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Preliminary Agreement on Tracking Sleep Between a Wrist-Worn Device Fitbit Alta and Consensus Sleep Diary.

Liu J, Wong WT, Zwetsloot IM, Hsu YC, Tsui KL.

Telemed J E Health. 2019 Jan 2. doi: 10.1089/tmj.2018.0202. [Epub ahead of print]


Oral Dextromethorphan for the Treatment of Diabetic Macular Edema: Results From a Phase I/II Clinical Study.

Valent DJ, Wong WT, Chew EY, Cukras CA.

Transl Vis Sci Technol. 2018 Dec 17;7(6):24. doi: 10.1167/tvst.7.6.24. eCollection 2018 Nov.


Ergosterol peroxide from marine fungus Phoma sp. induces ROS-dependent apoptosis and autophagy in human lung adenocarcinoma cells.

Wu HY, Yang FL, Li LH, Rao YK, Ju TC, Wong WT, Hsieh CY, Pivkin MV, Hua KF, Wu SH.

Sci Rep. 2018 Dec 18;8(1):17956. doi: 10.1038/s41598-018-36411-2.


Quantification of Beat-To-Beat Variability of Action Potential Durations in Langendorff-Perfused Mouse Hearts.

Tse G, Du Y, Hao G, Li KHC, Chan FYW, Liu T, Li G, Bazoukis G, Letsas KP, Wu WKK, Cheng SH, Wong WT.

Front Physiol. 2018 Nov 27;9:1578. doi: 10.3389/fphys.2018.01578. eCollection 2018.


Resveratrol ameliorates endothelial dysfunction in diabetic and obese mice through sirtuin 1 and peroxisome proliferator-activated receptor δ.

Cheang WS, Wong WT, Wang L, Cheng CK, Lau CW, Ma RCW, Xu A, Wang N, Huang Y, Tian XY.

Pharmacol Res. 2018 Nov 29;139:384-394. doi: 10.1016/j.phrs.2018.11.041. [Epub ahead of print]


DeepSeeNet: A Deep Learning Model for Automated Classification of Patient-based Age-related Macular Degeneration Severity from Color Fundus Photographs.

Peng Y, Dharssi S, Chen Q, Keenan TD, Agrón E, Wong WT, Chew EY, Lu Z.

Ophthalmology. 2018 Nov 22. pii: S0161-6420(18)32185-7. doi: 10.1016/j.ophtha.2018.11.015. [Epub ahead of print]


Professional burnout among physicians and nurses in Asian intensive care units: a multinational survey.

See KC, Zhao MY, Nakataki E, Chittawatanarat K, Fang WF, Faruq MO, Wahjuprajitno B, Arabi YM, Wong WT, Divatia JV, Palo JE, Shrestha BR, Nafees KMK, Binh NG, Al Rahma HN, Detleuxay K, Ong V, Phua J; SABA Study Investigators and the Asian Critical Care Clinical Trials Group.

Intensive Care Med. 2018 Dec;44(12):2079-2090. doi: 10.1007/s00134-018-5432-1. Epub 2018 Nov 16.


The TRPC5 channel regulates angiogenesis and promotes recovery from ischemic injury in mice.

Zhu Y, Gao M, Zhou T, Xie M, Mao A, Feng L, Yao X, Wong WT, Ma X.

J Biol Chem. 2019 Jan 4;294(1):28-37. doi: 10.1074/jbc.RA118.005392. Epub 2018 Nov 9.


Higher Dispersion Measures of Conduction and Repolarization in Type 1 Compared to Non-type 1 Brugada Syndrome Patients: An Electrocardiographic Study From a Single Center.

Tse G, Li KHC, Li G, Liu T, Bazoukis G, Wong WT, Chan MTV, Wong MCS, Xia Y, Letsas KP, Chan GCP, Chan YS, Wu WKK.

Front Cardiovasc Med. 2018 Oct 4;5:132. doi: 10.3389/fcvm.2018.00132. eCollection 2018.


Comparison of high-flow nasal cannula versus oxygen face mask for environmental bacterial contamination in critically ill pneumonia patients: a randomized controlled crossover trial.

Leung CCH, Joynt GM, Gomersall CD, Wong WT, Lee A, Ling L, Chan PKS, Lui PCW, Tsoi PCY, Ling CM, Hui M.

J Hosp Infect. 2019 Jan;101(1):84-87. doi: 10.1016/j.jhin.2018.10.007. Epub 2018 Oct 15.


Patent foramen ovale closure versus medical therapy for stroke prevention: A systematic review and meta-analysis of randomized controlled trials.

Lai JCL, Tse G, Wu WKK, Gong M, Bazoukis G, Wong WT, Wong SH, Lampropoulos K, Baranchuk A, Tse LA, Xia Y, Li G, Wong MCS, Chan YS, Mu N, Dong M, Liu T; International Health Informatics Study (IHIS) Network.

Version 2. F1000Res. 2017 Dec 27 [revised 2018 Jan 1];6:2178. doi: 10.12688/f1000research.13444.2. eCollection 2017.


Longitudinal Study of Dark Adaptation as a Functional Outcome Measure for Age-Related Macular Degeneration.

Chen KG, Alvarez JA, Yazdanie M, Papudesu C, Wong WT, Wiley HE, Keenan TD, Chew EY, Ferris FL 3rd, Cukras CA.

Ophthalmology. 2018 Sep 29. pii: S0161-6420(18)31121-7. doi: 10.1016/j.ophtha.2018.09.039. [Epub ahead of print]


What lies beneath? Experiencing emotions and caring in oncology.

Wong WT, Broom A, Kirby E, Lwin Z.

Health (London). 2018 Sep 24:1363459318800168. doi: 10.1177/1363459318800168. [Epub ahead of print]


Repositioning of the β-Blocker Carvedilol as a Novel Autophagy Inducer That Inhibits the NLRP3 Inflammasome.

Wong WT, Li LH, Rao YK, Yang SP, Cheng SM, Lin WY, Cheng CC, Chen A, Hua KF.

Front Immunol. 2018 Aug 22;9:1920. doi: 10.3389/fimmu.2018.01920. eCollection 2018.


Uncoupling Protein 2 in Cardiovascular Health and Disease.

Tian XY, Ma S, Tse G, Wong WT, Huang Y.

Front Physiol. 2018 Aug 2;9:1060. doi: 10.3389/fphys.2018.01060. eCollection 2018. Review.


Argininosuccinate Lyase Deficiency Causes an Endothelial-Dependent Form of Hypertension.

Kho J, Tian X, Wong WT, Bertin T, Jiang MM, Chen S, Jin Z, Shchelochkov OA, Burrage LC, Reddy AK, Jiang H, Abo-Zahrah R, Ma S, Zhang P, Bissig KD, Kim JJ, Devaraj S, Rodney GG, Erez A, Bryan NS, Nagamani SCS, Lee BH.

Am J Hum Genet. 2018 Aug 2;103(2):276-287. doi: 10.1016/j.ajhg.2018.07.008.


Palladium-Catalyzed N-Arylation of Sulfoximines with Aryl Sulfonates.

Yang Q, Choy PY, Zhao Q, Leung MP, Chan HS, So CM, Wong WT, Kwong FY.

J Org Chem. 2018 Sep 21;83(18):11369-11376. doi: 10.1021/acs.joc.8b01599. Epub 2018 Aug 13.


Progression of Geographic Atrophy in Age-related Macular Degeneration: AREDS2 Report Number 16.

Keenan TD, Agrón E, Domalpally A, Clemons TE, van Asten F, Wong WT, Danis RG, Sadda S, Rosenfeld PJ, Klein ML, Ratnapriya R, Swaroop A, Ferris FL 3rd, Chew EY; AREDS2 Research Group.

Ophthalmology. 2018 Dec;125(12):1913-1928. doi: 10.1016/j.ophtha.2018.05.028. Epub 2018 Jul 27.


Planar cell polarity gene Fuz triggers apoptosis in neurodegenerative disease models.

Chen ZS, Li L, Peng S, Chen FM, Zhang Q, An Y, Lin X, Li W, Koon AC, Chan TF, Lau KF, Ngo JCK, Wong WT, Kwan KM, Chan HYE.

EMBO Rep. 2018 Sep;19(9). pii: e45409. doi: 10.15252/embr.201745409. Epub 2018 Jul 19.


Microglia in the Retina: Roles in Development, Maturity, and Disease.

Silverman SM, Wong WT.

Annu Rev Vis Sci. 2018 Sep 15;4:45-77. doi: 10.1146/annurev-vision-091517-034425. Epub 2018 May 31.


TRPV6 protects ER stress-induced apoptosis via ATF6α-TRPV6-JNK pathway in human embryonic stem cell-derived cardiomyocytes.

Li Z, Meng Z, Lu J, Chen FM, Wong WT, Tse G, Zheng C, Keung W, Tse K, Li RA, Jiang L, Yao X.

J Mol Cell Cardiol. 2018 Jul;120:1-11. doi: 10.1016/j.yjmcc.2018.05.008. Epub 2018 May 16.


Repopulating retinal microglia restore endogenous organization and function under CX3CL1-CX3CR1 regulation.

Zhang Y, Zhao L, Wang X, Ma W, Lazere A, Qian HH, Zhang J, Abu-Asab M, Fariss RN, Roger JE, Wong WT.

Sci Adv. 2018 Mar 21;4(3):eaap8492. doi: 10.1126/sciadv.aap8492. eCollection 2018 Mar.


Multispectral Photoacoustic Imaging of Tumor Protease Activity with a Gold Nanocage-Based Activatable Probe.

Liu C, Li S, Gu Y, Xiong H, Wong WT, Sun L.

Mol Imaging Biol. 2018 May 7. doi: 10.1007/s11307-018-1203-1. [Epub ahead of print]


Evaluation of Meropenem Pharmacokinetics in an Experimental Acute Respiratory Distress Syndrome (ARDS) Model during Extracorporeal Membrane Oxygenation (ECMO) by Using a PenP β-Lactamase Biosensor.

Andresen M, Araos J, Wong KY, Leung YC, So LY, Wong WT, Cabrera S, Silva C, Alegria L, Bruhn A, Soto D.

Sensors (Basel). 2018 May 4;18(5). pii: E1424. doi: 10.3390/s18051424.


Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) in clinical practice.

Li KHC, Bazoukis G, Liu T, Li G, Wu WKK, Wong SH, Wong WT, Chan YS, Wong MCS, Wassilew K, Vassiliou VS, Tse G.

J Arrhythm. 2017 Dec 21;34(1):11-22. doi: 10.1002/joa3.12021. eCollection 2018 Feb. Review.


Genotype-guided warfarin dosing vs. conventional dosing strategies: a systematic review and meta-analysis of randomized controlled trials.

Tse G, Gong M, Li G, Wong SH, Wu WKK, Wong WT, Roever L, Lee APW, Lip GYH, Wong MCS, Liu T; International Health Informatics Study (IHIS) Network.

Br J Clin Pharmacol. 2018 Sep;84(9):1868-1882. doi: 10.1111/bcp.13621. Epub 2018 Jun 21.


Optical Coherence Tomography Minimum Intensity as an Objective Measure for the Detection of Hydroxychloroquine Toxicity.

Allahdina AM, Stetson PF, Vitale S, Wong WT, Chew EY, Ferris FL III, Sieving PA, Cukras C.

Invest Ophthalmol Vis Sci. 2018 Apr 1;59(5):1953-1963. doi: 10.1167/iovs.17-22668.


Scalable synthesis enabling multilevel bio-evaluations of natural products for discovery of lead compounds.

Zhu L, Ma W, Zhang M, Lee MM, Wong WY, Chan BD, Yang Q, Wong WT, Tai WC, Lee CS.

Nat Commun. 2018 Mar 29;9(1):1283. doi: 10.1038/s41467-018-03546-9.


Design of Polymeric Gene Carriers for Effective Intracellular Delivery.

Lai WF, Wong WT.

Trends Biotechnol. 2018 Jul;36(7):713-728. doi: 10.1016/j.tibtech.2018.02.006. Epub 2018 Mar 7. Review.


Light-Dependent OCT Structure Changes in Photoreceptor Degenerative rd 10 Mouse Retina.

Li Y, Zhang Y, Chen S, Vernon G, Wong WT, Qian H.

Invest Ophthalmol Vis Sci. 2018 Feb 1;59(2):1084-1094. doi: 10.1167/iovs.17-23011.


Fibroblast growth factor 21 in cardio-metabolic disorders: a systematic review and meta-analysis.

Lakhani I, Gong M, Wong WT, Bazoukis G, Lampropoulos K, Wong SH, Wu WKK, Wong MCS, Ong KL, Liu T, Tse G; International Health Informatics Study (IHIS) Network.

Metabolism. 2018 Jun;83:11-17. doi: 10.1016/j.metabol.2018.01.017. Epub 2018 Feb 2.


Efficient expression and isolation of recombinant human interleukin-11 (rhIL-11) in Pichia pastoris.

Yu KM, Yiu-Nam Lau J, Fok M, Yeung YK, Fok SP, Shek F, Wong WT, Choo QL.

Protein Expr Purif. 2018 Jun;146:69-77. doi: 10.1016/j.pep.2018.01.012. Epub 2018 Feb 3.


Preclinical evaluation of the mono-PEGylated recombinant human interleukin-11 in cynomolgus monkeys.

Yu KM, Lau JY, Fok M, Yeung YK, Fok SP, Zhang S, Ye P, Zhang K, Li X, Li J, Xu Q, Wong WT, Choo QL.

Toxicol Appl Pharmacol. 2018 Mar 1;342:39-49. doi: 10.1016/j.taap.2018.01.016. Epub 2018 Feb 2.


Cancer antigen-125 and risk of atrial fibrillation: a systematic review and meta-analysis.

Cheung A, Gong M, Bellanti R, Ali-Hasan-Al-Saegh S, Li G, Roig E, Núñez J, Stamos TD, Yilmaz MB, Hakki K, Wu WKK, Wong SH, Wong WT, Bazoukis G, Lampropoulos K, Tse LA, Zhao J, Lip GYH, Baranchuk A, Wong MCS, Liu T, Tse G.

Heart Asia. 2018 Jan 7;10(1):e010970. doi: 10.1136/heartasia-2017-010970. eCollection 2018.


Clostridium difficile toxin B induces autophagic cell death in colonocytes.

Chan H, Zhao S, Zhang L, Ho J, Leung CCH, Wong WT, Tian Y, Liu X, Kwong TNY, Chan RCY, Yu SSB, Wang MHT, Tse G, Wong SH, Chan MTV, Wu WKK.

J Cell Mol Med. 2018 Apr;22(4):2469-2477. doi: 10.1111/jcmm.13555. Epub 2018 Jan 31.


Population-Wide Genetic Risk Prediction of Complex Diseases: A Pilot Feasibility Study in Macau Population for Precision Public Healthcare Planning.

Tsui NBY, Cheng G, Chung T, Lam CWK, Yee A, Chung PKC, Kwan TK, Ko E, He D, Wong WT, Lau JYN, Lau LT, Fok M.

Sci Rep. 2018 Jan 30;8(1):1853. doi: 10.1038/s41598-017-19017-y.


808 nm excited energy migration upconversion nanoparticles driven by a Nd3+-Trinity system with color-tunability and superior luminescence properties.

Guo S, Tsang MK, Lo WS, Hao J, Wong WT.

Nanoscale. 2018 Feb 8;10(6):2790-2803. doi: 10.1039/c7nr07026h.


Worldwide end-of-life practice for patients in ICUs.

Wong WT, Phua J, Joynt GM.

Curr Opin Anaesthesiol. 2018 Apr;31(2):172-178. doi: 10.1097/ACO.0000000000000563. Review.


Deletion of the von Hippel-Lindau Gene in Hemangioblasts Causes Hemangioblastoma-like Lesions in Murine Retina.

Wang H, Shepard MJ, Zhang C, Dong L, Walker D, Guedez L, Park S, Wang Y, Chen S, Pang Y, Zhang Q, Gao C, Wong WT, Wiley H, Pacak K, Chew EY, Zhuang Z, Chan CC.

Cancer Res. 2018 Mar 1;78(5):1266-1274. doi: 10.1158/0008-5472.CAN-17-1718. Epub 2018 Jan 4.


Medical students and professionalism - Do the hidden curriculum and current role models fail our future doctors?

Joynt GM, Wong WT, Ling L, Lee A.

Med Teach. 2018 Apr;40(4):395-399. doi: 10.1080/0142159X.2017.1408897. Epub 2017 Dec 21.


Spontaneous type 1 pattern, ventricular arrhythmias and sudden cardiac death in Brugada Syndrome: an updated systematic review and meta-analysis.

Bayoumy A, Gong MQ, Christien Li KH, Wong SH, Wu WK, Li GP, Bazoukis G, Letsas KP, Wong WT, Xia YL, Liu T, Tse G; International Health Informatics Study (IHIS) Network.

J Geriatr Cardiol. 2017 Oct;14(10):639-643. doi: 10.11909/j.issn.1671-5411.2017.10.010. No abstract available.


Pentraxin-3 as a marker of sepsis severity and predictor of mortality outcomes: A systematic review and meta-analysis.

Lee YT, Gong M, Chau A, Wong WT, Bazoukis G, Wong SH, Lampropoulos K, Xia Y, Li G, Wong MCS, Liu T, Wu WKK, Tse G; International Heath Informatics Study (IHIS) Network.

J Infect. 2018 Jan;76(1):1-10. doi: 10.1016/j.jinf.2017.10.016. Epub 2017 Nov 23.


Molecular design of upconversion nanoparticles for gene delivery.

Lai WF, Rogach AL, Wong WT.

Chem Sci. 2017 Nov 1;8(11):7339-7358. doi: 10.1039/c7sc02956j. Epub 2017 Aug 29. Review.


Effects of pharmacological gap junction and sodium channel blockade on S1S2 restitution properties in Langendorff-perfused mouse hearts.

Tse G, Liu T, Li G, Keung W, Yeo JM, Fiona Chan YW, Yan BP, Chan YS, Wong SH, Li RA, Zhao J, Wu WKK, Wong WT.

Oncotarget. 2017 Jul 28;8(49):85341-85352. doi: 10.18632/oncotarget.19675. eCollection 2017 Oct 17.


Gynostemma pentaphyllum saponins attenuate inflammation in vitro and in vivo by inhibition of NF-κB and STAT3 signaling.

Wong WY, Lee MM, Chan BD, Ma VW, Zhang W, Yip TT, Wong WT, Tai WC.

Oncotarget. 2017 Sep 18;8(50):87401-87414. doi: 10.18632/oncotarget.20997. eCollection 2017 Oct 20.


Frailty and Clinical Outcomes in Advanced Heart Failure Patients Undergoing Left Ventricular Assist Device Implantation: A Systematic Review and Meta-analysis.

Tse G, Gong M, Wong SH, Wu WKK, Bazoukis G, Lampropoulos K, Wong WT, Xia Y, Wong MCS, Liu T, Woo J; International Health Informatics Study (IHIS) Network.

J Am Med Dir Assoc. 2018 Mar;19(3):255-261.e1. doi: 10.1016/j.jamda.2017.09.022. Epub 2017 Nov 9.


Exploring the scope of communication content of mechanically ventilated patients.

Leung CCH, Pun J, Lock G, Slade D, Gomersall CD, Wong WT, Joynt GM.

J Crit Care. 2018 Apr;44:136-141. doi: 10.1016/j.jcrc.2017.10.044. Epub 2017 Oct 29.


Frailty and Mortality Outcomes After Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis.

Tse G, Gong M, Nunez J, Sanchis J, Li G, Ali-Hasan-Al-Saegh S, Wong WT, Wong SH, Wu WKK, Bazoukis G, Yan GX, Lampropoulos K, Baranchuk AM, Tse LA, Xia Y, Liu T, Woo J; International Health Informatics Study (IHIS) Network.

J Am Med Dir Assoc. 2017 Dec 1;18(12):1097.e1-1097.e10. doi: 10.1016/j.jamda.2017.09.002. Epub 2017 Nov 1. Review.


Chiral transcription in self-assembled tetrahedral Eu4L6 chiral cages displaying sizable circularly polarized luminescence.

Yeung CT, Yim KH, Wong HY, Pal R, Lo WS, Yan SC, Yee-Man Wong M, Yufit D, Smiles DE, McCormick LJ, Teat SJ, Shuh DK, Wong WT, Law GL.

Nat Commun. 2017 Oct 24;8(1):1128. doi: 10.1038/s41467-017-01025-1.


Eosinophilia and clinical outcome of chronic obstructive pulmonary disease: a meta-analysis.

Ho J, He W, Chan MTV, Tse G, Liu T, Wong SH, Leung CCH, Wong WT, Tsang S, Zhang L, Chan RYP, Gin T, Leung J, Lau BWM, Wu WKK, Ngai SPC.

Sci Rep. 2017 Oct 18;7(1):13451. doi: 10.1038/s41598-017-13745-x.

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