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Items: 1 to 50 of 109

1.

VU6005806/AZN-00016130, an advanced M4 positive allosteric modulator (PAM) profiled as a potential preclinical development candidate.

Engers DW, Melancon BJ, Gregro AR, Bertron JL, Bollinger SR, Felts AS, Konkol LC, Wood MR, Bollinger KA, Luscombe VB, Rodriguez AL, Jones CK, Bubser M, Yohn SE, Wood MW, Brandon NJ, Dugan ME, Niswender CM, Jeffrey Conn P, Bridges TM, Lindsley CW.

Bioorg Med Chem Lett. 2019 Jul 15;29(14):1714-1718. doi: 10.1016/j.bmcl.2019.05.026. Epub 2019 May 16.

PMID:
31113706
2.

Acute bladder decentralization in hound dogs: Preliminary results of effects on hypogastric nerve electroneurograms and detrusor pressure responses to spinal root and hypogastric nerve stimulation.

Tiwari E, Barbe MF, Lemay MA, Salvadeo DM, Wood MW, Mazzei M, Musser LV, Delalic ZJ, Braverman AS, Ruggieri MR Sr.

PLoS One. 2019 Apr 10;14(4):e0215036. doi: 10.1371/journal.pone.0215036. eCollection 2019.

3.

Corrigendum to "Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amides" [Bioorg. Med. Chem. Lett. 27(23) (2017) 5179-5184].

Tarr JC, Wood MR, Noetzel MJ, Melancon BJ, Lamsal A, Luscombe VB, Rodriguez AL, Byers FW, Chang S, Cho HP, Engers DW, Jones CK, Niswender CM, Wood MW, Brandon NJ, Duggan ME, Conn PJ, Bridges TM, Lindsley CW.

Bioorg Med Chem Lett. 2018 Sep 15;28(17):3014. doi: 10.1016/j.bmcl.2018.07.022. Epub 2018 Jul 31. No abstract available.

PMID:
30076050
4.

Prostatic collagen architecture in neutered and intact canines.

Ruetten H, Wegner KA, Romero MF, Wood MW, Marker PC, Strand D, Colopy SA, Vezina CM.

Prostate. 2018 Aug;78(11):839-848. doi: 10.1002/pros.23641. Epub 2018 May 8.

PMID:
29740846
5.

Small molecule inducers of ABCA1 and apoE that act through indirect activation of the LXR pathway.

Fan J, Zhao RQ, Parro C, Zhao W, Chou HY, Robert J, Deeb TZ, Raynoschek C, Barichievy S, Engkvist O, Maresca M, Hicks R, Meuller J, Moss SJ, Brandon NJ, Wood MW, Kulic I, Wellington CL.

J Lipid Res. 2018 May;59(5):830-842. doi: 10.1194/jlr.M081851. Epub 2018 Mar 21.

6.

Bicyclo((aryl)methyl)benzamides as inhibitors of GlyT1.

Varnes JG, Xiong H, Forst JM, Holmquist CR, Ernst GE, Frietze W, Dembofsky B, Andisik DW, Palmer WE, Hinkley L, Steelman GB, Wilkins DE, Tian G, Jonak G, Potts WM, Wang X, Brugel TA, Alhambra C, Wood MW, Veale CA, Albert JS.

Bioorg Med Chem Lett. 2018 Apr 1;28(6):1043-1049. doi: 10.1016/j.bmcl.2018.02.029. Epub 2018 Feb 14.

PMID:
29486970
7.

Lumbar to sacral root rerouting to restore bladder function in a feline spinal cord injury model: Urodynamic and retrograde nerve tracing results from a pilot study.

Lam Van Ba O, Barbe MF, Caremel R, Aharony S, Loutochin O, Jacques L, Wood MW, Tiwari E, Tuite GF, Campeau L, Corcos J, Ruggieri MR Sr.

Neurourol Urodyn. 2018 Jan;37(1):153-162. doi: 10.1002/nau.23394. Epub 2018 Jan 4.

8.

Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amides.

Tarr JC, Wood MR, Noetzel MJ, Melancon BJ, Lamsal A, Luscombe VB, Rodriguez AL, Byers FW, Chang S, Cho HP, Engers DW, Jones CK, Niswender CM, Wood MW, Brandon NJ, Duggan ME, Conn PJ, Bridges TM, Lindsley CW.

Bioorg Med Chem Lett. 2017 Dec 1;27(23):5179-5184. doi: 10.1016/j.bmcl.2017.10.053. Epub 2017 Oct 24. Erratum in: Bioorg Med Chem Lett. 2018 Sep 15;28(17):3014.

9.

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy.

Shi Y, Yamada K, Liddelow SA, Smith ST, Zhao L, Luo W, Tsai RM, Spina S, Grinberg LT, Rojas JC, Gallardo G, Wang K, Roh J, Robinson G, Finn MB, Jiang H, Sullivan PM, Baufeld C, Wood MW, Sutphen C, McCue L, Xiong C, Del-Aguila JL, Morris JC, Cruchaga C; Alzheimer’s Disease Neuroimaging Initiative, Fagan AM, Miller BL, Boxer AL, Seeley WW, Butovsky O, Barres BA, Paul SM, Holtzman DM.

Nature. 2017 Sep 28;549(7673):523-527. doi: 10.1038/nature24016. Epub 2017 Sep 20.

10.

Cognitive enhancement and antipsychotic-like activity following repeated dosing with the selective M4 PAM VU0467154.

Gould RW, Grannan MD, Gunter BW, Ball J, Bubser M, Bridges TM, Wess J, Wood MW, Brandon NJ, Duggan ME, Niswender CM, Lindsley CW, Conn PJ, Jones CK.

Neuropharmacology. 2018 Jan;128:492-502. doi: 10.1016/j.neuropharm.2017.07.013. Epub 2017 Jul 17.

PMID:
28729220
11.

Broad analgesic activity of a novel, selective M1 agonist.

Wood MW, Martino G, Coupal M, Lindberg M, Schroeder P, Santhakumar V, Valiquette M, Sandin J, Widzowski D, Laird J.

Neuropharmacology. 2017 Sep 1;123:233-241. doi: 10.1016/j.neuropharm.2017.06.010. Epub 2017 Jun 13.

12.

Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and in vivo characterization of a series of 3-aminoazetidine-derived amides.

Tarr JC, Wood MR, Noetzel MJ, Bertron JL, Weiner RL, Rodriguez AL, Lamsal A, Byers FW, Chang S, Cho HP, Jones CK, Niswender CM, Wood MW, Brandon NJ, Duggan ME, Conn PJ, Bridges TM, Lindsley CW.

Bioorg Med Chem Lett. 2017 Jul 1;27(13):2990-2995. doi: 10.1016/j.bmcl.2017.05.014. Epub 2017 May 6.

13.

Optimization of M4 positive allosteric modulators (PAMs): The discovery of VU0476406, a non-human primate in vivo tool compound for translational pharmacology.

Melancon BJ, Wood MR, Noetzel MJ, Nance KD, Engelberg EM, Han C, Lamsal A, Chang S, Cho HP, Byers FW, Bubser M, Jones CK, Niswender CM, Wood MW, Engers DW, Wu D, Brandon NJ, Duggan ME, Conn PJ, Bridges TM, Lindsley CW.

Bioorg Med Chem Lett. 2017 Jun 1;27(11):2296-2301. doi: 10.1016/j.bmcl.2017.04.043. Epub 2017 Apr 13.

14.

Discovery of VU0467485/AZ13713945: An M4 PAM Evaluated as a Preclinical Candidate for the Treatment of Schizophrenia.

Wood MR, Noetzel MJ, Melancon BJ, Poslusney MS, Nance KD, Hurtado MA, Luscombe VB, Weiner RL, Rodriguez AL, Lamsal A, Chang S, Bubser M, Blobaum AL, Engers DW, Niswender CM, Jones CK, Brandon NJ, Wood MW, Duggan ME, Conn PJ, Bridges TM, Lindsley CW.

ACS Med Chem Lett. 2016 Dec 16;8(2):233-238. doi: 10.1021/acsmedchemlett.6b00461. eCollection 2017 Feb 9.

15.

Challenges in the development of an M4 PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs.

Wood MR, Noetzel MJ, Poslusney MS, Melancon BJ, Tarr JC, Lamsal A, Chang S, Luscombe VB, Weiner RL, Cho HP, Bubser M, Jones CK, Niswender CM, Wood MW, Engers DW, Brandon NJ, Duggan ME, Conn PJ, Bridges TM, Lindsley CW.

Bioorg Med Chem Lett. 2017 Jan 15;27(2):171-175. doi: 10.1016/j.bmcl.2016.11.086. Epub 2016 Nov 30.

16.

Identification of a Chrysanthemic Ester as an Apolipoprotein E Inducer in Astrocytes.

Fan J, Zareyan S, Zhao W, Shimizu Y, Pfeifer TA, Tak JH, Isman MB, Van den Hoven B, Duggan ME, Wood MW, Wellington CL, Kulic I.

PLoS One. 2016 Sep 6;11(9):e0162384. doi: 10.1371/journal.pone.0162384. eCollection 2016.

17.

Discovery and SAR of a novel series of potent, CNS penetrant M4 PAMs based on a non-enolizable ketone core: Challenges in disposition.

Wood MR, Noetzel MJ, Tarr JC, Rodriguez AL, Lamsal A, Chang S, Foster JJ, Smith E, Chase P, Hodder PS, Engers DW, Niswender CM, Brandon NJ, Wood MW, Duggan ME, Conn PJ, Bridges TM, Lindsley CW.

Bioorg Med Chem Lett. 2016 Sep 1;26(17):4282-6. doi: 10.1016/j.bmcl.2016.07.042. Epub 2016 Jul 21.

18.

Listeria monocytogenes septicemia in an immunocompromised dog.

Pritchard JC, Jacob ME, Ward TJ, Parsons CT, Kathariou S, Wood MW.

Vet Clin Pathol. 2016 Jun;45(2):254-259. doi: 10.1111/vcp.12363. Epub 2016 May 24.

PMID:
27218230
19.

Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine core.

Wood MR, Noetzel MJ, Engers JL, Bollinger KA, Melancon BJ, Tarr JC, Han C, West M, Gregro AR, Lamsal A, Chang S, Ajmera S, Smith E, Chase P, Hodder PS, Bubser M, Jones CK, Hopkins CR, Emmitte KA, Niswender CM, Wood MW, Duggan ME, Conn PJ, Bridges TM, Lindsley CW.

Bioorg Med Chem Lett. 2016 Jul 1;26(13):3029-3033. doi: 10.1016/j.bmcl.2016.05.010. Epub 2016 May 5.

20.

State-dependent alterations in sleep/wake architecture elicited by the M4 PAM VU0467154 - Relation to antipsychotic-like drug effects.

Gould RW, Nedelcovych MT, Gong X, Tsai E, Bubser M, Bridges TM, Wood MR, Duggan ME, Brandon NJ, Dunlop J, Wood MW, Ivarsson M, Noetzel MJ, Daniels JS, Niswender CM, Lindsley CW, Conn PJ, Jones CK.

Neuropharmacology. 2016 Mar;102:244-53. doi: 10.1016/j.neuropharm.2015.11.016. Epub 2015 Nov 23.

21.

Fragment-assisted hit investigation involving integrated HTS and fragment screening: Application to the identification of phosphodiesterase 10A (PDE10A) inhibitors.

Varnes JG, Geschwindner S, Holmquist CR, Forst J, Wang X, Dekker N, Scott CW, Tian G, Wood MW, Albert JS.

Bioorg Med Chem Lett. 2016 Jan 1;26(1):197-202. doi: 10.1016/j.bmcl.2015.10.100. Epub 2015 Nov 11.

PMID:
26597534
22.

Quetiapine and its metabolite norquetiapine: translation from in vitro pharmacology to in vivo efficacy in rodent models.

Cross AJ, Widzowski D, Maciag C, Zacco A, Hudzik T, Liu J, Nyberg S, Wood MW.

Br J Pharmacol. 2016 Jan;173(1):155-66. doi: 10.1111/bph.13346. Epub 2015 Dec 1.

23.

Selective activation of M4 muscarinic acetylcholine receptors reverses MK-801-induced behavioral impairments and enhances associative learning in rodents.

Bubser M, Bridges TM, Dencker D, Gould RW, Grannan M, Noetzel MJ, Lamsal A, Niswender CM, Daniels JS, Poslusney MS, Melancon BJ, Tarr JC, Byers FW, Wess J, Duggan ME, Dunlop J, Wood MW, Brandon NJ, Wood MR, Lindsley CW, Conn PJ, Jones CK.

ACS Chem Neurosci. 2014 Oct 15;5(10):920-42. doi: 10.1021/cn500128b. Epub 2014 Aug 19.

24.

Copperhead (Agkistrodon contortrix) envenomation of dogs: 52 cases (2004-2011).

Pritchard JC, Birkenheuer AJ, Hanel RM, Wood MW.

J Am Anim Hosp Assoc. 2014 Sep-Oct;50(5):338-44. doi: 10.5326/JAAHA-MS-6131.

PMID:
25028441
25.
26.

Vaginal microbiota of spayed dogs with or without recurrent urinary tract infections.

Hutchins RG, Vaden SL, Jacob ME, Harris TL, Bowles KD, Wood MW, Bailey CS.

J Vet Intern Med. 2014 Mar-Apr;28(2):300-4. doi: 10.1111/jvim.12299. Epub 2014 Jan 27.

27.

Tracheal reconstruction in a canine model.

Wood MW, Murphy SV, Feng X, Wright SC Jr.

Otolaryngol Head Neck Surg. 2014 Mar;150(3):428-33. doi: 10.1177/0194599813516751. Epub 2013 Dec 23.

PMID:
24367052
28.

The effect of an oral probiotic containing lactobacillus, bifidobacterium, and bacillus species on the vaginal microbiota of spayed female dogs.

Hutchins RG, Bailey CS, Jacob ME, Harris TL, Wood MW, Saker KE, Vaden SL.

J Vet Intern Med. 2013 Nov-Dec;27(6):1368-71. doi: 10.1111/jvim.12174. Epub 2013 Aug 28.

29.

Azepines and piperidines with dual norepinephrine dopamine uptake inhibition and antidepressant activity.

Brown DG, Bernstein PR, Wu Y, Urbanek RA, Becker CW, Throner SR, Dembofsky BT, Steelman GB, Lazor LA, Scott CW, Wood MW, Wesolowski SS, Nugiel DA, Koch S, Yu J, Pivonka DE, Li S, Thompson C, Zacco A, Elmore CS, Schroeder P, Liu J, Hurley CA, Ward S, Hunt HJ, Williams K, McLaughlin J, Hoesch V, Sydserff S, Maier D, Aharony D.

ACS Med Chem Lett. 2012 Nov 12;4(1):46-51. doi: 10.1021/ml300262e. eCollection 2013 Jan 10.

30.

Dysphonia and dermatomyositis: an unusual manifestation.

Wood MW, McNeill E, Mims JW, Wright SC Jr.

Laryngoscope. 2013 Feb;123(2):460-2. doi: 10.1002/lary.23540. Epub 2012 Oct 5.

PMID:
23042610
31.

Uropathogenic E. coli promote a paracellular urothelial barrier defect characterized by altered tight junction integrity, epithelial cell sloughing and cytokine release.

Wood MW, Breitschwerdt EB, Nordone SK, Linder KE, Gookin JL.

J Comp Pathol. 2012 Jul;147(1):11-9. doi: 10.1016/j.jcpa.2011.09.005. Epub 2011 Oct 19.

32.

2,6-Disubstituted pyrazines and related analogs as NR2B site antagonists of the NMDA receptor with anti-depressant activity.

Brown DG, Maier DL, Sylvester MA, Hoerter TN, Menhaji-Klotz E, Lasota CC, Hirata LT, Wilkins DE, Scott CW, Trivedi S, Chen T, McCarthy DJ, Maciag CM, Sutton EJ, Cumberledge J, Mathisen D, Roberts J, Gupta A, Liu F, Elmore CS, Alhambra C, Krumrine JR, Wang X, Ciaccio PJ, Wood MW, Campbell JB, Johansson MJ, Xia J, Wen X, Jiang J, Wang X, Peng Z, Hu T, Wang J.

Bioorg Med Chem Lett. 2011 Jun 1;21(11):3399-403. doi: 10.1016/j.bmcl.2011.03.117. Epub 2011 Apr 8.

PMID:
21524576
33.
34.

Autocrine effects of interleukin-6 mediate acute-phase proinflammatory and tissue-reparative transcriptional responses of canine bladder mucosa.

Wood MW, Breitschwerdt EB, Gookin JL.

Infect Immun. 2011 Feb;79(2):708-15. doi: 10.1128/IAI.01102-10. Epub 2010 Nov 29.

35.
36.

Identification of N-(2-(azepan-1-yl)-2-phenylethyl)-benzenesulfonamides as novel inhibitors of GlyT1.

Varnes JG, Forst JM, Hoerter TN, Holmquist CR, Wilkins DE, Tian G, Jonak G, Wang X, Potts WM, Wood MW, Alhambra C, Brugel TA, Albert JS.

Bioorg Med Chem Lett. 2010 Aug 15;20(16):4878-81. doi: 10.1016/j.bmcl.2010.06.085. Epub 2010 Jun 19.

PMID:
20637614
37.

A totally implantable hearing system--design and function characterization in 3D computational model and temporal bones.

Gan RZ, Dai C, Wang X, Nakmali D, Wood MW.

Hear Res. 2010 May;263(1-2):138-44. doi: 10.1016/j.heares.2009.09.003. Epub 2009 Sep 20.

PMID:
19772909
38.

Finite element modeling of sound transmission with perforations of tympanic membrane.

Gan RZ, Cheng T, Dai C, Yang F, Wood MW.

J Acoust Soc Am. 2009 Jul;126(1):243-53. doi: 10.1121/1.3129129.

39.

The human-animal bond in veterinary medical education: accessing web-based information.

Hart LA, Wood MW.

J Vet Med Educ. 2008 Winter;35(4):520-4. doi: 10.3138/jvme.35.4.520.

40.

Combined effect of fluid and pressure on middle ear function.

Dai C, Wood MW, Gan RZ.

Hear Res. 2008 Feb;236(1-2):22-32. Epub 2007 Nov 24.

41.

Cystoscopic-guided balloon dilation of a urethral stricture in a female dog.

Wood MW, Vaden S, Cerda-Gonzalez S, Keene B.

Can Vet J. 2007 Jul;48(7):731-3.

42.
43.

Fixation and detachment of superior and anterior malleolar ligaments in human middle ear: experiment and modeling.

Dai C, Cheng T, Wood MW, Gan RZ.

Hear Res. 2007 Aug;230(1-2):24-33. Epub 2007 Apr 20.

44.

Bacterial contamination of stethoscopes with antimicrobial diaphragm covers.

Wood MW, Lund RC, Stevenson KB.

Am J Infect Control. 2007 May;35(4):263-6.

PMID:
17482998
45.

Laser interferometry measurements of middle ear fluid and pressure effects on sound transmission.

Gan RZ, Dai C, Wood MW.

J Acoust Soc Am. 2006 Dec;120(6):3799-810.

PMID:
17225407
46.

Salmonella typhimurium infection triggers dendritic cells and macrophages to adopt distinct migration patterns in vivo.

Zhao C, Wood MW, Galyov EE, Höpken UE, Lipp M, Bodmer HC, Tough DF, Carter RW.

Eur J Immunol. 2006 Nov;36(11):2939-50.

47.

Mainstreaming alternatives in veterinary medical education: resource development and curricular reform.

Hart LA, Wood MW, Weng HY.

J Vet Med Educ. 2005 Winter;32(4):473-80.

PMID:
16421831
48.
49.
50.

A homogeneous fluorescent cell-based assay for detection of heterologously expressed nitric oxide synthase activity.

Wood MW, Hastings RC, Sygowski LA.

J Biomol Screen. 2005 Dec;10(8):849-55. Epub 2005 Oct 18.

PMID:
16234340

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