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Items: 49

1.

The central role of the tail in switching off 10S myosin II activity.

Yang S, Lee KH, Woodhead JL, Sato O, Ikebe M, Craig R.

J Gen Physiol. 2019 Aug 6. pii: jgp.201912431. doi: 10.1085/jgp.201912431. [Epub ahead of print]

PMID:
31387899
2.

Analyzing the Mechanisms Behind Macrolide Antibiotic-Induced Liver Injury Using Quantitative Systems Toxicology Modeling.

Woodhead JL, Yang K, Oldach D, MacLauchlin C, Fernandes P, Watkins PB, Siler SQ, Howell BA.

Pharm Res. 2019 Feb 7;36(3):48. doi: 10.1007/s11095-019-2582-y.

3.

Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-Induced Liver Injury.

Longo DM, Woodhead JL, Walker P, Herédi-Szabó K, Mogyorósi K, Wolenski FS, Dragan YP, Mosedale M, Siler SQ, Watkins PB, Howell BA.

Toxicol Sci. 2019 Feb 1;167(2):458-467. doi: 10.1093/toxsci/kfy253.

4.

Prediction of Safety Margin and Optimization of Dosing Protocol for a Novel Antibiotic using Quantitative Systems Pharmacology Modeling.

Woodhead JL, Paech F, Maurer M, Engelhardt M, Schmitt-Hoffmann AH, Spickermann J, Messner S, Wind M, Witschi AT, Krähenbühl S, Siler SQ, Watkins PB, Howell BA.

Clin Transl Sci. 2018 Sep;11(5):498-505. doi: 10.1111/cts.12560. Epub 2018 Jun 7.

5.

The role of quantitative systems pharmacology modeling in the prediction and explanation of idiosyncratic drug-induced liver injury.

Woodhead JL, Watkins PB, Howell BA, Siler SQ, Shoda LKM.

Drug Metab Pharmacokinet. 2017 Feb;32(1):40-45. doi: 10.1016/j.dmpk.2016.11.008. Epub 2016 Nov 21. Review.

6.

Systems pharmacology modeling of drug-induced hyperbilirubinemia: Differentiating hepatotoxicity and inhibition of enzymes/transporters.

Yang K, Battista C, Woodhead JL, Stahl SH, Mettetal JT, Watkins PB, Siler SQ, Howell BA.

Clin Pharmacol Ther. 2017 Apr;101(4):501-509. doi: 10.1002/cpt.619. Epub 2017 Feb 17.

7.

Application of a Mechanistic Model to Evaluate Putative Mechanisms of Tolvaptan Drug-Induced Liver Injury and Identify Patient Susceptibility Factors.

Woodhead JL, Brock WJ, Roth SE, Shoaf SE, Brouwer KL, Church R, Grammatopoulos TN, Stiles L, Siler SQ, Howell BA, Mosedale M, Watkins PB, Shoda LK.

Toxicol Sci. 2017 Jan;155(1):61-74. doi: 10.1093/toxsci/kfw193. Epub 2016 Sep 21.

8.

Sandwich-Cultured Hepatocytes as a Tool to Study Drug Disposition and Drug-Induced Liver Injury.

Yang K, Guo C, Woodhead JL, St Claire RL 3rd, Watkins PB, Siler SQ, Howell BA, Brouwer KLR.

J Pharm Sci. 2016 Feb;105(2):443-459. doi: 10.1016/j.xphs.2015.11.008. Review.

9.

An approach to improve the resolution of helical filaments with a large axial rise and flexible subunits.

Yang S, Woodhead JL, Zhao FQ, Sulbarán G, Craig R.

J Struct Biol. 2016 Jan;193(1):45-54. doi: 10.1016/j.jsb.2015.11.007. Epub 2015 Nov 22.

10.

Through Thick and Thin--Interfilament Communication in Muscle.

Woodhead JL, Craig R.

Biophys J. 2015 Aug 18;109(4):665-7. doi: 10.1016/j.bpj.2015.07.019. No abstract available.

11.

MITOsym®: A Mechanistic, Mathematical Model of Hepatocellular Respiration and Bioenergetics.

Yang Y, Nadanaciva S, Will Y, Woodhead JL, Howell BA, Watkins PB, Siler SQ.

Pharm Res. 2015 Jun;32(6):1975-92. doi: 10.1007/s11095-014-1591-0. Epub 2014 Dec 12.

12.

Exploring BSEP inhibition-mediated toxicity with a mechanistic model of drug-induced liver injury.

Woodhead JL, Yang K, Siler SQ, Watkins PB, Brouwer KL, Barton HA, Howell BA.

Front Pharmacol. 2014 Nov 7;5:240. doi: 10.3389/fphar.2014.00240. eCollection 2014.

13.

Systems pharmacology modeling predicts delayed presentation and species differences in bile acid-mediated troglitazone hepatotoxicity.

Yang K, Woodhead JL, Watkins PB, Howell BA, Brouwer KL.

Clin Pharmacol Ther. 2014 Nov;96(5):589-98. doi: 10.1038/clpt.2014.158. Epub 2014 Jul 28.

14.

Mechanistic Modeling Reveals the Critical Knowledge Gaps in Bile Acid-Mediated DILI.

Woodhead JL, Yang K, Brouwer KL, Siler SQ, Stahl SH, Ambroso JL, Baker D, Watkins PB, Howell BA.

CPT Pharmacometrics Syst Pharmacol. 2014 Jul 9;3:e123. doi: 10.1038/psp.2014.21.

15.

A mechanistic model of drug-induced liver injury AIDS the interpretation of elevated liver transaminase levels in a phase I clinical trial.

Howell BA, Siler SQ, Shoda LK, Yang Y, Woodhead JL, Watkins PB.

CPT Pharmacometrics Syst Pharmacol. 2014 Feb 5;3:e98. doi: 10.1038/psp.2013.74.

16.

Linking physiology to toxicity using DILIsym®, a mechanistic mathematical model of drug-induced liver injury.

Shoda LK, Woodhead JL, Siler SQ, Watkins PB, Howell BA.

Biopharm Drug Dispos. 2014 Jan;35(1):33-49. doi: 10.1002/bdd.1878. Epub 2013 Nov 25. Review.

PMID:
24214486
17.

Structural basis of the relaxed state of a Ca2+-regulated myosin filament and its evolutionary implications.

Woodhead JL, Zhao FQ, Craig R.

Proc Natl Acad Sci U S A. 2013 May 21;110(21):8561-6. doi: 10.1073/pnas.1218462110. Epub 2013 May 6.

18.

Modeling drug- and chemical-induced hepatotoxicity with systems biology approaches.

Bhattacharya S, Shoda LK, Zhang Q, Woods CG, Howell BA, Siler SQ, Woodhead JL, Yang Y, McMullen P, Watkins PB, Andersen ME.

Front Physiol. 2012 Dec 14;3:462. doi: 10.3389/fphys.2012.00462. eCollection 2012.

19.

In vitro to in vivo extrapolation and species response comparisons for drug-induced liver injury (DILI) using DILIsym™: a mechanistic, mathematical model of DILI.

Howell BA, Yang Y, Kumar R, Woodhead JL, Harrill AH, Clewell HJ 3rd, Andersen ME, Siler SQ, Watkins PB.

J Pharmacokinet Pharmacodyn. 2012 Oct;39(5):527-41. doi: 10.1007/s10928-012-9266-0. Epub 2012 Aug 9.

PMID:
22875368
20.

An analysis of N-acetylcysteine treatment for acetaminophen overdose using a systems model of drug-induced liver injury.

Woodhead JL, Howell BA, Yang Y, Harrill AH, Clewell HJ 3rd, Andersen ME, Siler SQ, Watkins PB.

J Pharmacol Exp Ther. 2012 Aug;342(2):529-40. doi: 10.1124/jpet.112.192930. Epub 2012 May 16.

PMID:
22593093
21.
22.

Simulation of micelle formation in the presence of solutes.

Woodhead JL, Hall CK.

Langmuir. 2010 Oct 5;26(19):15135-41. doi: 10.1021/la1024444.

PMID:
20825214
23.

Head-head interaction characterizes the relaxed state of Limulus muscle myosin filaments.

Zhao FQ, Craig R, Woodhead JL.

J Mol Biol. 2009 Jan 16;385(2):423-31. doi: 10.1016/j.jmb.2008.10.038. Epub 2008 Oct 19.

24.

Electron-phonon interactions in ce3+-doped yttrium aluminum garnet nanophosphors.

Su LT, Tok AI, Zhao Y, Ng N, Boey FY, Woodhead JL, Summers CJ.

J Phys Chem B. 2008 Sep 4;112(35):10830-2. doi: 10.1021/jp803179r. Epub 2008 Aug 12.

PMID:
18698711
25.

Three-dimensional structure of vertebrate cardiac muscle myosin filaments.

Zoghbi ME, Woodhead JL, Moss RL, Craig R.

Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2386-90. doi: 10.1073/pnas.0708912105. Epub 2008 Feb 5.

26.

Structure and function of myosin filaments.

Craig R, Woodhead JL.

Curr Opin Struct Biol. 2006 Apr;16(2):204-12. Epub 2006 Mar 24. Review.

PMID:
16563742
27.

Atomic model of a myosin filament in the relaxed state.

Woodhead JL, Zhao FQ, Craig R, Egelman EH, Alamo L, Padrón R.

Nature. 2005 Aug 25;436(7054):1195-9.

PMID:
16121187
28.

Helical order in tarantula thick filaments requires the "closed" conformation of the myosin head.

Zoghbi ME, Woodhead JL, Craig R, Padrón R.

J Mol Biol. 2004 Sep 24;342(4):1223-36.

PMID:
15351647
29.

The structure of lipoprotein(a) and ligand-induced conformational changes.

Weisel JW, Nagaswami C, Woodhead JL, Higazi AA, Cain WJ, Marcovina SM, Koschinsky ML, Cines DB, Bdeir K.

Biochemistry. 2001 Sep 4;40(35):10424-35.

PMID:
11523984
30.

The tip of the coiled-coil rod determines the filament formation of smooth muscle and nonmuscle myosin.

Ikebe M, Komatsu S, Woodhead JL, Mabuchi K, Ikebe R, Saito J, Craig R, Higashihara M.

J Biol Chem. 2001 Aug 10;276(32):30293-300. Epub 2001 Jun 6.

31.

Efficient rooting and acclimation of micropropagated Ruppia maritima Loisel.

Woodhead JL, Bird KT.

J Mar Biotechnol. 1998 Aug;6(3):152-6.

PMID:
9701636
32.

The ultrastructure of fibrinogen Caracas II molecules, fibers, and clots.

Woodhead JL, Nagaswami C, Matsuda M, Arocha-Piñango CL, Weisel JW.

J Biol Chem. 1996 Mar 1;271(9):4946-53.

33.

Fibrinogen Dusart: electron microscopy of molecules, fibers and clots, and viscoelastic properties of clots.

Collet JP, Woodhead JL, Soria J, Soria C, Mirshahi M, Caen JP, Weisel JW.

Biophys J. 1996 Jan;70(1):500-10.

34.

The chicken muscle thick filament: temperature and the relaxed cross-bridge arrangement.

Kensler RW, Woodhead JL.

J Muscle Res Cell Motil. 1995 Feb;16(1):79-90.

PMID:
7751407
35.
36.
37.

Effects of phosphorylation by myosin light chain kinase on the structure of Limulus thick filaments.

Levine RJ, Chantler PD, Kensler RW, Woodhead JL.

J Cell Biol. 1991 May;113(3):563-72.

38.

Crosslinking of single-stranded DNA to resins.

Woodhead JL, Langdale JA, Malcolm AD.

Methods Mol Biol. 1988;4:431-6. doi: 10.1385/0-89603-127-6:431.

PMID:
21424654
39.

Detection of DNA sequences using biotinylated probes.

Woodhead JL, Figueiredo H, Malcolm AD.

Methods Mol Biol. 1988;4:425-30. doi: 10.1385/0-89603-127-6:425.

PMID:
21424653
40.

Luminescent detection of specific DNA sequences.

Woodhead JL, Figueiredo H, Malcolm AD.

Methods Mol Biol. 1988;4:421-4. doi: 10.1385/0-89603-127-6:421.

PMID:
21424652
41.

Enzyme-labeled DNA probes.

Woodhead JL, Fallon R, Figueiredo H, Malcolm AD.

Methods Mol Biol. 1988;4:415-20. doi: 10.1385/0-89603-127-6:415.

PMID:
21424651
42.

DNA probes in human disease.

Malcolm AD, Fallon RA, Langdale JA, Figueiredo H, Nicholls PJ, Voss UB, Wickenden C, Woodhead JL.

Biochem Soc Symp. 1987;53:131-43. Review.

PMID:
3332764
43.
44.

Size and shape of skeletal muscle M-protein.

Woodhead JL, Lowey S.

J Mol Biol. 1982 May 5;157(1):149-54. No abstract available.

PMID:
7108956
45.

The essential carboxyl group in restriction endonuclease EcoRI.

Woodhead JL, Malcolm AD.

Eur J Biochem. 1981 Nov;120(1):125-8.

46.

Cation dependence of restriction endonuclease EcoRI activity.

Woodhead JL, Bhave N, Malcolm AD.

Eur J Biochem. 1981 Apr;115(2):293-6.

47.

Cation-dependence of the restriction endodeoxyribonuclease EcoRI.

Bhave N, Woodhead JL, Malcolm AD.

Biochem Soc Trans. 1980 Oct;8(5):634. No abstract available.

PMID:
6256238
48.

Restriction endonuclease EcoR1 binds non-specifically to deoxyribonucleic acid [proceedings].

Woodhead JL, Malcolm AD.

Biochem Soc Trans. 1980 Feb;8(1):90-1. No abstract available.

PMID:
6245965
49.

Non-specific binding of restriction endonuclease EcoR1 to DNA.

Woodhead JL, Malcolm AD.

Nucleic Acids Res. 1980 Jan 25;8(2):389-402.

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