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Fully automated leg tracking of Drosophila neurodegeneration models reveals distinct conserved movement signatures.

Wu S, Tan KJ, Govindarajan LN, Stewart JC, Gu L, Ho JWH, Katarya M, Wong BH, Tan EK, Li D, Claridge-Chang A, Libedinsky C, Cheng L, Aw SS.

PLoS Biol. 2019 Jun 27;17(6):e3000346. doi: 10.1371/journal.pbio.3000346. eCollection 2019 Jun.


The Lysophosphatidylcholine Transporter MFSD2A Is Essential for CD8+ Memory T Cell Maintenance and Secondary Response to Infection.

Piccirillo AR, Hyzny EJ, Beppu LY, Menk AV, Wallace CT, Hawse WF, Buechel HM, Wong BH, Foo JC, Cazenave-Gassiot A, Wenk MR, Delgoffe GM, Watkins SC, Silver DL, D'Cruz LM.

J Immunol. 2019 Jul 1;203(1):117-126. doi: 10.4049/jimmunol.1801585. Epub 2019 May 24.


Identification and characterization of GLDC as host susceptibility gene to severe influenza.

Zhou J, Wang D, Wong BH, Li C, Poon VK, Wen L, Zhao X, Chiu MC, Liu X, Ye Z, Yuan S, Sze KH, Chan JF, Chu H, To KK, Yuen KY.

EMBO Mol Med. 2019 Jan;11(1). pii: e9528. doi: 10.15252/emmm.201809528.


The lysolipid transporter Mfsd2a regulates lipogenesis in the developing brain.

Chan JP, Wong BH, Chin CF, Galam DLA, Foo JC, Wong LC, Ghosh S, Wenk MR, Cazenave-Gassiot A, Silver DL.

PLoS Biol. 2018 Aug 3;16(8):e2006443. doi: 10.1371/journal.pbio.2006443. eCollection 2018 Aug.


Homozygous mutation in MFSD2A, encoding a lysolipid transporter for docosahexanoic acid, is associated with microcephaly and hypomyelination.

Harel T, Quek DQY, Wong BH, Cazenave-Gassiot A, Wenk MR, Fan H, Berger I, Shmueli D, Shaag A, Silver DL, Elpeleg O, Edvardson S.

Neurogenetics. 2018 Dec;19(4):227-235. doi: 10.1007/s10048-018-0556-6. Epub 2018 Jul 24.


Differentiated human airway organoids to assess infectivity of emerging influenza virus.

Zhou J, Li C, Sachs N, Chiu MC, Wong BH, Chu H, Poon VK, Wang D, Zhao X, Wen L, Song W, Yuan S, Wong KK, Chan JF, To KK, Chen H, Clevers H, Yuen KY.

Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):6822-6827. doi: 10.1073/pnas.1806308115. Epub 2018 Jun 11.


Large-scale sequence analysis reveals novel human-adaptive markers in PB2 segment of seasonal influenza A viruses.

Wen L, Chu H, Wong BH, Wang D, Li C, Zhao X, Chiu MC, Yuan S, Fan Y, Chen H, Zhou J, Yuen KY.

Emerg Microbes Infect. 2018 Mar 29;7(1):47. doi: 10.1038/s41426-018-0050-0.


The effect of risk factor misclassification on the partial population attributable risk.

Wong BHW, Peskoe SB, Spiegelman D.

Stat Med. 2018 Apr 15;37(8):1259-1275. doi: 10.1002/sim.7559. Epub 2018 Jan 15.


Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus.

Zhou J, Li C, Zhao G, Chu H, Wang D, Yan HH, Poon VK, Wen L, Wong BH, Zhao X, Chiu MC, Yang D, Wang Y, Au-Yeung RKH, Chan IH, Sun S, Chan JF, To KK, Memish ZA, Corman VM, Drosten C, Hung IF, Zhou Y, Leung SY, Yuen KY.

Sci Adv. 2017 Nov 15;3(11):eaao4966. doi: 10.1126/sciadv.aao4966. eCollection 2017 Nov.


Comparative genome and evolutionary analysis of naturally occurring Beilong virus in brown and black rats.

Woo PCY, Wong AYP, Wong BHL, Lam CSF, Fan RYY, Lau SKP, Yuen KY.

Infect Genet Evol. 2016 Nov;45:311-319. doi: 10.1016/j.meegid.2016.09.016. Epub 2016 Sep 20.


Novel residues in the PA protein of avian influenza H7N7 virus affect virulence in mammalian hosts.

Zhao H, Chu H, Zhao X, Shuai H, Wong BH, Wen L, Yuan S, Zheng BJ, Zhou J, Yuen KY.

Virology. 2016 Nov;498:1-8. doi: 10.1016/j.virol.2016.08.004. Epub 2016 Aug 12.


Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 Is an Important Surface Attachment Factor That Facilitates Entry of Middle East Respiratory Syndrome Coronavirus.

Chan CM, Chu H, Wang Y, Wong BH, Zhao X, Zhou J, Yang D, Leung SP, Chan JF, Yeung ML, Yan J, Lu G, Gao GF, Yuen KY.

J Virol. 2016 Sep 29;90(20):9114-27. doi: 10.1128/JVI.01133-16. Print 2016 Oct 15.


Mfsd2a Is a Transporter for the Essential ω-3 Fatty Acid Docosahexaenoic Acid (DHA) in Eye and Is Important for Photoreceptor Cell Development.

Wong BH, Chan JP, Cazenave-Gassiot A, Poh RW, Foo JC, Galam DL, Ghosh S, Nguyen LN, Barathi VA, Yeo SW, Luu CD, Wenk MR, Silver DL.

J Biol Chem. 2016 May 13;291(20):10501-14. doi: 10.1074/jbc.M116.721340. Epub 2016 Mar 22.


Identification of GlcNAcylated alpha-1-antichymotrypsin as an early biomarker in human non-small-cell lung cancer by quantitative proteomic analysis with two lectins.

Jin Y, Wang J, Ye X, Su Y, Yu G, Yang Q, Liu W, Yu W, Cai J, Chen X, Liang Y, Chen Y, Wong BH, Fu X, Sun H.

Br J Cancer. 2016 Mar 1;114(5):532-44. doi: 10.1038/bjc.2015.348. Epub 2016 Feb 23.


Genomic landscapes of breast fibroepithelial tumors.

Tan J, Ong CK, Lim WK, Ng CC, Thike AA, Ng LM, Rajasegaran V, Myint SS, Nagarajan S, Thangaraju S, Dey S, Nasir ND, Wijaya GC, Lim JQ, Huang D, Li Z, Wong BH, Chan JY, McPherson JR, Cutcutache I, Poore G, Tay ST, Tan WJ, Putti TC, Ahmad BS, Iau P, Chan CW, Tang AP, Yong WS, Madhukumar P, Ho GH, Tan VK, Wong CY, Hartman M, Ong KW, Tan BK, Rozen SG, Tan P, Tan PH, Teh BT.

Nat Genet. 2015 Nov;47(11):1341-5. doi: 10.1038/ng.3409. Epub 2015 Oct 5.


Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways.

Chu H, Zhou J, Wong BH, Li C, Chan JF, Cheng ZS, Yang D, Wang D, Lee AC, Li C, Yeung ML, Cai JP, Chan IH, Ho WK, To KK, Zheng BJ, Yao Y, Qin C, Yuen KY.

J Infect Dis. 2016 Mar 15;213(6):904-14. doi: 10.1093/infdis/jiv380. Epub 2015 Jul 22.


Inactivating mutations in MFSD2A, required for omega-3 fatty acid transport in brain, cause a lethal microcephaly syndrome.

Guemez-Gamboa A, Nguyen LN, Yang H, Zaki MS, Kara M, Ben-Omran T, Akizu N, Rosti RO, Rosti B, Scott E, Schroth J, Copeland B, Vaux KK, Cazenave-Gassiot A, Quek DQ, Wong BH, Tan BC, Wenk MR, Gunel M, Gabriel S, Chi NC, Silver DL, Gleeson JG.

Nat Genet. 2015 Jul;47(7):809-13. doi: 10.1038/ng.3311. Epub 2015 May 25.


Functional variants regulating LGALS1 (Galectin 1) expression affect human susceptibility to influenza A(H7N9).

Chen Y, Zhou J, Cheng Z, Yang S, Chu H, Fan Y, Li C, Wong BH, Zheng S, Zhu Y, Yu F, Wang Y, Liu X, Gao H, Yu L, Tang L, Cui D, Hao K, Bossé Y, Obeidat M, Brandsma CA, Song YQ, To KK, Sham PC, Yuen KY, Li L.

Sci Rep. 2015 Feb 17;5:8517. doi: 10.1038/srep08517.


Lethal protein in mass consumption edible mushroom Agrocybe aegerita linked to strong hepatic toxicity.

Jin Y, Che T, Yin Y, Yu G, Yang Q, Liu W, Ye X, Yu W, Alok S, Chen Y, Wong BH, Cheng P, Sun H.

Toxicon. 2014 Nov;90:273-85. doi: 10.1016/j.toxicon.2014.08.066. Epub 2014 Aug 28.


Targeting cancer stem cell plasticity through modulation of epidermal growth factor and insulin-like growth factor receptor signaling in head and neck squamous cell cancer.

Leong HS, Chong FT, Sew PH, Lau DP, Wong BH, Teh BT, Tan DS, Iyer NG.

Stem Cells Transl Med. 2014 Sep;3(9):1055-65. doi: 10.5966/sctm.2013-0214. Epub 2014 Jul 14.


Productive replication of Middle East respiratory syndrome coronavirus in monocyte-derived dendritic cells modulates innate immune response.

Chu H, Zhou J, Wong BH, Li C, Cheng ZS, Lin X, Poon VK, Sun T, Lau CC, Chan JF, To KK, Chan KH, Lu L, Zheng BJ, Yuen KY.

Virology. 2014 Apr;454-455:197-205. doi: 10.1016/j.virol.2014.02.018. Epub 2014 Mar 7.


Exome sequencing identifies distinct mutational patterns in liver fluke-related and non-infection-related bile duct cancers.

Chan-On W, Nairismägi ML, Ong CK, Lim WK, Dima S, Pairojkul C, Lim KH, McPherson JR, Cutcutache I, Heng HL, Ooi L, Chung A, Chow P, Cheow PC, Lee SY, Choo SP, Tan IB, Duda D, Nastase A, Myint SS, Wong BH, Gan A, Rajasegaran V, Ng CC, Nagarajan S, Jusakul A, Zhang S, Vohra P, Yu W, Huang D, Sithithaworn P, Yongvanit P, Wongkham S, Khuntikeo N, Bhudhisawasdi V, Popescu I, Rozen SG, Tan P, Teh BT.

Nat Genet. 2013 Dec;45(12):1474-8. doi: 10.1038/ng.2806. Epub 2013 Nov 3.


Active replication of Middle East respiratory syndrome coronavirus and aberrant induction of inflammatory cytokines and chemokines in human macrophages: implications for pathogenesis.

Zhou J, Chu H, Li C, Wong BH, Cheng ZS, Poon VK, Sun T, Lau CC, Wong KK, Chan JY, Chan JF, To KK, Chan KH, Zheng BJ, Yuen KY.

J Infect Dis. 2014 May 1;209(9):1331-42. doi: 10.1093/infdis/jit504. Epub 2013 Sep 24.


Identification and characterization of a novel paramyxovirus, porcine parainfluenza virus 1, from deceased pigs.

Lau SK, Woo PC, Wu Y, Wong AY, Wong BH, Lau CC, Fan RY, Cai JP, Tsoi HW, Chan KH, Yuen KY.

J Gen Virol. 2013 Oct;94(Pt 10):2184-90. doi: 10.1099/vir.0.052985-0. Epub 2013 Aug 5.


Transcriptome and proteome exploration to provide a resource for the study of Agrocybe aegerita.

Wang M, Gu B, Huang J, Jiang S, Chen Y, Yin Y, Pan Y, Yu G, Li Y, Wong BH, Liang Y, Sun H.

PLoS One. 2013;8(2):e56686. doi: 10.1371/journal.pone.0056686. Epub 2013 Feb 13.


Purification and characterization of an antitumor protein with deoxyribonuclease activity from edible mushroom Agrocybe aegerita.

Chen Y, Jiang S, Jin Y, Yin Y, Yu G, Lan X, Cui M, Liang Y, Wong BH, Guo L, Sun H.

Mol Nutr Food Res. 2012 Nov;56(11):1729-38. doi: 10.1002/mnfr.201200316. Epub 2012 Oct 4.


Deep insight into the Ganoderma lucidum by comprehensive analysis of its transcriptome.

Yu GJ, Wang M, Huang J, Yin YL, Chen YJ, Jiang S, Jin YX, Lan XQ, Wong BH, Liang Y, Sun H.

PLoS One. 2012;7(8):e44031. doi: 10.1371/journal.pone.0044031. Epub 2012 Aug 27.


Recent transmission of a novel alphacoronavirus, bat coronavirus HKU10, from Leschenault's rousettes to pomona leaf-nosed bats: first evidence of interspecies transmission of coronavirus between bats of different suborders.

Lau SK, Li KS, Tsang AK, Shek CT, Wang M, Choi GK, Guo R, Wong BH, Poon RW, Lam CS, Wang SY, Fan RY, Chan KH, Zheng BJ, Woo PC, Yuen KY.

J Virol. 2012 Nov;86(21):11906-18. doi: 10.1128/JVI.01305-12. Epub 2012 Aug 29.


Novel variant of Beilong Paramyxovirus in rats, China.

Woo PC, Lau SK, Wong BH, Wu Y, Lam CS, Yuen KY.

Emerg Infect Dis. 2012 Jun;18(6):1022-4. doi: 10.3201/eid1806.111901. No abstract available.


Exome sequencing of liver fluke-associated cholangiocarcinoma.

Ong CK, Subimerb C, Pairojkul C, Wongkham S, Cutcutache I, Yu W, McPherson JR, Allen GE, Ng CC, Wong BH, Myint SS, Rajasegaran V, Heng HL, Gan A, Zang ZJ, Wu Y, Wu J, Lee MH, Huang D, Ong P, Chan-on W, Cao Y, Qian CN, Lim KH, Ooi A, Dykema K, Furge K, Kukongviriyapan V, Sripa B, Wongkham C, Yongvanit P, Futreal PA, Bhudhisawasdi V, Rozen S, Tan P, Teh BT.

Nat Genet. 2012 May 6;44(6):690-3. doi: 10.1038/ng.2273.


Feline morbillivirus, a previously undescribed paramyxovirus associated with tubulointerstitial nephritis in domestic cats.

Woo PC, Lau SK, Wong BH, Fan RY, Wong AY, Zhang AJ, Wu Y, Choi GK, Li KS, Hui J, Wang M, Zheng BJ, Chan KH, Yuen KY.

Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5435-40. doi: 10.1073/pnas.1119972109. Epub 2012 Mar 19.


A novel lectin from Agrocybe aegerita shows high binding selectivity for terminal N-acetylglucosamine.

Jiang S, Chen Y, Wang M, Yin Y, Pan Y, Gu B, Yu G, Li Y, Wong BH, Liang Y, Sun H.

Biochem J. 2012 Apr 15;443(2):369-78. doi: 10.1042/BJ20112061.


Complete genome sequence of a novel paramyxovirus, Tailam virus, discovered in Sikkim rats.

Woo PC, Lau SK, Wong BH, Wong AY, Poon RW, Yuen KY.

J Virol. 2011 Dec;85(24):13473-4. doi: 10.1128/JVI.06356-11.


Visualization and biochemical analyses of the emerging mammalian 14-3-3-phosphoproteome.

Johnson C, Tinti M, Wood NT, Campbell DG, Toth R, Dubois F, Geraghty KM, Wong BH, Brown LJ, Tyler J, Gernez A, Chen S, Synowsky S, MacKintosh C.

Mol Cell Proteomics. 2011 Oct;10(10):M110.005751. doi: 10.1074/mcp.M110.005751. Epub 2011 Jul 1.


Increasing phosphoproteome coverage and identification of phosphorylation motifs through combination of different HPLC fractionation methods.

Chen X, Wu D, Zhao Y, Wong BH, Guo L.

J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Jan 1;879(1):25-34. doi: 10.1016/j.jchromb.2010.11.004. Epub 2010 Nov 10.


Coexistence of different genotypes in the same bat and serological characterization of Rousettus bat coronavirus HKU9 belonging to a novel Betacoronavirus subgroup.

Lau SK, Poon RW, Wong BH, Wang M, Huang Y, Xu H, Guo R, Li KS, Gao K, Chan KH, Zheng BJ, Woo PC, Yuen KY.

J Virol. 2010 Nov;84(21):11385-94. doi: 10.1128/JVI.01121-10. Epub 2010 Aug 11.


Identification and complete genome analysis of three novel paramyxoviruses, Tuhoko virus 1, 2 and 3, in fruit bats from China.

Lau SK, Woo PC, Wong BH, Wong AY, Tsoi HW, Wang M, Lee P, Xu H, Poon RW, Guo R, Li KS, Chan KH, Zheng BJ, Yuen KY.

Virology. 2010 Aug 15;404(1):106-16. doi: 10.1016/j.virol.2010.03.049.


Comparative analysis of twelve genomes of three novel group 2c and group 2d coronaviruses reveals unique group and subgroup features.

Woo PC, Wang M, Lau SK, Xu H, Poon RW, Guo R, Wong BH, Gao K, Tsoi HW, Huang Y, Li KS, Lam CS, Chan KH, Zheng BJ, Yuen KY.

J Virol. 2007 Feb;81(4):1574-85. Epub 2006 Nov 22.


Phosphorylation and 14-3-3 binding of Arabidopsis trehalose-phosphate synthase 5 in response to 2-deoxyglucose.

Harthill JE, Meek SE, Morrice N, Peggie MW, Borch J, Wong BH, Mackintosh C.

Plant J. 2006 Jul;47(2):211-23. Epub 2006 Jun 8.


Molecular diversity of coronaviruses in bats.

Woo PC, Lau SK, Li KS, Poon RW, Wong BH, Tsoi HW, Yip BC, Huang Y, Chan KH, Yuen KY.

Virology. 2006 Jul 20;351(1):180-7. Epub 2006 May 2.


Clinical and molecular epidemiological features of coronavirus HKU1-associated community-acquired pneumonia.

Woo PC, Lau SK, Tsoi HW, Huang Y, Poon RW, Chu CM, Lee RA, Luk WK, Wong GK, Wong BH, Cheng VC, Tang BS, Wu AK, Yung RW, Chen H, Guan Y, Chan KH, Yuen KY.

J Infect Dis. 2005 Dec 1;192(11):1898-907. Epub 2005 Oct 20.


Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats.

Lau SK, Woo PC, Li KS, Huang Y, Tsoi HW, Wong BH, Wong SS, Leung SY, Chan KH, Yuen KY.

Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):14040-5. Epub 2005 Sep 16.


SARS coronavirus detection methods.

Lau SK, Che XY, Woo PC, Wong BH, Cheng VC, Woo GK, Hung IF, Poon RW, Chan KH, Peiris JS, Yuen KY.

Emerg Infect Dis. 2005 Jul;11(7):1108-11.


SARS coronavirus spike polypeptide DNA vaccine priming with recombinant spike polypeptide from Escherichia coli as booster induces high titer of neutralizing antibody against SARS coronavirus.

Woo PC, Lau SK, Tsoi HW, Chen ZW, Wong BH, Zhang L, Chan JK, Wong LP, He W, Ma C, Chan KH, Ho DD, Yuen KY.

Vaccine. 2005 Oct 10;23(42):4959-68.


Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia.

Woo PC, Lau SK, Chu CM, Chan KH, Tsoi HW, Huang Y, Wong BH, Poon RW, Cai JJ, Luk WK, Poon LL, Wong SS, Guan Y, Peiris JS, Yuen KY.

J Virol. 2005 Jan;79(2):884-95.


Streptococcus sinensis may react with Lancefield group F antiserum.

Woo PC, Teng JL, Leung KW, Lau SK, Tse H, Wong BH, Yuen KY.

J Med Microbiol. 2004 Nov;53(Pt 11):1083-8.


Detection of severe acute respiratory syndrome (SARS) coronavirus nucleocapsid protein in sars patients by enzyme-linked immunosorbent assay.

Lau SK, Woo PC, Wong BH, Tsoi HW, Woo GK, Poon RW, Chan KH, Wei WI, Peiris JS, Yuen KY.

J Clin Microbiol. 2004 Jul;42(7):2884-9.

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