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Items: 1 to 50 of 291

1.

How to continually make the case for fundamental science - from the perspective of a protein kinase.

Woodgett JR.

Biochem Cell Biol. 2019 May 21. doi: 10.1139/bcb-2019-0130. [Epub ahead of print]

PMID:
31112656
2.

Cardiomyocyte-GSK-3α promotes mPTP opening and heart failure in mice with chronic pressure overload.

Ahmad F, Singh AP, Tomar D, Rahmani M, Zhang Q, Woodgett JR, Tilley DG, Lal H, Force T.

J Mol Cell Cardiol. 2019 May;130:65-75. doi: 10.1016/j.yjmcc.2019.03.020. Epub 2019 Mar 27.

PMID:
30928428
3.

A subgroup of microRNAs defines PTEN-deficient, triple-negative breast cancer patients with poorest prognosis and alterations in RB1, MYC, and Wnt signaling.

Wang DY, Gendoo DMA, Ben-David Y, Woodgett JR, Zacksenhaus E.

Breast Cancer Res. 2019 Jan 31;21(1):18. doi: 10.1186/s13058-019-1098-z.

4.

Podocyte GSK3 is an evolutionarily conserved critical regulator of kidney function.

Hurcombe JA, Hartley P, Lay AC, Ni L, Bedford JJ, Leader JP, Singh S, Murphy A, Scudamore CL, Marquez E, Barrington AF, Pinto V, Marchetti M, Wong LF, Uney J, Saleem MA, Mathieson PW, Patel S, Walker RJ, Woodgett JR, Quaggin SE, Welsh GI, Coward RJM.

Nat Commun. 2019 Jan 24;10(1):403. doi: 10.1038/s41467-018-08235-1.

5.

Polypharmacological Profiles Underlying the Antitumor Property of Salvia miltiorrhiza Root (Danshen) Interfering with NOX-Dependent Neutrophil Extracellular Traps.

Tao L, Xu M, Dai X, Ni T, Li D, Jin F, Wang H, Tao L, Pan B, Woodgett JR, Qian Y, Liu Y.

Oxid Med Cell Longev. 2018 Aug 19;2018:4908328. doi: 10.1155/2018/4908328. eCollection 2018.

6.

A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases.

Garzia L, Kijima N, Morrissy AS, De Antonellis P, Guerreiro-Stucklin A, Holgado BL, Wu X, Wang X, Parsons M, Zayne K, Manno A, Kuzan-Fischer C, Nor C, Donovan LK, Liu J, Qin L, Garancher A, Liu KW, Mansouri S, Luu B, Thompson YY, Ramaswamy V, Peacock J, Farooq H, Skowron P, Shih DJH, Li A, Ensan S, Robbins CS, Cybulsky M, Mitra S, Ma Y, Moore R, Mungall A, Cho YJ, Weiss WA, Chan JA, Hawkins CE, Massimino M, Jabado N, Zapotocky M, Sumerauer D, Bouffet E, Dirks P, Tabori U, Sorensen PHB, Brastianos PK, Aldape K, Jones SJM, Marra MA, Woodgett JR, Wechsler-Reya RJ, Fults DW, Taylor MD.

Cell. 2018 May 31;173(6):1549. doi: 10.1016/j.cell.2018.05.033. Epub 2018 May 31. No abstract available.

7.

Identification of CDC25 as a Common Therapeutic Target for Triple-Negative Breast Cancer.

Liu JC, Granieri L, Shrestha M, Wang DY, Vorobieva I, Rubie EA, Jones R, Ju Y, Pellecchia G, Jiang Z, Palmerini CA, Ben-David Y, Egan SE, Woodgett JR, Bader GD, Datti A, Zacksenhaus E.

Cell Rep. 2018 Apr 3;23(1):112-126. doi: 10.1016/j.celrep.2018.03.039.

8.

A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases.

Garzia L, Kijima N, Morrissy AS, De Antonellis P, Guerreiro-Stucklin A, Holgado BL, Wu X, Wang X, Parsons M, Zayne K, Manno A, Kuzan-Fischer C, Nor C, Donovan LK, Liu J, Qin L, Garancher A, Liu KW, Mansouri S, Luu B, Thompson YY, Ramaswamy V, Peacock J, Farooq H, Skowron P, Shih DJH, Li A, Ensan S, Robbins CS, Cybulsky M, Mitra S, Ma Y, Moore R, Mungall A, Cho YJ, Weiss WA, Chan JA, Hawkins CE, Massimino M, Jabado N, Zapotocky M, Sumerauer D, Bouffet E, Dirks P, Tabori U, Sorensen PHB, Brastianos PK, Aldape K, Jones SJM, Marra MA, Woodgett JR, Wechsler-Reya RJ, Fults DW, Taylor MD.

Cell. 2018 Feb 22;172(5):1050-1062.e14. doi: 10.1016/j.cell.2018.01.038. Erratum in: Cell. 2018 May 31;173(6):1549.

9.

Isoform-specific requirement for GSK3α in sperm for male fertility.

Bhattacharjee R, Goswami S, Dey S, Gangoda M, Brothag C, Eisa A, Woodgett J, Phiel C, Kline D, Vijayaraghavan S.

Biol Reprod. 2018 Aug 1;99(2):384-394. doi: 10.1093/biolre/ioy020.

PMID:
29385396
10.

Gimap5-dependent inactivation of GSK3β is required for CD4+ T cell homeostasis and prevention of immune pathology.

Patterson AR, Endale M, Lampe K, Aksoylar HI, Flagg A, Woodgett JR, Hildeman D, Jordan MB, Singh H, Kucuk Z, Bleesing J, Hoebe K.

Nat Commun. 2018 Jan 30;9(1):430. doi: 10.1038/s41467-018-02897-7.

11.

Correction of GSK3β at young age prevents muscle pathology in mice with myotonic dystrophy type 1.

Wei C, Stock L, Valanejad L, Zalewski ZA, Karns R, Puymirat J, Nelson D, Witte D, Woodgett J, Timchenko NA, Timchenko L.

FASEB J. 2018 Apr;32(4):2073-2085. doi: 10.1096/fj.201700700R. Epub 2018 Jan 5.

12.

Glycogen Synthase Kinase-3 Modulates Cbl-b and Constrains T Cell Activation.

Tran CW, Saibil SD, Le Bihan T, Hamilton SR, Lang KS, You H, Lin AE, Garza KM, Elford AR, Tai K, Parsons ME, Wigmore K, Vainberg MG, Penninger JM, Woodgett JR, Mak TW, Ohashi PS.

J Immunol. 2017 Dec 15;199(12):4056-4065. doi: 10.4049/jimmunol.1600396. Epub 2017 Nov 6.

13.

Xanthatin triggers Chk1-mediated DNA damage response and destabilizes Cdc25C via lysosomal degradation in lung cancer cells.

Tao L, Cao Y, Wei Z, Jia Q, Yu S, Zhong J, Wang A, Woodgett JR, Lu Y.

Toxicol Appl Pharmacol. 2017 Dec 15;337:85-94. doi: 10.1016/j.taap.2017.10.015. Epub 2017 Oct 23.

PMID:
29074359
14.

Recent advances in understanding the cellular roles of GSK-3.

Cormier KW, Woodgett JR.

F1000Res. 2017 Feb 20;6. pii: F1000 Faculty Rev-167. doi: 10.12688/f1000research.10557.1. eCollection 2017. Review.

15.

Glycogen Synthase Kinase 3: A Kinase for All Pathways?

Patel P, Woodgett JR.

Curr Top Dev Biol. 2017;123:277-302. doi: 10.1016/bs.ctdb.2016.11.011. Epub 2016 Dec 28. Review.

PMID:
28236969
16.

Gsk3 is a metabolic checkpoint regulator in B cells.

Jellusova J, Cato MH, Apgar JR, Ramezani-Rad P, Leung CR, Chen C, Richardson AD, Conner EM, Benschop RJ, Woodgett JR, Rickert RC.

Nat Immunol. 2017 Mar;18(3):303-312. doi: 10.1038/ni.3664. Epub 2017 Jan 23.

17.

A ZIP6-ZIP10 heteromer controls NCAM1 phosphorylation and integration into focal adhesion complexes during epithelial-to-mesenchymal transition.

Brethour D, Mehrabian M, Williams D, Wang X, Ghodrati F, Ehsani S, Rubie EA, Woodgett JR, Sevalle J, Xi Z, Rogaeva E, Schmitt-Ulms G.

Sci Rep. 2017 Jan 18;7:40313. doi: 10.1038/srep40313.

18.

Regulation of the protein kinase activity of ShaggyZeste-white3 by components of the Wingless pathway in Drosophila cells and embryos.

Ruel L, Stambolic V, Ali A, Manoukian AS, Woodgett JR.

J Biol Chem. 2016 Oct 28;291(44):23364. No abstract available.

19.

Enabling the Next 25 Years of Cell Biology.

Woodgett J, Loughlin DT.

Trends Cell Biol. 2016 Nov;26(11):789-791. doi: 10.1016/j.tcb.2016.09.009. Epub 2016 Sep 29. No abstract available.

PMID:
27693132
20.

Nuclear GSK3β promotes tumorigenesis by phosphorylating KDM1A and inducing its deubiquitylation by USP22.

Zhou A, Lin K, Zhang S, Chen Y, Zhang N, Xue J, Wang Z, Aldape KD, Xie K, Woodgett JR, Huang S.

Nat Cell Biol. 2016 Sep;18(9):954-966. doi: 10.1038/ncb3396. Epub 2016 Aug 8.

21.

Xanthatin anti-tumor cytotoxicity is mediated via glycogen synthase kinase-3β and β-catenin.

Tao L, Sheng X, Zhang L, Li W, Wei Z, Zhu P, Zhang F, Wang A, Woodgett JR, Lu Y.

Biochem Pharmacol. 2016 Sep 1;115:18-27. doi: 10.1016/j.bcp.2016.06.009. Epub 2016 Jun 16.

PMID:
27321043
22.

Loss of Adult Cardiac Myocyte GSK-3 Leads to Mitotic Catastrophe Resulting in Fatal Dilated Cardiomyopathy.

Zhou J, Ahmad F, Parikh S, Hoffman NE, Rajan S, Verma VK, Song J, Yuan A, Shanmughapriya S, Guo Y, Gao E, Koch W, Woodgett JR, Madesh M, Kishore R, Lal H, Force T.

Circ Res. 2016 Apr 15;118(8):1208-22. doi: 10.1161/CIRCRESAHA.116.308544. Epub 2016 Mar 14.

23.

Mutational Analysis of Glycogen Synthase Kinase 3β Protein Kinase Together with Kinome-Wide Binding and Stability Studies Suggests Context-Dependent Recognition of Kinases by the Chaperone Heat Shock Protein 90.

Jin J, Tian R, Pasculescu A, Dai AY, Williton K, Taylor L, Savitski MM, Bantscheff M, Woodgett JR, Pawson T, Colwill K.

Mol Cell Biol. 2016 Jan 11;36(6):1007-18. doi: 10.1128/MCB.01045-15.

24.

Ras Signaling Is a Key Determinant for Metastatic Dissemination and Poor Survival of Luminal Breast Cancer Patients.

Wright KL, Adams JR, Liu JC, Loch AJ, Wong RG, Jo CE, Beck LA, Santhanam DR, Weiss L, Mei X, Lane TF, Koralov SB, Done SJ, Woodgett JR, Zacksenhaus E, Hu P, Egan SE.

Cancer Res. 2015 Nov 15;75(22):4960-72. doi: 10.1158/0008-5472.CAN-14-2992. Epub 2015 Sep 23.

25.

Fine-Tuning of the RIG-I-Like Receptor/Interferon Regulatory Factor 3-Dependent Antiviral Innate Immune Response by the Glycogen Synthase Kinase 3/β-Catenin Pathway.

Khan KA, Dô F, Marineau A, Doyon P, Clément JF, Woodgett JR, Doble BW, Servant MJ.

Mol Cell Biol. 2015 Sep 1;35(17):3029-43. doi: 10.1128/MCB.00344-15. Epub 2015 Jun 22.

26.

Glycogen synthase kinase-3β promotes cyst expansion in polycystic kidney disease.

Tao S, Kakade VR, Woodgett JR, Pandey P, Suderman ED, Rajagopal M, Rao R.

Kidney Int. 2015 Jun;87(6):1164-75. doi: 10.1038/ki.2014.427. Epub 2015 Jan 28.

27.

Glycogen synthase kinase 3α regulates urine concentrating mechanism in mice.

Nørregaard R, Tao S, Nilsson L, Woodgett JR, Kakade V, Yu AS, Howard C, Rao R.

Am J Physiol Renal Physiol. 2015 Mar 15;308(6):F650-60. doi: 10.1152/ajprenal.00516.2014. Epub 2015 Jan 21.

28.

The GSK-3 family as therapeutic target for myocardial diseases.

Lal H, Ahmad F, Woodgett J, Force T.

Circ Res. 2015 Jan 2;116(1):138-49. doi: 10.1161/CIRCRESAHA.116.303613. Review.

29.

mTOR regulates brain morphogenesis by mediating GSK3 signaling.

Ka M, Condorelli G, Woodgett JR, Kim WY.

Development. 2014 Nov;141(21):4076-86. doi: 10.1242/dev.108282. Epub 2014 Oct 1.

30.

Burning platforms: friending social media's role in #scicomm.

Woodgett J.

Trends Cell Biol. 2014 Oct;24(10):555-7. doi: 10.1016/j.tcb.2014.08.002. Review.

PMID:
25260836
31.

Effect of glycogen synthase kinase-3 inactivation on mouse mammary gland development and oncogenesis.

Dembowy J, Adissu HA, Liu JC, Zacksenhaus E, Woodgett JR.

Oncogene. 2015 Jul;34(27):3514-26. doi: 10.1038/onc.2014.279. Epub 2014 Sep 8.

32.

Cardiomyocyte-specific deletion of Gsk3α mitigates post-myocardial infarction remodeling, contractile dysfunction, and heart failure.

Ahmad F, Lal H, Zhou J, Vagnozzi RJ, Yu JE, Shang X, Woodgett JR, Gao E, Force T.

J Am Coll Cardiol. 2014 Aug 19;64(7):696-706. doi: 10.1016/j.jacc.2014.04.068.

33.

Neuronal deletion of GSK3β increases microtubule speed in the growth cone and enhances axon regeneration via CRMP-2 and independently of MAP1B and CLASP2.

Liz MA, Mar FM, Santos TE, Pimentel HI, Marques AM, Morgado MM, Vieira S, Sousa VF, Pemble H, Wittmann T, Sutherland C, Woodgett JR, Sousa MM.

BMC Biol. 2014 Jun 12;12:47. doi: 10.1186/1741-7007-12-47.

34.

Cardiac fibroblast glycogen synthase kinase-3β regulates ventricular remodeling and dysfunction in ischemic heart.

Lal H, Ahmad F, Zhou J, Yu JE, Vagnozzi RJ, Guo Y, Yu D, Tsai EJ, Woodgett J, Gao E, Force T.

Circulation. 2014 Jul 29;130(5):419-30. doi: 10.1161/CIRCULATIONAHA.113.008364. Epub 2014 Jun 4.

35.

Signals controlling un-differentiated states in embryonic stem and cancer cells: role of the phosphatidylinositol 3' kinase pathway.

Voskas D, Ling LS, Woodgett JR.

J Cell Physiol. 2014 Oct;229(10):1312-22. doi: 10.1002/jcp.24603. Review.

36.

Impact: Akin to quantifying dreams.

Woodgett J.

Nature. 2013 Nov 14;503(7475):198. doi: 10.1038/503198a. No abstract available.

PMID:
24226881
37.

The responses of neural stem cells to the level of GSK-3 depend on the tissue of origin.

Holowacz T, Alexson TO, Coles BL, Doble BW, Kelly KF, Woodgett JR, Van Der Kooy D.

Biol Open. 2013 Jun 20;2(8):812-21. doi: 10.1242/bio.20131941. eCollection 2013 Aug 15.

38.

GSK-3β function in bone regulates skeletal development, whole-body metabolism, and male life span.

Gillespie JR, Bush JR, Bell GI, Aubrey LA, Dupuis H, Ferron M, Kream B, DiMattia G, Patel S, Woodgett JR, Karsenty G, Hess DA, Beier F.

Endocrinology. 2013 Oct;154(10):3702-18. doi: 10.1210/en.2013-1155. Epub 2013 Jul 31.

39.

There's more to lithium than Nirvana.

Woodgett J.

Nat Rev Mol Cell Biol. 2013 Aug;14(8):466. doi: 10.1038/nrm3628. Epub 2013 Jul 10. No abstract available.

PMID:
23839580
40.

Regulation of Th1 cells and experimental autoimmune encephalomyelitis by glycogen synthase kinase-3.

Beurel E, Kaidanovich-Beilin O, Yeh WI, Song L, Palomo V, Michalek SM, Woodgett JR, Harrington LE, Eldar-Finkelman H, Martinez A, Jope RS.

J Immunol. 2013 May 15;190(10):5000-11. doi: 10.4049/jimmunol.1203057. Epub 2013 Apr 19.

41.

Single unpurified breast tumor-initiating cells from multiple mouse models efficiently elicit tumors in immune-competent hosts.

Kurpios NA, Girgis-Gabardo A, Hallett RM, Rogers S, Gludish DW, Kockeritz L, Woodgett J, Cardiff R, Hassell JA.

PLoS One. 2013;8(3):e58151. doi: 10.1371/journal.pone.0058151. Epub 2013 Mar 26.

42.

GSK-3α is a central regulator of age-related pathologies in mice.

Zhou J, Freeman TA, Ahmad F, Shang X, Mangano E, Gao E, Farber J, Wang Y, Ma XL, Woodgett J, Vagnozzi RJ, Lal H, Force T.

J Clin Invest. 2013 Apr;123(4):1821-32. doi: 10.1172/JCI64398. Epub 2013 Mar 15.

43.

Activation of PDK-1 maintains mouse embryonic stem cell self-renewal in a PKB-dependent manner.

Ling LS, Voskas D, Woodgett JR.

Oncogene. 2013 Nov 21;32(47):5397-408. doi: 10.1038/onc.2013.44. Epub 2013 Mar 4.

44.

NIH funding: Thousand-citation papers are outliers.

Woodgett J.

Nature. 2012 Dec 20;492(7429):356. doi: 10.1038/492356b. No abstract available.

PMID:
23257869
45.

Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes.

Ly PT, Wu Y, Zou H, Wang R, Zhou W, Kinoshita A, Zhang M, Yang Y, Cai F, Woodgett J, Song W.

J Clin Invest. 2013 Jan;123(1):224-35. doi: 10.1172/JCI64516. Epub 2012 Dec 3.

46.

GSK3β mediates muscle pathology in myotonic dystrophy.

Jones K, Wei C, Iakova P, Bugiardini E, Schneider-Gold C, Meola G, Woodgett J, Killian J, Timchenko NA, Timchenko LT.

J Clin Invest. 2012 Dec;122(12):4461-72. doi: 10.1172/JCI64081. Epub 2012 Nov 19.

47.

Inactivation of the enzyme GSK3α by the kinase IKKi promotes AKT-mTOR signaling pathway that mediates interleukin-1-induced Th17 cell maintenance.

Gulen MF, Bulek K, Xiao H, Yu M, Gao J, Sun L, Beurel E, Kaidanovich-Beilin O, Fox PL, DiCorleto PE, Wang JA, Qin J, Wald DN, Woodgett JR, Jope RS, Carman J, Dongre A, Li X.

Immunity. 2012 Nov 16;37(5):800-12. doi: 10.1016/j.immuni.2012.08.019. Epub 2012 Nov 8.

48.

We must be open about our mistakes.

Woodgett J.

Nature. 2012 Sep 6;489(7414):7. No abstract available.

PMID:
22962696
49.

The effects of glycogen synthase kinase-3beta in serotonin neurons.

Zhou W, Chen L, Paul J, Yang S, Li F, Sampson K, Woodgett JR, Beaulieu JM, Gamble KL, Li X.

PLoS One. 2012;7(8):e43262. doi: 10.1371/journal.pone.0043262. Epub 2012 Aug 17.

50.

Specific deletion of glycogen synthase kinase-3β in the renal proximal tubule protects against acute nephrotoxic injury in mice.

Howard C, Tao S, Yang HC, Fogo AB, Woodgett JR, Harris RC, Rao R.

Kidney Int. 2012 Nov;82(9):1000-9. doi: 10.1038/ki.2012.239. Epub 2012 Jul 11.

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