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Identifying the genetic causes for prenatally diagnosed structural congenital anomalies (SCAs) by whole-exome sequencing (WES).

Leung GKC, Mak CCY, Fung JLF, Wong WHS, Tsang MHY, Yu MHC, Pei SLC, Yeung KS, Mok GTK, Lee CP, Hui APW, Tang MHY, Chan KYK, Liu APY, Yang W, Sham PC, Kan ASY, Chung BHY.

BMC Med Genomics. 2018 Oct 25;11(1):93. doi: 10.1186/s12920-018-0409-z.


CRISPR Activation Screens Systematically Identify Factors that Drive Neuronal Fate and Reprogramming.

Liu Y, Yu C, Daley TP, Wang F, Cao WS, Bhate S, Lin X, Still C 2nd, Liu H, Zhao D, Wang H, Xie XS, Ding S, Wong WH, Wernig M, Qi LS.

Cell Stem Cell. 2018 Nov 1;23(5):758-771.e8. doi: 10.1016/j.stem.2018.09.003. Epub 2018 Oct 11.


CRISPhieRmix: a hierarchical mixture model for CRISPR pooled screens.

Daley TP, Lin Z, Lin X, Liu Y, Wong WH, Qi LS.

Genome Biol. 2018 Oct 8;19(1):159. doi: 10.1186/s13059-018-1538-6.


Healthcare burden of rare diseases in Hong Kong - adopting ORPHAcodes in ICD-10 based healthcare administrative datasets.

Chiu ATG, Chung CCY, Wong WHS, Lee SL, Chung BHY.

Orphanet J Rare Dis. 2018 Aug 28;13(1):147. doi: 10.1186/s13023-018-0892-5. Review.


Rare Event Detection Using Error-corrected DNA and RNA Sequencing.

Wong WH, Tong RS, Young AL, Druley TE.

J Vis Exp. 2018 Aug 3;(138). doi: 10.3791/57509.


Linking Healthcare and Social Service Databases to Study the Epidemiology of Child Maltreatment and Associated Health Problems: Hong Kong's Experience.

Lo CK, Ho FK, Chan KL, Wong WH, Wong RS, Chow CB, Tsang AM, Tso WW, Ip P.

J Pediatr. 2018 Nov;202:291-299.e1. doi: 10.1016/j.jpeds.2018.06.033. Epub 2018 Jul 18.


Integrative analysis of single-cell genomics data by coupled nonnegative matrix factorizations.

Duren Z, Chen X, Zamanighomi M, Zeng W, Satpathy AT, Chang HY, Wang Y, Wong WH.

Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):7723-7728. doi: 10.1073/pnas.1805681115. Epub 2018 Jul 9.


Unsupervised clustering and epigenetic classification of single cells.

Zamanighomi M, Lin Z, Daley T, Chen X, Duren Z, Schep A, Greenleaf WJ, Wong WH.

Nat Commun. 2018 Jun 20;9(1):2410. doi: 10.1038/s41467-018-04629-3.


CancerDetector: ultrasensitive and non-invasive cancer detection at the resolution of individual reads using cell-free DNA methylation sequencing data.

Li W, Li Q, Kang S, Same M, Zhou Y, Sun C, Liu CC, Matsuoka L, Sher L, Wong WH, Alber F, Zhou XJ.

Nucleic Acids Res. 2018 Sep 6;46(15):e89. doi: 10.1093/nar/gky423.


Utility of global hemostatic assays in the management of anticoagulation in a haemophilia patient.

Wu IQ, Tan CW, Wong WH, Ng HJ.

Haemophilia. 2018 Jul;24(4):e261-e263. doi: 10.1111/hae.13530. Epub 2018 Jun 5. No abstract available.


Cross-interference of rivaroxaban and enoxaparin on Berichrom anti-Xa heparin and Biophen direct Xa inhibitor assays.

Wong WH, Kaur H, Tan CW, Lee LH, Ng HJ.

Int J Lab Hematol. 2018 Aug;40(4):e63-e65. doi: 10.1111/ijlh.12829. Epub 2018 Apr 17. No abstract available.


Declining ambient water phosphorus concentrations in Massachusetts' rivers from 1999 to 2013: Environmental protection works.

Wong WH, Dudula JJ, Beaudoin T, Groff K, Kimball W, Swigor J.

Water Res. 2018 Aug 1;139:108-117. doi: 10.1016/j.watres.2018.03.053. Epub 2018 Mar 26.


Toxicity of Potassium Chloride Compared to Sodium Chloride for Zebra Mussel Decontamination.

Davis EA, Wong WH, Harman WN.

J Aquat Anim Health. 2018 Mar;30(1):3-12. doi: 10.1002/aah.10013.


Rasch validation of the Chinese parent-child interaction scale (CPCIS).

Ip P, Tso W, Rao N, Ho FKW, Chan KL, Fu KW, Li SL, Goh W, Wong WH, Chow CB.

World J Pediatr. 2018 Jun;14(3):238-246. doi: 10.1007/s12519-018-0132-z. Epub 2018 Mar 15.


A prospective cohort study to investigate parental stress and child health in low-income Chinese families: protocol paper.

Wong RSM, Yu EYT, Guo VY, Wan EY, Chin WY, Wong CKH, Fung CSC, Tung KTS, Wong WH, Ip P, Tiwari AFY, Lam CLK.

BMJ Open. 2018 Feb 22;8(2):e018792. doi: 10.1136/bmjopen-2017-018792.


Acquired factor V deficiency in a patient with myeloma and amyloidosis.

Quek JKS, Wong WH, Tan CW, Tha MH, Nagarajan C, Lee LH, Ng HJ.

Thromb Res. 2018 Apr;164:1-3. doi: 10.1016/j.thromres.2018.01.045. Epub 2018 Jan 31.


Integrating Functional Analysis in the Next-Generation Sequencing Diagnostic Pipeline of RASopathies.

Leung GKC, Luk HM, Tang VHM, Gao WW, Mak CCY, Yu MHC, Wong WL, Chu YWY, Yang WL, Wong WHS, Ma ACH, Leung AYH, Jin DY, Chan KYK, Allanson J, Lo IFM, Chung BHY.

Sci Rep. 2018 Feb 5;8(1):2421. doi: 10.1038/s41598-018-20894-0.


Rotational Pedicle Myocutaneous Forearm Fillet Flap Used to Fill Forequarter Amputation Defect: Indications and Uses.

Shah SA, Wong WH, Adhvaryu D.

J Hand Surg Am. 2018 Apr;43(4):390.e1-390.e4. doi: 10.1016/j.jhsa.2017.12.016. Epub 2018 Feb 1. Review.


Saving for a Better Retirement: How Risk Attitudes Affect Choice of Retirement Scheme.

Wong RS, Osman M, Wong WH, Lin Y, Ho K.

Psychol Rep. 2018 Jan 1:33294118755093. doi: 10.1177/0033294118755093. [Epub ahead of print]


Simultaneous inference of phenotype-associated genes and relevant tissues from GWAS data via Bayesian integration of multiple tissue-specific gene networks.

Wu M, Lin Z, Ma S, Chen T, Jiang R, Wong WH.

J Mol Cell Biol. 2017 Dec 1;9(6):436-452. doi: 10.1093/jmcb/mjx059.


Scalable multi-sample single-cell data analysis by Partition-Assisted Clustering and Multiple Alignments of Networks.

Li YH, Li D, Samusik N, Wang X, Guan L, Nolan GP, Wong WH.

PLoS Comput Biol. 2017 Dec 27;13(12):e1005875. doi: 10.1371/journal.pcbi.1005875. eCollection 2017 Dec.


The Influence of Race on Plasma Thrombin Generation In Healthy Subjects In Singapore.

Tan CW, Wong WH, Tan CK, Chan YH, Kaur H, Lee LH, Ng HJ.

Clin Appl Thromb Hemost. 2018 Oct;24(7):1144-1147. doi: 10.1177/1076029617744319. Epub 2017 Dec 4.


Increasing hospital presentations for anaphylaxis in the pediatric population in Hong Kong.

Wang Y, Koplin JJ, Ho MHK, Wong WHS, Allen KJ.

J Allergy Clin Immunol Pract. 2018 May - Jun;6(3):1050-1052.e2. doi: 10.1016/j.jaip.2017.09.018. Epub 2017 Nov 3. No abstract available.


Childhood Obesity and Physical Activity-Friendly School Environments.

Ip P, Ho FK, Louie LH, Chung TW, Cheung YF, Lee SL, Hui SS, Ho WK, Ho DS, Wong WH, Jiang F.

J Pediatr. 2017 Dec;191:110-116. doi: 10.1016/j.jpeds.2017.08.017. Epub 2017 Oct 4.


Toxicity of Potassium Chloride Compared to Sodium Chloride for Zebra Mussel Decontamination.

Davis EA, Wong WH, Harman WN.

J Aquat Anim Health. 2017 Oct 5. doi: 10.1080/08997659.2017.1388866. [Epub ahead of print]


A Sports-Based Youth Development Program, Teen Mental Health, and Physical Fitness: An RCT.

Ho FKW, Louie LHT, Wong WH, Chan KL, Tiwari A, Chow CB, Ho W, Wong W, Chan M, Chen EYH, Cheung YF, Ip P.

Pediatrics. 2017 Oct;140(4). pii: e20171543. doi: 10.1542/peds.2017-1543.


A simple, compact, low-cost, highly efficient thermometer based on green fluorescence of Er3+/Yb3+-codoped NaYF4 microcrystals.

Yuan N, Sun HX, Ju DD, Liu DY, Zhang ZB, Wong WH, Song F, Yu DY, Pun EY, Zhang DL.

Mater Sci Eng C Mater Biol Appl. 2017 Dec 1;81:177-181. doi: 10.1016/j.msec.2017.07.055. Epub 2017 Jul 31.


Family History of Early Infant Death Correlates with Earlier Age at Diagnosis But Not Shorter Time to Diagnosis for Severe Combined Immunodeficiency.

Luk ADW, Lee PP, Mao H, Chan KW, Chen XY, Chen TX, He JX, Kechout N, Suri D, Tao YB, Xu YB, Jiang LP, Liew WK, Jirapongsananuruk O, Daengsuwan T, Gupta A, Singh S, Rawat A, Abdul Latiff AH, Lee ACW, Shek LP, Nguyen TVA, Chin TJ, Chien YH, Latiff ZA, Le TMH, Le NNQ, Lee BW, Li Q, Raj D, Barbouche MR, Thong MK, Ang MCD, Wang XC, Xu CG, Yu HG, Yu HH, Lee TL, Yau FYS, Wong WH, Tu W, Yang W, Chong PCY, Ho MHK, Lau YL.

Front Immunol. 2017 Jul 12;8:808. doi: 10.3389/fimmu.2017.00808. eCollection 2017.


Maternal mental quality of life mediates the associations between intimate partner abuse against mothers and their children's behaviours and quality of life in low-income Chinese families.

Guo VY, Yu EYT, Wong RSM, Ip P, Tiwari AFY, Wong CKH, Fung CSC, Wong WHS, Lam CLK.

Qual Life Res. 2017 Dec;26(12):3297-3306. doi: 10.1007/s11136-017-1664-8. Epub 2017 Jul 24.


A randomized, double-blind, placebo- controlled study on the anti-haemostatic effects of Curcuma longa, Angelica sinensis and Panax ginseng.

Fung FY, Wong WH, Ang SK, Koh HL, Kun MC, Lee LH, Li X, Ng HJ, Tan CW, Zhao Y, Linn YC.

Phytomedicine. 2017 Aug 15;32:88-96. doi: 10.1016/j.phymed.2017.04.004. Epub 2017 Apr 10.


A mixed-methods study to explore the supportive care needs of breast cancer survivors.

Cheng KKF, Cheng HL, Wong WH, Koh C.

Psychooncology. 2018 Jan;27(1):265-271. doi: 10.1002/pon.4503. Epub 2017 Aug 18.


Modeling the causal regulatory network by integrating chromatin accessibility and transcriptome data.

Wang Y, Jiang R, Wong WH.

Natl Sci Rev. 2016 Jun;3(2):240-251. doi: 10.1093/nsr/nww025. Epub 2016 Apr 19.


Gaining comprehensive biological insight into the transcriptome by performing a broad-spectrum RNA-seq analysis.

Sahraeian SME, Mohiyuddin M, Sebra R, Tilgner H, Afshar PT, Au KF, Bani Asadi N, Gerstein MB, Wong WH, Snyder MP, Schadt E, Lam HYK.

Nat Commun. 2017 Jul 5;8(1):59. doi: 10.1038/s41467-017-00050-4.


Reversal of rivaroxaban using Prothromplex Total, a 4-factor prothrombin complex.

Kaur H, Yeang SH, See E, Grant D, Tan CW, Wong WH, Tan D, Ng HJ, Lee LH.

Thromb Res. 2017 Aug;156:117-118. doi: 10.1016/j.thromres.2017.06.006. Epub 2017 Jun 7. No abstract available.


Stock Market Fluctuations and Self-Harm among Children and Adolescents in Hong Kong.

Wong WH, Lee JC, Ho FK, Li TM, Ip P, Chow CB.

Int J Environ Res Public Health. 2017 Jun 9;14(6). pii: E623. doi: 10.3390/ijerph14060623.


COSINE: non-seeding method for mapping long noisy sequences.

Afshar PT, Wong WH.

Nucleic Acids Res. 2017 Aug 21;45(14):e132. doi: 10.1093/nar/gkx511.


Modeling gene regulation from paired expression and chromatin accessibility data.

Duren Z, Chen X, Jiang R, Wang Y, Wong WH.

Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):E4914-E4923. doi: 10.1073/pnas.1704553114. Epub 2017 Jun 2.


Relevance of ethnic differences in factor XIII activity on laboratory reference ranges.

Wong WH, Tan CK, Ho LP, Tan CW, Kaur H, Lee LH, Ng HJ.

Int J Lab Hematol. 2017 Oct;39(5):e113-e116. doi: 10.1111/ijlh.12684. Epub 2017 May 10. No abstract available.


Predicting transcription factor binding motifs from DNA-binding domains, chromatin accessibility and gene expression data.

Zamanighomi M, Lin Z, Wang Y, Jiang R, Wong WH.

Nucleic Acids Res. 2017 Jun 2;45(10):5666-5677. doi: 10.1093/nar/gkx358.


Left Ventricular Stiffness in Adolescents and Young Adults with Repaired Tetralogy of Fallot.

Yu CK, Wong WH, Li VW, Cheung YF.

Sci Rep. 2017 Apr 28;7(1):1252. doi: 10.1038/s41598-017-01448-2.


Optical damage resistant Ti-diffused Zr/Er-codoped lithium niobate strip waveguide for high-power 980 nm pumping.

Sun WB, Yang XF, Zhang ZB, Wong WH, Yu DY, Pun EY, Zhang DL.

Opt Express. 2017 Apr 17;25(8):8653-8658. doi: 10.1364/OE.25.008653.


Risk factors for child physical abuse and neglect among Chinese young mothers.

Lo CKM, Tung KTS, Chan KL, Yip PSF, Lau JTF, Wong WHS, Wong RS, Tsang AMC, Tsang HYH, Tso WWY, Ip P.

Child Abuse Negl. 2017 May;67:193-206. doi: 10.1016/j.chiabu.2017.02.031.


Fall-related attendance and associated hospitalisation of children and adolescents in Hong Kong: a 12-year retrospective study.

Lee JC, Tung KT, Li TM, Ho FK, Ip P, Wong WH, Chow CB.

BMJ Open. 2017 Feb 7;7(2):e013724. doi: 10.1136/bmjopen-2016-013724.


Phased Genome Sequencing Through Chromosome Sorting.

Chen X, Yang H, Wong WH.

Methods Mol Biol. 2017;1551:171-188. doi: 10.1007/978-1-4939-6750-6_10.


Genome-Wide DNA Methylation Analysis of Chinese Patients with Systemic Lupus Erythematosus Identified Hypomethylation in Genes Related to the Type I Interferon Pathway.

Yeung KS, Chung BH, Choufani S, Mok MY, Wong WL, Mak CC, Yang W, Lee PP, Wong WH, Chen YA, Grafodatskaya D, Wong RW, Lau CS, Chan DT, Weksberg R, Lau YL.

PLoS One. 2017 Jan 13;12(1):e0169553. doi: 10.1371/journal.pone.0169553. eCollection 2017.


Simultaneous dimension reduction and adjustment for confounding variation.

Lin Z, Yang C, Zhu Y, Duchi J, Fu Y, Wang Y, Jiang B, Zamanighomi M, Xu X, Li M, Sestan N, Zhao H, Wong WH.

Proc Natl Acad Sci U S A. 2016 Dec 20;113(51):14662-14667. doi: 10.1073/pnas.1617317113. Epub 2016 Dec 7.


Rivaroxaban for heparin-induced thrombocytopenia: adding to the evidence.

Ong SY, Chin YA, Than H, Tan CW, Yap ES, Wong WH, Ng HJ.

Ann Hematol. 2017 Mar;96(3):525-527. doi: 10.1007/s00277-016-2871-z. Epub 2016 Nov 7. No abstract available.


Effectiveness of a Technology-Based Injury Prevention Program for Enhancing Mothers' Knowledge of Child Safety: Protocol for a Randomized Controlled Trial.

Chow CB, Wong WH, Leung WC, Tang MH, Chan KL, Or CK, Li TM, Ho FK, Lo D, Ip P.

JMIR Res Protoc. 2016 Oct 31;5(4):e205.


Note: Electro-optic coefficients of Li-deficient MgO-doped LiNbO3 crystal.

Du WY, Zhang ZB, Ren S, Wong WH, Yu DY, Pun EY, Zhang DL.

Rev Sci Instrum. 2016 Sep;87(9):096105.


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