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Argininosuccinate Lyase Deficiency Causes an Endothelial-Dependent Form of Hypertension.

Kho J, Tian X, Wong WT, Bertin T, Jiang MM, Chen S, Jin Z, Shchelochkov OA, Burrage LC, Reddy AK, Jiang H, Abo-Zahrah R, Ma S, Zhang P, Bissig KD, Kim JJ, Devaraj S, Rodney GG, Erez A, Bryan NS, Nagamani SCS, Lee BH.

Am J Hum Genet. 2018 Aug 2;103(2):276-287. doi: 10.1016/j.ajhg.2018.07.008.


Palladium-Catalyzed N-Arylation of Sulfoximines with Aryl Sulfonates.

Yang Q, Choy PY, Zhao Q, Leung MP, Chan HS, So CM, Wong WT, Kwong FY.

J Org Chem. 2018 Aug 13. doi: 10.1021/acs.joc.8b01599. [Epub ahead of print]


Progression of Geographic Atrophy in Age-related Macular Degeneration: AREDS2 Report Number 16.

Keenan TD, Agrón E, Domalpally A, Clemons TE, van Asten F, Wong WT, Danis RG, Sadda S, Rosenfeld PJ, Klein ML, Ratnapriya R, Swaroop A, Ferris FL 3rd, Chew EY; AREDS2 Research Group.

Ophthalmology. 2018 Jul 27. pii: S0161-6420(18)30875-3. doi: 10.1016/j.ophtha.2018.05.028. [Epub ahead of print]


Planar cell polarity gene Fuz triggers apoptosis in neurodegenerative disease models.

Chen ZS, Li L, Peng S, Chen FM, Zhang Q, An Y, Lin X, Li W, Koon AC, Chan TF, Lau KF, Ngo JCK, Wong WT, Kwan KM, Chan HYE.

EMBO Rep. 2018 Jul 19. pii: e45409. doi: 10.15252/embr.201745409. [Epub ahead of print]


Microglia in the Retina: Roles in Development, Maturity, and Disease.

Silverman SM, Wong WT.

Annu Rev Vis Sci. 2018 May 31. doi: 10.1146/annurev-vision-091517-034425. [Epub ahead of print]


TRPV6 protects ER stress-induced apoptosis via ATF6α-TRPV6-JNK pathway in human embryonic stem cell-derived cardiomyocytes.

Li Z, Meng Z, Lu J, Chen FM, Wong WT, Tse G, Zheng C, Keung W, Tse K, Li RA, Jiang L, Yao X.

J Mol Cell Cardiol. 2018 Jul;120:1-11. doi: 10.1016/j.yjmcc.2018.05.008. Epub 2018 May 16.


Repopulating retinal microglia restore endogenous organization and function under CX3CL1-CX3CR1 regulation.

Zhang Y, Zhao L, Wang X, Ma W, Lazere A, Qian HH, Zhang J, Abu-Asab M, Fariss RN, Roger JE, Wong WT.

Sci Adv. 2018 Mar 21;4(3):eaap8492. doi: 10.1126/sciadv.aap8492. eCollection 2018 Mar.


Multispectral Photoacoustic Imaging of Tumor Protease Activity with a Gold Nanocage-Based Activatable Probe.

Liu C, Li S, Gu Y, Xiong H, Wong WT, Sun L.

Mol Imaging Biol. 2018 May 7. doi: 10.1007/s11307-018-1203-1. [Epub ahead of print]


Evaluation of Meropenem Pharmacokinetics in an Experimental Acute Respiratory Distress Syndrome (ARDS) Model during Extracorporeal Membrane Oxygenation (ECMO) by Using a PenP β-Lactamase Biosensor.

Andresen M, Araos J, Wong KY, Leung YC, So LY, Wong WT, Cabrera S, Silva C, Alegria L, Bruhn A, Soto D.

Sensors (Basel). 2018 May 4;18(5). pii: E1424. doi: 10.3390/s18051424.


Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) in clinical practice.

Li KHC, Bazoukis G, Liu T, Li G, Wu WKK, Wong SH, Wong WT, Chan YS, Wong MCS, Wassilew K, Vassiliou VS, Tse G.

J Arrhythm. 2017 Dec 21;34(1):11-22. doi: 10.1002/joa3.12021. eCollection 2018 Feb. Review.


Genotype-guided warfarin dosing vs. conventional dosing strategies: a systematic review and meta-analysis of randomized controlled trials.

Tse G, Gong M, Li G, Wong SH, Wu WKK, Wong WT, Roever L, Lee APW, Lip GYH, Wong MCS, Liu T; International Health Informatics Study (IHIS) Network.

Br J Clin Pharmacol. 2018 Apr 28. doi: 10.1111/bcp.13621. [Epub ahead of print]


Optical Coherence Tomography Minimum Intensity as an Objective Measure for the Detection of Hydroxychloroquine Toxicity.

Allahdina AM, Stetson PF, Vitale S, Wong WT, Chew EY, Ferris FL III, Sieving PA, Cukras C.

Invest Ophthalmol Vis Sci. 2018 Apr 1;59(5):1953-1963. doi: 10.1167/iovs.17-22668.


Scalable synthesis enabling multilevel bio-evaluations of natural products for discovery of lead compounds.

Zhu L, Ma W, Zhang M, Lee MM, Wong WY, Chan BD, Yang Q, Wong WT, Tai WC, Lee CS.

Nat Commun. 2018 Mar 29;9(1):1283. doi: 10.1038/s41467-018-03546-9.


Design of Polymeric Gene Carriers for Effective Intracellular Delivery.

Lai WF, Wong WT.

Trends Biotechnol. 2018 Jul;36(7):713-728. doi: 10.1016/j.tibtech.2018.02.006. Epub 2018 Mar 7. Review.


Light-Dependent OCT Structure Changes in Photoreceptor Degenerative rd 10 Mouse Retina.

Li Y, Zhang Y, Chen S, Vernon G, Wong WT, Qian H.

Invest Ophthalmol Vis Sci. 2018 Feb 1;59(2):1084-1094. doi: 10.1167/iovs.17-23011.


Fibroblast growth factor 21 in cardio-metabolic disorders: a systematic review and meta-analysis.

Lakhani I, Gong M, Wong WT, Bazoukis G, Lampropoulos K, Wong SH, Wu WKK, Wong MCS, Ong KL, Liu T, Tse G; International Health Informatics Study (IHIS) Network.

Metabolism. 2018 Jun;83:11-17. doi: 10.1016/j.metabol.2018.01.017. Epub 2018 Feb 2.


Efficient expression and isolation of recombinant human interleukin-11 (rhIL-11) in Pichia pastoris.

Yu KM, Yiu-Nam Lau J, Fok M, Yeung YK, Fok SP, Shek F, Wong WT, Choo QL.

Protein Expr Purif. 2018 Jun;146:69-77. doi: 10.1016/j.pep.2018.01.012. Epub 2018 Feb 3.


Preclinical evaluation of the mono-PEGylated recombinant human interleukin-11 in cynomolgus monkeys.

Yu KM, Lau JY, Fok M, Yeung YK, Fok SP, Zhang S, Ye P, Zhang K, Li X, Li J, Xu Q, Wong WT, Choo QL.

Toxicol Appl Pharmacol. 2018 Mar 1;342:39-49. doi: 10.1016/j.taap.2018.01.016. Epub 2018 Feb 2.


Cancer antigen-125 and risk of atrial fibrillation: a systematic review and meta-analysis.

Cheung A, Gong M, Bellanti R, Ali-Hasan-Al-Saegh S, Li G, Roig E, Núñez J, Stamos TD, Yilmaz MB, Hakki K, Wu WKK, Wong SH, Wong WT, Bazoukis G, Lampropoulos K, Tse LA, Zhao J, Lip GYH, Baranchuk A, Wong MCS, Liu T, Tse G.

Heart Asia. 2018 Jan 7;10(1):e010970. doi: 10.1136/heartasia-2017-010970. eCollection 2018.


Clostridium difficile toxin B induces autophagic cell death in colonocytes.

Chan H, Zhao S, Zhang L, Ho J, Leung CCH, Wong WT, Tian Y, Liu X, Kwong TNY, Chan RCY, Yu SSB, Wang MHT, Tse G, Wong SH, Chan MTV, Wu WKK.

J Cell Mol Med. 2018 Apr;22(4):2469-2477. doi: 10.1111/jcmm.13555. Epub 2018 Jan 31.


Population-Wide Genetic Risk Prediction of Complex Diseases: A Pilot Feasibility Study in Macau Population for Precision Public Healthcare Planning.

Tsui NBY, Cheng G, Chung T, Lam CWK, Yee A, Chung PKC, Kwan TK, Ko E, He D, Wong WT, Lau JYN, Lau LT, Fok M.

Sci Rep. 2018 Jan 30;8(1):1853. doi: 10.1038/s41598-017-19017-y.


808 nm excited energy migration upconversion nanoparticles driven by a Nd3+-Trinity system with color-tunability and superior luminescence properties.

Guo S, Tsang MK, Lo WS, Hao J, Wong WT.

Nanoscale. 2018 Feb 8;10(6):2790-2803. doi: 10.1039/c7nr07026h.


Worldwide end-of-life practice for patients in ICUs.

Wong WT, Phua J, Joynt GM.

Curr Opin Anaesthesiol. 2018 Apr;31(2):172-178. doi: 10.1097/ACO.0000000000000563.


Deletion of the von Hippel-Lindau Gene in Hemangioblasts Causes Hemangioblastoma-like Lesions in Murine Retina.

Wang H, Shepard MJ, Zhang C, Dong L, Walker D, Guedez L, Park S, Wang Y, Chen S, Pang Y, Zhang Q, Gao C, Wong WT, Wiley H, Pacak K, Chew EY, Zhuang Z, Chan CC.

Cancer Res. 2018 Mar 1;78(5):1266-1274. doi: 10.1158/0008-5472.CAN-17-1718. Epub 2018 Jan 4.


Medical students and professionalism - Do the hidden curriculum and current role models fail our future doctors?

Joynt GM, Wong WT, Ling L, Lee A.

Med Teach. 2018 Apr;40(4):395-399. doi: 10.1080/0142159X.2017.1408897. Epub 2017 Dec 21.


Spontaneous type 1 pattern, ventricular arrhythmias and sudden cardiac death in Brugada Syndrome: an updated systematic review and meta-analysis.

Bayoumy A, Gong MQ, Christien Li KH, Wong SH, Wu WK, Li GP, Bazoukis G, Letsas KP, Wong WT, Xia YL, Liu T, Tse G; International Health Informatics Study (IHIS) Network.

J Geriatr Cardiol. 2017 Oct;14(10):639-643. doi: 10.11909/j.issn.1671-5411.2017.10.010. No abstract available.


Pentraxin-3 as a marker of sepsis severity and predictor of mortality outcomes: A systematic review and meta-analysis.

Lee YT, Gong M, Chau A, Wong WT, Bazoukis G, Wong SH, Lampropoulos K, Xia Y, Li G, Wong MCS, Liu T, Wu WKK, Tse G; International Heath Informatics Study (IHIS) Network.

J Infect. 2018 Jan;76(1):1-10. doi: 10.1016/j.jinf.2017.10.016. Epub 2017 Nov 23.


Molecular design of upconversion nanoparticles for gene delivery.

Lai WF, Rogach AL, Wong WT.

Chem Sci. 2017 Nov 1;8(11):7339-7358. doi: 10.1039/c7sc02956j. Epub 2017 Aug 29. Review.


Effects of pharmacological gap junction and sodium channel blockade on S1S2 restitution properties in Langendorff-perfused mouse hearts.

Tse G, Liu T, Li G, Keung W, Yeo JM, Fiona Chan YW, Yan BP, Chan YS, Wong SH, Li RA, Zhao J, Wu WKK, Wong WT.

Oncotarget. 2017 Jul 28;8(49):85341-85352. doi: 10.18632/oncotarget.19675. eCollection 2017 Oct 17.


Gynostemma pentaphyllum saponins attenuate inflammation in vitro and in vivo by inhibition of NF-κB and STAT3 signaling.

Wong WY, Lee MM, Chan BD, Ma VW, Zhang W, Yip TT, Wong WT, Tai WC.

Oncotarget. 2017 Sep 18;8(50):87401-87414. doi: 10.18632/oncotarget.20997. eCollection 2017 Oct 20.


Frailty and Clinical Outcomes in Advanced Heart Failure Patients Undergoing Left Ventricular Assist Device Implantation: A Systematic Review and Meta-analysis.

Tse G, Gong M, Wong SH, Wu WKK, Bazoukis G, Lampropoulos K, Wong WT, Xia Y, Wong MCS, Liu T, Woo J; International Health Informatics Study (IHIS) Network.

J Am Med Dir Assoc. 2018 Mar;19(3):255-261.e1. doi: 10.1016/j.jamda.2017.09.022. Epub 2017 Nov 9.


Exploring the scope of communication content of mechanically ventilated patients.

Leung CCH, Pun J, Lock G, Slade D, Gomersall CD, Wong WT, Joynt GM.

J Crit Care. 2018 Apr;44:136-141. doi: 10.1016/j.jcrc.2017.10.044. Epub 2017 Oct 29.


Frailty and Mortality Outcomes After Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis.

Tse G, Gong M, Nunez J, Sanchis J, Li G, Ali-Hasan-Al-Saegh S, Wong WT, Wong SH, Wu WKK, Bazoukis G, Yan GX, Lampropoulos K, Baranchuk AM, Tse LA, Xia Y, Liu T, Woo J; International Health Informatics Study (IHIS) Network.

J Am Med Dir Assoc. 2017 Dec 1;18(12):1097.e1-1097.e10. doi: 10.1016/j.jamda.2017.09.002. Epub 2017 Nov 1. Review.


Chiral transcription in self-assembled tetrahedral Eu4L6 chiral cages displaying sizable circularly polarized luminescence.

Yeung CT, Yim KH, Wong HY, Pal R, Lo WS, Yan SC, Yee-Man Wong M, Yufit D, Smiles DE, McCormick LJ, Teat SJ, Shuh DK, Wong WT, Law GL.

Nat Commun. 2017 Oct 24;8(1):1128. doi: 10.1038/s41467-017-01025-1.


Eosinophilia and clinical outcome of chronic obstructive pulmonary disease: a meta-analysis.

Ho J, He W, Chan MTV, Tse G, Liu T, Wong SH, Leung CCH, Wong WT, Tsang S, Zhang L, Chan RYP, Gin T, Leung J, Lau BWM, Wu WKK, Ngai SPC.

Sci Rep. 2017 Oct 18;7(1):13451. doi: 10.1038/s41598-017-13745-x.


Lifestyle Medicine: A Brief Review of Its Dramatic Impact on Health and Survival.

Bodai BI, Nakata TE, Wong WT, Clark DR, Lawenda S, Tsou C, Liu R, Shiue L, Cooper N, Rehbein M, Ha BP, Mckeirnan A, Misquitta R, Vij P, Klonecke A, Mejia CS, Dionysian E, Hashmi S, Greger M, Stoll S, Campbell TM.

Perm J. 2017;22. doi: 10.7812/TPP/17-025.


Uncoupling Protein 2 Inhibits Myointimal Hyperplasia in Preclinical Animal Models of Vascular Injury.

Zhang Y, Zhang Y, Li W, Wang P, Gu R, Feng Y, Wei S, Peng K, Zhang Y, Su L, Wang Q, Li, Yang D, Wong WT, Yang Y, Ma S.

J Am Heart Assoc. 2017 Oct 12;6(10). pii: e002641. doi: 10.1161/JAHA.117.006593.


Predictive value of inter-atrial block for new onset or recurrent atrial fibrillation: A systematic review and meta-analysis.

Tse G, Wong CW, Gong M, Wong WT, Bazoukis G, Wong SH, Li G, Wu WKK, Tse LA, Lampropoulos K, Xia Y, Liu T, Baranchuk A; International Health Informatics Study (IHIS) Network.

Int J Cardiol. 2018 Jan 1;250:152-156. doi: 10.1016/j.ijcard.2017.09.176. Epub 2017 Oct 3. Review.


Vascular Aging: Implications for Cardiovascular Disease and Therapy.

Ghebre YT, Yakubov E, Wong WT, Krishnamurthy P, Sayed N, Sikora AG, Bonnen MD.

Transl Med (Sunnyvale). 2016 Dec;6(4). pii: 183. doi: 10.4172/2161-1025.1000183. Epub 2016 Aug 30.


Chemistry and engineering of cyclodextrins for molecular imaging.

Lai WF, Rogach AL, Wong WT.

Chem Soc Rev. 2017 Oct 16;46(20):6379-6419. doi: 10.1039/c7cs00040e. Review.


Total cosine R-to-T for predicting ventricular arrhythmic and mortality outcomes: A systematic review and meta-analysis.

Tse G, Gong M, Wong CW, Chan C, Georgopoulos S, Chan YS, Yan BP, Li G, Whittaker P, Ciobanu A, Ali-Hasan-Al-Saegh S, Wong SH, Wu WKK, Bazoukis G, Lampropoulos K, Wong WT, Tse LA, Baranchuk AM, Letsas KP, Liu T; International Health Informatics Study (IHIS) Network.

Ann Noninvasive Electrocardiol. 2018 Mar;23(2):e12495. doi: 10.1111/anec.12495. Epub 2017 Sep 12.


An Approach to the Welwistatin Core via a Diazoketone Rearrangement-Ring Expansion Strategy.

Lam SM, Wong WT, Chiu P.

Org Lett. 2017 Sep 1;19(17):4468-4471. doi: 10.1021/acs.orglett.7b01988. Epub 2017 Aug 22.


Rearrangements of α-Diazo-β-hydroxyketones for the Synthesis of Bicyclo[m.n.1]alkanones.

Li Z, Lam SM, Ip I, Wong WT, Chiu P.

Org Lett. 2017 Sep 1;19(17):4464-4467. doi: 10.1021/acs.orglett.7b01963. Epub 2017 Aug 22.


Monocyte infiltration and proliferation reestablish myeloid cell homeostasis in the mouse retina following retinal pigment epithelial cell injury.

Ma W, Zhang Y, Gao C, Fariss RN, Tam J, Wong WT.

Sci Rep. 2017 Aug 16;7(1):8433. doi: 10.1038/s41598-017-08702-7.


Synthesis and Characterization of Luminescent Cyclometalated Platinum(II) Complexes with Tunable Emissive Colors and Studies of Their Application in Organic Memories and Organic Light-Emitting Devices.

Chan AK, Ng M, Wong YC, Chan MY, Wong WT, Yam VW.

J Am Chem Soc. 2017 Aug 9;139(31):10750-10761. doi: 10.1021/jacs.7b04952. Epub 2017 Jul 31.


Improvement of bone mineral density after enzyme replacement therapy in Chinese late-onset Pompe disease patients.

Sheng B, Chu YP, Wong WT, Yau EKC, Chen SPL, Luk WH.

BMC Res Notes. 2017 Jul 28;10(1):351. doi: 10.1186/s13104-017-2681-y.


A GalNAc/Gal-specific lectin from the sea mussel Crenomytilus grayanus modulates immune response in macrophages and in mice.

Chernikov OV, Wong WT, Li LH, Chikalovets IV, Molchanova VI, Wu SH, Liao JH, Hua KF.

Sci Rep. 2017 Jul 24;7(1):6315. doi: 10.1038/s41598-017-06647-5.


Obesity reshapes stem cell extracellular vesicles.

Ma S, Wong WT, Wang DH.

Cytometry A. 2018 Feb;93(2):177-179. doi: 10.1002/cyto.a.23166. Epub 2017 Jul 12. No abstract available.


Inhibition of miR-92a Suppresses Oxidative Stress and Improves Endothelial Function by Upregulating Heme Oxygenase-1 in db/db Mice.

Gou L, Zhao L, Song W, Wang L, Liu J, Zhang H, Huang Y, Lau CW, Yao X, Tian XY, Wong WT, Luo JY, Huang Y.

Antioxid Redox Signal. 2018 Feb 10;28(5):358-370. doi: 10.1089/ars.2017.7005. Epub 2017 Aug 7.


Systemic Sunitinib Malate Treatment for Advanced Juxtapapillary Retinal Hemangioblastomas Associated with von Hippel-Lindau Disease.

Knickelbein JE, Jacobs-El N, Wong WT, Wiley HE, Cukras CA, Meyerle CB, Chew EY.

Ophthalmol Retina. 2017 May-Jun;1(3):181-187. doi: 10.1016/j.oret.2016.10.007.

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