar.2011.02.041. Epub 2011 Mar 1.

PMID:
21371449
39.

Comprehensive two-dimensional gas chromatography, retention indices and time-of-flight mass spectra of flavonoids and chalcones.

Gao X, Williams SJ, Woodman OL, Marriott PJ.

J Chromatogr A. 2010 Dec 24;1217(52):8317-26. doi: 10.1016/j.chroma.2010.10.093. Epub 2010 Oct 30.

PMID:
21094947
40.

Modulation of the glucagon-like peptide-1 receptor signaling by naturally occurring and synthetic flavonoids.

Wootten D, Simms J, Koole C, Woodman OL, Summers RJ, Christopoulos A, Sexton PM.

J Pharmacol Exp Ther. 2011 Feb;336(2):540-50. doi: 10.1124/jpet.110.176362. Epub 2010 Nov 12.

41.

Impairment of both nitric oxide-mediated and EDHF-type relaxation in small mesenteric arteries from rats with streptozotocin-induced diabetes.

Leo CH, Hart JL, Woodman OL.

Br J Pharmacol. 2011 Jan;162(2):365-77. doi: 10.1111/j.1476-5381.2010.01023.x.

42.

Effects of resveratrol and flavonols on cardiovascular function: Physiological mechanisms.

Yap S, Qin C, Woodman OL.

Biofactors. 2010 Sep-Oct;36(5):350-9. doi: 10.1002/biof.111. Review.

PMID:
20803524
43.

Allosteric ligands of the glucagon-like peptide 1 receptor (GLP-1R) differentially modulate endogenous and exogenous peptide responses in a pathway-selective manner: implications for drug screening.

Koole C, Wootten D, Simms J, Valant C, Sridhar R, Woodman OL, Miller LJ, Summers RJ, Christopoulos A, Sexton PM.

Mol Pharmacol. 2010 Sep;78(3):456-65. doi: 10.1124/mol.110.065664. Epub 2010 Jun 14.

44.

Short-term type 1 diabetes alters the mechanism of endothelium-dependent relaxation in the rat carotid artery.

Leo CH, Joshi A, Woodman OL.

Am J Physiol Heart Circ Physiol. 2010 Aug;299(2):H502-11. doi: 10.1152/ajpheart.01197.2009. Epub 2010 Jun 11.

45.

Effects of 3',4'-dihydroxyflavonol on vascular contractions of rat aortic rings.

Song MJ, Baek I, Seo M, Kim SH, Suk K, Woodman OL, Williams SJ, Kim IK.

Clin Exp Pharmacol Physiol. 2010 Aug;37(8):803-10. doi: 10.1111/j.1440-1681.2010.05384.x. Epub 2010 Mar 30.

PMID:
20374259
46.

High-fructose diet elevates myocardial superoxide generation in mice in the absence of cardiac hypertrophy.

Mellor K, Ritchie RH, Meredith G, Woodman OL, Morris MJ, Delbridge LM.

Nutrition. 2010 Jul-Aug;26(7-8):842-8. doi: 10.1016/j.nut.2009.08.017. Epub 2009 Nov 20.

PMID:
19932004
47.

Antioxidants in the prevention of myocardial ischemia/reperfusion injury.

Qin C, Yap S, Woodman OL.

Expert Rev Clin Pharmacol. 2009 Nov;2(6):673-95. doi: 10.1586/ecp.09.41.

PMID:
22112260
48.

3',4'-Dihydroxyflavonol improves post-ischaemic coronary endothelial function following 7days reperfusion in sheep.

Wang S, Thomas CJ, Dusting GJ, Woodman OL, May CN.

Eur J Pharmacol. 2009 Dec 10;624(1-3):31-7. doi: 10.1016/j.ejphar.2009.10.001. Epub 2009 Oct 13.

PMID:
19825372
49.

3',4'-Dihydroxyflavonol prevents diabetes-induced endothelial dysfunction in rat aorta.

Woodman OL, Malakul W.

Life Sci. 2009 Jul 3;85(1-2):54-9. doi: 10.1016/j.lfs.2009.04.012. Epub 2009 May 3.

PMID:
19409910
50.

Discovery of water-soluble antioxidant flavonols without vasorelaxant activity.

Yap S, Loft KJ, Woodman OL, Williams SJ.

ChemMedChem. 2008 Oct;3(10):1572-9. doi: 10.1002/cmdc.200800146.

PMID:
18756557

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