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A single-cell transcriptome atlas of the adult human retina.

Lukowski SW, Lo CY, Sharov AA, Nguyen Q, Fang L, Hung SS, Zhu L, Zhang T, Grünert U, Nguyen T, Senabouth A, Jabbari JS, Welby E, Sowden JC, Waugh HS, Mackey A, Pollock G, Lamb TD, Wang PY, Hewitt AW, Gillies MC, Powell JE, Wong RC.

EMBO J. 2019 Sep 16;38(18):e100811. doi: 10.15252/embj.2018100811. Epub 2019 Aug 22.


Using transcription factors for direct reprogramming of neurons in vitro.

El Wazan L, Urrutia-Cabrera D, Wong RC.

World J Stem Cells. 2019 Jul 26;11(7):431-444. doi: 10.4252/wjsc.v11.i7.431. Review.


Utility of self-destructing CRISPR/Cas constructs for targeted gene editing in the retina.

Li F, Hung SSC, Mohd Khalid MKN, Wang JH, Chrysostomou V, Wong VHY, Singh V, Wing K, Tu L, Bender JA, Pebay A, King AE, Cook AL, Wong RCB, Bui BV, Hewitt AW, Liu GS.

Hum Gene Ther. 2019 Aug 2. doi: 10.1089/hum.2019.021. [Epub ahead of print]


Construction of cathepsin B-responsive fluorescent probe and photosensitizer using a ferrocenyl boron dipyrromethene dark quencher.

Wang Q, Yu L, Wong RCH, Lo PC.

Eur J Med Chem. 2019 Oct 1;179:828-836. doi: 10.1016/j.ejmech.2019.06.082. Epub 2019 Jun 29.


Juxta-articular tumoral calcinosis associated with the temporomandibular joint: a case report and concise review.

Sha Y, Hong K, Liew MKM, Lum JL, Wong RCW.

BMC Oral Health. 2019 Jul 9;19(1):138. doi: 10.1186/s12903-019-0816-3.


Corrigendum: Potentials of Cellular Reprogramming as a Novel Strategy for Neuroregeneration.

Fang L, El Wazan L, Tan C, Nguyen T, Hung SSC, Hewitt AW, Wong RCB.

Front Cell Neurosci. 2019 May 3;13:147. doi: 10.3389/fncel.2019.00147. eCollection 2019.


An integrin-targeting glutathione-activated zinc(II) phthalocyanine for dual targeted photodynamic therapy.

Ha SYY, Wong RCH, Wong CTT, Ng DKP.

Eur J Med Chem. 2019 Jul 15;174:56-65. doi: 10.1016/j.ejmech.2019.04.049. Epub 2019 Apr 19.


Screening of CRISPR/Cas base editors to target the AMD high-risk Y402H complement factor H variant.

Tran MTN, Khalid MKNM, Pébay A, Cook AL, Liang HH, Wong RCB, Craig JE, Liu GS, Hung SS, Hewitt AW.

Mol Vis. 2019 Mar 16;25:174-182. eCollection 2019.


Rational design of silicon structures for optically controlled multiscale biointerfaces.

Jiang Y, Li X, Liu B, Yi J, Fang Y, Shi F, Gao X, Sudzilovsky E, Parameswaran R, Koehler K, Nair V, Yue J, Guo K, Fang Y, Tsai HM, Freyermuth G, Wong RCS, Kao CM, Chen CT, Nicholls AW, Wu X, Shepherd GMG, Tian B.

Nat Biomed Eng. 2018 Jul;2(7):508-521. doi: 10.1038/s41551-018-0230-1. Epub 2018 Apr 30.


Use of Doppler Probe in Nonvariceal Upper-Gastrointestinal Bleeding Is Less Costly and More Effective Than Standard of Care.

Barkun AN, Adam V, Wong RCK.

Clin Gastroenterol Hepatol. 2019 Feb 14. pii: S1542-3565(19)30179-X. doi: 10.1016/j.cgh.2019.02.016. [Epub ahead of print]


A Simple Cloning-free Method to Efficiently Induce Gene Expression Using CRISPR/Cas9.

Fang L, Hung SSC, Yek J, El Wazan L, Nguyen T, Khan S, Lim SY, Hewitt AW, Wong RCB.

Mol Ther Nucleic Acids. 2019 Mar 1;14:184-191. doi: 10.1016/j.omtn.2018.11.008. Epub 2018 Nov 20.


Potentials of Cellular Reprogramming as a Novel Strategy for Neuroregeneration.

Fang L, El Wazan L, Tan C, Nguyen T, Hung SSC, Hewitt AW, Wong RCB.

Front Cell Neurosci. 2018 Nov 30;12:460. doi: 10.3389/fncel.2018.00460. eCollection 2018. Review. Erratum in: Front Cell Neurosci. 2019 May 03;13:147.


Long-term follow-up of patients with myasthenia gravis treated with low-dose rituximab.

Chan F, Swayne A, Gillis D, Walsh M, Henderson RD, McCombe PA, Wong RC, Blum S.

J Neurol Neurosurg Psychiatry. 2019 Aug;90(8):955-956. doi: 10.1136/jnnp-2018-319410. Epub 2018 Nov 19. No abstract available.


Takotsubo hypertrophic obstructive cardiomyopathy and bicuspid valvulopathy: implication of multiple imaging modalities.

Kong WK, Loh PH, Teo L, Ong CC, Wong RC.

Eur Heart J. 2019 Jul 1;40(26):2172. doi: 10.1093/eurheartj/ehy673. No abstract available.


Endoscopic Doppler Probe in the Diagnosis and Management of Upper Gastrointestinal Hemorrhage.

Satyavada S, Davitkov P, Akbar Ali M, Cooper G, Wong RCK, Chak A.

ACG Case Rep J. 2018 Sep 26;5:e68. doi: 10.14309/crj.2018.68. eCollection 2018.


The prevalence and treatment outcomes of antineuronal antibody-positive patients admitted with first episode of psychosis.

Scott JG, Gillis D, Ryan AE, Hargovan H, Gundarpi N, McKeon G, Hatherill S, Newman MP, Parry P, Prain K, Patterson S, Wong RCW, Wilson RJ, Blum S.

BJPsych Open. 2018 Mar 16;4(2):69-74. doi: 10.1192/bjo.2018.8. eCollection 2018 Mar.


Effect of Cardiac Rehabilitation on Quality of Life, Depression and Anxiety in Asian Patients.

Choo CC, Chew PKH, Lai SM, Soo SC, Ho CS, Ho RC, Wong RC.

Int J Environ Res Public Health. 2018 May 28;15(6). pii: E1095. doi: 10.3390/ijerph15061095.


Atretic aortic valvular cusp causing severe aortic regurgitation.

Wong RC, Yip JWL, Tay ELW, Kong WKF.

Eur Heart J Cardiovasc Imaging. 2018 Sep 1;19(9):1072-1073. doi: 10.1093/ehjci/jey074. No abstract available.


Effect of multimorbidity on survival of patients diagnosed with heart failure: a retrospective cohort study in Singapore.

Kaur P, Saxena N, You AX, Wong RCC, Lim CP, Loh SY, George PP.

BMJ Open. 2018 May 20;8(5):e021291. doi: 10.1136/bmjopen-2017-021291.


Recent Modifications and Validation of QuEChERS-dSPE Coupled to LC-MS and GC-MS Instruments for Determination of Pesticide/Agrochemical Residues in Fruits and Vegetables: Review.

Lawal A, Wong RCS, Tan GH, Abdulra'uf LB, Alsharif AMA.

J Chromatogr Sci. 2018 Aug 1;56(7):656-669. doi: 10.1093/chromsci/bmy032. Review.


Mitochondrial fission protein Drp1 inhibition promotes cardiac mesodermal differentiation of human pluripotent stem cells.

Hoque A, Sivakumaran P, Bond ST, Ling NXY, Kong AM, Scott JW, Bandara N, Hernández D, Liu GS, Wong RCB, Ryan MT, Hausenloy DJ, Kemp BE, Oakhill JS, Drew BG, Pébay A, Lim SY.

Cell Death Discov. 2018 Mar 5;4:39. doi: 10.1038/s41420-018-0042-9. eCollection 2018 Dec.


Disulfide-Linked Dendritic Oligomeric Phthalocyanines as Glutathione-Responsive Photosensitizers for Photodynamic Therapy.

Chow SYS, Wong RCH, Zhao S, Lo PC, Ng DKP.

Chemistry. 2018 Apr 17;24(22):5779-5789. doi: 10.1002/chem.201706128. Epub 2018 Mar 2.


Single-dose intravenous iron in Southeast Asian heart failure patients: A pilot randomized placebo-controlled study (PRACTICE-ASIA-HF).

Yeo TJ, Yeo PSD, Hadi FA, Cushway T, Lee KY, Yin FF, Ching A, Li R, Loh SY, Lim SL, Wong RC, Tai BC, Richards AM, Lam CSP.

ESC Heart Fail. 2018 Apr;5(2):344-353. doi: 10.1002/ehf2.12250. Epub 2018 Jan 18.


Generation of a human induced pluripotent stem cell line CERAi001-A-6 using episomal vectors.

Wong RCB, Hung SS, Jackson S, Singh V, Khan S, Liang HH, Kearns LS, Nguyen T, Conquest A, Daniszewski M, Hewitt AW, Pébay A.

Stem Cell Res. 2017 Jul;22:13-15. doi: 10.1016/j.scr.2017.05.007. Epub 2017 May 19.


Drusen in patient-derived hiPSC-RPE models of macular dystrophies.

Galloway CA, Dalvi S, Hung SSC, MacDonald LA, Latchney LR, Wong RCB, Guymer RH, Mackey DA, Williams DS, Chung MM, Gamm DM, Pébay A, Hewitt AW, Singh R.

Proc Natl Acad Sci U S A. 2017 Sep 26;114(39):E8214-E8223. doi: 10.1073/pnas.1710430114. Epub 2017 Sep 6.


Neuroregeneration using in vivo cellular reprogramming.

Nguyen T, Wong RC.

Neural Regen Res. 2017 Jul;12(7):1073-1074. doi: 10.4103/1673-5374.211182. No abstract available.


Transitional Care to Reduce Heart Failure Readmission Rates in South East Asia.

Chan WX, Lin W, Wong RCC.

Card Fail Rev. 2016 Nov;2(2):85-89. doi: 10.15420/cfr.2016:9:2.


Encapsulating pH-Responsive Doxorubicin-Phthalocyanine Conjugates in Mesoporous Silica Nanoparticles for Combined Photodynamic Therapy and Controlled Chemotherapy.

Wong RCH, Ng DKP, Fong WP, Lo PC.

Chemistry. 2017 Nov 21;23(65):16505-16515. doi: 10.1002/chem.201703188. Epub 2017 Sep 19.


pH-Responsive Dimeric Zinc(II) Phthalocyanine in Mesoporous Silica Nanoparticles as an Activatable Nanophotosensitizing System for Photodynamic Therapy.

Wong RCH, Chow SYS, Zhao S, Fong WP, Ng DKP, Lo PC.

ACS Appl Mater Interfaces. 2017 Jul 19;9(28):23487-23496. doi: 10.1021/acsami.7b06353. Epub 2017 Jul 6.


Thymosin Beta-4 Is Elevated in Women With Heart Failure With Preserved Ejection Fraction.

Drum CL, Tan WKY, Chan SP, Pakkiri LS, Chong JPC, Liew OW, Ng TP, Ling LH, Sim D, Leong KG, Yeo DPS, Ong HY, Jaufeerally F, Wong RCC, Chai P, Low AF, Davidsson P, Liljeblad M, Söderling AS, Gan LM, Bhat RV, Purnamawati K, Lam CSP, Richards AM.

J Am Heart Assoc. 2017 Jun 13;6(6). pii: e005586. doi: 10.1161/JAHA.117.005586.


Automated Cell Culture Systems and Their Applications to Human Pluripotent Stem Cell Studies.

Daniszewski M, Crombie DE, Henderson R, Liang HH, Wong RCB, Hewitt AW, Pébay A.

SLAS Technol. 2018 Aug;23(4):315-325. doi: 10.1177/2472630317712220. Epub 2017 Jun 2. Review.


Friedreich's ataxia induced pluripotent stem cell-derived cardiomyocytes display electrophysiological abnormalities and calcium handling deficiency.

Crombie DE, Curl CL, Raaijmakers AJ, Sivakumaran P, Kulkarni T, Wong RC, Minami I, Evans-Galea MV, Lim SY, Delbridge L, Corben LA, Dottori M, Nakatsuji N, Trounce IA, Hewitt AW, Delatycki MB, Pera MF, Pébay A.

Aging (Albany NY). 2017 May 30;9(5):1440-1452. doi: 10.18632/aging.101247.


Incidence and prevalence of NMOSD in Australia and New Zealand.

Bukhari W, Prain KM, Waters P, Woodhall M, O'Gorman CM, Clarke L, Silvestrini RA, Bundell CS, Abernethy D, Bhuta S, Blum S, Boggild M, Boundy K, Brew BJ, Brown M, Brownlee WJ, Butzkueven H, Carroll WM, Chen C, Coulthard A, Dale RC, Das C, Dear K, Fabis-Pedrini MJ, Fulcher D, Gillis D, Hawke S, Heard R, Henderson APD, Heshmat S, Hodgkinson S, Jimenez-Sanchez S, Killpatrick T, King J, Kneebone C, Kornberg AJ, Lechner-Scott J, Lin MW, Lynch C, Macdonell R, Mason DF, McCombe PA, Pender MP, Pereira JA, Pollard JD, Reddel SW, Shaw C, Spies J, Stankovich J, Sutton I, Vucic S, Walsh M, Wong RC, Yiu EM, Barnett MH, Kermode AG, Marriott MP, Parratt JDE, Slee M, Taylor BV, Willoughby E, Wilson RJ, Vincent A, Broadley SA.

J Neurol Neurosurg Psychiatry. 2017 Aug;88(8):632-638. doi: 10.1136/jnnp-2016-314839. Epub 2017 May 26.


Mitochondrial replacement in an iPSC model of Leber's hereditary optic neuropathy.

Wong RCB, Lim SY, Hung SSC, Jackson S, Khan S, Van Bergen NJ, De Smit E, Liang HH, Kearns LS, Clarke L, Mackey DA, Hewitt AW, Trounce IA, Pébay A.

Aging (Albany NY). 2017 Apr;9(4):1341-1350. doi: 10.18632/aging.101231.


Maintenance of Human Embryonic Stem Cells by Sphingosine-1-Phosphate and Platelet-Derived Growth Factor.

Wong RCB, Pera MF, Pébay A.

Methods Mol Biol. 2018;1697:133-140. doi: 10.1007/7651_2017_4.


Development of a Modular Automated System for Maintenance and Differentiation of Adherent Human Pluripotent Stem Cells.

Crombie DE, Daniszewski M, Liang HH, Kulkarni T, Li F, Lidgerwood GE, Conquest A, Hernández D, Hung SS, Gill KP, De Smit E, Kearns LS, Clarke L, Sluch VM, Chamling X, Zack DJ, Wong RCB, Hewitt AW, Pébay A.

SLAS Discov. 2017 Sep;22(8):1016-1025. doi: 10.1177/2472555217696797. Epub 2017 Mar 13.


Drug discovery using induced pluripotent stem cell models of neurodegenerative and ocular diseases.

Hung SSC, Khan S, Lo CY, Hewitt AW, Wong RCB.

Pharmacol Ther. 2017 Sep;177:32-43. doi: 10.1016/j.pharmthera.2017.02.026. Epub 2017 Feb 14. Review.


Changes in bite force after orthognathic surgical correction of mandibular prognathism: a systematic review.

Islam I, Lim AAT, Wong RCW.

Int J Oral Maxillofac Surg. 2017 Jun;46(6):746-755. doi: 10.1016/j.ijom.2017.01.012. Epub 2017 Feb 13. Review.


How adults with cardiac conditions in Singapore understand the Patient Activation Measure (PAM-13) items: a cognitive interviewing study.

Ngooi BX, Packer TL, Warner G, Kephart G, Koh KWL, Wong RCC, Lim SP.

Disabil Rehabil. 2018 Mar;40(5):587-596. doi: 10.1080/09638288.2016.1261413. Epub 2016 Dec 15.


Binary colloidal crystals (BCCs) as a feeder-free system to generate human induced pluripotent stem cells (hiPSCs).

Wang PY, Hung SS, Thissen H, Kingshott P, Wong RC.

Sci Rep. 2016 Nov 11;6:36845. doi: 10.1038/srep36845.


A biotin-conjugated glutathione-responsive FRET-based fluorescent probe with a ferrocenyl BODIPY as the dark quencher.

Shi WJ, Lo PC, Zhao S, Wong RC, Wang Q, Fong WP, Ng DK.

Dalton Trans. 2016 Nov 28;45(44):17798-17806. Epub 2016 Oct 24.


Validation of the Patient Activation Measure (PAM-13) among adults with cardiac conditions in Singapore.

Ngooi BX, Packer TL, Kephart G, Warner G, Koh KW, Wong RC, Lim SP.

Qual Life Res. 2017 Apr;26(4):1071-1080. doi: 10.1007/s11136-016-1412-5. Epub 2016 Sep 19.


The use of induced pluripotent stem cells for studying and treating optic neuropathies.

Khan S, Hung SS, Wong RC.

Curr Opin Organ Transplant. 2016 Oct;21(5):484-9. doi: 10.1097/MOT.0000000000000348. Review.


Enriched retinal ganglion cells derived from human embryonic stem cells.

Gill KP, Hung SS, Sharov A, Lo CY, Needham K, Lidgerwood GE, Jackson S, Crombie DE, Nayagam BA, Cook AL, Hewitt AW, Pébay A, Wong RC.

Sci Rep. 2016 Aug 10;6:30552. doi: 10.1038/srep30552.


AAV-Mediated CRISPR/Cas Gene Editing of Retinal Cells In Vivo.

Hung SS, Chrysostomou V, Li F, Lim JK, Wang JH, Powell JE, Tu L, Daniszewski M, Lo C, Wong RC, Crowston JG, Pébay A, King AE, Bui BV, Liu GS, Hewitt AW.

Invest Ophthalmol Vis Sci. 2016 Jun 1;57(7):3470-6. doi: 10.1167/iovs.16-19316.


Geographic variations in the PARADIGM-HF heart failure trial.

Kristensen SL, Martinez F, Jhund PS, Arango JL, Bĕlohlávek J, Boytsov S, Cabrera W, Gomez E, Hagège AA, Huang J, Kiatchoosakun S, Kim KS, Mendoza I, Senni M, Squire IB, Vinereanu D, Wong RC, Gong J, Lefkowitz MP, Rizkala AR, Rouleau JL, Shi VC, Solomon SD, Swedberg K, Zile MR, Packer M, McMurray JJ.

Eur Heart J. 2016 Nov 1;37(41):3167-3174. Epub 2016 Jun 28.


Heterogeneous silicon mesostructures for lipid-supported bioelectric interfaces.

Jiang Y, Carvalho-de-Souza JL, Wong RC, Luo Z, Isheim D, Zuo X, Nicholls AW, Jung IW, Yue J, Liu DJ, Wang Y, De Andrade V, Xiao X, Navrazhnykh L, Weiss DE, Wu X, Seidman DN, Bezanilla F, Tian B.

Nat Mater. 2016 Sep;15(9):1023-30. doi: 10.1038/nmat4673. Epub 2016 Jun 27.


Study of mitochondrial respiratory defects on reprogramming to human induced pluripotent stem cells.

Hung SS, Van Bergen NJ, Jackson S, Liang H, Mackey DA, Hernández D, Lim SY, Hewitt AW, Trounce I, Pébay A, Wong RC.

Aging (Albany NY). 2016 May;8(5):945-57. doi: 10.18632/aging.100950.


ALPK3-deficient cardiomyocytes generated from patient-derived induced pluripotent stem cells and mutant human embryonic stem cells display abnormal calcium handling and establish that ALPK3 deficiency underlies familial cardiomyopathy.

Phelan DG, Anderson DJ, Howden SE, Wong RC, Hickey PF, Pope K, Wilson GR, Pébay A, Davis AM, Petrou S, Elefanty AG, Stanley EG, James PA, Macciocca I, Bahlo M, Cheung MM, Amor DJ, Elliott DA, Lockhart PJ.

Eur Heart J. 2016 Sep 1;37(33):2586-90. doi: 10.1093/eurheartj/ehw160. Epub 2016 Apr 22.


An Interactive Multimedia Approach to Improving Informed Consent for Induced Pluripotent Stem Cell Research.

McCaughey T, Liang HH, Chen C, Fenwick E, Rees G, Wong RC, Vickers JC, Summers MJ, MacGregor C, Craig JE, Munsie M, Pébay A, Hewitt AW.

Cell Stem Cell. 2016 Mar 3;18(3):307-8. doi: 10.1016/j.stem.2016.02.006. No abstract available.

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