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Long-term safety and treatment effects of cannabidiol in children and adults with treatment-resistant epilepsies: Expanded access program results.

Szaflarski JP, Bebin EM, Comi AM, Patel AD, Joshi C, Checketts D, Beal JC, Laux LC, De Boer LM, Wong MH, Lopez M, Devinsky O, Lyons PD, Zentil PP, Wechsler R; CBD EAP study group.

Epilepsia. 2018 Jul 12. doi: 10.1111/epi.14477. [Epub ahead of print]


Special issue: bioremediation of contaminated soil and water: GeoTrop 2017.

Tsang YF, Ok YS, Sarmah AK, Cao B, Wong MH.

Biodegradation. 2018 Aug;29(4):311-312. doi: 10.1007/s10532-018-9842-0. No abstract available.


Discovery of rafoxanide as a dual CDK4/6 inhibitor for the treatment of skin cancer.

Shi X, Li H, Shi A, Yao H, Ke K, Dong C, Zhu Y, Qin Y, Ding Y, He YH, Liu X, Li L, Lei L, Hai Q, Chen W, Leung KS, Wong MH, Kung HF, Lin MC.

Oncol Rep. 2018 Jun 27. doi: 10.3892/or.2018.6533. [Epub ahead of print]


Monoclonal Antibodies Reveal Dynamic Plasticity Between Lgr5- and Bmi1-Expressing Intestinal Cell Populations.

Smith NR, Swain JR, Davies PS, Gallagher AC, Parappilly MS, Beach CZ, Streeter PR, Williamson IA, Magness ST, Wong MH.

Cell Mol Gastroenterol Hepatol. 2018 Mar 10;6(1):79-96. doi: 10.1016/j.jcmgh.2018.02.007. eCollection 2018.


Background levels of methane in Mars' atmosphere show strong seasonal variations.

Webster CR, Mahaffy PR, Atreya SK, Moores JE, Flesch GJ, Malespin C, McKay CP, Martinez G, Smith CL, Martin-Torres J, Gomez-Elvira J, Zorzano MP, Wong MH, Trainer MG, Steele A, Archer D Jr, Sutter B, Coll PJ, Freissinet C, Meslin PY, Gough RV, House CH, Pavlov A, Eigenbrode JL, Glavin DP, Pearson JC, Keymeulen D, Christensen LE, Schwenzer SP, Navarro-Gonzalez R, Pla-García J, Rafkin SCR, Vicente-Retortillo Á, Kahanpää H, Viudez-Moreiras D, Smith MD, Harri AM, Genzer M, Hassler DM, Lemmon M, Crisp J, Sander SP, Zurek RW, Vasavada AR.

Science. 2018 Jun 8;360(6393):1093-1096. doi: 10.1126/science.aaq0131.


Functional genomic analysis of phthalate acid ester (PAE) catabolism genes in the versatile PAE-mineralising bacterium Rhodococcus sp. 2G.

Zhao HM, Hu RW, Du H, Xin XP, Li YW, Li H, Cai QY, Mo CH, Liu JS, Zhou DM, Wong MH, He ZL.

Sci Total Environ. 2018 Jun 2;640-641:646-652. doi: 10.1016/j.scitotenv.2018.05.337. [Epub ahead of print]


Distribution and speciation of mercury affected by humic acid in mariculture sites at the Pearl River estuary.

Ding L, Zhao K, Zhang L, Liang P, Wu S, Wong MH, Tao H.

Environ Pollut. 2018 Sep;240:623-629. doi: 10.1016/j.envpol.2018.04.142. Epub 2018 May 15.


Genotypic variation and mechanism in uptake and translocation of perfluorooctanoic acid (PFOA) in lettuce (Lactuca sativa L.) cultivars grown in PFOA-polluted soils.

Xiang L, Chen L, Yu LY, Yu PF, Zhao HM, Mo CH, Li YW, Li H, Cai QY, Zhou DM, Wong MH.

Sci Total Environ. 2018 Sep 15;636:999-1008. doi: 10.1016/j.scitotenv.2018.04.354. Epub 2018 May 3.


Global Picture of Protein Regulation in Response to Dibutyl Phthalate (DBP) Stress of Two Brassica parachinensis Cultivars Differing in DBP Accumulation.

Zhao HM, Huang HB, Du H, Xiang L, Mo CH, Li YW, Cai QY, Li H, Liu JS, Zhou DM, Wong MH.

J Agric Food Chem. 2018 May 9;66(18):4768-4779. doi: 10.1021/acs.jafc.8b01157. Epub 2018 Apr 27.


First detection of a blaCTX-M-15-carrying plasmid in Vibrio alginolyticus.

Zheng Z, Li R, Wong MH, Chan EW, Xia X, Chen S.

J Glob Antimicrob Resist. 2018 Jun;13:206-208. doi: 10.1016/j.jgar.2018.04.007. Epub 2018 Apr 19. No abstract available.


Variation in accumulation, transport, and distribution of phthalic acid esters (PAEs) in soil columns grown with low- and high-PAE accumulating rice cultivars.

Wu Y, Chen XX, Zhu TK, Li X, Chen XH, Mo CH, Li YW, Cai QY, Wong MH.

Environ Sci Pollut Res Int. 2018 Jun;25(18):17768-17780. doi: 10.1007/s11356-018-1938-x. Epub 2018 Apr 19.


Phthalate esters distribution in coastal mariculture of Hong Kong, China.

Cheng Z, Li HH, Yu L, Yang ZB, Xu XX, Wang HS, Wong MH.

Environ Sci Pollut Res Int. 2018 Jun;25(18):17321-17329. doi: 10.1007/s11356-018-1735-6. Epub 2018 Apr 13.


Applying β-cyclodextrin to amaranth inoculated with white-rot fungus for more efficient remediation of soil co-contaminated with Cd and BDE-209.

Li X, Chen AY, Wu Y, Wu L, Xiang L, Zhao HM, Cai QY, Li YW, Mo CH, Wong MH, Li H.

Sci Total Environ. 2018 Sep 1;634:417-426. doi: 10.1016/j.scitotenv.2018.03.310. Epub 2018 Apr 6.


Phthalates contamination in China: Status, trends and human exposure-with an emphasis on oral intake.

Wang W, Leung AOW, Chu LH, Wong MH.

Environ Pollut. 2018 Jul;238:771-782. doi: 10.1016/j.envpol.2018.02.088. Epub 2018 Apr 4. Review.


Soil contamination and sources of phthalates and its health risk in China: A review.

Lü H, Mo CH, Zhao HM, Xiang L, Katsoyiannis A, Li YW, Cai QY, Wong MH.

Environ Res. 2018 Jul;164:417-429. doi: 10.1016/j.envres.2018.03.013. Epub 2018 Mar 21. Review.


Randomized, dose-ranging safety trial of cannabidiol in Dravet syndrome.

Devinsky O, Patel AD, Thiele EA, Wong MH, Appleton R, Harden CL, Greenwood S, Morrison G, Sommerville K; GWPCARE1 Part A Study Group.

Neurology. 2018 Apr 3;90(14):e1204-e1211. doi: 10.1212/WNL.0000000000005254. Epub 2018 Mar 14.


The Impact of Protein Structure and Sequence Similarity on the Accuracy of Machine-Learning Scoring Functions for Binding Affinity Prediction.

Li H, Peng J, Leung Y, Leung KS, Wong MH, Lu G, Ballester PJ.

Biomolecules. 2018 Mar 14;8(1). pii: E12. doi: 10.3390/biom8010012.


Sorption kinetics, isotherms, and mechanism of aniline aerofloat to agricultural soils with various physicochemical properties.

Xiang L, Xiao T, Mo CH, Zhao HM, Li YW, Li H, Cai QY, Zhou DM, Wong MH.

Ecotoxicol Environ Saf. 2018 Jun 15;154:84-91. doi: 10.1016/j.ecoenv.2018.01.032. Epub 2018 Feb 22.


Intraspecific variability of ciprofloxacin accumulation, tolerance, and metabolism in Chinese flowering cabbage (Brassica parachinensis).

Zhao HM, Huang HB, Du H, Lin J, Xiang L, Li YW, Cai QY, Li H, Mo CH, Liu JS, Wong MH, Zhou DM.

J Hazard Mater. 2018 May 5;349:252-261. doi: 10.1016/j.jhazmat.2018.01.015. Epub 2018 Jan 9.


Efficient generation of complete sequences of MDR-encoding plasmids by rapid assembly of MinION barcoding sequencing data.

Li R, Xie M, Dong N, Lin D, Yang X, Wong MHY, Chan EW, Chen S.

Gigascience. 2018 Mar 1;7(3):1-9. doi: 10.1093/gigascience/gix132.


Econazole nitrate inhibits PI3K activity and promotes apoptosis in lung cancer cells.

Dong C, Yang R, Li H, Ke K, Luo C, Yang F, Shi XN, Zhu Y, Liu X, Wong MH, Lin G, Wang X, Leung KS, Kung HF, Chen C, Lin MC.

Sci Rep. 2017 Dec 21;7(1):17987. doi: 10.1038/s41598-017-18178-0.


Identification of Clinically Approved Drugs Indacaterol and Canagliflozin for Repurposing to Treat Epidermal Growth Factor Tyrosine Kinase Inhibitor-Resistant Lung Cancer.

Li H, Tong CW, Leung Y, Wong MH, To KK, Leung KS.

Front Oncol. 2017 Nov 29;7:288. doi: 10.3389/fonc.2017.00288. eCollection 2017.


Effects of biochar on hydraulic conductivity of compacted kaolin clay.

Wong JTF, Chen Z, Wong AYY, Ng CWW, Wong MH.

Environ Pollut. 2018 Mar;234:468-472. doi: 10.1016/j.envpol.2017.11.079. Epub 2017 Dec 21.


Macrophage-Dependent Cytoplasmic Transfer during Melanoma Invasion In Vivo.

Roh-Johnson M, Shah AN, Stonick JA, Poudel KR, Kargl J, Yang GH, di Martino J, Hernandez RE, Gast CE, Zarour LR, Antoku S, Houghton AM, Bravo-Cordero JJ, Wong MH, Condeelis J, Moens CB.

Dev Cell. 2017 Dec 4;43(5):549-562.e6. doi: 10.1016/j.devcel.2017.11.003.


A Nanobionic Light-Emitting Plant.

Kwak SY, Giraldo JP, Wong MH, Koman VB, Lew TTS, Ell J, Weidman MC, Sinclair RM, Landry MP, Tisdale WA, Strano MS.

Nano Lett. 2017 Dec 13;17(12):7951-7961. doi: 10.1021/acs.nanolett.7b04369. Epub 2017 Dec 1.


Old drug, new indication: Olsalazine sodium reduced serum uric acid levels in mice via inhibiting xanthine oxidoreductase activity.

Niu Y, Li H, Gao L, Lin H, Kung H, Lin MC, Leung KS, Wong MH, Xiong W, Li L.

J Pharmacol Sci. 2017 Nov;135(3):114-120. doi: 10.1016/j.jphs.2017.10.007. Epub 2017 Oct 31.


Persistent drought monitoring using a microfluidic-printed electro-mechanical sensor of stomata in planta.

Koman VB, Lew TTS, Wong MH, Kwak SY, Giraldo JP, Strano MS.

Lab Chip. 2017 Nov 21;17(23):4015-4024. doi: 10.1039/c7lc00930e.


Biodegradation of di-n-butyl phthalate (DBP) by a novel endophytic Bacillus megaterium strain YJB3.

Feng NX, Yu J, Mo CH, Zhao HM, Li YW, Wu BX, Cai QY, Li H, Zhou DM, Wong MH.

Sci Total Environ. 2018 Mar;616-617:117-127. doi: 10.1016/j.scitotenv.2017.10.298. Epub 2017 Nov 4.


Emergence of carbapenem-resistant hypervirulent Klebsiella pneumoniae.

Wong MHY, Shum HP, Chen JHK, Man MY, Wu A, Chan EW, Yuen KY, Chen S.

Lancet Infect Dis. 2018 Jan;18(1):24. doi: 10.1016/S1473-3099(17)30629-1. Epub 2017 Nov 1. No abstract available.


IS26-mediated formation of a virulence and resistance plasmid in Salmonella Enteritidis.

Wong MH, Chan EW, Chen S.

J Antimicrob Chemother. 2017 Oct 1;72(10):2750-2754. doi: 10.1093/jac/dkx238.


Bisphosphonates and other bone agents for breast cancer.

O'Carrigan B, Wong MH, Willson ML, Stockler MR, Pavlakis N, Goodwin A.

Cochrane Database Syst Rev. 2017 Oct 30;10:CD003474. doi: 10.1002/14651858.CD003474.pub4. Review.


Fate of bisphenol A, perfluorooctanoic acid and perfluorooctanesulfonate in two different types of sewage treatment works in Hong Kong.

Man YB, Chow KL, Tsang YF, Lau FTK, Fung WC, Wong MH.

Chemosphere. 2018 Jan;190:358-367. doi: 10.1016/j.chemosphere.2017.10.001. Epub 2017 Oct 3.


Use of food waste, fish waste and food processing waste for China's aquaculture industry: Needs and challenge.

Mo WY, Man YB, Wong MH.

Sci Total Environ. 2018 Feb 1;613-614:635-643. doi: 10.1016/j.scitotenv.2017.08.321. Epub 2017 Sep 18.


Phytoremediation of soil co-contaminated with Cd and BDE-209 using hyperaccumulator enhanced by AM fungi and surfactant.

Li H, Li X, Xiang L, Zhao HM, Li YW, Cai QY, Zhu L, Mo CH, Wong MH.

Sci Total Environ. 2018 Feb 1;613-614:447-455. doi: 10.1016/j.scitotenv.2017.09.066. Epub 2017 Sep 14.


Determination of Trace Perfluoroalkyl Carboxylic Acids in Edible Crop Matrices: Matrix Effect and Method Development.

Xiang L, Chen L, Xiao T, Mo CH, Li YW, Cai QY, Li H, Zhou DM, Wong MH.

J Agric Food Chem. 2017 Oct 4;65(39):8763-8772. doi: 10.1021/acs.jafc.7b02677. Epub 2017 Sep 25.


Low-molecular-weight organic acids correlate with cultivar variation in ciprofloxacin accumulation in Brassica parachinensis L.

Zhao HM, Xiang L, Wu XL, Jiang YN, Li H, Li YW, Cai QY, Mo CH, Liu JS, Wong MH.

Sci Rep. 2017 Aug 31;7(1):10301. doi: 10.1038/s41598-017-10701-7.


Effects of Fe plaque and organic acids on metal uptake by wetland plants under drained and waterlogged conditions.

Li WC, Deng H, Wong MH.

Environ Pollut. 2017 Dec;231(Pt 1):732-741. doi: 10.1016/j.envpol.2017.08.012. Epub 2017 Aug 29.


Surgical Procedures and Methodology for a Preclinical Murine Model of De Novo Mammary Cancer Metastasis.

Gast CE, Shaw AK, Wong MH, Coussens LM.

J Vis Exp. 2017 Jul 29;(125). doi: 10.3791/54852.


Intestinal Enteroendocrine Lineage Cells Possess Homeostatic and Injury-Inducible Stem Cell Activity.

Yan KS, Gevaert O, Zheng GXY, Anchang B, Probert CS, Larkin KA, Davies PS, Cheng ZF, Kaddis JS, Han A, Roelf K, Calderon RI, Cynn E, Hu X, Mandleywala K, Wilhelmy J, Grimes SM, Corney DC, Boutet SC, Terry JM, Belgrader P, Ziraldo SB, Mikkelsen TS, Wang F, von Furstenberg RJ, Smith NR, Chandrakesan P, May R, Chrissy MAS, Jain R, Cartwright CA, Niland JC, Hong YK, Carrington J, Breault DT, Epstein J, Houchen CW, Lynch JP, Martin MG, Plevritis SK, Curtis C, Ji HP, Li L, Henning SJ, Wong MH, Kuo CJ.

Cell Stem Cell. 2017 Jul 6;21(1):78-90.e6. doi: 10.1016/j.stem.2017.06.014.


Evolution and comparative genomics of pAQU-like conjugative plasmids in Vibrio species.

Li R, Ye L, Wong MHY, Zheng Z, Chan EWC, Chen S.

J Antimicrob Chemother. 2017 Sep 1;72(9):2503-2506. doi: 10.1093/jac/dkx193.


Arsenic sorption by red mud-modified biochar produced from rice straw.

Wu C, Huang L, Xue SG, Huang YY, Hartley W, Cui MQ, Wong MH.

Environ Sci Pollut Res Int. 2017 Aug;24(22):18168-18178. doi: 10.1007/s11356-017-9466-7. Epub 2017 Jun 20.


Variations in microbial community and ciprofloxacin removal in rhizospheric soils between two cultivars of Brassica parachinensis L.

Huang XP, Mo CH, Yu J, Zhao HM, Meng C, Li YW, Li H, Cai QY, Wong MH.

Sci Total Environ. 2017 Dec 15;603-604:66-76. doi: 10.1016/j.scitotenv.2017.06.040. Epub 2017 Jun 23.


Nanosensor Technology Applied to Living Plant Systems.

Kwak SY, Wong MH, Lew TTS, Bisker G, Lee MA, Kaplan A, Dong J, Liu AT, Koman VB, Sinclair R, Hamann C, Strano MS.

Annu Rev Anal Chem (Palo Alto Calif). 2017 Jun 12;10(1):113-140. doi: 10.1146/annurev-anchem-061516-045310. Review.


The Hong Kong Reference Frameworks-for our doctors and our community.

Wong MM.

Hong Kong Med J. 2017 Jun;23(3):220-1. doi: 10.12809/hkmj175067. No abstract available.


A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance.

O'Neill PM, Amewu RK, Charman SA, Sabbani S, Gnädig NF, Straimer J, Fidock DA, Shore ER, Roberts NL, Wong MH, Hong WD, Pidathala C, Riley C, Murphy B, Aljayyoussi G, Gamo FJ, Sanz L, Rodrigues J, Cortes CG, Herreros E, Angulo-Barturén I, Jiménez-Díaz MB, Bazaga SF, Martínez-Martínez MS, Campo B, Sharma R, Ryan E, Shackleford DM, Campbell S, Smith DA, Wirjanata G, Noviyanti R, Price RN, Marfurt J, Palmer MJ, Copple IM, Mercer AE, Ruecker A, Delves MJ, Sinden RE, Siegl P, Davies J, Rochford R, Kocken CHM, Zeeman AM, Nixon GL, Biagini GA, Ward SA.

Nat Commun. 2017 May 24;8:15159. doi: 10.1038/ncomms15159.


Does arbuscular mycorrhizal fungus affect cadmium uptake and chemical forms in rice at different growth stages?

Luo N, Li X, Chen AY, Zhang LJ, Zhao HM, Xiang L, Cai QY, Mo CH, Wong MH, Li H.

Sci Total Environ. 2017 Dec 1;599-600:1564-1572. doi: 10.1016/j.scitotenv.2017.05.047. Epub 2017 May 18.


A pilot study on health risk assessment based on body loadings of PCBs of lactating mothers at Taizhou, China, the world's major site for recycling transformers.

Man YB, Chow KL, Xing GH, Chan JKY, Wu SC, Wong MH.

Environ Pollut. 2017 Aug;227:364-371. doi: 10.1016/j.envpol.2017.04.069. Epub 2017 May 5.


The association of environmental toxicants and autism spectrum disorders in children.

Ye BS, Leung AOW, Wong MH.

Environ Pollut. 2017 Aug;227:234-242. doi: 10.1016/j.envpol.2017.04.039. Epub 2017 May 2. Review.


Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal.

Yan KS, Janda CY, Chang J, Zheng GXY, Larkin KA, Luca VC, Chia LA, Mah AT, Han A, Terry JM, Ootani A, Roelf K, Lee M, Yuan J, Li X, Bolen CR, Wilhelmy J, Davies PS, Ueno H, von Furstenberg RJ, Belgrader P, Ziraldo SB, Ordonez H, Henning SJ, Wong MH, Snyder MP, Weissman IL, Hsueh AJ, Mikkelsen TS, Garcia KC, Kuo CJ.

Nature. 2017 May 11;545(7653):238-242. doi: 10.1038/nature22313. Epub 2017 May 3.


Cell Adhesion Molecule CD166/ALCAM Functions Within the Crypt to Orchestrate Murine Intestinal Stem Cell Homeostasis.

Smith NR, Davies PS, Levin TG, Gallagher AC, Keene DR, Sengupta SK, Wieghard N, El Rassi E, Wong MH.

Cell Mol Gastroenterol Hepatol. 2017 Jan 25;3(3):389-409. doi: 10.1016/j.jcmgh.2016.12.010. eCollection 2017 May.

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