Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 32

1.

Colony-stimulating factor (CSF) 1 receptor blockade reduces inflammation in human and murine models of rheumatoid arthritis.

Garcia S, Hartkamp LM, Malvar-Fernandez B, van Es IE, Lin H, Wong J, Long L, Zanghi JA, Rankin AL, Masteller EL, Wong BR, Radstake TR, Tak PP, Reedquist KA.

Arthritis Res Ther. 2016 Mar 31;18:75. doi: 10.1186/s13075-016-0973-6.

2.

Primary Langerhans cell histiocytosis of the lacrimal gland in an adult.

Pace ST, Gelman BB, Wong BR.

Can J Ophthalmol. 2015 Jun;50(3):e40-3. doi: 10.1016/j.jcjo.2015.02.007. No abstract available.

PMID:
26040231
3.

Design, synthesis of diaminopyrimidine inhibitors targeting IgE- and IgG-mediated activation of Fc receptor signaling.

Argade A, Bhamidipati S, Li H, Sylvain C, Clough J, Carroll D, Keim H, Braselmann S, Taylor V, Zhao H, Herlaar E, Issakani SD, Wong BR, Masuda ES, Payan DG, Singh R.

Bioorg Med Chem Lett. 2015;25(10):2122-8. doi: 10.1016/j.bmcl.2015.03.072. Epub 2015 Apr 1.

PMID:
25891105
4.

Deorphanization of the human leukocyte tyrosine kinase (LTK) receptor by a signaling screen of the extracellular proteome.

Zhang H, Pao LI, Zhou A, Brace AD, Halenbeck R, Hsu AW, Bray TL, Hestir K, Bosch E, Lee E, Wang G, Liu H, Wong BR, Kavanaugh WM, Williams LT.

Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):15741-5. doi: 10.1073/pnas.1412009111. Epub 2014 Oct 20.

5.

Targeting IL-34 in chronic inflammation.

Masteller EL, Wong BR.

Drug Discov Today. 2014 Aug;19(8):1212-6. doi: 10.1016/j.drudis.2014.05.016. Epub 2014 Jun 4. Review.

6.

The mechanism of shared but distinct CSF-1R signaling by the non-homologous cytokines IL-34 and CSF-1.

Liu H, Leo C, Chen X, Wong BR, Williams LT, Lin H, He X.

Biochim Biophys Acta. 2012 Jul;1824(7):938-45. doi: 10.1016/j.bbapap.2012.04.012. Epub 2012 May 8.

7.

Discovery of 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one (pamapimod) and 6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (R1487) as orally bioavailable and highly selective inhibitors of p38╬▒ mitogen-activated protein kinase.

Goldstein DM, Soth M, Gabriel T, Dewdney N, Kuglstatter A, Arzeno H, Chen J, Bingenheimer W, Dalrymple SA, Dunn J, Farrell R, Frauchiger S, La Fargue J, Ghate M, Graves B, Hill RJ, Li F, Litman R, Loe B, McIntosh J, McWeeney D, Papp E, Park J, Reese HF, Roberts RT, Rotstein D, San Pablo B, Sarma K, Stahl M, Sung ML, Suttman RT, Sjogren EB, Tan Y, Trejo A, Welch M, Weller P, Wong BR, Zecic H.

J Med Chem. 2011 Apr 14;54(7):2255-65. doi: 10.1021/jm101423y. Epub 2011 Mar 4.

PMID:
21375264
8.

A modeling-derived hypothesis on chronicity in respiratory diseases: desensitized pathogen recognition secondary to hyperactive IRAK/TRAF6 signaling.

Zhang T, Song KW, Hekmat-Nejad M, Morris DG, Wong BR.

PLoS One. 2009;4(4):e5332. doi: 10.1371/journal.pone.0005332. Epub 2009 Apr 24.

9.

The kinase activities of interleukin-1 receptor associated kinase (IRAK)-1 and 4 are redundant in the control of inflammatory cytokine expression in human cells.

Song KW, Talamas FX, Suttmann RT, Olson PS, Barnett JW, Lee SW, Thompson KD, Jin S, Hekmat-Nejad M, Cai TZ, Manning AM, Hill RJ, Wong BR.

Mol Immunol. 2009 Apr;46(7):1458-66. doi: 10.1016/j.molimm.2008.12.012. Epub 2009 Jan 31.

PMID:
19181383
10.

Pamapimod, a novel p38 mitogen-activated protein kinase inhibitor: preclinical analysis of efficacy and selectivity.

Hill RJ, Dabbagh K, Phippard D, Li C, Suttmann RT, Welch M, Papp E, Song KW, Chang KC, Leaffer D, Kim YN, Roberts RT, Zabka TS, Aud D, Dal Porto J, Manning AM, Peng SL, Goldstein DM, Wong BR.

J Pharmacol Exp Ther. 2008 Dec;327(3):610-9. doi: 10.1124/jpet.108.139006. Epub 2008 Sep 5.

PMID:
18776065
11.

R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation.

Braselmann S, Taylor V, Zhao H, Wang S, Sylvain C, Baluom M, Qu K, Herlaar E, Lau A, Young C, Wong BR, Lovell S, Sun T, Park G, Argade A, Jurcevic S, Pine P, Singh R, Grossbard EB, Payan DG, Masuda ES.

J Pharmacol Exp Ther. 2006 Dec;319(3):998-1008. Epub 2006 Aug 31. Erratum in: J Pharmacol Exp Ther. 2013 May;345(2):326.

PMID:
16946104
12.
13.

Targeting Syk as a treatment for allergic and autoimmune disorders.

Wong BR, Grossbard EB, Payan DG, Masuda ES.

Expert Opin Investig Drugs. 2004 Jul;13(7):743-62. Review.

PMID:
15212616
14.

Drug discovery in the ubiquitin regulatory pathway.

Wong BR, Parlati F, Qu K, Demo S, Pray T, Huang J, Payan DG, Bennett MK.

Drug Discov Today. 2003 Aug 15;8(16):746-54. Review.

PMID:
12944097
15.

Cell cycle regulatory E3 ubiquitin ligases as anticancer targets.

Pray TR, Parlati F, Huang J, Wong BR, Payan DG, Bennett MK, Issakani SD, Molineaux S, Demo SD.

Drug Resist Updat. 2002 Dec;5(6):249-58. Review.

PMID:
12531181
16.

Multiple myeloma disrupts the TRANCE/ osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression.

Pearse RN, Sordillo EM, Yaccoby S, Wong BR, Liau DF, Colman N, Michaeli J, Epstein J, Choi Y.

Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11581-6. Epub 2001 Sep 18.

17.

Selectivity of IMAC columns in trypsin inhibitor purification.

Yeomans-Reina H, Ruiz-Manriquez A, Wong BR, Mansir AT.

Biotechnol Prog. 2001 Jul-Aug;17(4):729-33.

PMID:
11485435
18.

A positive regulatory role for Cbl family proteins in tumor necrosis factor-related activation-induced cytokine (trance) and CD40L-mediated Akt activation.

Arron JR, Vologodskaia M, Wong BR, Naramura M, Kim N, Gu H, Choi Y.

J Biol Chem. 2001 Aug 10;276(32):30011-7. Epub 2001 Jun 13.

19.

Regulation of peripheral lymph node genesis by the tumor necrosis factor family member TRANCE.

Kim D, Mebius RE, MacMicking JD, Jung S, Cupedo T, Castellanos Y, Rho J, Wong BR, Josien R, Kim N, Rennert PD, Choi Y.

J Exp Med. 2000 Nov 20;192(10):1467-78.

20.

Osteoclast lineage commitment of bone marrow precursors through expression of membrane-bound TRANCE.

Lean JM, Matsuo K, Fox SW, Fuller K, Gibson FM, Draycott G, Wani MR, Bayley KE, Wong BR, Choi Y, Wagner EF, Chambers TJ.

Bone. 2000 Jul;27(1):29-40.

PMID:
10865206
21.

TRANCE, a tumor necrosis factor family member, enhances the longevity and adjuvant properties of dendritic cells in vivo.

Josien R, Li HL, Ingulli E, Sarma S, Wong BR, Vologodskaia M, Steinman RM, Choi Y.

J Exp Med. 2000 Feb 7;191(3):495-502.

22.

TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src.

Wong BR, Besser D, Kim N, Arron JR, Vologodskaia M, Hanafusa H, Choi Y.

Mol Cell. 1999 Dec;4(6):1041-9.

23.

TRANCE is a TNF family member that regulates dendritic cell and osteoclast function.

Wong BR, Josien R, Choi Y.

J Leukoc Biol. 1999 Jun;65(6):715-24. Review.

PMID:
10380891
24.

Evidence for a role of a tumor necrosis factor-alpha (TNF-alpha)-converting enzyme-like protease in shedding of TRANCE, a TNF family member involved in osteoclastogenesis and dendritic cell survival.

Lum L, Wong BR, Josien R, Becherer JD, Erdjument-Bromage H, Schl├Ândorff J, Tempst P, Choi Y, Blobel CP.

J Biol Chem. 1999 May 7;274(19):13613-8.

25.

TRANCE, a tumor necrosis factor family member critical for CD40 ligand-independent T helper cell activation.

Bachmann MF, Wong BR, Josien R, Steinman RM, Oxenius A, Choi Y.

J Exp Med. 1999 Apr 5;189(7):1025-31.

26.
27.

The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor.

Wong BR, Josien R, Lee SY, Vologodskaia M, Steinman RM, Choi Y.

J Biol Chem. 1998 Oct 23;273(43):28355-9.

29.

TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells.

Wong BR, Rho J, Arron J, Robinson E, Orlinick J, Chao M, Kalachikov S, Cayani E, Bartlett FS 3rd, Frankel WN, Lee SY, Choi Y.

J Biol Chem. 1997 Oct 3;272(40):25190-4.

30.

Two rat homologs of clathrin-associated adaptor proteins.

Pevsner J, Volknandt W, Wong BR, Scheller RH.

Gene. 1994 Sep 2;146(2):279-83.

PMID:
8076832
31.
32.

The need to be.

Wong BR.

Can J Psychiatr Nurs. 1968 May;9(5):5-8. No abstract available.

PMID:
5185922

Supplemental Content

Support Center