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Items: 1 to 50 of 232

1.

Polypharmacological Profiles Underlying the Antitumor Property of Salvia miltiorrhiza Root (Danshen) Interfering with NOX-Dependent Neutrophil Extracellular Traps.

Tao L, Xu M, Dai X, Ni T, Li D, Jin F, Wang H, Tao L, Pan B, Woodgett JR, Qian Y, Liu Y.

Oxid Med Cell Longev. 2018 Aug 19;2018:4908328. doi: 10.1155/2018/4908328. eCollection 2018.

2.

A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases.

Garzia L, Kijima N, Morrissy AS, De Antonellis P, Guerreiro-Stucklin A, Holgado BL, Wu X, Wang X, Parsons M, Zayne K, Manno A, Kuzan-Fischer C, Nor C, Donovan LK, Liu J, Qin L, Garancher A, Liu KW, Mansouri S, Luu B, Thompson YY, Ramaswamy V, Peacock J, Farooq H, Skowron P, Shih DJH, Li A, Ensan S, Robbins CS, Cybulsky M, Mitra S, Ma Y, Moore R, Mungall A, Cho YJ, Weiss WA, Chan JA, Hawkins CE, Massimino M, Jabado N, Zapotocky M, Sumerauer D, Bouffet E, Dirks P, Tabori U, Sorensen PHB, Brastianos PK, Aldape K, Jones SJM, Marra MA, Woodgett JR, Wechsler-Reya RJ, Fults DW, Taylor MD.

Cell. 2018 May 31;173(6):1549. doi: 10.1016/j.cell.2018.05.033. Epub 2018 May 31. No abstract available.

PMID:
29856958
3.

Identification of CDC25 as a Common Therapeutic Target for Triple-Negative Breast Cancer.

Liu JC, Granieri L, Shrestha M, Wang DY, Vorobieva I, Rubie EA, Jones R, Ju Y, Pellecchia G, Jiang Z, Palmerini CA, Ben-David Y, Egan SE, Woodgett JR, Bader GD, Datti A, Zacksenhaus E.

Cell Rep. 2018 Apr 3;23(1):112-126. doi: 10.1016/j.celrep.2018.03.039.

4.

A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases.

Garzia L, Kijima N, Morrissy AS, De Antonellis P, Guerreiro-Stucklin A, Holgado BL, Wu X, Wang X, Parsons M, Zayne K, Manno A, Kuzan-Fischer C, Nor C, Donovan LK, Liu J, Qin L, Garancher A, Liu KW, Mansouri S, Luu B, Thompson YY, Ramaswamy V, Peacock J, Farooq H, Skowron P, Shih DJH, Li A, Ensan S, Robbins CS, Cybulsky M, Mitra S, Ma Y, Moore R, Mungall A, Cho YJ, Weiss WA, Chan JA, Hawkins CE, Massimino M, Jabado N, Zapotocky M, Sumerauer D, Bouffet E, Dirks P, Tabori U, Sorensen PHB, Brastianos PK, Aldape K, Jones SJM, Marra MA, Woodgett JR, Wechsler-Reya RJ, Fults DW, Taylor MD.

Cell. 2018 Feb 22;172(5):1050-1062.e14. doi: 10.1016/j.cell.2018.01.038. Erratum in: Cell. 2018 May 31;173(6):1549.

PMID:
29474906
5.

Gimap5-dependent inactivation of GSK3β is required for CD4+ T cell homeostasis and prevention of immune pathology.

Patterson AR, Endale M, Lampe K, Aksoylar HI, Flagg A, Woodgett JR, Hildeman D, Jordan MB, Singh H, Kucuk Z, Bleesing J, Hoebe K.

Nat Commun. 2018 Jan 30;9(1):430. doi: 10.1038/s41467-018-02897-7.

6.

Glycogen Synthase Kinase-3 Modulates Cbl-b and Constrains T Cell Activation.

Tran CW, Saibil SD, Le Bihan T, Hamilton SR, Lang KS, You H, Lin AE, Garza KM, Elford AR, Tai K, Parsons ME, Wigmore K, Vainberg MG, Penninger JM, Woodgett JR, Mak TW, Ohashi PS.

J Immunol. 2017 Dec 15;199(12):4056-4065. doi: 10.4049/jimmunol.1600396. Epub 2017 Nov 6.

PMID:
29109121
7.

Xanthatin triggers Chk1-mediated DNA damage response and destabilizes Cdc25C via lysosomal degradation in lung cancer cells.

Tao L, Cao Y, Wei Z, Jia Q, Yu S, Zhong J, Wang A, Woodgett JR, Lu Y.

Toxicol Appl Pharmacol. 2017 Dec 15;337:85-94. doi: 10.1016/j.taap.2017.10.015. Epub 2017 Oct 23.

PMID:
29074359
8.

Recent advances in understanding the cellular roles of GSK-3.

Cormier KW, Woodgett JR.

F1000Res. 2017 Feb 20;6. pii: F1000 Faculty Rev-167. doi: 10.12688/f1000research.10557.1. eCollection 2017. Review.

9.

Glycogen Synthase Kinase 3: A Kinase for All Pathways?

Patel P, Woodgett JR.

Curr Top Dev Biol. 2017;123:277-302. doi: 10.1016/bs.ctdb.2016.11.011. Epub 2016 Dec 28. Review.

PMID:
28236969
10.

Gsk3 is a metabolic checkpoint regulator in B cells.

Jellusova J, Cato MH, Apgar JR, Ramezani-Rad P, Leung CR, Chen C, Richardson AD, Conner EM, Benschop RJ, Woodgett JR, Rickert RC.

Nat Immunol. 2017 Mar;18(3):303-312. doi: 10.1038/ni.3664. Epub 2017 Jan 23.

11.

A ZIP6-ZIP10 heteromer controls NCAM1 phosphorylation and integration into focal adhesion complexes during epithelial-to-mesenchymal transition.

Brethour D, Mehrabian M, Williams D, Wang X, Ghodrati F, Ehsani S, Rubie EA, Woodgett JR, Sevalle J, Xi Z, Rogaeva E, Schmitt-Ulms G.

Sci Rep. 2017 Jan 18;7:40313. doi: 10.1038/srep40313.

12.

Regulation of the protein kinase activity of ShaggyZeste-white3 by components of the Wingless pathway in Drosophila cells and embryos.

Ruel L, Stambolic V, Ali A, Manoukian AS, Woodgett JR.

J Biol Chem. 2016 Oct 28;291(44):23364. No abstract available.

13.

Nuclear GSK3β promotes tumorigenesis by phosphorylating KDM1A and inducing its deubiquitylation by USP22.

Zhou A, Lin K, Zhang S, Chen Y, Zhang N, Xue J, Wang Z, Aldape KD, Xie K, Woodgett JR, Huang S.

Nat Cell Biol. 2016 Sep;18(9):954-966. doi: 10.1038/ncb3396. Epub 2016 Aug 8.

14.

Xanthatin anti-tumor cytotoxicity is mediated via glycogen synthase kinase-3β and β-catenin.

Tao L, Sheng X, Zhang L, Li W, Wei Z, Zhu P, Zhang F, Wang A, Woodgett JR, Lu Y.

Biochem Pharmacol. 2016 Sep 1;115:18-27. doi: 10.1016/j.bcp.2016.06.009. Epub 2016 Jun 16.

PMID:
27321043
15.

Loss of Adult Cardiac Myocyte GSK-3 Leads to Mitotic Catastrophe Resulting in Fatal Dilated Cardiomyopathy.

Zhou J, Ahmad F, Parikh S, Hoffman NE, Rajan S, Verma VK, Song J, Yuan A, Shanmughapriya S, Guo Y, Gao E, Koch W, Woodgett JR, Madesh M, Kishore R, Lal H, Force T.

Circ Res. 2016 Apr 15;118(8):1208-22. doi: 10.1161/CIRCRESAHA.116.308544. Epub 2016 Mar 14.

16.

Mutational Analysis of Glycogen Synthase Kinase 3β Protein Kinase Together with Kinome-Wide Binding and Stability Studies Suggests Context-Dependent Recognition of Kinases by the Chaperone Heat Shock Protein 90.

Jin J, Tian R, Pasculescu A, Dai AY, Williton K, Taylor L, Savitski MM, Bantscheff M, Woodgett JR, Pawson T, Colwill K.

Mol Cell Biol. 2016 Jan 11;36(6):1007-18. doi: 10.1128/MCB.01045-15.

17.

Ras Signaling Is a Key Determinant for Metastatic Dissemination and Poor Survival of Luminal Breast Cancer Patients.

Wright KL, Adams JR, Liu JC, Loch AJ, Wong RG, Jo CE, Beck LA, Santhanam DR, Weiss L, Mei X, Lane TF, Koralov SB, Done SJ, Woodgett JR, Zacksenhaus E, Hu P, Egan SE.

Cancer Res. 2015 Nov 15;75(22):4960-72. doi: 10.1158/0008-5472.CAN-14-2992. Epub 2015 Sep 23.

18.

Fine-Tuning of the RIG-I-Like Receptor/Interferon Regulatory Factor 3-Dependent Antiviral Innate Immune Response by the Glycogen Synthase Kinase 3/β-Catenin Pathway.

Khan KA, Dô F, Marineau A, Doyon P, Clément JF, Woodgett JR, Doble BW, Servant MJ.

Mol Cell Biol. 2015 Sep 1;35(17):3029-43. doi: 10.1128/MCB.00344-15. Epub 2015 Jun 22.

19.

Glycogen synthase kinase-3β promotes cyst expansion in polycystic kidney disease.

Tao S, Kakade VR, Woodgett JR, Pandey P, Suderman ED, Rajagopal M, Rao R.

Kidney Int. 2015 Jun;87(6):1164-75. doi: 10.1038/ki.2014.427. Epub 2015 Jan 28.

20.

Glycogen synthase kinase 3α regulates urine concentrating mechanism in mice.

Nørregaard R, Tao S, Nilsson L, Woodgett JR, Kakade V, Yu AS, Howard C, Rao R.

Am J Physiol Renal Physiol. 2015 Mar 15;308(6):F650-60. doi: 10.1152/ajprenal.00516.2014. Epub 2015 Jan 21.

21.

mTOR regulates brain morphogenesis by mediating GSK3 signaling.

Ka M, Condorelli G, Woodgett JR, Kim WY.

Development. 2014 Nov;141(21):4076-86. doi: 10.1242/dev.108282. Epub 2014 Oct 1.

22.

Effect of glycogen synthase kinase-3 inactivation on mouse mammary gland development and oncogenesis.

Dembowy J, Adissu HA, Liu JC, Zacksenhaus E, Woodgett JR.

Oncogene. 2015 Jul;34(27):3514-26. doi: 10.1038/onc.2014.279. Epub 2014 Sep 8.

23.

Cardiomyocyte-specific deletion of Gsk3α mitigates post-myocardial infarction remodeling, contractile dysfunction, and heart failure.

Ahmad F, Lal H, Zhou J, Vagnozzi RJ, Yu JE, Shang X, Woodgett JR, Gao E, Force T.

J Am Coll Cardiol. 2014 Aug 19;64(7):696-706. doi: 10.1016/j.jacc.2014.04.068.

24.

Neuronal deletion of GSK3β increases microtubule speed in the growth cone and enhances axon regeneration via CRMP-2 and independently of MAP1B and CLASP2.

Liz MA, Mar FM, Santos TE, Pimentel HI, Marques AM, Morgado MM, Vieira S, Sousa VF, Pemble H, Wittmann T, Sutherland C, Woodgett JR, Sousa MM.

BMC Biol. 2014 Jun 12;12:47. doi: 10.1186/1741-7007-12-47.

25.

Signals controlling un-differentiated states in embryonic stem and cancer cells: role of the phosphatidylinositol 3' kinase pathway.

Voskas D, Ling LS, Woodgett JR.

J Cell Physiol. 2014 Oct;229(10):1312-22. doi: 10.1002/jcp.24603. Review.

26.

The responses of neural stem cells to the level of GSK-3 depend on the tissue of origin.

Holowacz T, Alexson TO, Coles BL, Doble BW, Kelly KF, Woodgett JR, Van Der Kooy D.

Biol Open. 2013 Jun 20;2(8):812-21. doi: 10.1242/bio.20131941. eCollection 2013 Aug 15.

27.

GSK-3β function in bone regulates skeletal development, whole-body metabolism, and male life span.

Gillespie JR, Bush JR, Bell GI, Aubrey LA, Dupuis H, Ferron M, Kream B, DiMattia G, Patel S, Woodgett JR, Karsenty G, Hess DA, Beier F.

Endocrinology. 2013 Oct;154(10):3702-18. doi: 10.1210/en.2013-1155. Epub 2013 Jul 31.

28.

Regulation of Th1 cells and experimental autoimmune encephalomyelitis by glycogen synthase kinase-3.

Beurel E, Kaidanovich-Beilin O, Yeh WI, Song L, Palomo V, Michalek SM, Woodgett JR, Harrington LE, Eldar-Finkelman H, Martinez A, Jope RS.

J Immunol. 2013 May 15;190(10):5000-11. doi: 10.4049/jimmunol.1203057. Epub 2013 Apr 19.

29.

Activation of PDK-1 maintains mouse embryonic stem cell self-renewal in a PKB-dependent manner.

Ling LS, Voskas D, Woodgett JR.

Oncogene. 2013 Nov 21;32(47):5397-408. doi: 10.1038/onc.2013.44. Epub 2013 Mar 4.

30.

Inactivation of the enzyme GSK3α by the kinase IKKi promotes AKT-mTOR signaling pathway that mediates interleukin-1-induced Th17 cell maintenance.

Gulen MF, Bulek K, Xiao H, Yu M, Gao J, Sun L, Beurel E, Kaidanovich-Beilin O, Fox PL, DiCorleto PE, Wang JA, Qin J, Wald DN, Woodgett JR, Jope RS, Carman J, Dongre A, Li X.

Immunity. 2012 Nov 16;37(5):800-12. doi: 10.1016/j.immuni.2012.08.019. Epub 2012 Nov 8.

31.

The effects of glycogen synthase kinase-3beta in serotonin neurons.

Zhou W, Chen L, Paul J, Yang S, Li F, Sampson K, Woodgett JR, Beaulieu JM, Gamble KL, Li X.

PLoS One. 2012;7(8):e43262. doi: 10.1371/journal.pone.0043262. Epub 2012 Aug 17.

32.

Specific deletion of glycogen synthase kinase-3β in the renal proximal tubule protects against acute nephrotoxic injury in mice.

Howard C, Tao S, Yang HC, Fogo AB, Woodgett JR, Harris RC, Rao R.

Kidney Int. 2012 Nov;82(9):1000-9. doi: 10.1038/ki.2012.239. Epub 2012 Jul 11.

33.

GSK-3α and GSK-3β proteins are involved in early stages of chondrocyte differentiation with functional redundancy through RelA protein phosphorylation.

Itoh S, Saito T, Hirata M, Ushita M, Ikeda T, Woodgett JR, Algül H, Schmid RM, Chung UI, Kawaguchi H.

J Biol Chem. 2012 Aug 24;287(35):29227-36. doi: 10.1074/jbc.M112.372086. Epub 2012 Jul 3.

34.

Can a two-faced kinase be exploited for osteosarcoma?

Woodgett JR.

J Natl Cancer Inst. 2012 May 16;104(10):722-3. doi: 10.1093/jnci/djs223. Epub 2012 Apr 24. No abstract available.

35.

Neurological functions of the masterswitch protein kinase - gsk-3.

Kaidanovich-Beilin O, Beaulieu JM, Jope RS, Woodgett JR.

Front Mol Neurosci. 2012 Apr 9;5:48. doi: 10.3389/fnmol.2012.00048. eCollection 2012. No abstract available.

36.

Towards the preparation of radiolabeled 1-aryl-3-benzyl ureas: Radiosynthesis of [(11)C-carbonyl] AR-A014418 by [(11)C]CO(2) fixation.

Hicks JW, Wilson AA, Rubie EA, Woodgett JR, Houle S, Vasdev N.

Bioorg Med Chem Lett. 2012 Mar 1;22(5):2099-101. doi: 10.1016/j.bmcl.2011.12.139. Epub 2012 Jan 10.

PMID:
22321216
37.

GSK-3α/β kinases and amyloid production in vivo.

Jaworski T, Dewachter I, Lechat B, Gees M, Kremer A, Demedts D, Borghgraef P, Devijver H, Kügler S, Patel S, Woodgett JR, Van Leuven F.

Nature. 2011 Dec 7;480(7376):E4-5; discussion E6. doi: 10.1038/nature10615.

PMID:
22158250
38.

GSK-3: Functional Insights from Cell Biology and Animal Models.

Kaidanovich-Beilin O, Woodgett JR.

Front Mol Neurosci. 2011 Nov 16;4:40. doi: 10.3389/fnmol.2011.00040. eCollection 2011.

39.

Genetic inactivation of GSK3α rescues spine deficits in Disc1-L100P mutant mice.

Lee FH, Kaidanovich-Beilin O, Roder JC, Woodgett JR, Wong AH.

Schizophr Res. 2011 Jun;129(1):74-9. doi: 10.1016/j.schres.2011.03.032. Epub 2011 Apr 17.

PMID:
21498050
40.

Selective loss of glycogen synthase kinase-3α in birds reveals distinct roles for GSK-3 isozymes in tau phosphorylation.

Alon LT, Pietrokovski S, Barkan S, Avrahami L, Kaidanovich-Beilin O, Woodgett JR, Barnea A, Eldar-Finkelman H.

FEBS Lett. 2011 Apr 20;585(8):1158-62. doi: 10.1016/j.febslet.2011.03.025. Epub 2011 Mar 21.

41.

Assessment of social interaction behaviors.

Kaidanovich-Beilin O, Lipina T, Vukobradovic I, Roder J, Woodgett JR.

J Vis Exp. 2011 Feb 25;(48). pii: 2473. doi: 10.3791/2473.

42.

Deletion of glycogen synthase kinase-3β in cartilage results in up-regulation of glycogen synthase kinase-3α protein expression.

Gillespie JR, Ulici V, Dupuis H, Higgs A, Dimattia A, Patel S, Woodgett JR, Beier F.

Endocrinology. 2011 May;152(5):1755-66. doi: 10.1210/en.2010-1412. Epub 2011 Feb 15.

PMID:
21325041
43.

Does GSK-3 provide a shortcut for PI3K activation of Wnt signalling?

Voskas D, Ling LS, Woodgett JR.

F1000 Biol Rep. 2010 Nov 24;2:82. doi: 10.3410/B2-82.

44.

Tissue-specific analysis of glycogen synthase kinase-3α (GSK-3α) in glucose metabolism: effect of strain variation.

Patel S, Macaulay K, Woodgett JR.

PLoS One. 2011 Jan 6;6(1):e15845. doi: 10.1371/journal.pone.0015845.

45.

Inhibitory phosphorylation of GSK-3 by CaMKII couples depolarization to neuronal survival.

Song B, Lai B, Zheng Z, Zhang Y, Luo J, Wang C, Chen Y, Woodgett JR, Li M.

J Biol Chem. 2010 Dec 24;285(52):41122-34. doi: 10.1074/jbc.M110.130351. Epub 2010 Sep 14.

46.

Role of phosphoinositide 3-kinase {alpha}, protein kinase C, and L-type Ca2+ channels in mediating the complex actions of angiotensin II on mouse cardiac contractility.

Liang W, Oudit GY, Patel MM, Shah AM, Woodgett JR, Tsushima RG, Ward ME, Backx PH.

Hypertension. 2010 Sep;56(3):422-9. doi: 10.1161/HYPERTENSIONAHA.109.149344. Epub 2010 Aug 9.

47.

Genetic and pharmacological evidence for schizophrenia-related Disc1 interaction with GSK-3.

Lipina TV, Kaidanovich-Beilin O, Patel S, Wang M, Clapcote SJ, Liu F, Woodgett JR, Roder JC.

Synapse. 2011 Mar;65(3):234-48. doi: 10.1002/syn.20839.

48.

When pathways collide: collaboration and connivance among signalling proteins in development.

McNeill H, Woodgett JR.

Nat Rev Mol Cell Biol. 2010 Jun;11(6):404-13. doi: 10.1038/nrm2902. Epub 2010 May 12. Review.

49.

Glycogen synthase kinase-3beta regulates post-myocardial infarction remodeling and stress-induced cardiomyocyte proliferation in vivo.

Woulfe KC, Gao E, Lal H, Harris D, Fan Q, Vagnozzi R, DeCaul M, Shang X, Patel S, Woodgett JR, Force T, Zhou J.

Circ Res. 2010 May 28;106(10):1635-45. doi: 10.1161/CIRCRESAHA.109.211482. Epub 2010 Apr 1.

50.

Abnormalities in brain structure and behavior in GSK-3alpha mutant mice.

Kaidanovich-Beilin O, Lipina TV, Takao K, van Eede M, Hattori S, Laliberté C, Khan M, Okamoto K, Chambers JW, Fletcher PJ, MacAulay K, Doble BW, Henkelman M, Miyakawa T, Roder J, Woodgett JR.

Mol Brain. 2009 Nov 19;2:35. doi: 10.1186/1756-6606-2-35.

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