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Items: 32

1.

Design, synthesis and biological evaluation of 8-(2-amino-1-hydroxyethyl)-6-hydroxy-1,4-benzoxazine-3(4H)-one derivatives as potent β2-adrenoceptor agonists.

Yi C, Xing G, Wang S, Li X, Liu Y, Li J, Lin B, Woo AY, Zhang Y, Pan L, Cheng M.

Bioorg Med Chem. 2020 Jan 1;28(1):115178. doi: 10.1016/j.bmc.2019.115178. Epub 2019 Nov 11.

PMID:
31753798
2.

Discovery of β-arrestin-biased β2-adrenoceptor agonists from 2-amino-2-phenylethanol derivatives.

Woo AY, Ge XY, Pan L, Xing G, Mo YM, Xing RJ, Li XR, Zhang YY, Wainer IW, Cheng MS, Xiao RP.

Acta Pharmacol Sin. 2019 Aug;40(8):1095-1105. doi: 10.1038/s41401-018-0200-x. Epub 2019 Jan 14.

PMID:
30643208
3.

ADRB2 polymorphism Arg16Gly modifies the natural outcome of heart failure and dictates therapeutic response to β-blockers in patients with heart failure.

Huang J, Li C, Song Y, Fan X, You L, Tan L, Xiao L, Li Q, Ruan G, Hu S, Cui W, Li Z, Ni L, Chen C, Woo AY, Xiao RP, Wang DW.

Cell Discov. 2018 Oct 23;4:57. doi: 10.1038/s41421-018-0058-6. eCollection 2018.

4.

Synthesis, biological evaluation and molecular modeling of 2-amino-2-phenylethanol derivatives as novel β2-adrenoceptor agonists.

Ge X, Mo Y, Xing G, Ji L, Zhao H, Chen J, He B, Chen X, Xing R, Li X, Zhao Y, Li J, Yan H, Woo AY, Zhang Y, Lin B, Pan L, Cheng M.

Bioorg Chem. 2018 Sep;79:155-162. doi: 10.1016/j.bioorg.2018.04.017. Epub 2018 Apr 26.

PMID:
29751321
5.

Synthesis and biological evaluation of β2-adrenoceptor agonists bearing the 2-amino-2-phenylethanol scaffold.

Ge X, Woo AY, Xing G, Lu Y, Mo Y, Zhao Y, Lan Y, Li J, Yan H, Pan L, Zhang Y, Lin B, Cheng M.

Eur J Med Chem. 2018 May 25;152:424-435. doi: 10.1016/j.ejmech.2018.04.041. Epub 2018 Apr 30.

PMID:
29751236
6.

Biased Agonism at the Angiotensin Receptor: Blocker and Calcium Sensitizer at the Same Time.

Woo AY, Komuro I, Xiao RP.

Circulation. 2017 Mar 14;135(11):1071-1074. doi: 10.1161/CIRCULATIONAHA.117.027276. No abstract available.

PMID:
28289006
7.

GRK2/β-arrestin mediates arginine vasopressin-induced cardiac fibroblast proliferation.

Chen Y, Xu F, Zhang L, Wang X, Wang Y, Woo AY, Zhu W.

Clin Exp Pharmacol Physiol. 2017 Feb;44(2):285-293. doi: 10.1111/1440-1681.12696.

PMID:
27862165
8.

Vasopressin V1A receptor mediates cell proliferation through GRK2-EGFR-ERK1/2 pathway in A7r5 cells.

Zhang L, Wang X, Cao H, Chen Y, Chen X, Zhao X, Xu F, Wang Y, Woo AY, Zhu W.

Eur J Pharmacol. 2016 Dec 5;792:15-25. doi: 10.1016/j.ejphar.2016.10.023. Epub 2016 Oct 20.

PMID:
27773680
9.

Interaction of β1-adrenoceptor with RAGE mediates cardiomyopathy via CaMKII signaling.

Zhu W, Tsang S, Browe DM, Woo AY, Huang Y, Xu C, Liu JF, Lv F, Zhang Y, Xiao RP.

JCI Insight. 2016;1(1):e84969. doi: 10.1172/jci.insight.84969.

10.

Advances in receptor conformation research: the quest for functionally selective conformations focusing on the β2-adrenoceptor.

Woo AY, Song Y, Zhu W, Xiao RP.

Br J Pharmacol. 2015 Dec;172(23):5477-88. doi: 10.1111/bph.13049. Epub 2015 Feb 27. Review.

11.

Biased β2-adrenoceptor signalling in heart failure: pathophysiology and drug discovery.

Woo AY, Song Y, Xiao RP, Zhu W.

Br J Pharmacol. 2015 Dec;172(23):5444-56. doi: 10.1111/bph.12965. Epub 2014 Dec 17. Review.

12.

Tyrosine 308 is necessary for ligand-directed Gs protein-biased signaling of β2-adrenoceptor.

Woo AY, Jozwiak K, Toll L, Tanga MJ, Kozocas JA, Jimenez L, Huang Y, Song Y, Plazinska A, Pajak K, Paul RK, Bernier M, Wainer IW, Xiao RP.

J Biol Chem. 2014 Jul 11;289(28):19351-63. doi: 10.1074/jbc.M114.558882. Epub 2014 May 15.

13.

Dithiazolo[5,4-b:4',5'-d]phosphole: a highly luminescent electron-accepting building block.

He X, Woo AY, Borau-Garcia J, Baumgartner T.

Chemistry. 2013 Jun 3;19(23):7620-30. doi: 10.1002/chem.201204375. Epub 2013 Apr 8.

PMID:
23568602
14.

Dithieno[3,2-c:2',3'-e]-2,7-diketophosphepin: a unique building block for multifunctional π-conjugated materials.

He X, Borau-Garcia J, Woo AY, Trudel S, Baumgartner T.

J Am Chem Soc. 2013 Jan 23;135(3):1137-47. doi: 10.1021/ja310680x. Epub 2013 Jan 11.

PMID:
23308359
15.

β-Adrenergic receptor subtype signaling in heart: from bench to bedside.

Woo AY, Xiao RP.

Acta Pharmacol Sin. 2012 Mar;33(3):335-41. doi: 10.1038/aps.2011.201. Epub 2012 Jan 30. Review.

16.

β-adrenergic receptor subtype signaling in the heart: from bench to the bedside.

Zhu W, Woo AY, Zhang Y, Cao CM, Xiao RP.

Curr Top Membr. 2011;67:191-204. doi: 10.1016/B978-0-12-384921-2.00009-4. Review. No abstract available.

PMID:
21771491
17.

Effect of fenoterol stereochemistry on the β2 adrenergic receptor system: ligand-directed chiral recognition.

Jozwiak K, Plazinska A, Toll L, Jimenez L, Woo AY, Xiao RP, Wainer IW.

Chirality. 2011;23 Suppl 1:E1-6. doi: 10.1002/chir.20963. Epub 2011 May 26. Review.

18.

RGS2 is a primary terminator of β₂-adrenergic receptor-mediated G(i) signaling.

Chakir K, Zhu W, Tsang S, Woo AY, Yang D, Wang X, Zeng X, Rhee MH, Mende U, Koitabashi N, Takimoto E, Blumer KJ, Lakatta EG, Kass DA, Xiao RP.

J Mol Cell Cardiol. 2011 Jun;50(6):1000-7. doi: 10.1016/j.yjmcc.2011.01.015. Epub 2011 Feb 1.

19.

{Beta}2-adrenergic receptor agonists inhibit the proliferation of 1321N1 astrocytoma cells.

Toll L, Jimenez L, Waleh N, Jozwiak K, Woo AY, Xiao RP, Bernier M, Wainer IW.

J Pharmacol Exp Ther. 2011 Feb;336(2):524-32. doi: 10.1124/jpet.110.173971. Epub 2010 Nov 11.

20.

The effect of stereochemistry on the thermodynamic characteristics of the binding of fenoterol stereoisomers to the beta(2)-adrenoceptor.

Jozwiak K, Toll L, Jimenez L, Woo AY, Xiao RP, Wainer IW.

Biochem Pharmacol. 2010 Jun 1;79(11):1610-5. doi: 10.1016/j.bcp.2010.01.035. Epub 2010 Feb 6.

21.

Deregulation of RGS2 in cardiovascular diseases.

Tsang S, Woo AY, Zhu W, Xiao RP.

Front Biosci (Schol Ed). 2010 Jan 1;2:547-57. Review.

22.

Comparative molecular field analysis of fenoterol derivatives: A platform towards highly selective and effective beta(2)-adrenergic receptor agonists.

Jozwiak K, Woo AY, Tanga MJ, Toll L, Jimenez L, Kozocas JA, Plazinska A, Xiao RP, Wainer IW.

Bioorg Med Chem. 2010 Jan 15;18(2):728-36. doi: 10.1016/j.bmc.2009.11.062. Epub 2009 Dec 6.

23.

Stereochemistry of an agonist determines coupling preference of beta2-adrenoceptor to different G proteins in cardiomyocytes.

Woo AY, Wang TB, Zeng X, Zhu W, Abernethy DR, Wainer IW, Xiao RP.

Mol Pharmacol. 2009 Jan;75(1):158-65. doi: 10.1124/mol.108.051078. Epub 2008 Oct 7.

24.

Cardioprotective and survival benefits of long-term combined therapy with beta2 adrenoreceptor (AR) agonist and beta1 AR blocker in dilated cardiomyopathy postmyocardial infarction.

Ahmet I, Krawczyk M, Zhu W, Woo AY, Morrell C, Poosala S, Xiao RP, Lakatta EG, Talan MI.

J Pharmacol Exp Ther. 2008 May;325(2):491-9. doi: 10.1124/jpet.107.135335. Epub 2008 Feb 20.

PMID:
18287209
25.

Andrographolide up-regulates cellular-reduced glutathione level and protects cardiomyocytes against hypoxia/reoxygenation injury.

Woo AY, Waye MM, Tsui SK, Yeung ST, Cheng CH.

J Pharmacol Exp Ther. 2008 Apr;325(1):226-35. doi: 10.1124/jpet.107.133918. Epub 2008 Jan 3.

PMID:
18174384
26.
27.

Activation of CaMKIIdeltaC is a common intermediate of diverse death stimuli-induced heart muscle cell apoptosis.

Zhu W, Woo AY, Yang D, Cheng H, Crow MT, Xiao RP.

J Biol Chem. 2007 Apr 6;282(14):10833-9. Epub 2007 Feb 12.

28.

Calcyclin binding protein promotes DNA synthesis and differentiation in rat neonatal cardiomyocytes.

Au KW, Kou CY, Woo AY, Chim SS, Fung KP, Cheng CH, Waye MM, Tsui SK.

J Cell Biochem. 2006 Jun 1;98(3):555-66.

PMID:
16440310
29.

Baicalein protects rat cardiomyocytes from hypoxia/reoxygenation damage via a prooxidant mechanism.

Woo AY, Cheng CH, Waye MM.

Cardiovasc Res. 2005 Jan 1;65(1):244-53.

PMID:
15621053
30.

Inhibition of ATPases by Cleistocalyx operculatus. A possible mechanism for the cardiotonic actions of the herb.

Woo AY, Waye MM, Kwan HS, Chan MC, Chau CF, Cheng CH.

Vascul Pharmacol. 2002 Mar;38(3):163-8.

PMID:
12402515
31.

Inotropic and chronotropic actions of Ilex latifolia inhibition of adenosine-5 '-triphosphatases as a possible mechanism.

Woo AY, Jiang JM, Chau CF, Waye MM, Cheung WT, Kwan HS, Cheng CH.

Life Sci. 2001 Feb 2;68(11):1259-70.

PMID:
11233993
32.

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