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Aurone derivatives as Vps34 inhibitors that modulate autophagy.

Li G, Boyle JW, Ko CN, Zeng W, Wong VKW, Wan JB, Chan PWH, Ma DL, Leung CH.

Acta Pharm Sin B. 2019 May;9(3):537-544. doi: 10.1016/j.apsb.2019.01.016. Epub 2019 Jan 30.


Ca2+ signalling plays a role in celastrol-mediated suppression of synovial fibroblasts of rheumatoid arthritis patients and experimental arthritis in rats.

Wong VKW, Qiu C, Xu SW, Law BYK, Zeng W, Wang H, Michelangeli F, Dias IRSR, Qu YQ, Chan TW, Han Y, Zhang N, Mok SWF, Chen X, Yu L, Pan H, Hamdoun S, Efferth T, Yu WJ, Zhang W, Li Z, Xie Y, Luo R, Jiang Q, Liu L.

Br J Pharmacol. 2019 Aug;176(16):2922-2944. doi: 10.1111/bph.14718. Epub 2019 Jul 4.


The New Application of UHPLC-DAD-TOF/MS in Identification of Inhibitors on β-Amyloid Fibrillation From Scutellaria baicalensis.

Yu L, Wu AG, Wong VK, Qu LQ, Zhang N, Qin DL, Zeng W, Tang B, Wang HM, Wang Q, Law BY.

Front Pharmacol. 2019 Mar 18;10:194. doi: 10.3389/fphar.2019.00194. eCollection 2019.


Semi-synthetic isoflavones as BACE-1 inhibitors against Alzheimer's disease.

Ribaudo G, Coghi P, Zanforlin E, Law BYK, Wu YYJ, Han Y, Qiu AC, Qu YQ, Zagotto G, Wong VKW.

Bioorg Chem. 2019 Jun;87:474-483. doi: 10.1016/j.bioorg.2019.03.034. Epub 2019 Mar 15.


Identification of inhibitors of the polo-box domain of polo-like kinase 1 from natural and semisynthetic compounds.

Abdelfatah S, Fleischer E, Klinger A, Wong VKW, Efferth T.

Invest New Drugs. 2019 Mar 15. doi: 10.1007/s10637-019-00752-0. [Epub ahead of print]


A Functional Variant in Ubiquitin Conjugating Enzyme E2 L3 Contributes to Hepatitis B Virus Infection and Maintains Covalently Closed Circular DNA Stability by Inducing Degradation of Apolipoprotein B mRNA Editing Enzyme Catalytic Subunit 3A.

Zhou L, Ren JH, Cheng ST, Xu HM, Chen WX, Chen DP, Wong VKW, Law BYK, Liu Y, Cai XF, Tang H, Yu HB, Hu JL, Hu Y, Zhou HZ, Ren F, He L, Hu ZW, Jiang H, Xu HY, Huang AL, Chen J.

Hepatology. 2019 May;69(5):1885-1902. doi: 10.1002/hep.30497. Epub 2019 Mar 15.


Arsenic trioxide reverses the chemoresistance in hepatocellular carcinoma: a targeted intervention of 14-3-3η/NF-κB feedback loop.

Qiu Y, Dai Y, Zhang C, Yang Y, Jin M, Shan W, Shen J, Lu M, Tang Z, Ju L, Wang Y, Jiao R, Xia Y, Huang G, Yang L, Li Y, Zhang J, Wong VKW, Jiang Z.

J Exp Clin Cancer Res. 2018 Dec 20;37(1):321. doi: 10.1186/s13046-018-1005-y.


Emergence of dominant multidrug-resistant bacterial clades: Lessons from history and whole-genome sequencing.

Klemm EJ, Wong VK, Dougan G.

Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):12872-12877. doi: 10.1073/pnas.1717162115.


Method for Quantification of Ribonucleotides and Deoxyribonucleotides in Human Cells Using (Trimethylsilyl)diazomethane Derivatization Followed by Liquid Chromatography-Tandem Mass Spectrometry.

Li Z, Zhang HX, Li Y, Lam CWK, Wang CY, Zhang WJ, Wong VKW, Pang SS, Yao MC, Zhang W.

Anal Chem. 2019 Jan 2;91(1):1019-1026. doi: 10.1021/acs.analchem.8b04281. Epub 2018 Dec 11.


Crystal Structures and Cytotoxicity of ent-Kaurane-Type Diterpenoids from Two Aspilia Species.

Yaouba S, Valkonen A, Coghi P, Gao J, Guantai EM, Derese S, Wong VKW, Erdélyi M, Yenesew A.

Molecules. 2018 Dec 4;23(12). pii: E3199. doi: 10.3390/molecules23123199.


The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa.

Park SE, Pham DT, Boinett C, Wong VK, Pak GD, Panzner U, Espinoza LMC, von Kalckreuth V, Im J, Schütt-Gerowitt H, Crump JA, Breiman RF, Adu-Sarkodie Y, Owusu-Dabo E, Rakotozandrindrainy R, Soura AB, Aseffa A, Gasmelseed N, Keddy KH, May J, Sow AG, Aaby P, Biggs HM, Hertz JT, Montgomery JM, Cosmas L, Olack B, Fields B, Sarpong N, Razafindrabe TJL, Raminosoa TM, Kabore LP, Sampo E, Teferi M, Yeshitela B, El Tayeb MA, Sooka A, Meyer CG, Krumkamp R, Dekker DM, Jaeger A, Poppert S, Tall A, Niang A, Bjerregaard-Andersen M, Løfberg SV, Seo HJ, Jeon HJ, Deerin JF, Park J, Konings F, Ali M, Clemens JD, Hughes P, Sendagala JN, Vudriko T, Downing R, Ikumapayi UN, Mackenzie GA, Obaro S, Argimon S, Aanensen DM, Page A, Keane JA, Duchene S, Dyson Z, Holt KE, Dougan G, Marks F, Baker S.

Nat Commun. 2018 Nov 30;9(1):5094. doi: 10.1038/s41467-018-07370-z.


Novel dauricine derivatives suppress cancer via autophagy-dependent cell death.

Zhou X, Qu YQ, Zheng Z, Law BYK, Mok SWF, Jiang ZH, Wong VKW, Bai LP.

Bioorg Chem. 2019 Mar;83:450-460. doi: 10.1016/j.bioorg.2018.10.074. Epub 2018 Nov 2.


US Findings of First-Trimester Pregnancy RadioGraphics Fundamentals | Online Presentation.

Bahouth SM, Wong VK, Kampalath RV, Lin J, Mankowski-Gettle L.

Radiographics. 2018 Nov-Dec;38(7):2193-2194. doi: 10.1148/rg.2018180065. No abstract available.


Corrigendum: Novel Peroxides as Promising Anticancer Agents with Unexpected Depressed Antimalarial Activity.

Coghi P, Yaremenko IA, Prommana P, Radulov PS, Syroeshkin MA, Wu YJ, Gao JY, Gordillo FM, Mok S, Wong VKW, Uthaipibull C, Terent'ev AO.

ChemMedChem. 2018 Oct 22;13(20):2249. doi: 10.1002/cmdc.201800618. Epub 2018 Sep 25. No abstract available.


A systematic review of antimicrobial resistance in Salmonella enterica serovar Typhi, the etiological agent of typhoid.

Britto CD, Wong VK, Dougan G, Pollard AJ.

PLoS Negl Trop Dis. 2018 Oct 11;12(10):e0006779. doi: 10.1371/journal.pntd.0006779. eCollection 2018 Oct.


A Method for Rapid Screening of Anilide-Containing AMPK Modulators Based on Computational Docking and Biological Validation.

Mok SWF, Zeng W, Niu Y, Coghi P, Wu Y, Sin WM, Ng SI, Gordillo-Martínez F, Gao JY, Law BYK, Liu L, Yao X, Wong VKW.

Front Pharmacol. 2018 Jul 3;9:710. doi: 10.3389/fphar.2018.00710. eCollection 2018.


Selective Inhibition of Lysine-Specific Demethylase 5A (KDM5A) Using a Rhodium(III) Complex for Triple-Negative Breast Cancer Therapy.

Yang GJ, Wang W, Mok SWF, Wu C, Law BYK, Miao XM, Wu KJ, Zhong HJ, Wong CY, Wong VKW, Ma DL, Leung CH.

Angew Chem Int Ed Engl. 2018 Oct 1;57(40):13091-13095. doi: 10.1002/anie.201807305. Epub 2018 Jul 19.


Salubrinal Enhances Doxorubicin Sensitivity in Human Cholangiocarcinoma Cells Through Promoting DNA Damage.

Yu W, Xiang Y, Luo G, Zhao X, Xiao B, Cheng Y, Feng C, Duan C, Xia X, Wong VKW, Dai R.

Cancer Biother Radiopharm. 2018 Aug;33(6):258-265. doi: 10.1089/cbr.2018.2447. Epub 2018 Jun 29.


Effectiveness and Cognitive Changes With Ultrabrief Right Unilateral and Other Forms of Electroconvulsive Therapy in the Treatment of Mania.

Wong VKH, Tor PC, Martin DM, Mok YM, Loo C.

J ECT. 2019 Mar;35(1):40-43. doi: 10.1097/YCT.0000000000000519.


Establishing a Hybrid Wound and Ostomy Continuing Education Program.

Wong VK.

Nurs Educ Perspect. 2018 May/Jun;39(3):192-193. doi: 10.1097/01.NEP.0000000000000232.


SIRT3 restricts hepatitis B virus transcription and replication through epigenetic regulation of covalently closed circular DNA involving suppressor of variegation 3-9 homolog 1 and SET domain containing 1A histone methyltransferases.

Ren JH, Hu JL, Cheng ST, Yu HB, Wong VKW, Law BYK, Yang YF, Huang Y, Liu Y, Chen WX, Cai XF, Tang H, Hu Y, Zhang WL, Liu X, Long QX, Zhou L, Tao NN, Zhou HZ, Yang QX, Ren F, He L, Gong R, Huang AL, Chen J.

Hepatology. 2018 Oct;68(4):1260-1276. doi: 10.1002/hep.29912. Epub 2018 Jul 25.


2-Aminoethoxydiphenylborane sensitizes anti-tumor effect of bortezomib via suppression of calcium-mediated autophagy.

Qu YQ, Gordillo-Martinez F, Law BYK, Han Y, Wu A, Zeng W, Lam WK, Ho C, Mok SWF, He HQ, Wong VKW, Wang R.

Cell Death Dis. 2018 Mar 2;9(3):361. doi: 10.1038/s41419-018-0397-0.


Novel Peroxides as Promising Anticancer Agents with Unexpected Depressed Antimalarial Activity.

Coghi P, Yaremenko IA, Prommana P, Radulov PS, Syroeshkin MA, Wu YJ, Gao JY, Gordillo FM, Mok S, Wong VKW, Uthaipibull C, Terent'ev AO.

ChemMedChem. 2018 May 8;13(9):902-908. doi: 10.1002/cmdc.201700804. Epub 2018 Mar 15. Erratum in: ChemMedChem. 2018 Oct 22;13(20):2249.


Emergence of an Extensively Drug-Resistant Salmonella enterica Serovar Typhi Clone Harboring a Promiscuous Plasmid Encoding Resistance to Fluoroquinolones and Third-Generation Cephalosporins.

Klemm EJ, Shakoor S, Page AJ, Qamar FN, Judge K, Saeed DK, Wong VK, Dallman TJ, Nair S, Baker S, Shaheen G, Qureshi S, Yousafzai MT, Saleem MK, Hasan Z, Dougan G, Hasan R.

MBio. 2018 Feb 20;9(1). pii: e00105-18. doi: 10.1128/mBio.00105-18.


Inhibition of KRAS-dependent lung cancer cell growth by deltarasin: blockage of autophagy increases its cytotoxicity.

Leung ELH, Luo LX, Liu ZQ, Wong VKW, Lu LL, Xie Y, Zhang N, Qu YQ, Fan XX, Li Y, Huang M, Xiao DK, Huang J, Zhou YL, He JX, Ding J, Yao XJ, Ward DC, Liu L.

Cell Death Dis. 2018 Feb 13;9(2):216. doi: 10.1038/s41419-017-0065-9.


The Calcium-Induced Regulation in the Molecular and Transcriptional Circuitry of Human Inflammatory Response and Autoimmunity.

de Seabra Rodrigues Dias IR, Mok SWF, Gordillo-Martínez F, Khan I, Hsiao WWL, Law BYK, Wong VKW, Liu L.

Front Pharmacol. 2018 Jan 8;8:962. doi: 10.3389/fphar.2017.00962. eCollection 2017.


Saikosaponin-d, a calcium mobilizing agent, sensitizes chemoresistant ovarian cancer cells to cisplatin-induced apoptosis by facilitating mitochondrial fission and G2/M arrest.

Tsuyoshi H, Wong VKW, Han Y, Orisaka M, Yoshida Y, Tsang BK.

Oncotarget. 2017 Sep 16;8(59):99825-99840. doi: 10.18632/oncotarget.21076. eCollection 2017 Nov 21.


Novel direct AMPK activator suppresses non-small cell lung cancer through inhibition of lipid metabolism.

Chen X, Xie C, Fan XX, Jiang ZB, Wong VK, Xu JH, Yao XJ, Liu L, Leung EL.

Oncotarget. 2017 Oct 9;8(56):96089-96102. doi: 10.18632/oncotarget.21716. eCollection 2017 Nov 10.


Salmonella enterica serovar Typhi Producing CTX-M-15 Extended Spectrum β-Lactamase in the Democratic Republic of the Congo.

Phoba MF, Barbé B, Lunguya O, Masendu L, Lulengwa D, Dougan G, Wong VK, Bertrand S, Ceyssens PJ, Jacobs J, Van Puyvelde S, Deborggraeve S.

Clin Infect Dis. 2017 Oct 1;65(7):1229-1231. doi: 10.1093/cid/cix342.


Artemisinin Derivatives Target Topoisomerase 1 and Cause DNA Damage in Silico and in Vitro.

Kadioglu O, Chan A, Cong Ling Qiu A, Wong VKW, Colligs V, Wecklein S, Freund-Henni Rached H, Efferth T, Hsiao WW.

Front Pharmacol. 2017 Oct 9;8:711. doi: 10.3389/fphar.2017.00711. eCollection 2017.


New perspectives of cobalt tris(bipyridine) system: anti-cancer effect and its collateral sensitivity towards multidrug-resistant (MDR) cancers.

Law BYK, Qu YQ, Mok SWF, Liu H, Zeng W, Han Y, Gordillo-Martinez F, Chan WK, Wong KM, Wong VKW.

Oncotarget. 2017 Jul 5;8(33):55003-55021. doi: 10.18632/oncotarget.18991. eCollection 2017 Aug 15.


Four Prenylflavone Derivatives with Antiplasmodial Activities from the Stem of Tephrosia purpurea subsp. leptostachya.

Atilaw Y, Muiva-Mutisya L, Ndakala A, Akala HM, Yeda R, Wu YJ, Coghi P, Wong VKW, Erdélyi M, Yenesew A.

Molecules. 2017 Sep 10;22(9). pii: E1514. doi: 10.3390/molecules22091514.


Pathogenesis of thromboangiitis obliterans: Gene polymorphism and immunoregulation of human vascular endothelial cells.

Sun XL, Law BY, de Seabra Rodrigues Dias IR, Mok SWF, He YZ, Wong VK.

Atherosclerosis. 2017 Oct;265:258-265. doi: 10.1016/j.atherosclerosis.2017.08.009. Epub 2017 Aug 18. Review.


N-Desmethyldauricine Induces Autophagic Cell Death in Apoptosis-Defective Cells via Ca2+ Mobilization.

Law BYK, Mok SWF, Chen J, Michelangeli F, Jiang ZH, Han Y, Qu YQ, Qiu ACL, Xu SW, Xue WW, Yao XJ, Gao JY, Javed MU, Coghi P, Liu L, Wong VKW.

Front Pharmacol. 2017 Jun 16;8:388. doi: 10.3389/fphar.2017.00388. eCollection 2017.


Tetrandrine, an Activator of Autophagy, Induces Autophagic Cell Death via PKC-α Inhibition and mTOR-Dependent Mechanisms.

Wong VKW, Zeng W, Chen J, Yao XJ, Leung ELH, Wang QQ, Chiu P, Ko BCB, Law BYK.

Front Pharmacol. 2017 Jun 8;8:351. doi: 10.3389/fphar.2017.00351. eCollection 2017.


Mode of Action Analyses of Neferine, a Bisbenzylisoquinoline Alkaloid of Lotus (Nelumbo nucifera) against Multidrug-Resistant Tumor Cells.

Kadioglu O, Law BYK, Mok SWF, Xu SW, Efferth T, Wong VKW.

Front Pharmacol. 2017 May 5;8:238. doi: 10.3389/fphar.2017.00238. eCollection 2017.


Thalidezine, a novel AMPK activator, eliminates apoptosis-resistant cancer cells through energy-mediated autophagic cell death.

Law BYK, Gordillo-Martínez F, Qu YQ, Zhang N, Xu SW, Coghi PS, Mok SWF, Guo J, Zhang W, Leung ELH, Fan XX, Wu AG, Chan WK, Yao XJ, Wang JR, Liu L, Wong VKW.

Oncotarget. 2017 May 2;8(18):30077-30091. doi: 10.18632/oncotarget.15616.


An anti-prostate cancer benzofuran-conjugated iridium(III) complex as a dual inhibitor of STAT3 and NF-κB.

Kang TS, Wang W, Zhong HJ, Dong ZZ, Huang Q, Mok SW, Leung CH, Wong VK, Ma DL.

Cancer Lett. 2017 Jun 28;396:76-84. doi: 10.1016/j.canlet.2017.03.016. Epub 2017 Mar 18.


Clinical and Imaging Features of Noncutaneous Melanoma.

Wong VK, Lubner MG, Menias CO, Mellnick VM, Kennedy TA, Bhalla S, Pickhardt PJ.

AJR Am J Roentgenol. 2017 May;208(5):942-959. doi: 10.2214/AJR.16.16800. Epub 2017 Mar 16. Review.


Renal mass biopsy and thermal ablation: should biopsy be performed before or during the ablation procedure?

Wells SA, Wong VK, Wittmann TA, Lubner MG, Best SL, Ziemlewicz TJ, Hinshaw JL, Lee FT Jr, Abel EJ.

Abdom Radiol (NY). 2017 Jun;42(6):1773-1780. doi: 10.1007/s00261-016-1037-8.


Antagonizing STAT5B dimerization with an osmium complex.

Liu LJ, Wang W, Kang TS, Liang JX, Liu C, Kwong DWJ, Wong VKW, Ma DL, Leung CH.

Sci Rep. 2016 Nov 17;6:36044. doi: 10.1038/srep36044.


Profiling ribonucleotide and deoxyribonucleotide pools perturbed by gemcitabine in human non-small cell lung cancer cells.

Guo JR, Chen QQ, Lam CW, Wang CY, Wong VK, Chang ZF, Zhang W.

Sci Rep. 2016 Nov 15;6:37250. doi: 10.1038/srep37250.


Hederagenin and α-hederin promote degradation of proteins in neurodegenerative diseases and improve motor deficits in MPTP-mice.

Wu AG, Zeng W, Wong VK, Zhu YZ, Lo AC, Liu L, Law BY.

Pharmacol Res. 2017 Jan;115:25-44. doi: 10.1016/j.phrs.2016.11.002. Epub 2016 Nov 9.


Opioid therapy for chronic non-cancer pain: guidelines for Hong Kong.

Cheung CW, Chan TC, Chen PP, Chu MC, Chui WC, Ho PT, Lam F, Law SW, Lee JL, Wong SH, Wong VK.

Hong Kong Med J. 2016 Oct;22(5):496-505. doi: 10.12809/hkmj164920. Review.


An extended genotyping framework for Salmonella enterica serovar Typhi, the cause of human typhoid.

Wong VK, Baker S, Connor TR, Pickard D, Page AJ, Dave J, Murphy N, Holliman R, Sefton A, Millar M, Dyson ZA, Dougan G, Holt KE; International Typhoid Consortium.

Nat Commun. 2016 Oct 5;7:12827. doi: 10.1038/ncomms12827.


Engineering A11 Minibody-Conjugated, Polypeptide-Based Gold Nanoshells for Prostate Stem Cell Antigen (PSCA)-Targeted Photothermal Therapy.

Mayle KM, Dern KR, Wong VK, Chen KY, Sung S, Ding K, Rodriguez AR, Knowles S, Taylor Z, Zhou ZH, Grundfest WS, Wu AM, Deming TJ, Kamei DT.

SLAS Technol. 2017 Feb;22(1):26-35. doi: 10.1177/2211068216669710. Epub 2016 Sep 26.


Molecular Surveillance Identifies Multiple Transmissions of Typhoid in West Africa.

International Typhoid Consortium, Wong VK, Holt KE, Okoro C, Baker S, Pickard DJ, Marks F, Page AJ, Olanipekun G, Munir H, Alter R, Fey PD, Feasey NA, Weill FX, Le Hello S, Hart PJ, Kariuki S, Breiman RF, Gordon MA, Heyderman RS, Jacobs J, Lunguya O, Msefula C, MacLennan CA, Keddy KH, Smith AM, Onsare RS, De Pinna E, Nair S, Amos B, Dougan G, Obaro S.

PLoS Negl Trop Dis. 2016 Sep 22;10(9):e0004781. doi: 10.1371/journal.pntd.0004781. eCollection 2016 Sep.


Isoliquiritigenin suppresses human T Lymphocyte activation via covalently binding cysteine 46 of IκB kinase.

Yan F, Yang F, Wang R, Yao XJ, Bai L, Zeng X, Huang J, Wong VKW, Lam CWK, Zhou H, Su X, Liu J, Li T, Liu L.

Oncotarget. 2017 May 23;8(21):34223-34235. doi: 10.18632/oncotarget.11934.


Autophagic degradation of epidermal growth factor receptor in gefitinib-resistant lung cancer by celastrol.

Xu SW, Law BY, Mok SW, Leung EL, Fan XX, Coghi PS, Zeng W, Leung CH, Ma DL, Liu L, Wong VK.

Int J Oncol. 2016 Oct;49(4):1576-88. doi: 10.3892/ijo.2016.3644. Epub 2016 Aug 3.


Advanced research technology for discovery of new effective compounds from Chinese herbal medicine and their molecular targets.

Wong VK, Law BY, Yao XJ, Chen X, Xu SW, Liu L, Leung EL.

Pharmacol Res. 2016 Sep;111:546-555. doi: 10.1016/j.phrs.2016.07.022. Epub 2016 Jul 20. Review.


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