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Isoprenoids and protein prenylation: implications in the pathogenesis and therapeutic intervention of Alzheimer's disease.

Jeong A, Suazo KF, Wood WG, Distefano MD, Li L.

Crit Rev Biochem Mol Biol. 2018 Jun;53(3):279-310. doi: 10.1080/10409238.2018.1458070. Review.


Enhancer deletion generates cellular phenotypic diversity due to bimodal gene expression.

De Gobbi M, Brazel AJ, Sharpe JA, Sloane-Stanley JA, Smith AJ, Wood WG, Vernimmen D.

Blood Cells Mol Dis. 2017 May;64:10-12. doi: 10.1016/j.bcmd.2017.02.006. Epub 2017 Mar 1. No abstract available.


Crude extract of Euphorbia formosana induces apoptosis of DU145 human prostate cancer cells acts through the caspase-dependent and independent signaling pathway.

Yang JL, Lien JC, Chen YY, Hsu SC, Chang SJ, Huang AC, Amagaya S, Funayana S, Wood WG, Kuo CL, Chung JG.

Environ Toxicol. 2016 Nov;31(11):1600-1611. doi: 10.1002/tox.22164. Epub 2015 Jun 30.


Nutraceuticals in Neurodegeneration and Aging.

Ong WY, Sun GY, Wood WG, Lin TN.

Neuromolecular Med. 2016 Sep;18(3):239-40. doi: 10.1007/s12017-016-8432-8. No abstract available.


Genetic dissection of the α-globin super-enhancer in vivo.

Hay D, Hughes JR, Babbs C, Davies JOJ, Graham BJ, Hanssen L, Kassouf MT, Marieke Oudelaar AM, Sharpe JA, Suciu MC, Telenius J, Williams R, Rode C, Li PS, Pennacchio LA, Sloane-Stanley JA, Ayyub H, Butler S, Sauka-Spengler T, Gibbons RJ, Smith AJH, Wood WG, Higgs DR.

Nat Genet. 2016 Aug;48(8):895-903. doi: 10.1038/ng.3605. Epub 2016 Jul 4.


Trans-Cinnamaldehyde, An Essential Oil in Cinnamon Powder, Ameliorates Cerebral Ischemia-Induced Brain Injury via Inhibition of Neuroinflammation Through Attenuation of iNOS, COX-2 Expression and NFκ-B Signaling Pathway.

Chen YF, Wang YW, Huang WS, Lee MM, Wood WG, Leung YM, Tsai HY.

Neuromolecular Med. 2016 Sep;18(3):322-33. doi: 10.1007/s12017-016-8395-9. Epub 2016 Apr 18.


Beneficial effects of dietary EGCG and voluntary exercise on behavior in an Alzheimer's disease mouse model.

Walker JM, Klakotskaia D, Ajit D, Weisman GA, Wood WG, Sun GY, Serfozo P, Simonyi A, Schachtman TR.

J Alzheimers Dis. 2015;44(2):561-72. doi: 10.3233/JAD-140981.


Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.

Galluzzi L, Bravo-San Pedro JM, Vitale I, Aaronson SA, Abrams JM, Adam D, Alnemri ES, Altucci L, Andrews D, Annicchiarico-Petruzzelli M, Baehrecke EH, Bazan NG, Bertrand MJ, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Campanella M, Candi E, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, Di Daniele N, Dixit VM, Dynlacht BD, El-Deiry WS, Fimia GM, Flavell RA, Fulda S, Garrido C, Gougeon ML, Green DR, Gronemeyer H, Hajnoczky G, Hardwick JM, Hengartner MO, Ichijo H, Joseph B, Jost PJ, Kaufmann T, Kepp O, Klionsky DJ, Knight RA, Kumar S, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lugli E, Madeo F, Malorni W, Marine JC, Martin SJ, Martinou JC, Medema JP, Meier P, Melino S, Mizushima N, Moll U, Muñoz-Pinedo C, Nuñez G, Oberst A, Panaretakis T, Penninger JM, Peter ME, Piacentini M, Pinton P, Prehn JH, Puthalakath H, Rabinovich GA, Ravichandran KS, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Shi Y, Simon HU, Stockwell BR, Szabadkai G, Tait SW, Tang HL, Tavernarakis N, Tsujimoto Y, Vanden Berghe T, Vandenabeele P, Villunger A, Wagner EF, Walczak H, White E, Wood WG, Yuan J, Zakeri Z, Zhivotovsky B, Melino G, Kroemer G.

Cell Death Differ. 2015 Jan;22(1):58-73. doi: 10.1038/cdd.2014.137. Epub 2014 Sep 19. Review.


Latex of Euphorbia antiquorum-induced S-phase arrest via active ATM kinase and MAPK pathways in human cervical cancer HeLa cells.

Hsieh WT, Lin HY, Chen JH, Lin WC, Kuo YH, Wood WG, Lu HF, Chung JG.

Environ Toxicol. 2015 Sep;30(10):1205-15. doi: 10.1002/tox.21992. Epub 2014 Apr 5.


Statins and neuroprotection: basic pharmacology needed.

Wood WG, Mΰller WE, Eckert GP.

Mol Neurobiol. 2014 Aug;50(1):214-20. doi: 10.1007/s12035-014-8647-3. Epub 2014 Jan 29. Review.


Impaired geranylgeranyltransferase-I regulation reduces membrane-associated Rho protein levels in aged mouse brain.

Afshordel S, Wood WG, Igbavboa U, Muller WE, Eckert GP.

J Neurochem. 2014 May;129(4):732-42. doi: 10.1111/jnc.12654. Epub 2014 Feb 7.


Cholesterol as a causative factor in Alzheimer's disease: a debatable hypothesis.

Wood WG, Li L, Müller WE, Eckert GP.

J Neurochem. 2014 May;129(4):559-72. doi: 10.1111/jnc.12637. Epub 2014 Jan 2. Review.


An educational web-based external quality assessment outcome and evaluation: first experiences with urinary sediment and hemostaseology.

Schürer-Maly C, Wood WG, Falbo R, Brambilla P, Heller C, Schwarz P, Illigen D, Adler M, Heitzmann N, Bauer D, Fischer M, Spannagl M.

Clin Lab. 2013;59(9-10):1061-9.


Effects of chitosan on xenograft models of melanoma in C57BL/6 mice and hepatoma formation in SCID mice.

Yeh MY, Wu MF, Shang HS, Chang JB, Shih YL, Chen YL, Hung HF, Lu HF, Yeh C, Wood WG, Hung FM, Chung JG.

Anticancer Res. 2013 Nov;33(11):4867-73.


Evaluation of prenylated peptides for use in cellular imaging and biochemical analysis.

Ochocki JD, Igbavboa U, Wood WG, Arriaga EA, Wattenberg EV, Distefano MD.

Methods Mol Biol. 2014;1088:213-23. doi: 10.1007/978-1-62703-673-3_14.


Pathways of neurotoxicity and innovative neuroprotective strategies. Preface.

Patterson TA, Wood WG, Andrews RJ, Slikker W Jr.

Mol Neurobiol. 2013 Oct;48(2):271-3. doi: 10.1007/s12035-013-8513-8. Epub 2013 Jul 26. No abstract available.


Statins, Bcl-2, and apoptosis: cell death or cell protection?

Wood WG, Igbavboa U, Muller WE, Eckert GP.

Mol Neurobiol. 2013 Oct;48(2):308-14. doi: 10.1007/s12035-013-8496-5. Epub 2013 Jul 3. Review.


Up-regulation and activation of the P2Y(2) nucleotide receptor mediate neurite extension in IL-1β-treated mouse primary cortical neurons.

Peterson TS, Thebeau CN, Ajit D, Camden JM, Woods LT, Wood WG, Petris MJ, Sun GY, Erb L, Weisman GA.

J Neurochem. 2013 Jun;125(6):885-96. doi: 10.1111/jnc.12252. Epub 2013 Apr 25.


Crude extract of Euphorbia formosana inhibits the migration and invasion of DU145 human prostate cancer cells: The role of matrix metalloproteinase-2/9 inhibition via the MAPK signaling pathway.

Yang JL, Lin JH, Weng SW, Chen JC, Yang JS, Amagaya S, Funayana S, Wood WG, Kuo CL, Chung JG.

Mol Med Rep. 2013 May;7(5):1403-8. doi: 10.3892/mmr.2013.1380. Epub 2013 Mar 20.


Myelolipoma in the spleen: a rare discovery of extra-adrenal hematopoietic tissue.

Wood WG, Restivo TE, Axelsson KL, Svahn JD.

J Surg Case Rep. 2013 Mar 12;2013(3). pii: rjt007. doi: 10.1093/jscr/rjt007.


The crude extract of Corni Fructus induces apoptotic cell death through reactive oxygen species-modulated pathways in U-2 OS human osteosarcoma cells.

Liao CL, Hsu SC, Yu CC, Yang JS, Tang NY, Wood WG, Lin JG, Chung JG.

Environ Toxicol. 2014 Sep;29(9):1020-31. doi: 10.1002/tox.21832. Epub 2012 Dec 12.


Screening Helicobacter pylori genes induced during infection of mouse stomachs.

Singh A, Hodgson N, Yan M, Joo J, Gu L, Sang H, Gregory-Bryson E, Wood WG, Ni Y, Smith K, Jackson SH, Coleman WG.

World J Gastroenterol. 2012 Aug 28;18(32):4323-34. doi: 10.3748/wjg.v18.i32.4323.


Green Tea Extract Ameliorates Learning and Memory Deficits in Ischemic Rats via Its Active Component Polyphenol Epigallocatechin-3-gallate by Modulation of Oxidative Stress and Neuroinflammation.

Wu KJ, Hsieh MT, Wu CR, Wood WG, Chen YF.

Evid Based Complement Alternat Med. 2012;2012:163106. doi: 10.1155/2012/163106. Epub 2012 Aug 2.


Alzheimer's disease: new perspectives on therapeutic targets and pathways. Foreword.

Müller WE, Eckert GP, Sun GY, Wood WG.

Mol Neurobiol. 2012 Aug;46(1):1-2. doi: 10.1007/s12035-012-8306-5. No abstract available.


Brain isoprenoids farnesyl pyrophosphate and geranylgeranyl pyrophosphate are increased in aged mice.

Hooff GP, Wood WG, Kim JH, Igbavboa U, Ong WY, Muller WE, Eckert GP.

Mol Neurobiol. 2012 Aug;46(1):179-85. doi: 10.1007/s12035-012-8285-6. Epub 2012 Jun 13.


Chrysophanol-induced necrotic-like cell death through an impaired mitochondrial ATP synthesis in Hep3B human liver cancer cells.

Ni CH, Chen PY, Lu HF, Yang JS, Huang HY, Wu SH, Ip SW, Wu CT, Chiang SY, Lin JG, Wood WG, Chung JG.

Arch Pharm Res. 2012 May;35(5):887-95. doi: 10.1007/s12272-012-0514-z. Epub 2012 May 29.


An extract of Agaricus blazei Murill administered orally promotes immune responses in murine leukemia BALB/c mice in vivo.

Lin JG, Fan MJ, Tang NY, Yang JS, Hsia TC, Lin JJ, Lai KC, Wu RS, Ma CY, Wood WG, Chung JG.

Integr Cancer Ther. 2012 Mar;11(1):29-36. doi: 10.1177/1534735411400314.


Solanum lyratum Extracts Induce Extrinsic and Intrinsic Pathways of Apoptosis in WEHI-3 Murine Leukemia Cells and Inhibit Allograft Tumor.

Yang JS, Wu CC, Kuo CL, Lan YH, Yeh CC, Yu CC, Lien JC, Hsu YM, Kuo WW, Wood WG, Tsuzuki M, Chung JG.

Evid Based Complement Alternat Med. 2012;2012:254960. doi: 10.1155/2012/254960. Epub 2012 May 7.


Nprl3 is required for normal development of the cardiovascular system.

Kowalczyk MS, Hughes JR, Babbs C, Sanchez-Pulido L, Szumska D, Sharpe JA, Sloane-Stanley JA, Morriss-Kay GM, Smoot LB, Roberts AE, Watkins H, Bhattacharya S, Gibbons RJ, Ponting CP, Wood WG, Higgs DR.

Mamm Genome. 2012 Aug;23(7-8):404-15. doi: 10.1007/s00335-012-9398-y. Epub 2012 Apr 27.


AP-2β regulates amyloid beta-protein stimulation of apolipoprotein E transcription in astrocytes.

Rossello XS, Igbavboa U, Weisman GA, Sun GY, Wood WG.

Brain Res. 2012 Mar 20;1444:87-95. doi: 10.1016/j.brainres.2012.01.017. Epub 2012 Jan 18.


Intragenic enhancers act as alternative promoters.

Kowalczyk MS, Hughes JR, Garrick D, Lynch MD, Sharpe JA, Sloane-Stanley JA, McGowan SJ, De Gobbi M, Hosseini M, Vernimmen D, Brown JM, Gray NE, Collavin L, Gibbons RJ, Flint J, Taylor S, Buckle VJ, Milne TA, Wood WG, Higgs DR.

Mol Cell. 2012 Feb 24;45(4):447-58. doi: 10.1016/j.molcel.2011.12.021. Epub 2012 Jan 19.


Benzyl isothiocyanate (BITC) induces G2/M phase arrest and apoptosis in human melanoma A375.S2 cells through reactive oxygen species (ROS) and both mitochondria-dependent and death receptor-mediated multiple signaling pathways.

Huang SH, Wu LW, Huang AC, Yu CC, Lien JC, Huang YP, Yang JS, Yang JH, Hsiao YP, Wood WG, Yu CS, Chung JG.

J Agric Food Chem. 2012 Jan 18;60(2):665-75. doi: 10.1021/jf204193v. Epub 2012 Jan 6.


Latex of Euphorbia antiquorum induces apoptosis in human cervical cancer cells via c-jun n-terminal kinase activation and reactive oxygen species production.

Hsieh WT, Lin HY, Chen JH, Kuo YH, Fan MJ, Wu RS, Wu KC, Wood WG, Chung JG.

Nutr Cancer. 2011 Nov;63(8):1339-47. doi: 10.1080/01635581.2011.608481. Epub 2011 Nov 1.


Posterior glenohumeral joint dislocation: a rare complication of central venous cannulation in a patient undergoing coronary artery surgery.

Wood WG, Guy TS, Arora K, Firoozabadi R, Kim H, Kukreja J, Pagel PS, Brzezinski M.

J Cardiothorac Vasc Anesth. 2013 Feb;27(1):101-2. doi: 10.1053/j.jvca.2011.06.013. Epub 2011 Aug 20. No abstract available.


Capsaicin mediates apoptosis in human nasopharyngeal carcinoma NPC-TW 039 cells through mitochondrial depolarization and endoplasmic reticulum stress.

Ip SW, Lan SH, Lu HF, Huang AC, Yang JS, Lin JP, Huang HY, Lien JC, Ho CC, Chiu CF, Wood W, Chung JG.

Hum Exp Toxicol. 2012 Jun;31(6):539-49. doi: 10.1177/0960327111417269. Epub 2011 Aug 22.


Gypenosides suppress growth of human oral cancer SAS cells in vitro and in a murine xenograft model: the role of apoptosis mediated by caspase-dependent and caspase-independent pathways.

Lu KW, Chen JC, Lai TY, Yang JS, Weng SW, Ma YS, Lin HY, Wu RS, Wu KC, Wood WG, Chung JG.

Integr Cancer Ther. 2012 Jun;11(2):129-40. doi: 10.1177/1534735411403306. Epub 2011 Jun 10.


Molecular evidence of anti-leukemia activity of gypenosides on human myeloid leukemia HL-60 cells in vitro and in vivo using a HL-60 cells murine xenograft model.

Lin JJ, Hsu HY, Yang JS, Lu KW, Wu RS, Wu KC, Lai TY, Chen PY, Ma CY, Wood WG, Chung JG.

Phytomedicine. 2011 Sep 15;18(12):1075-85. doi: 10.1016/j.phymed.2011.03.009. Epub 2011 May 18.


Spatial learning and memory impairment and increased locomotion in a transgenic amyloid precursor protein mouse model of Alzheimer's disease.

Walker JM, Fowler SW, Miller DK, Sun AY, Weisman GA, Wood WG, Sun GY, Simonyi A, Schachtman TR.

Behav Brain Res. 2011 Sep 12;222(1):169-75. doi: 10.1016/j.bbr.2011.03.049. Epub 2011 Apr 1.


Prolonged exposure of cortical neurons to oligomeric amyloid-β impairs NMDA receptor function via NADPH oxidase-mediated ROS production: protective effect of green tea (-)-epigallocatechin-3-gallate.

He Y, Cui J, Lee JC, Ding S, Chalimoniuk M, Simonyi A, Sun AY, Gu Z, Weisman GA, Wood WG, Sun GY.

ASN Neuro. 2011 Feb 8;3(1):e00050. doi: 10.1042/AN20100025.


Codanin-1 mutations in congenital dyserythropoietic anemia type 1 affect HP1{alpha} localization in erythroblasts.

Renella R, Roberts NA, Brown JM, De Gobbi M, Bird LE, Hassanali T, Sharpe JA, Sloane-Stanley J, Ferguson DJ, Cordell J, Buckle VJ, Higgs DR, Wood WG.

Blood. 2011 Jun 23;117(25):6928-38. doi: 10.1182/blood-2010-09-308478. Epub 2011 Mar 1.


Education partnerships between GRECCs and other VA organizations, Non-VA governmental agencies, academic medical centers, and centers of excellence.

Tumosa N, Fitzgerald JT, Wood WG, Thielke S, Shay K, Howe JL, Chernoff R, Kramer J, Bales C, Huh J, Horvath K.

Gerontol Geriatr Educ. 2011;32(1):22-37. doi: 10.1080/02701960.2011.550212.


Global gene expression analysis of human erythroid progenitors.

Merryweather-Clarke AT, Atzberger A, Soneji S, Gray N, Clark K, Waugh C, McGowan SJ, Taylor S, Nandi AK, Wood WG, Roberts DJ, Higgs DR, Buckle VJ, Robson KJ.

Blood. 2011 Mar 31;117(13):e96-108. doi: 10.1182/blood-2010-07-290825. Epub 2011 Jan 26. Erratum in: Blood. 2011 Dec 22;118(26):6993.


Cholesterol asymmetry in synaptic plasma membranes.

Wood WG, Igbavboa U, Müller WE, Eckert GP.

J Neurochem. 2011 Mar;116(5):684-9. doi: 10.1111/j.1471-4159.2010.07017.x. Epub 2011 Jan 7.


2-(3-Methoxyphenyl)-6, 7-methylenedioxoquinolin-4-one, a novel synthetic compound, inhibited migration and invasion in TSGH8301 human bladder cancer cells.

Lai KC, Hsu SC, Yang JS, Kuo CL, Ip SW, Lai TY, Lin SY, Huang CC, Kuo SC, Wood WG, Chung JG.

Hum Exp Toxicol. 2011 Aug;30(8):1045-52. doi: 10.1177/0960327110386257. Epub 2010 Oct 7.


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