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Items: 1 to 50 of 246

1.

HDL Cholesterol: A "Pathogen Lipid Sink" for Sepsis?

Jones TK, Wong HR, Meyer NJ.

Am J Respir Crit Care Med. 2018 Nov 14. doi: 10.1164/rccm.201811-2084ED. [Epub ahead of print] No abstract available.

PMID:
30428278
2.

Hyperchloremia is associated with acute kidney injury in pediatric patients with septic shock.

Stenson EK, Cvijanovich NZ, Allen GL, Thomas NJ, Bigham MT, Weiss SL, Fitzgerald JC, Jain PN, Meyer K, Quasney M, Hall M, Gedeit R, Freishtat RJ, Nowak J, Lutfi R, Gertz S, Grunwell JR, Wong HR, Anas N.

Intensive Care Med. 2018 Nov;44(11):2004-2005. doi: 10.1007/s00134-018-5368-5. Epub 2018 Oct 15. No abstract available.

PMID:
30324289
3.

The glucocorticoid receptor and cortisol levels in pediatric septic shock.

Alder MN, Opoka AM, Wong HR.

Crit Care. 2018 Sep 29;22(1):244. doi: 10.1186/s13054-018-2177-8.

4.

Phase 1 safety and pharmacokinetic study on the use of pioglitazone in critically ill patients with sepsis: a randomized clinical trial.

Kaplan JM, Zingarelli B, Krallman K, Tang Girdwood S, Lagory D, Mizuno T, Fei L, Wong HR, Vinks AA.

Intensive Care Med. 2018 Nov;44(11):2006-2008. doi: 10.1007/s00134-018-5374-7. Epub 2018 Sep 25. No abstract available.

PMID:
30255316
5.

Random serum free cortisol and total cortisol measurements in pediatric septic shock.

Menon K, McNally D, Acharya A, O'Hearn K, Choong K, Wong HR, McIntyre L, Lawson M; Canadian Critical Care Trials Group.

J Pediatr Endocrinol Metab. 2018 Jul 26;31(7):757-762. doi: 10.1515/jpem-2018-0027.

PMID:
29953408
6.

The relative resistance of children to sepsis mortality: from pathways to drug candidates.

Joachim RB, Altschuler GM, Hutchinson JN, Wong HR, Hide WA, Kobzik L.

Mol Syst Biol. 2018 May 17;14(5):e7998. doi: 10.15252/msb.20177998.

7.

Characterization of the Glucocorticoid Receptor in Children Undergoing Cardiac Surgery.

Flores S, Cooper DS, Opoka AM, Iliopoulos I, Pluckebaum S, Alder MN, Krallman KA, Sahay RD, Fei L, Wong HR.

Pediatr Crit Care Med. 2018 Aug;19(8):705-712. doi: 10.1097/PCC.0000000000001572.

PMID:
29677033
8.

Unsupervised Analysis of Transcriptomics in Bacterial Sepsis Across Multiple Datasets Reveals Three Robust Clusters.

Sweeney TE, Azad TD, Donato M, Haynes WA, Perumal TM, Henao R, Bermejo-Martin JF, Almansa R, Tamayo E, Howrylak JA, Choi A, Parnell GP, Tang B, Nichols M, Woods CW, Ginsburg GS, Kingsmore SF, Omberg L, Mangravite LM, Wong HR, Tsalik EL, Langley RJ, Khatri P.

Crit Care Med. 2018 Jun;46(6):915-925. doi: 10.1097/CCM.0000000000003084.

PMID:
29537985
9.

A community approach to mortality prediction in sepsis via gene expression analysis.

Sweeney TE, Perumal TM, Henao R, Nichols M, Howrylak JA, Choi AM, Bermejo-Martin JF, Almansa R, Tamayo E, Davenport EE, Burnham KL, Hinds CJ, Knight JC, Woods CW, Kingsmore SF, Ginsburg GS, Wong HR, Parnell GP, Tang B, Moldawer LL, Moore FE, Omberg L, Khatri P, Tsalik EL, Mangravite LM, Langley RJ.

Nat Commun. 2018 Feb 15;9(1):694. doi: 10.1038/s41467-018-03078-2.

10.

Beyond Survival: Pediatric Critical Care Interventional Trial Outcome Measure Preferences of Families and Healthcare Professionals.

Merritt C, Menon K, Agus MSD, Choong K, McNally D, O'Hearn K, Watson RS, Wong HR, Duffett M, Wypij D, Zimmerman JJ.

Pediatr Crit Care Med. 2018 Feb;19(2):e105-e111. doi: 10.1097/PCC.0000000000001409.

PMID:
29394234
11.

Hyperchloremia Is Associated With Complicated Course and Mortality in Pediatric Patients With Septic Shock.

Stenson EK, Cvijanovich NZ, Anas N, Allen GL, Thomas NJ, Bigham MT, Weiss SL, Fitzgerald JC, Checchia PA, Meyer K, Quasney M, Hall M, Gedeit R, Freishtat RJ, Nowak J, Raj SS, Gertz S, Grunwell JR, Wong HR.

Pediatr Crit Care Med. 2018 Feb;19(2):155-160. doi: 10.1097/PCC.0000000000001401.

PMID:
29394222
12.

Multicohort Analysis of Whole-Blood Gene Expression Data Does Not Form a Robust Diagnostic for Acute Respiratory Distress Syndrome.

Sweeney TE, Thomas NJ, Howrylak JA, Wong HR, Rogers AJ, Khatri P.

Crit Care Med. 2018 Feb;46(2):244-251. doi: 10.1097/CCM.0000000000002839.

13.

Embracing Enrichment and Unknown Unknowns.

Wong HR.

Crit Care Med. 2018 Jan;46(1):156-158. doi: 10.1097/CCM.0000000000002781. No abstract available.

PMID:
29252942
14.

Endotype Transitions During the Acute Phase of Pediatric Septic Shock Reflect Changing Risk and Treatment Response.

Wong HR, Cvijanovich NZ, Anas N, Allen GL, Thomas NJ, Bigham MT, Weiss SL, Fitzgerald JC, Checchia PA, Meyer K, Quasney M, Hall M, Gedeit R, Freishtat RJ, Nowak J, Lutfi R, Gertz S, Grunwell JR, Lindsell CJ.

Crit Care Med. 2018 Mar;46(3):e242-e249. doi: 10.1097/CCM.0000000000002932.

PMID:
29252929
15.

Adaptation of a Biomarker-Based Sepsis Mortality Risk Stratification Tool for Pediatric Acute Respiratory Distress Syndrome.

Yehya N, Wong HR.

Crit Care Med. 2018 Jan;46(1):e9-e16. doi: 10.1097/CCM.0000000000002754.

PMID:
28991832
16.

Pediatric Sepsis Endotypes Among Adults With Sepsis.

Wong HR, Sweeney TE, Hart KW, Khatri P, Lindsell CJ.

Crit Care Med. 2017 Dec;45(12):e1289-e1291. doi: 10.1097/CCM.0000000000002733.

PMID:
28991828
17.

Biomarkers to estimate the probability of complicated appendicitis.

Daly MC, von Allmen D, Wong HR.

J Pediatr Surg. 2018 Mar;53(3):437-440. doi: 10.1016/j.jpedsurg.2017.09.004. Epub 2017 Sep 9.

PMID:
28951011
18.

Classification of patients with sepsis according to blood genomic endotype: a prospective cohort study.

Scicluna BP, van Vught LA, Zwinderman AH, Wiewel MA, Davenport EE, Burnham KL, N├╝rnberg P, Schultz MJ, Horn J, Cremer OL, Bonten MJ, Hinds CJ, Wong HR, Knight JC, van der Poll T; MARS consortium.

Lancet Respir Med. 2017 Oct;5(10):816-826. doi: 10.1016/S2213-2600(17)30294-1. Epub 2017 Aug 29.

PMID:
28864056
19.

Comparison of Consent Models in a Randomized Trial of Corticosteroids in Pediatric Septic Shock.

Menon K, O'Hearn K, McNally JD, Acharya A, Wong HR, Lawson M, Ramsay T, McIntyre L, Gilfoyle E, Tucci M, Wensley D, Gottesman R, Morrison G, Choong K.

Pediatr Crit Care Med. 2017 Nov;18(11):1009-1018. doi: 10.1097/PCC.0000000000001301.

PMID:
28817507
20.

Leveraging Transcriptomics to Disentangle Sepsis Heterogeneity.

Wong HR, Marshall JC.

Am J Respir Crit Care Med. 2017 Aug 1;196(3):258-260. doi: 10.1164/rccm.201701-0143ED. No abstract available.

21.

Early Diagnosis of Sepsis: Is an Integrated Omics Approach the Way Forward?

Langley RJ, Wong HR.

Mol Diagn Ther. 2017 Oct;21(5):525-537. doi: 10.1007/s40291-017-0282-z. Review.

22.

Sepsis Subclasses: Be Careful of What You Wish for.

Jacobs L, Wong HR.

Pediatr Crit Care Med. 2017 Jun;18(6):591-592. doi: 10.1097/PCC.0000000000001132. No abstract available.

23.

High Frequency of Neuroimaging Abnormalities Among Pediatric Patients With Sepsis Who Undergo Neuroimaging.

Sandquist MK, Clee MS, Patel SK, Howard KA, Yunger T, Nagaraj UD, Jones BV, Fei L, Vadivelu S, Wong HR.

Pediatr Crit Care Med. 2017 Jul;18(7):607-613. doi: 10.1097/PCC.0000000000001173.

24.

Searching for a Pediatric Severe Sepsis Phenotype: We Might Indeed Be There.

Wong HR.

Pediatr Crit Care Med. 2017 May;18(5):502-503. doi: 10.1097/PCC.0000000000001146. No abstract available.

25.

An International Survey of Corticosteroid Use for the Management of Low Cardiac Output Syndrome.

Flores S, FitzGerald MR, Iliopoulos I, Daily JA, Rodriguez M, Nelson DP, Wong HR, Menon K, Cooper DS.

Pediatr Crit Care Med. 2017 Jul;18(7):630-637. doi: 10.1097/PCC.0000000000001180.

26.

Validation of the Sepsis MetaScore for Diagnosis of Neonatal Sepsis.

Sweeney TE, Wynn JL, Cernada M, Serna E, Wong HR, Baker HV, Vento M, Khatri P.

J Pediatric Infect Dis Soc. 2018 May 15;7(2):129-135. doi: 10.1093/jpids/pix021.

PMID:
28419265
27.

A Randomized Controlled Trial of Corticosteroids in Pediatric Septic Shock: A Pilot Feasibility Study.

Menon K, McNally D, O'Hearn K, Acharya A, Wong HR, Lawson M, Ramsay T, McIntyre L, Gilfoyle E, Tucci M, Wensley D, Gottesman R, Morrison G, Choong K; Canadian Critical Care Trials Group.

Pediatr Crit Care Med. 2017 Jun;18(6):505-512. doi: 10.1097/PCC.0000000000001121.

28.

Second Generation Triple-Helical Peptide Inhibitors of Matrix Metalloproteinases.

Bhowmick M, Tokmina-Roszyk D, Onwuha-Ekpete L, Harmon K, Robichaud T, Fuerst R, Stawikowska R, Steffensen B, Roush W, Wong HR, Fields GB.

J Med Chem. 2017 May 11;60(9):3814-3827. doi: 10.1021/acs.jmedchem.7b00018. Epub 2017 Apr 19.

PMID:
28394608
29.

Improved Risk Stratification in Pediatric Septic Shock Using Both Protein and mRNA Biomarkers. PERSEVERE-XP.

Wong HR, Cvijanovich NZ, Anas N, Allen GL, Thomas NJ, Bigham MT, Weiss SL, Fitzgerald JC, Checchia PA, Meyer K, Quasney M, Hall M, Gedeit R, Freishtat RJ, Nowak J, Raj SS, Gertz S, Grunwell JR, Lindsell CJ.

Am J Respir Crit Care Med. 2017 Aug 15;196(4):494-501. doi: 10.1164/rccm.201701-0066OC.

30.

Monitoring Severity of Multiple Organ Dysfunction Syndrome: New Technologies.

Typpo KV, Wong HR, Finley SD, Daniels RC, Seely AJ, Lacroix J.

Pediatr Crit Care Med. 2017 Mar;18(3_suppl Suppl 1):S24-S31. doi: 10.1097/PCC.0000000000001050. Review.

31.

Intensive care medicine in 2050: precision medicine.

Wong HR.

Intensive Care Med. 2017 Oct;43(10):1507-1509. doi: 10.1007/s00134-017-4727-y. Epub 2017 Feb 24. No abstract available.

32.

Glucocorticoid Receptor Polymorphisms and Outcomes in Pediatric Septic Shock.

Cvijanovich NZ, Anas N, Allen GL, Thomas NJ, Bigham MT, Weiss SL, Fitzgerald J, Checchia PA, Meyer K, Quasney M, Gedeit R, Freishtat RJ, Nowak J, Raj SS, Gertz S, Grunwell JR, Opoka A, Wong HR.

Pediatr Crit Care Med. 2017 Apr;18(4):299-303. doi: 10.1097/PCC.0000000000001058.

33.

Primary Outcome Measures in Pediatric Septic Shock Trials: A Systematic Review.

Menon K, McNally JD, Zimmerman JJ, Agus MS, O'Hearn K, Watson RS, Wong HR, Duffett M, Wypij D, Choong K.

Pediatr Crit Care Med. 2017 Mar;18(3):e146-e154. doi: 10.1097/PCC.0000000000001078. Review.

34.

Simplification of a Septic Shock Endotyping Strategy for Clinical Application.

Wong HR, Sweeney TE, Lindsell CJ.

Am J Respir Crit Care Med. 2017 Jan 15;195(2):263-265. doi: 10.1164/rccm.201607-1535LE. No abstract available.

35.

Zinc supplementation leads to immune modulation and improved survival in a juvenile model of murine sepsis.

Ganatra HA, Varisco BM, Harmon K, Lahni P, Opoka A, Wong HR.

Innate Immun. 2017 Jan;23(1):67-76. doi: 10.1177/1753425916677073. Epub 2016 Nov 30.

PMID:
27821649
36.

Pediatric Sepsis Biomarker Risk Model-II: Redefining the Pediatric Sepsis Biomarker Risk Model With Septic Shock Phenotype.

Wong HR, Cvijanovich NZ, Anas N, Allen GL, Thomas NJ, Bigham MT, Weiss SL, Fitzgerald J, Checchia PA, Meyer K, Quasney M, Hall M, Gedeit R, Freishtat RJ, Nowak J, Raj SS, Gertz S, Howard K, Harmon K, Lahni P, Frank E, Hart KW, Nguyen TC, Lindsell CJ.

Crit Care Med. 2016 Nov;44(11):2010-2017.

37.

Olfactomedin-4 Is a Candidate Marker for a Pathogenic Neutrophil Subset in Septic Shock.

Alder MN, Opoka AM, Lahni P, Hildeman DA, Wong HR.

Crit Care Med. 2017 Apr;45(4):e426-e432. doi: 10.1097/CCM.0000000000002102.

38.

Estimating Mortality Risk of Pediatric Critical Illness: A Worthy Obsession.

Wong HR.

Pediatr Crit Care Med. 2016 Sep;17(9):887-8. doi: 10.1097/PCC.0000000000000862. No abstract available.

39.

Emerging infection and sepsis biomarkers: will they change current therapies?

Jacobs L, Wong HR.

Expert Rev Anti Infect Ther. 2016 Oct;14(10):929-41. doi: 10.1080/14787210.2016.1222272. Epub 2016 Aug 17. Review.

40.

Matrix Metalloproteinase-8 Augments Bacterial Clearance in a Juvenile Sepsis Model.

Atkinson SJ, Varisco BM, Sandquist M, Daly MN, Klingbeil L, Kuethe JW, Midura EF, Harmon K, Opaka A, Lahni P, Piraino G, Hake P, Zingarelli B, Mortenson JE, Wynn JL, Wong HR.

Mol Med. 2016 Oct;22:455-463. doi: 10.2119/molmed.2016.00058. Epub 2016 Aug 8.

41.

Sepsis in Pediatric Cardiac Intensive Care.

Wheeler DS, Wong HR.

Pediatr Crit Care Med. 2016 Aug;17(8 Suppl 1):S266-71. doi: 10.1097/PCC.0000000000000796. Review.

42.

An Enrichment Strategy For Sepsis Clinical Trials.

Wong HR, Lindsell CJ.

Shock. 2016 Dec;46(6):632-634.

43.

Excessive Reversal of Epidermal Growth Factor Receptor and Ephrin Signaling Following Tracheal Occlusion in Rabbit Model of Congenital Diaphragmatic Hernia.

Varisco BM, Sbragia L, Chen J, Scorletti F, Joshi R, Wong HR, Lopes-Figueira R, Oria M, Peiro J.

Mol Med. 2016 Sep;22:398-411. doi: 10.2119/molmed.2016.00121. Epub 2016 Jul 19.

44.

Role of matrix metalloproteinase-8 as a mediator of injury in intestinal ischemia and reperfusion.

Daly MC, Atkinson SJ, Varisco BM, Klingbeil L, Hake P, Lahni P, Piraino G, Wu D, Hogan SP, Zingarelli B, Wong HR.

FASEB J. 2016 Oct;30(10):3453-3460. Epub 2016 Jul 19.

45.

Robust classification of bacterial and viral infections via integrated host gene expression diagnostics.

Sweeney TE, Wong HR, Khatri P.

Sci Transl Med. 2016 Jul 6;8(346):346ra91. doi: 10.1126/scitranslmed.aaf7165.

46.

Histological chorioamnionitis shapes the neonatal transcriptomic immune response.

Weitkamp JH, Guthrie SO, Wong HR, Moldawer LL, Baker HV, Wynn JL.

Early Hum Dev. 2016 Jul;98:1-6. doi: 10.1016/j.earlhumdev.2016.06.001. Epub 2016 Jun 16.

47.

Combining Prognostic and Predictive Enrichment Strategies to Identify Children With Septic Shock Responsive to Corticosteroids.

Wong HR, Atkinson SJ, Cvijanovich NZ, Anas N, Allen GL, Thomas NJ, Bigham MT, Weiss SL, Fitzgerald JC, Checchia PA, Meyer K, Quasney M, Hall M, Gedeit R, Freishtat RJ, Nowak J, Raj SS, Gertz S, Lindsell CJ.

Crit Care Med. 2016 Oct;44(10):e1000-3. doi: 10.1097/CCM.0000000000001833.

48.

Risk Stratification and Prognosis in Sepsis: What Have We Learned from Microarrays?

Sweeney TE, Wong HR.

Clin Chest Med. 2016 Jun;37(2):209-18. doi: 10.1016/j.ccm.2016.01.003. Epub 2016 Mar 10. Review.

49.

Steroids in fluid and/or vasoactive infusion dependent pediatric shock: study protocol for a randomized controlled trial.

O'Hearn K, McNally D, Choong K, Acharya A, Wong HR, Lawson M, Ramsay T, McIntyre L, Gilfoyle E, Tucci M, Wensley D, Gottesman R, Morrison G, Menon K; Canadian Critical Care Trials Group.

Trials. 2016 May 6;17(1):238. doi: 10.1186/s13063-016-1365-6.

50.

Targeting IL-17A attenuates neonatal sepsis mortality induced by IL-18.

Wynn JL, Wilson CS, Hawiger J, Scumpia PO, Marshall AF, Liu JH, Zharkikh I, Wong HR, Lahni P, Benjamin JT, Plosa EJ, Weitkamp JH, Sherwood ER, Moldawer LL, Ungaro R, Baker HV, Lopez MC, McElroy SJ, Colliou N, Mohamadzadeh M, Moore DJ.

Proc Natl Acad Sci U S A. 2016 May 10;113(19):E2627-35. doi: 10.1073/pnas.1515793113. Epub 2016 Apr 25.

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