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Items: 1 to 50 of 76

1.

Adapting an Established Clinical Chemistry Quality Control Measure for Droplet Generation Performance in Digital PCR.

Goh SK, Wong BKL, Muralidharan V, Christophi C, Do H, Dobrovic A.

Clin Chem. 2018 Aug;64(8):1255-1257. doi: 10.1373/clinchem.2018.291120. Epub 2018 Jun 11. No abstract available.

PMID:
29891513
2.

Comparative Whole-Genomic Analysis of an Ancient L2 Lineage Mycobacterium tuberculosis Reveals a Novel Phylogenetic Clade and Common Genetic Determinants of Hypervirulent Strains.

Rajwani R, Yam WC, Zhang Y, Kang Y, Wong BKC, Leung KSS, Tam KKG, Tulu KT, Zhu L, Siu GKH.

Front Cell Infect Microbiol. 2018 Jan 12;7:539. doi: 10.3389/fcimb.2017.00539. eCollection 2017.

3.

Risk factors for progression of diabetic retinopathy in Alberta First Nations communities.

Rudnisky CJ, Wong BK, Virani H, Tennant MTS.

Can J Ophthalmol. 2017 Nov;52 Suppl 1:S19-S29. doi: 10.1016/j.jcjo.2017.09.023.

PMID:
29074008
4.

Independent variant analysis of TEAD1 and OCEL1 in 38 Aicardi syndrome patients.

Wong BK, Sutton VR, Lewis RA, Van den Veyver IB.

Mol Genet Genomic Med. 2017 Jan 25;5(2):117-121. doi: 10.1002/mgg3.250. eCollection 2017 Mar.

5.

Co-activator candidate interactions for orphan nuclear receptor NR2E1.

Corso-Díaz X, de Leeuw CN, Alonso V, Melchers D, Wong BK, Houtman R, Simpson EM.

BMC Genomics. 2016 Oct 26;17(1):832.

6.

Association of clinical parameters with periodontal bacterial haemolytic activity.

Wong BK, McGregor NR, Butt HL, Knight R, Liu LY, Darby IB.

J Clin Periodontol. 2016 Jun;43(6):503-11. doi: 10.1111/jcpe.12554. Epub 2016 May 4.

PMID:
27105613
7.

Single concentration loss of activity assay provides an improved assessment of drug-drug interaction risk compared to IC50-shift.

Wong SG, Lee M, Wong BK.

Xenobiotica. 2016 Nov;46(11):953-66. doi: 10.3109/00498254.2016.1143139. Epub 2016 Mar 9.

PMID:
26956546
8.

Recruitment of small synergistic movement makes a good pianist.

Jelfs B, Zhou S, Wong BK, Tin C, Chan RH.

Conf Proc IEEE Eng Med Biol Soc. 2015;2015:242-5. doi: 10.1109/EMBC.2015.7318345.

PMID:
26736245
9.

Performance Evaluation of the Verigene Gram-Positive and Gram-Negative Blood Culture Test for Direct Identification of Bacteria and Their Resistance Determinants from Positive Blood Cultures in Hong Kong.

Siu GK, Chen JH, Ng TK, Lee RA, Fung KS, To SW, Wong BK, Cheung S, Wong IW, Tam MM, Lee SS, Yam WC.

PLoS One. 2015 Oct 2;10(10):e0139728. doi: 10.1371/journal.pone.0139728. eCollection 2015.

10.

The association between clinical periodontal parameters and free haem concentration within the gingival crevicular fluid: a pilot study.

Liu LY, McGregor N, Wong BK, Butt H, Darby IB.

J Periodontal Res. 2016 Feb;51(1):86-94. doi: 10.1111/jre.12286. Epub 2015 Jun 11.

PMID:
26094689
11.

Pharmacokinetics and metabolism of AMG 232, a novel orally bioavailable inhibitor of the MDM2-p53 interaction, in rats, dogs and monkeys: in vitro-in vivo correlation.

Ye Q, Jiang M, Huang WT, Ling Y, Olson SH, Sun D, Xu G, Yan X, Wong BK, Jin L.

Xenobiotica. 2015;45(8):681-92. doi: 10.3109/00498254.2015.1010632. Epub 2015 Mar 23.

PMID:
25798742
12.

Partial rescue of some features of Huntington Disease in the genetic absence of caspase-6 in YAC128 mice.

Wong BKY, Ehrnhoefer DE, Graham RK, Martin DDO, Ladha S, Uribe V, Stanek LM, Franciosi S, Qiu X, Deng Y, Kovalik V, Zhang W, Pouladi MA, Shihabuddin LS, Hayden MR.

Neurobiol Dis. 2015 Apr;76:24-36. doi: 10.1016/j.nbd.2014.12.030. Epub 2015 Jan 9.

PMID:
25583186
13.

Structural mechanism of laforin function in glycogen dephosphorylation and lafora disease.

Raththagala M, Brewer MK, Parker MW, Sherwood AR, Wong BK, Hsu S, Bridges TM, Paasch BC, Hellman LM, Husodo S, Meekins DA, Taylor AO, Turner BD, Auger KD, Dukhande VV, Chakravarthy S, Sanz P, Woods VL Jr, Li S, Vander Kooi CW, Gentry MS.

Mol Cell. 2015 Jan 22;57(2):261-72. doi: 10.1016/j.molcel.2014.11.020. Epub 2014 Dec 24.

14.

Is keratinized mucosa indispensable to maintain peri-implant health? A systematic review of the literature.

Brito C, Tenenbaum HC, Wong BK, Schmitt C, Nogueira-Filho G.

J Biomed Mater Res B Appl Biomater. 2014 Apr;102(3):643-50. doi: 10.1002/jbm.b.33042. Epub 2013 Oct 7. Review.

PMID:
24124021
15.

Primary acute angle closure: long-term clinical outcomes over a 10-year period in the Chinese population.

Lee JW, Wong BK, Yick DW, Wong IY, Yuen CY, Lai JS.

Int Ophthalmol. 2014 Apr;34(2):165-9. doi: 10.1007/s10792-013-9806-7. Epub 2013 Jun 4.

PMID:
23733280
16.

Risk factors for progression of diabetic retinopathy in Alberta First Nations communities.

Rudnisky CJ, Wong BK, Virani H, Tennant MT.

Can J Ophthalmol. 2012 Aug;47(4):365-75. doi: 10.1016/j.jcjo.2012.04.006. Epub 2012 Jun 15.

PMID:
22883847
17.

Deletion of Abcg2 has differential effects on excretion and pharmacokinetics of probe substrates in rats.

Huang L, Be X, Tchaparian EH, Colletti AE, Roberts J, Langley M, Ling Y, Wong BK, Jin L.

J Pharmacol Exp Ther. 2012 Nov;343(2):316-24. doi: 10.1124/jpet.112.197046. Epub 2012 Aug 6.

18.

Building a health literate workplace.

Wong BK.

Workplace Health Saf. 2012 Aug;60(8):363-9; quiz 370. doi: 10.3928/21650799-20120726-67.

PMID:
22850136
19.

Feasibility and effectiveness of a Chen-style Tai Chi programme for stress reduction in junior secondary school students.

Lee LY, Chong YL, Li NY, Li MC, Lin LN, Wong LY, Wong BK, Yip WP, Hon CH, Chung PK, Man SY.

Stress Health. 2013 Apr;29(2):117-24. doi: 10.1002/smi.2435. Epub 2012 Jun 5.

PMID:
22674634
20.

Sequential metabolism of AMG 487, a novel CXCR3 antagonist, results in formation of quinone reactive metabolites that covalently modify CYP3A4 Cys239 and cause time-dependent inhibition of the enzyme.

Henne KR, Tran TB, VandenBrink BM, Rock DA, Aidasani DK, Subramanian R, Mason AK, Stresser DM, Teffera Y, Wong SG, Johnson MG, Chen X, Tonn GR, Wong BK.

Drug Metab Dispos. 2012 Jul;40(7):1429-40. doi: 10.1124/dmd.112.045708. Epub 2012 Apr 19.

21.

Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice.

Uribe V, Wong BK, Graham RK, Cusack CL, Skotte NH, Pouladi MA, Xie Y, Feinberg K, Ou Y, Ouyang Y, Deng Y, Franciosi S, Bissada N, Spreeuw A, Zhang W, Ehrnhoefer DE, Vaid K, Miller FD, Deshmukh M, Howland D, Hayden MR.

Hum Mol Genet. 2012 May 1;21(9):1954-67. doi: 10.1093/hmg/dds005. Epub 2012 Jan 18.

22.

Convergent pathogenic pathways in Alzheimer's and Huntington's diseases: shared targets for drug development.

Ehrnhoefer DE, Wong BK, Hayden MR.

Nat Rev Drug Discov. 2011 Oct 21;10(11):853-67. doi: 10.1038/nrd3556. Review.

23.

Retrospective analysis of the risk factors for developing phacomorphic glaucoma.

Lee JW, Lai JS, Lam RF, Wong BK, Yick DW, Tse RK.

Indian J Ophthalmol. 2011 Nov-Dec;59(6):471-4. doi: 10.4103/0301-4738.86316.

24.

Human schistosomiasis resistance to praziquantel in China: should we be worried?

Seto EY, Wong BK, Lu D, Zhong B.

Am J Trop Med Hyg. 2011 Jul;85(1):74-82. doi: 10.4269/ajtmh.2011.10-0542.

25.

P3 optimization of functional potency, in vivo efficacy and oral bioavailability in 3-aminopyrazinone thrombin inhibitors bearing non-charged groups at the P1 position.

Isaacs RC, Newton CL, Cutrona KJ, Mercer SP, Dorsey BD, McDonough CM, Cook JJ, Krueger JA, Lewis SD, Lucas BJ, Lyle EA, Lynch JJ, Miller-Stein C, Michener MT, Wallace AA, White RB, Wong BK.

Bioorg Med Chem Lett. 2011 Mar 1;21(5):1532-5. doi: 10.1016/j.bmcl.2010.12.108. Epub 2010 Dec 28.

PMID:
21295466
26.

A regulatory toolbox of MiniPromoters to drive selective expression in the brain.

Portales-Casamar E, Swanson DJ, Liu L, de Leeuw CN, Banks KG, Ho Sui SJ, Fulton DL, Ali J, Amirabbasi M, Arenillas DJ, Babyak N, Black SF, Bonaguro RJ, Brauer E, Candido TR, Castellarin M, Chen J, Chen Y, Cheng JC, Chopra V, Docking TR, Dreolini L, D'Souza CA, Flynn EK, Glenn R, Hatakka K, Hearty TG, Imanian B, Jiang S, Khorasan-zadeh S, Komljenovic I, Laprise S, Liao NY, Lim JS, Lithwick S, Liu F, Liu J, Lu M, McConechy M, McLeod AJ, Milisavljevic M, Mis J, O'Connor K, Palma B, Palmquist DL, Schmouth JF, Swanson MI, Tam B, Ticoll A, Turner JL, Varhol R, Vermeulen J, Watkins RF, Wilson G, Wong BK, Wong SH, Wong TY, Yang GS, Ypsilanti AR, Jones SJ, Holt RA, Goldowitz D, Wasserman WW, Simpson EM.

Proc Natl Acad Sci U S A. 2010 Sep 21;107(38):16589-94. doi: 10.1073/pnas.1009158107. Epub 2010 Aug 31.

27.

Hyperactivity, startle reactivity and cell-proliferation deficits are resistant to chronic lithium treatment in adult Nr2e1(frc/frc) mice.

Wong BK, Hossain SM, Trinh E, Ottmann GA, Budaghzadeh S, Zheng QY, Simpson EM.

Genes Brain Behav. 2010 Oct;9(7):681-94. doi: 10.1111/j.1601-183X.2010.00602.x. Epub 2010 Jun 21.

29.

The identification of potent, orally bioavailable tricyclic CGRP receptor antagonists.

Bell IM, Bednar RA, Corcoran HA, Fay JF, Gallicchio SN, Johnston VK, Hershey JC, Miller-Stein CM, Moore EL, Mosser SD, Roller SA, Salvatore CA, Theberge CR, Wong BK, Blair Zartman C, Kane SA, Williams TM, Graham SL, Vacca JP.

Bioorg Med Chem Lett. 2009 Aug 15;19(16):4740-2. doi: 10.1016/j.bmcl.2009.06.057. Epub 2009 Jun 17.

PMID:
19577468
30.

An inhibitory metabolite leads to dose- and time-dependent pharmacokinetics of (R)-N-{1-[3-(4-ethoxy-phenyl)-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-ethyl}-N-pyridin-3-yl-methyl-2-(4-trifluoromethoxy-phenyl)-acetamide (AMG 487) in human subjects after multiple dosing.

Tonn GR, Wong SG, Wong SC, Johnson MG, Ma J, Cho R, Floren LC, Kersey K, Berry K, Marcus AP, Wang X, Van Lengerich B, Medina JC, Pearson PG, Wong BK.

Drug Metab Dispos. 2009 Mar;37(3):502-13. doi: 10.1124/dmd.108.021931. Epub 2008 Dec 16.

31.

A fully automated plasma protein precipitation sample preparation method for LC-MS/MS bioanalysis.

Ma J, Shi J, Le H, Cho R, Huang JC, Miao S, Wong BK.

J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Feb 1;862(1-2):219-26. doi: 10.1016/j.jchromb.2007.12.012. Epub 2007 Dec 24.

PMID:
18226589
32.

Potent, orally bioavailable calcitonin gene-related peptide receptor antagonists for the treatment of migraine: discovery of N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1- (2,2,2-trifluoroethyl)azepan-3-yl]-4- (2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin- 1-yl)piperidine-1-carboxamide (MK-0974).

Paone DV, Shaw AW, Nguyen DN, Burgey CS, Deng JZ, Kane SA, Koblan KS, Salvatore CA, Mosser SD, Johnston VK, Wong BK, Miller-Stein CM, Hershey JC, Graham SL, Vacca JP, Williams TM.

J Med Chem. 2007 Nov 15;50(23):5564-7. Epub 2007 Oct 11.

PMID:
17929795
33.

Radiographic study of ethnic variation in alveolar bone height among New Zealand dental students.

Wong BK, Leichter JW, Chandler NP, Cullinan MP, Holborow DW.

J Periodontol. 2007 Jun;78(6):1070-4.

PMID:
17539721
34.

Identification of novel, orally bioavailable spirohydantoin CGRP receptor antagonists.

Bell IM, Bednar RA, Fay JF, Gallicchio SN, Hochman JH, McMasters DR, Miller-Stein C, Moore EL, Mosser SD, Pudvah NT, Quigley AG, Salvatore CA, Stump CA, Theberge CR, Wong BK, Zartman CB, Zhang XF, Kane SA, Graham SL, Vacca JP, Williams TM.

Bioorg Med Chem Lett. 2006 Dec 15;16(24):6165-9. Epub 2006 Oct 5.

PMID:
17027263
35.

The impact of the popular media on cosmetic dentistry.

Theobald AH, Wong BK, Quick AN, Thomson WM.

N Z Dent J. 2006 Sep;102(3):58-63.

PMID:
16986302
36.

Discovery of potent, selective 4-fluoroproline-based thrombin inhibitors with improved metabolic stability.

Staas DD, Savage KL, Sherman VL, Shimp HL, Lyle TA, Tran LO, Wiscount CM, McMasters DR, Sanderson PE, Williams PD, Lucas BJ Jr, Krueger JA, Lewis SD, White RB, Yu S, Wong BK, Kochansky CJ, Anari MR, Yan Y, Vacca JP.

Bioorg Med Chem. 2006 Oct 15;14(20):6900-16. Epub 2006 Jul 25.

PMID:
16870455
37.

The big OE: New Zealand dental graduates' self-reported experience of working overseas.

Wong BK, Theobald AH, Thomson WM, Quick A.

N Z Dent J. 2006 Jun;102(2):35-8.

PMID:
16773795
38.

Potent 2-[(pyrimidin-4-yl)amine}-1,3-thiazole-5-carbonitrile-based inhibitors of VEGFR-2 (KDR) kinase.

Sisko JT, Tucker TJ, Bilodeau MT, Buser CA, Ciecko PA, Coll KE, Fernandes C, Gibbs JB, Koester TJ, Kohl N, Lynch JJ, Mao X, McLoughlin D, Miller-Stein CM, Rodman LD, Rickert KW, Sepp-Lorenzino L, Shipman JM, Thomas KA, Wong BK, Hartman GD.

Bioorg Med Chem Lett. 2006 Mar 1;16(5):1146-50. Epub 2005 Dec 20.

PMID:
16368234
39.

Deletion of the nuclear receptor Nr2e1 impairs synaptic plasticity and dendritic structure in the mouse dentate gyrus.

Christie BR, Li AM, Redila VA, Booth H, Wong BK, Eadie BD, Ernst C, Simpson EM.

Neuroscience. 2006 Feb;137(3):1031-7. Epub 2005 Nov 14.

PMID:
16289828
40.

A series of 5-(5,6)-dihydrouracil substituted 8-hydroxy-[1,6]naphthyridine-7-carboxylic acid 4-fluorobenzylamide inhibitors of HIV-1 integrase and viral replication in cells.

Embrey MW, Wai JS, Funk TW, Homnick CF, Perlow DS, Young SD, Vacca JP, Hazuda DJ, Felock PJ, Stillmock KA, Witmer MV, Moyer G, Schleif WA, Gabryelski LJ, Jin L, Chen IW, Ellis JD, Wong BK, Lin JH, Leonard YM, Tsou NN, Zhuang L.

Bioorg Med Chem Lett. 2005 Oct 15;15(20):4550-4.

PMID:
16102965
41.

In vitro metabolism of a thrombin inhibitor and quantitation of metabolically generated cyanide.

Lin CC, Wong BK, Burgey CS, Gibson CR, Singh R.

J Pharm Biomed Anal. 2005 Oct 4;39(5):1014-20. Epub 2005 Jul 14.

PMID:
16023819
42.

Potent N-(1,3-thiazol-2-yl)pyridin-2-amine vascular endothelial growth factor receptor tyrosine kinase inhibitors with excellent pharmacokinetics and low affinity for the hERG ion channel.

Bilodeau MT, Balitza AE, Koester TJ, Manley PJ, Rodman LD, Buser-Doepner C, Coll KE, Fernandes C, Gibbs JB, Heimbrook DC, Huckle WR, Kohl N, Lynch JJ, Mao X, McFall RC, McLoughlin D, Miller-Stein CM, Rickert KW, Sepp-Lorenzino L, Shipman JM, Subramanian R, Thomas KA, Wong BK, Yu S, Hartman GD.

J Med Chem. 2004 Dec 2;47(25):6363-72.

PMID:
15566305
43.

A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase.

Hazuda DJ, Anthony NJ, Gomez RP, Jolly SM, Wai JS, Zhuang L, Fisher TE, Embrey M, Guare JP Jr, Egbertson MS, Vacca JP, Huff JR, Felock PJ, Witmer MV, Stillmock KA, Danovich R, Grobler J, Miller MD, Espeseth AS, Jin L, Chen IW, Lin JH, Kassahun K, Ellis JD, Wong BK, Xu W, Pearson PG, Schleif WA, Cortese R, Emini E, Summa V, Holloway MK, Young SD.

Proc Natl Acad Sci U S A. 2004 Aug 3;101(31):11233-8. Epub 2004 Jul 26.

44.

Comparative disposition of [14C]ertapenem, a novel carbapenem antibiotic, in rat, monkey and man.

Wong BK, Sahly Y, Mistry G, Waldman S, Musson D, Majumdar A, Xu X, Yu S, Lin JH, Singh R, Holland S.

Xenobiotica. 2004 Apr;34(4):379-89.

PMID:
15268982
45.

Low molecular weight thrombin inhibitors with excellent potency, metabolic stability, and oral bioavailability.

Morrissette MM, Stauffer KJ, Williams PD, Lyle TA, Vacca JP, Krueger JA, Lewis SD, Lucas BJ, Wong BK, White RB, Miller-Stein C, Lyle EA, Wallace AA, Leonard YM, Welsh DC, Lynch JJ, McMasters DR.

Bioorg Med Chem Lett. 2004 Aug 16;14(16):4161-4.

PMID:
15261262
46.

Effectiveness of no-rub contact lens cleaning on protein removal: a pilot study.

Mok KH, Cheung RW, Wong BK, Yip KK, Lee VW.

Optom Vis Sci. 2004 Jun;81(6):468-70.

PMID:
15201721
47.

The dark phase improves genetic discrimination for some high throughput mouse behavioral phenotyping.

Hossain SM, Wong BK, Simpson EM.

Genes Brain Behav. 2004 Jun;3(3):167-77.

48.

Optimization of the indolyl quinolinone class of KDR (VEGFR-2) kinase inhibitors: effects of 5-amido- and 5-sulphonamido-indolyl groups on pharmacokinetics and hERG binding.

Fraley ME, Arrington KL, Buser CA, Ciecko PA, Coll KE, Fernandes C, Hartman GD, Hoffman WF, Lynch JJ, McFall RC, Rickert K, Singh R, Smith S, Thomas KA, Wong BK.

Bioorg Med Chem Lett. 2004 Jan 19;14(2):351-5.

PMID:
14698157
49.

Metabolic activation of a pyrazinone-containing thrombin inhibitor. Evidence for novel biotransformation involving pyrazinone ring oxidation, rearrangement, and covalent binding to proteins.

Singh R, Silva Elipe MV, Pearson PG, Arison BH, Wong BK, White R, Yu X, Burgey CS, Lin JH, Baillie TA.

Chem Res Toxicol. 2003 Feb;16(2):198-207.

PMID:
12588191
50.

A prostate-specific antigen (PSA)-activated vinblastine prodrug selectively kills PSA-secreting cells in vivo.

DeFeo-Jones D, Brady SF, Feng DM, Wong BK, Bolyar T, Haskell K, Kiefer DM, Leander K, McAvoy E, Lumma P, Pawluczyk JM, Wai J, Motzel SL, Keenan K, Van Zwieten M, Lin JH, Garsky VM, Freidinger R, Oliff A, Jones RE.

Mol Cancer Ther. 2002 May;1(7):451-9.

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