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Physiologically Based Modeling Approach to Predict Dopamine D2 Receptor Occupancy of Antipsychotics in Brain: Translation From Rat to Human.

Wong YC, Centanni M, de Lange ECM.

J Clin Pharmacol. 2019 Jan 24. doi: 10.1002/jcph.1365. [Epub ahead of print]


Metanephric adenoma with low apparent diffusion coefficient value mimicking renal cell carcinoma: A case report.

Chang CB, Ng KF, Wong YC, Lee SY, Chuang CK, Wang LJ.

Medicine (Baltimore). 2018 Dec;97(49):e13539. doi: 10.1097/MD.0000000000013539.


Synaptic, Mitochondrial, and Lysosomal Dysfunction in Parkinson's Disease.

Nguyen M, Wong YC, Ysselstein D, Severino A, Krainc D.

Trends Neurosci. 2019 Feb;42(2):140-149. doi: 10.1016/j.tins.2018.11.001. Epub 2018 Nov 30. Review.


Detection and characterization of traumatic bile leaks using Gd-EOB-DTPA enhanced magnetic resonance cholangiography.

Wong YC, Wang LJ, Wu CH, Chen HW, Fu CJ, Yuan KC, Lin BC, Hsu YP, Kang SC.

Sci Rep. 2018 Oct 2;8(1):14612. doi: 10.1038/s41598-018-32976-0.


Fingerprints of CNS drug effects: a plasma neuroendocrine reflection of D2 receptor activation using multi-biomarker pharmacokinetic/pharmacodynamic modelling.

van den Brink WJ, van den Berg DJ, Bonsel FEM, Hartman R, Wong YC, van der Graaf PH, de Lange ECM.

Br J Pharmacol. 2018 Oct;175(19):3832-3843. doi: 10.1111/bph.14452. Epub 2018 Aug 31.


Risk Stratification of Upper Urinary Tract Urothelial Carcinoma Patients for Survival Prediction: A Simple Summation Scoring Method.

Wang LJ, Chou WC, Pang ST, Yang CW, Chuang CK, Chang YH, Hsieh ML, Wong YC.

J Cancer. 2018 Jun 6;9(13):2284-2294. doi: 10.7150/jca.24815. eCollection 2018.


Intranasal delivery of a novel acetylcholinesterase inhibitor HLS-3 for treatment of Alzheimer's disease.

Qian S, He L, Wang Q, Wong YC, Mak M, Ho CY, Han Y, Zuo Z.

Life Sci. 2018 Aug 15;207:428-435. doi: 10.1016/j.lfs.2018.06.032. Epub 2018 Jun 30.


DNA prime/MVTT boost regimen with HIV-1 mosaic Gag enhances the potency of antigen-specific immune responses.

Liu W, Wong YC, Chen SMY, Tang J, Wang H, Cheung AKL, Chen Z.

Vaccine. 2018 Jul 25;36(31):4621-4632. doi: 10.1016/j.vaccine.2018.06.047. Epub 2018 Jun 28.


Negative symptom dimensions differentially impact on functioning in individuals at-risk for psychosis.

Chang WC, Lee HC, Chan SI, Chiu SY, Lee HM, Chan KW, Wong MC, Chan KL, Yeung WS, Choy LW, Chong SY, Siu MW, Lo TL, Yan WC, Ng MK, Poon LT, Pang PF, Lam WC, Wong YC, Chung WS, Mo YM, Lui SY, Hui LM, Chen EYH.

Schizophr Res. 2018 Dec;202:310-315. doi: 10.1016/j.schres.2018.06.041. Epub 2018 Jun 21. No abstract available.


Genetic Determinants Associated With in Vivo Survival of Burkholderia cenocepacia in the Caenorhabditis elegans Model.

Wong YC, Abd El Ghany M, Ghazzali RNM, Yap SJ, Hoh CC, Pain A, Nathan S.

Front Microbiol. 2018 May 29;9:1118. doi: 10.3389/fmicb.2018.01118. eCollection 2018.


Analysis for Patient Survival after Open Abdomen for Torso Trauma and the Impact of Achieving Primary Fascial Closure: A Single-Center Experience.

Hsu YP, Wong YC, Fu CY, Wang SY, Liao CH, Yang CO, Yuan KC.

Sci Rep. 2018 Apr 18;8(1):6213. doi: 10.1038/s41598-018-24482-0.


Transarterial embolization for postpartum hemorrhage: lessons learned.

Fu CJ, Irama W, Wong YC, Tseng HJ, Wang LJ, Yeow KM, Wu CH.

Acta Radiol. 2018 Dec;59(12):1451-1457. doi: 10.1177/0284185118769691. Epub 2018 Apr 18.


Perovskite-Initiated Photopolymerization for Singly Dispersed Luminescent Nanocomposites.

Wong YC, De Andrew Ng J, Tan ZK.

Adv Mater. 2018 May;30(21):e1800774. doi: 10.1002/adma.201800774. Epub 2018 Apr 11.


Highly Emissive Fused Heterocyclic Alkynylgold(III) Complexes for Multiple Color Emission Spanning from Green to Red for Solution-Processable Organic Light-Emitting Devices.

Tang MC, Lee CH, Ng M, Wong YC, Chan MY, Yam VW.

Angew Chem Int Ed Engl. 2018 May 4;57(19):5463-5466. doi: 10.1002/anie.201711846. Epub 2018 Mar 30.


α4β7+ CD4+ Effector/Effector Memory T Cells Differentiate into Productively and Latently Infected Central Memory T Cells by Transforming Growth Factor β1 during HIV-1 Infection.

Cheung KW, Wu T, Ho SF, Wong YC, Liu L, Wang H, Chen Z.

J Virol. 2018 Mar 28;92(8). pii: e01510-17. doi: 10.1128/JVI.01510-17. Print 2018 Apr 15.


Mitochondria-lysosome contacts regulate mitochondrial fission via RAB7 GTP hydrolysis.

Wong YC, Ysselstein D, Krainc D.

Nature. 2018 Feb 15;554(7692):382-386. doi: 10.1038/nature25486. Epub 2018 Jan 24.


Predictors of active arterial hemorrhage on angiography in pelvic fracture patients.

Lai YC, Wu CH, Chen HW, Wang LJ, Wong YC.

Jpn J Radiol. 2018 Mar;36(3):223-230. doi: 10.1007/s11604-017-0716-x. Epub 2017 Dec 27.


Correlation of defective mitotic checkpoint with aberrantly reduced expression of MAD2 protein in nasopharyngeal carcinoma cells.

Wang X, Jin DY, Wong YC, Cheung ALM, Chun ACS, Lo AKF, Liu Y, Tsao SW.

Carcinogenesis. 2018 Feb 9;39(2):305. doi: 10.1093/carcin/bgx127. No abstract available.


Prediction of traumatic carotid-cavernous sinus fistula via noncontrast computed tomography by fracture pattern and abnormality of venous system.

Mao SH, Lin TC, Chen CH, Chou PY, Wang SY, Wong YC, Chen CT.

J Trauma Acute Care Surg. 2018 Feb;84(2):312-318. doi: 10.1097/TA.0000000000001749.


Distal embolization versus combined embolization techniques for blunt splenic injuries: comparison of the efficacy and complications.

Wong YC, Wu CH, Wang LJ, Chen HW, Yuan KC, Lin BC, Hsu YP, Kang SC.

Oncotarget. 2017 Oct 5;8(56):95596-95605. doi: 10.18632/oncotarget.21527. eCollection 2017 Nov 10.


Multi-functional bis(alkynyl)gold(iii) N⁁C complexes with distinct mechanochromic luminescence and electroluminescence properties.

Wong BY, Wong HL, Wong YC, Au VK, Chan MY, Yam VW.

Chem Sci. 2017 Oct 1;8(10):6936-6946. doi: 10.1039/c7sc02410j. Epub 2017 Aug 23.


Prediction of human CNS pharmacokinetics using a physiologically-based pharmacokinetic modeling approach.

Yamamoto Y, Välitalo PA, Wong YC, Huntjens DR, Proost JH, Vermeulen A, Krauwinkel W, Beukers MW, Kokki H, Kokki M, Danhof M, van Hasselt JGC, de Lange ECM.

Eur J Pharm Sci. 2018 Jan 15;112:168-179. doi: 10.1016/j.ejps.2017.11.011. Epub 2017 Nov 11.


Development of a population pharmacokinetic model to predict brain distribution and dopamine D2 receptor occupancy of raclopride in non-anesthetized rat.

Wong YC, Ilkova T, van Wijk RC, Hartman R, de Lange ECM.

Eur J Pharm Sci. 2018 Jan 1;111:514-525. doi: 10.1016/j.ejps.2017.10.031. Epub 2017 Nov 5.


Progranulin-mediated deficiency of cathepsin D results in FTD and NCL-like phenotypes in neurons derived from FTD patients.

Valdez C, Wong YC, Schwake M, Bu G, Wszolek ZK, Krainc D.

Hum Mol Genet. 2017 Dec 15;26(24):4861-4872. doi: 10.1093/hmg/ddx364.


Corrigendum: Correlation of defective mitotic checkpoint with aberrantly reduced expression of MAD2 protein in nasopharyngeal carcinoma cells.

Wang X, Jin DY, Wong YC, Cheung ALM, Chun ACS, Lo AKF, Liu Y, Tsao SW.

Carcinogenesis. 2017 Oct 26;38(11):1155. doi: 10.1093/carcin/bgx086. No abstract available. Erratum in: Carcinogenesis. 2018 Feb 9;39(2):305.


Novel CNS drug discovery and development approach: model-based integration to predict neuro-pharmacokinetics and pharmacodynamics.

de Lange ECM, van den Brink W, Yamamoto Y, de Witte WEA, Wong YC.

Expert Opin Drug Discov. 2017 Dec;12(12):1207-1218. doi: 10.1080/17460441.2017.1380623. Epub 2017 Sep 21. Review.


Analysis of blood-based gene expression in idiopathic Parkinson disease.

Shamir R, Klein C, Amar D, Vollstedt EJ, Bonin M, Usenovic M, Wong YC, Maver A, Poths S, Safer H, Corvol JC, Lesage S, Lavi O, Deuschl G, Kuhlenbaeumer G, Pawlack H, Ulitsky I, Kasten M, Riess O, Brice A, Peterlin B, Krainc D.

Neurology. 2017 Oct 17;89(16):1676-1683. doi: 10.1212/WNL.0000000000004516. Epub 2017 Sep 15.


Rapid Emergency Medicine Score: A novel prognostic tool for predicting the outcomes of adult patients with hepatic portal venous gas in the emergency department.

Seak CJ, Yen DH, Ng CJ, Wong YC, Hsu KH, Seak JC, Chen HY, Seak CK.

PLoS One. 2017 Sep 15;12(9):e0184813. doi: 10.1371/journal.pone.0184813. eCollection 2017.


Predicting Drug Concentration-Time Profiles in Multiple CNS Compartments Using a Comprehensive Physiologically-Based Pharmacokinetic Model.

Yamamoto Y, Välitalo PA, Huntjens DR, Proost JH, Vermeulen A, Krauwinkel W, Beukers MW, van den Berg DJ, Hartman R, Wong YC, Danhof M, van Hasselt JGC, de Lange ECM.

CPT Pharmacometrics Syst Pharmacol. 2017 Nov;6(11):765-777. doi: 10.1002/psp4.12250. Epub 2017 Oct 13.


Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson's disease.

Burbulla LF, Song P, Mazzulli JR, Zampese E, Wong YC, Jeon S, Santos DP, Blanz J, Obermaier CD, Strojny C, Savas JN, Kiskinis E, Zhuang X, Krüger R, Surmeier DJ, Krainc D.

Science. 2017 Sep 22;357(6357):1255-1261. doi: 10.1126/science.aam9080. Epub 2017 Sep 7.


Embracing the setting sun: provision of palliative care via a collaborative model between hospital and community for patients with intellectual disabilities.

Li CW, Wong YC, Lo YM, Sham MK, Cheng HW, Lai T, Lau WK, Chan KY.

Ann Palliat Med. 2018 Jul;7(3):365-367. doi: 10.21037/apm.2017.08.03. Epub 2017 Aug 26. No abstract available.


A Liver Capsular Network of Monocyte-Derived Macrophages Restricts Hepatic Dissemination of Intraperitoneal Bacteria by Neutrophil Recruitment.

Sierro F, Evrard M, Rizzetto S, Melino M, Mitchell AJ, Florido M, Beattie L, Walters SB, Tay SS, Lu B, Holz LE, Roediger B, Wong YC, Warren A, Ritchie W, McGuffog C, Weninger W, Le Couteur DG, Ginhoux F, Britton WJ, Heath WR, Saunders BM, McCaughan GW, Luciani F, MacDonald KPA, Ng LG, Bowen DG, Bertolino P.

Immunity. 2017 Aug 15;47(2):374-388.e6. doi: 10.1016/j.immuni.2017.07.018.


Transarterial embolisation for congenital renal arteriovenous malformations improves clinical condition even with partial obliteration.

Sheng TW, Wong YC, Wu CH, Wang LJ.

Clin Radiol. 2017 Dec;72(12):1053-1059. doi: 10.1016/j.crad.2017.07.008. Epub 2017 Aug 7.


Predictive factors for length of hospital stay following primary total knee replacement in a total joint replacement centre in Hong Kong.

Lo CK, Lee QJ, Wong YC.

Hong Kong Med J. 2017 Oct;23(5):435-40. doi: 10.12809/hkmj166113. Epub 2017 Aug 4.


Synthesis and Characterization of Luminescent Cyclometalated Platinum(II) Complexes with Tunable Emissive Colors and Studies of Their Application in Organic Memories and Organic Light-Emitting Devices.

Chan AK, Ng M, Wong YC, Chan MY, Wong WT, Yam VW.

J Am Chem Soc. 2017 Aug 9;139(31):10750-10761. doi: 10.1021/jacs.7b04952. Epub 2017 Jul 31.


Sky-Blue-Emitting Dendritic Alkynylgold(III) Complexes for Solution-Processable Organic Light-Emitting Devices.

Lee CH, Tang MC, Wong YC, Chan MY, Yam VW.

J Am Chem Soc. 2017 Aug 2;139(30):10539-10550. doi: 10.1021/jacs.7b05872. Epub 2017 Jul 21.


Differential gene expression at different stages of mesocarp development in high- and low-yielding oil palm.

Wong YC, Teh HF, Mebus K, Ooi TEK, Kwong QB, Koo KL, Ong CK, Mayes S, Chew FT, Appleton DR, Kulaveerasingam H.

BMC Genomics. 2017 Jun 21;18(1):470. doi: 10.1186/s12864-017-3855-7.


Physical activity and risk of prostate and bladder cancer in China: The South and East China case-control study on prostate and bladder cancer.

Reulen RC, de Vogel S, Zhong W, Zhong Z, Xie LP, Hu Z, Deng Y, Yang K, Liang Y, Zeng X, Wong YC, Tam PC, Hemelt M, Zeegers MP.

PLoS One. 2017 Jun 2;12(6):e0178613. doi: 10.1371/journal.pone.0178613. eCollection 2017.


Strategy for the Realization of Efficient Solution-Processable Phosphorescent Organic Light-Emitting Devices: Design and Synthesis of Bipolar Alkynylplatinum(II) Complexes.

Kong FK, Tang MC, Wong YC, Ng M, Chan MY, Yam VW.

J Am Chem Soc. 2017 May 10;139(18):6351-6362. doi: 10.1021/jacs.7b00479. Epub 2017 Apr 28.


Brain Uptake of Bioactive Flavones in Scutellariae Radix and Its Relationship to Anxiolytic Effect in Mice.

Fong SYK, Li C, Ho YC, Li R, Wang Q, Wong YC, Xue H, Zuo Z.

Mol Pharm. 2017 Sep 5;14(9):2908-2916. doi: 10.1021/acs.molpharmaceut.7b00029. Epub 2017 May 1.


Kinetics for Drug Discovery: an industry-driven effort to target drug residence time.

Schuetz DA, de Witte WEA, Wong YC, Knasmueller B, Richter L, Kokh DB, Sadiq SK, Bosma R, Nederpelt I, Heitman LH, Segala E, Amaral M, Guo D, Andres D, Georgi V, Stoddart LA, Hill S, Cooke RM, De Graaf C, Leurs R, Frech M, Wade RC, de Lange ECM, IJzerman AP, Müller-Fahrnow A, Ecker GF.

Drug Discov Today. 2017 Jun;22(6):896-911. doi: 10.1016/j.drudis.2017.02.002. Epub 2017 Apr 13. Review.


Treatment of Intracranial Aneurysms with Flow Re-direction Endoluminal Device - A Single Centre Experience with Short-term Follow-up Results.

Mahboobani NR, Chong WH, Lam SS, Siu JC, Tan CB, Wong YC.

Neurointervention. 2017 Mar;12(1):11-19. doi: 10.5469/neuroint.2017.12.1.11. Epub 2017 Mar 6.


Major pancreatic duct continuity is the crucial determinant in the management of blunt pancreatic injury: a pancreatographic classification.

Lin BC, Wong YC, Chen RJ, Liu NJ, Wu CH, Hwang TL, Hsu YP.

Surg Endosc. 2017 Oct;31(10):4201-4210. doi: 10.1007/s00464-017-5478-0. Epub 2017 Mar 9.


Blood Sparing Efficacy of Oral Tranexamic Acid in Primary Total Knee Arthroplasty: A Randomized Controlled Trial.

Lee QJ, Ching WY, Wong YC.

Knee Surg Relat Res. 2017 Mar 1;29(1):57-62. doi: 10.5792/ksrr.16.074.


Management and Outcomes of Fetal Hydrops in a Tertiary Care Centre in Singapore.

Thong XY, Lee LY, Chia DA, Wong YC, Biswas A.

Ann Acad Med Singapore. 2017 Jan;46(1):4-10.


α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies.

Wong YC, Krainc D.

Nat Med. 2017 Feb 7;23(2):1-13. doi: 10.1038/nm.4269. Review.


The Parkinson's disease-linked protein TMEM230 is required for Rab8a-mediated secretory vesicle trafficking and retromer trafficking.

Kim MJ, Deng HX, Wong YC, Siddique T, Krainc D.

Hum Mol Genet. 2017 Feb 15;26(4):729-741. doi: 10.1093/hmg/ddw413.


Peritoneal fluid of low CT Hounsfield units as a screening criterion for traumatic bowel perforation.

Wong YC, Wang LJ, Wu CH, Chen HW, Lin BC, Hsu YP.

Jpn J Radiol. 2017 Apr;35(4):145-150. doi: 10.1007/s11604-017-0613-3. Epub 2017 Jan 13.


Versatile Synthesis of Luminescent Tetradentate Cyclometalated Alkynylgold(III) Complexes and Their Application in Solution-Processable Organic Light-Emitting Devices.

Wong BY, Wong HL, Wong YC, Chan MY, Yam VW.

Angew Chem Int Ed Engl. 2017 Jan 2;56(1):302-305. doi: 10.1002/anie.201607816. Epub 2016 Nov 29.


The CD8 T-cell response during tolerance induction in liver transplantation.

Wong YC, McCaughan GW, Bowen DG, Bertolino P.

Clin Transl Immunology. 2016 Oct 14;5(10):e102. eCollection 2016 Oct. Review.

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