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Genomically informed small-molecule drugs overcome resistance to a sustained-release formulation of an engineered death receptor agonist in patient-derived tumor models.

Manzari MT, Anderson GR, Lin KH, Soderquist RS, Çakir M, Zhang M, Moore CE, Skelton RN, Fèvre M, Li X, Bellucci JJ, Wardell SE, Costa SA, Wood KC, Chilkoti A.

Sci Adv. 2019 Sep 4;5(9):eaaw9162. doi: 10.1126/sciadv.aaw9162. eCollection 2019 Sep.


Decoding the role of SOD2 in sickle cell disease.

Dosunmu-Ogunbi AM, Wood KC, Novelli EM, Straub AC.

Blood Adv. 2019 Sep 10;3(17):2679-2687. doi: 10.1182/bloodadvances.2019000527. Review.


Neurons in primary auditory cortex represent sound source location in a cue-invariant manner.

Wood KC, Town SM, Bizley JK.

Nat Commun. 2019 Jul 9;10(1):3019. doi: 10.1038/s41467-019-10868-9.


Label propagation defines signaling networks associated with recurrently mutated cancer genes.

Cakir M, Mukherjee S, Wood KC.

Sci Rep. 2019 Jun 28;9(1):9401. doi: 10.1038/s41598-019-45603-3.


Antagonism of Forkhead Box Subclass O Transcription Factors Elicits Loss of Soluble Guanylyl Cyclase Expression.

Galley JC, Durgin BG, Miller MP, Hahn SA, Yuan S, Wood KC, Straub AC.

Mol Pharmacol. 2019 Jun;95(6):629-637. doi: 10.1124/mol.118.115386. Epub 2019 Apr 15.


Bayesian Approximate Kernel Regression with Variable Selection.

Crawford L, Wood KC, Zhou X, Mukherjee S.

J Am Stat Assoc. 2018;113(524):1710-1721. doi: 10.1080/01621459.2017.1361830. Epub 2018 Jun 19.


Systematic Dissection of the Metabolic-Apoptotic Interface in AML Reveals Heme Biosynthesis to Be a Regulator of Drug Sensitivity.

Lin KH, Xie A, Rutter JC, Ahn YR, Lloyd-Cowden JM, Nichols AG, Soderquist RS, Koves TR, Muoio DM, MacIver NJ, Lamba JK, Pardee TS, McCall CM, Rizzieri DA, Wood KC.

Cell Metab. 2019 May 7;29(5):1217-1231.e7. doi: 10.1016/j.cmet.2019.01.011. Epub 2019 Feb 14.


Sound identity is represented robustly in auditory cortex during perceptual constancy.

Town SM, Wood KC, Bizley JK.

Nat Commun. 2018 Nov 14;9(1):4786. doi: 10.1038/s41467-018-07237-3.


Synthetic lethality between HER2 and transaldolase in intrinsically resistant HER2-positive breast cancers.

Ding Y, Gong C, Huang, Chen R, Sui P, Lin KH, Liang G, Yuan L, Xiang H, Chen J, Yin T, Alexander PB, Wang QF, Song EW, Li QJ, Wood KC, Wang XF.

Nat Commun. 2018 Oct 15;9(1):4274. doi: 10.1038/s41467-018-06651-x.


Systematic mapping of BCL-2 gene dependencies in cancer reveals molecular determinants of BH3 mimetic sensitivity.

Soderquist RS, Crawford L, Liu E, Lu M, Agarwal A, Anderson GR, Lin KH, Winter PS, Cakir M, Wood KC.

Nat Commun. 2018 Aug 29;9(1):3513. doi: 10.1038/s41467-018-05815-z.


Multisensory stimuli improve relative localisation judgments compared to unisensory auditory or visual stimuli.

Freeman LCA, Wood KC, Bizley JK.

J Acoust Soc Am. 2018 Jun;143(6):EL516. doi: 10.1121/1.5042759.


An acoustofluidic trap and transfer approach for organizing a high density single cell array.

Ohiri KA, Kelly ST, Motschman JD, Lin KH, Wood KC, Yellen BB.

Lab Chip. 2018 Jul 10;18(14):2124-2133. doi: 10.1039/c8lc00196k.


Mapping Effector-Phenotype Landscapes in KRAS-Driven Cancers.

Winter PS, Wood KC.

Trends Cancer. 2018 May;4(5):333-335. doi: 10.1016/j.trecan.2018.02.004. Epub 2018 Mar 7.


Dysregulation of mitochondrial dynamics proteins are a targetable feature of human tumors.

Anderson GR, Wardell SE, Cakir M, Yip C, Ahn YR, Ali M, Yllanes AP, Chao CA, McDonnell DP, Wood KC.

Nat Commun. 2018 Apr 26;9(1):1677. doi: 10.1038/s41467-018-04033-x.


Redox regulation of soluble guanylyl cyclase.

Shah RC, Sanker S, Wood KC, Durgin BG, Straub AC.

Nitric Oxide. 2018 Jun 1;76:97-104. doi: 10.1016/j.niox.2018.03.013. Epub 2018 Mar 22. Review.


Integration of Visual Information in Auditory Cortex Promotes Auditory Scene Analysis through Multisensory Binding.

Atilgan H, Town SM, Wood KC, Jones GP, Maddox RK, Lee AKC, Bizley JK.

Neuron. 2018 Feb 7;97(3):640-655.e4. doi: 10.1016/j.neuron.2017.12.034. Epub 2018 Jan 26.


Nitric Oxide-Independent Soluble Guanylate Cyclase Activation Improves Vascular Function and Cardiac Remodeling in Sickle Cell Disease.

Potoka KP, Wood KC, Baust JJ, Bueno M, Hahn SA, Vanderpool RR, Bachman T, Mallampalli GM, Osei-Hwedieh DO, Schrott V, Sun B, Bullock GC, Becker-Pelster EM, Wittwer M, Stampfuss J, Mathar I, Stasch JP, Truebel H, Sandner P, Mora AL, Straub AC, Gladwin MT.

Am J Respir Cell Mol Biol. 2018 May;58(5):636-647. doi: 10.1165/rcmb.2017-0292OC.


Melanoma Therapeutic Strategies that Select against Resistance by Exploiting MYC-Driven Evolutionary Convergence.

Singleton KR, Crawford L, Tsui E, Manchester HE, Maertens O, Liu X, Liberti MV, Magpusao AN, Stein EM, Tingley JP, Frederick DT, Boland GM, Flaherty KT, McCall SJ, Krepler C, Sproesser K, Herlyn M, Adams DJ, Locasale JW, Cichowski K, Mukherjee S, Wood KC.

Cell Rep. 2017 Dec 5;21(10):2796-2812. doi: 10.1016/j.celrep.2017.11.022.


Cortical inhibitory interneurons control sensory processing.

Wood KC, Blackwell JM, Geffen MN.

Curr Opin Neurobiol. 2017 Oct;46:200-207. doi: 10.1016/j.conb.2017.08.018. Epub 2017 Sep 20. Review.


A Landscape of Therapeutic Cooperativity in KRAS Mutant Cancers Reveals Principles for Controlling Tumor Evolution.

Anderson GR, Winter PS, Lin KH, Nussbaum DP, Cakir M, Stein EM, Soderquist RS, Crawford L, Leeds JC, Newcomb R, Stepp P, Yip C, Wardell SE, Tingley JP, Ali M, Xu M, Ryan M, McCall SJ, McRee AJ, Counter CM, Der CJ, Wood KC.

Cell Rep. 2017 Jul 25;20(4):999-1015. doi: 10.1016/j.celrep.2017.07.006.


Codon bias imposes a targetable limitation on KRAS-driven therapeutic resistance.

Ali M, Kaltenbrun E, Anderson GR, Stephens SJ, Arena S, Bardelli A, Counter CM, Wood KC.

Nat Commun. 2017 Jun 8;8:15617. doi: 10.1038/ncomms15617.


Cytochrome b5 Reductase 3 Modulates Soluble Guanylate Cyclase Redox State and cGMP Signaling.

Rahaman MM, Nguyen AT, Miller MP, Hahn SA, Sparacino-Watkins C, Jobbagy S, Carew NT, Cantu-Medellin N, Wood KC, Baty CJ, Schopfer FJ, Kelley EE, Gladwin MT, Martin E, Straub AC.

Circ Res. 2017 Jul 7;121(2):137-148. doi: 10.1161/CIRCRESAHA.117.310705. Epub 2017 Jun 5.


Epstein-Barr virus ensures B cell survival by uniquely modulating apoptosis at early and late times after infection.

Price AM, Dai J, Bazot Q, Patel L, Nikitin PA, Djavadian R, Winter PS, Salinas CA, Barry AP, Wood KC, Johannsen EC, Letai A, Allday MJ, Luftig MA.

Elife. 2017 Apr 20;6. pii: e22509. doi: 10.7554/eLife.22509.


Suppressing oncogenic transcription with a little healthy competition.

Wood KC.

Sci Transl Med. 2017 Jan 25;9(374). pii: eaal5000. doi: 10.1126/scitranslmed.aal5000.


Acute Inactivation of Primary Auditory Cortex Causes a Sound Localisation Deficit in Ferrets.

Wood KC, Town SM, Atilgan H, Jones GP, Bizley JK.

PLoS One. 2017 Jan 18;12(1):e0170264. doi: 10.1371/journal.pone.0170264. eCollection 2017.


PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation.

Anderson GR, Wardell SE, Cakir M, Crawford L, Leeds JC, Nussbaum DP, Shankar PS, Soderquist RS, Stein EM, Tingley JP, Winter PS, Zieser-Misenheimer EK, Alley HM, Yllanes A, Haney V, Blackwell KL, McCall SJ, McDonnell DP, Wood KC.

Sci Transl Med. 2016 Dec 14;8(369):369ra175.


An EXITS strategy for decreasing cancer risk in women.

Wood KC.

Sci Transl Med. 2016 Dec 7;8(368):368ec197. No abstract available.


Erratum: Relative sound localisation abilities in human listeners [J. Acoust. Soc. Am. 138, 674-686 (2015)].

Wood KC, Bizley JK.

J Acoust Soc Am. 2016 Jun;139(6):3043. doi: 10.1121/1.4952412. No abstract available.


Targeting MCL-1/BCL-XL Forestalls the Acquisition of Resistance to ABT-199 in Acute Myeloid Leukemia.

Lin KH, Winter PS, Xie A, Roth C, Martz CA, Stein EM, Anderson GR, Tingley JP, Wood KC.

Sci Rep. 2016 Jun 10;6:27696. doi: 10.1038/srep27696.


An Automated High-throughput Array Microscope for Cancer Cell Mechanics.

Cribb JA, Osborne LD, Beicker K, Psioda M, Chen J, O'Brien ET, Taylor Ii RM, Vicci L, Hsiao JP, Shao C, Falvo M, Ibrahim JG, Wood KC, Blobe GC, Superfine R.

Sci Rep. 2016 Jun 6;6:27371. doi: 10.1038/srep27371.


ERRα-Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer.

Park S, Chang CY, Safi R, Liu X, Baldi R, Jasper JS, Anderson GR, Liu T, Rathmell JC, Dewhirst MW, Wood KC, Locasale JW, McDonnell DP.

Cell Rep. 2016 Apr 12;15(2):323-35. doi: 10.1016/j.celrep.2016.03.026. Epub 2016 Mar 31.


Simultaneous Assessment of Speech Identification and Spatial Discrimination: A Potential Testing Approach for Bilateral Cochlear Implant Users?

Bizley JK, Elliott N, Wood KC, Vickers DA.

Trends Hear. 2015 Dec 30;19. pii: 2331216515619573. doi: 10.1177/2331216515619573.


Vertical suppression of the EGFR pathway prevents onset of resistance in colorectal cancers.

Misale S, Bozic I, Tong J, Peraza-Penton A, Lallo A, Baldi F, Lin KH, Truini M, Trusolino L, Bertotti A, Di Nicolantonio F, Nowak MA, Zhang L, Wood KC, Bardelli A.

Nat Commun. 2015 Sep 22;6:8305. doi: 10.1038/ncomms9305.


Mapping the Pathways of Resistance to Targeted Therapies.

Wood KC.

Cancer Res. 2015 Oct 15;75(20):4247-51. doi: 10.1158/0008-5472.CAN-15-1248. Epub 2015 Sep 21. Review.


High Prevalence of Low Bone Mineral Density and Substantial Bone Loss over 4 Years Among HIV-Infected Persons in the Era of Modern Antiretroviral Therapy.

Escota GV, Mondy K, Bush T, Conley L, Brooks JT, Önen N, Patel P, Kojic EM, Henry K, Hammer J, Wood KC, Lichtenstein KA, Overton ET.

AIDS Res Hum Retroviruses. 2016 Jan;32(1):59-67. doi: 10.1089/aid.2015.0158. Epub 2015 Sep 14.


Relative sound localisation abilities in human listeners.

Wood KC, Bizley JK.

J Acoust Soc Am. 2015 Aug;138(2):674-86. doi: 10.1121/1.4923452. Erratum in: J Acoust Soc Am. 2016 Jun;139(6):3043.


Statin Use Is Associated With Incident Diabetes Mellitus Among Patients in the HIV Outpatient Study.

Lichtenstein KA, Hart RL, Wood KC, Bozzette S, Buchacz K, Brooks JT; HIV Outpatient Study Investigators.

J Acquir Immune Defic Syndr. 2015 Jul 1;69(3):306-11. doi: 10.1097/QAI.0000000000000581.


The role of spectral cues in timbre discrimination by ferrets and humans.

Town SM, Atilgan H, Wood KC, Bizley JK.

J Acoust Soc Am. 2015 May;137(5):2870-83. doi: 10.1121/1.4916690.


RAS signaling promotes resistance to JAK inhibitors by suppressing BAD-mediated apoptosis.

Winter PS, Sarosiek KA, Lin KH, Meggendorfer M, Schnittger S, Letai A, Wood KC.

Sci Signal. 2014 Dec 23;7(357):ra122. doi: 10.1126/scisignal.2005301.


Systematic identification of signaling pathways with potential to confer anticancer drug resistance.

Martz CA, Ottina KA, Singleton KR, Jasper JS, Wardell SE, Peraza-Penton A, Anderson GR, Winter PS, Wang T, Alley HM, Kwong LN, Cooper ZA, Tetzlaff M, Chen PL, Rathmell JC, Flaherty KT, Wargo JA, McDonnell DP, Sabatini DM, Wood KC.

Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877.


Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation.

Gerriets VA, Kishton RJ, Nichols AG, Macintyre AN, Inoue M, Ilkayeva O, Winter PS, Liu X, Priyadharshini B, Slawinska ME, Haeberli L, Huck C, Turka LA, Wood KC, Hale LP, Smith PA, Schneider MA, MacIver NJ, Locasale JW, Newgard CB, Shinohara ML, Rathmell JC.

J Clin Invest. 2015 Jan;125(1):194-207. doi: 10.1172/JCI76012. Epub 2014 Dec 1.


Uncovering scaling laws to infer multidrug response of resistant microbes and cancer cells.

Wood KB, Wood KC, Nishida S, Cluzel P.

Cell Rep. 2014 Mar 27;6(6):1073-1084. doi: 10.1016/j.celrep.2014.02.007. Epub 2014 Mar 6.


Improved genetically-encoded, FlincG-type fluorescent biosensors for neural cGMP imaging.

Bhargava Y, Hampden-Smith K, Chachlaki K, Wood KC, Vernon J, Allerston CK, Batchelor AM, Garthwaite J.

Front Mol Neurosci. 2013 Sep 24;6:26. doi: 10.3389/fnmol.2013.00026. eCollection 2013.


Circulating blood endothelial nitric oxide synthase contributes to the regulation of systemic blood pressure and nitrite homeostasis.

Wood KC, Cortese-Krott MM, Kovacic JC, Noguchi A, Liu VB, Wang X, Raghavachari N, Boehm M, Kato GJ, Kelm M, Gladwin MT.

Arterioscler Thromb Vasc Biol. 2013 Aug;33(8):1861-71. doi: 10.1161/ATVBAHA.112.301068. Epub 2013 May 23.


Feasibility of gestural feedback treatment for upper extremity movement in children with cerebral palsy.

Wood KC, Lathan CE, Kaufman KR.

IEEE Trans Neural Syst Rehabil Eng. 2013 Mar;21(2):300-5. doi: 10.1109/TNSRE.2012.2227804. Epub 2012 Nov 16.


Selective endothelial overexpression of arginase II induces endothelial dysfunction and hypertension and enhances atherosclerosis in mice.

Vaisman BL, Andrews KL, Khong SM, Wood KC, Moore XL, Fu Y, Kepka-Lenhart DM, Morris SM Jr, Remaley AT, Chin-Dusting JP.

PLoS One. 2012;7(7):e39487. doi: 10.1371/journal.pone.0039487. Epub 2012 Jul 19.


MicroSCALE screening reveals genetic modifiers of therapeutic response in melanoma.

Wood KC, Konieczkowski DJ, Johannessen CM, Boehm JS, Tamayo P, Botvinnik OB, Mesirov JP, Hahn WC, Root DE, Garraway LA, Sabatini DM.

Sci Signal. 2012 May 15;5(224):rs4. doi: 10.1126/scisignal.2002612.


Report of the National Heart, Lung, and Blood Institute Working Group on epigenetics and hypertension.

Cowley AW Jr, Nadeau JH, Baccarelli A, Berecek K, Fornage M, Gibbons GH, Harrison DG, Liang M, Nathanielsz PW, O'Connor DT, Ordovas J, Peng W, Soares MB, Szyf M, Tolunay HE, Wood KC, Zhao K, Galis ZS.

Hypertension. 2012 May;59(5):899-905. doi: 10.1161/HYPERTENSIONAHA.111.190116. Epub 2012 Mar 19. Review. No abstract available.


Picomolar nitric oxide signals from central neurons recorded using ultrasensitive detector cells.

Wood KC, Batchelor AM, Bartus K, Harris KL, Garthwaite G, Vernon J, Garthwaite J.

J Biol Chem. 2011 Dec 16;286(50):43172-81. doi: 10.1074/jbc.M111.289777. Epub 2011 Oct 20.

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