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Novel Mechanisms for IGF-I Regulation by Glucagon in Carp Hepatocytes: Up-Regulation of HNF1α and CREB Expression via Signaling Crosstalk for IGF-I Gene Transcription.

Bai J, Jiang X, He M, Chan BCB, Wong AOL.

Front Endocrinol (Lausanne). 2019 Sep 3;10:605. doi: 10.3389/fendo.2019.00605. eCollection 2019.


IGFs Potentiate TAC3-induced SLα Expression via Upregulation of TACR3 Expression in Grass Carp Pituitary Cells.

Hu G, He M, Ko WKW, Ye C, Hu Q, Wong AOL.

Cells. 2019 Aug 13;8(8). pii: E887. doi: 10.3390/cells8080887.


Correlation between frataxin expression and contractility revealed by in vitro Friedreich's ataxia cardiac tissue models engineered from human pluripotent stem cells.

Wong AO, Wong G, Shen M, Chow MZ, Tse WW, Gurung B, Mak SY, Lieu DK, Costa KD, Chan CW, Martelli A, Nabhan JF, Li RA.

Stem Cell Res Ther. 2019 Jul 8;10(1):203. doi: 10.1186/s13287-019-1305-y.


Modulation of chromatin remodeling proteins SMYD1 and SMARCD1 promotes contractile function of human pluripotent stem cell-derived ventricular cardiomyocyte in 3D-engineered cardiac tissues.

Chow MZ, Sadrian SN, Keung W, Geng L, Ren L, Kong CW, Wong AO, Hulot JS, Chen CS, Costa KD, Hajjar RJ, Li RA.

Sci Rep. 2019 May 16;9(1):7502. doi: 10.1038/s41598-019-42953-w.


Mechanisms for Temperature Modulation of Feeding in Goldfish and Implications on Seasonal Changes in Feeding Behavior and Food Intake.

Chen T, Wong MKH, Chan BCB, Wong AOL.

Front Endocrinol (Lausanne). 2019 Mar 7;10:133. doi: 10.3389/fendo.2019.00133. eCollection 2019.


Human Cardiac Ventricular-Like Organoid Chambers and Tissue Strips From Pluripotent Stem Cells as a Two-Tiered Assay for Inotropic Responses.

Keung W, Chan PKW, Backeris PC, Lee EK, Wong N, Wong AOT, Wong GKY, Chan CWY, Fermini B, Costa KD, Li RA.

Clin Pharmacol Ther. 2019 Aug;106(2):402-414. doi: 10.1002/cpt.1385. Epub 2019 Mar 28.


Mechanisms Underlying the Synergistic Action of Insulin and Growth Hormone on IGF-I and -II Expression in Grass Carp Hepatocytes.

Jiang Q, Bai J, He M, Yuen KWY, Wong AOL.

Front Endocrinol (Lausanne). 2018 Jun 21;9:336. doi: 10.3389/fendo.2018.00336. eCollection 2018.


Probing flecainide block of INa using human pluripotent stem cell-derived ventricular cardiomyocytes adapted to automated patch-clamping and 2D monolayers.

Geng L, Kong CW, Wong AOT, Shum AM, Chow MZY, Che H, Zhang C, Yau KL, Chan CW, Keung W, Li RA.

Toxicol Lett. 2018 Sep 15;294:61-72. doi: 10.1016/j.toxlet.2018.05.006. Epub 2018 May 21.


Spexin Acts as Novel Regulator for Bile Acid Synthesis.

Lin CY, Zhao L, Huang T, Lu L, Khan M, Liu J, Zhong LLD, Cai ZW, Fan BM, Wong AOL, Bian ZX.

Front Physiol. 2018 Apr 10;9:378. doi: 10.3389/fphys.2018.00378. eCollection 2018.


Human ISL1+ Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction.

Foo KS, Lehtinen ML, Leung CY, Lian X, Xu J, Keung W, Geng L, Kolstad TRS, Thams S, Wong AO, Wong N, Bylund K, Zhou C, He X, Jin SB, Clarke J, Lendahl U, Li RA, Louch WE, Chien KR.

Mol Ther. 2018 Jul 5;26(7):1644-1659. doi: 10.1016/j.ymthe.2018.02.012. Epub 2018 Feb 17.


Grass Carp Prolactin Gene: Structural Characterization and Signal Transduction for PACAP-induced Prolactin Promoter Activity.

Lin C, Bai J, He M, Wong AOL.

Sci Rep. 2018 Mar 15;8(1):4655. doi: 10.1038/s41598-018-23092-0.


Bioengineering an electro-mechanically functional miniature ventricular heart chamber from human pluripotent stem cells.

Li RA, Keung W, Cashman TJ, Backeris PC, Johnson BV, Bardot ES, Wong AOT, Chan PKW, Chan CWY, Costa KD.

Biomaterials. 2018 May;163:116-127. doi: 10.1016/j.biomaterials.2018.02.024. Epub 2018 Feb 10.


Spexin as a neuroendocrine signal with emerging functions.

Ma A, Bai J, He M, Wong AOL.

Gen Comp Endocrinol. 2018 Sep 1;265:90-96. doi: 10.1016/j.ygcen.2018.01.015. Epub 2018 Jan 31. Review.


Renitence vacuoles facilitate protection against phagolysosomal damage in activated macrophages.

Wong AO, Marthi M, Mendel ZI, Gregorka B, Swanson MS, Swanson JA.

Mol Biol Cell. 2018 Mar 1;29(5):657-668. doi: 10.1091/mbc.E17-07-0486. Epub 2017 Dec 27.


Grass Carp Follisatin: Molecular Cloning, Functional Characterization, Dopamine D1 Regulation at Pituitary Level, and Implication in Growth Hormone Regulation.

Fung RSK, Jin B, He M, Yuen KWY, Wong AOL.

Front Endocrinol (Lausanne). 2017 Aug 24;8:211. doi: 10.3389/fendo.2017.00211. eCollection 2017.


Dual Role of Insulin in Spexin Regulation: Functional Link Between Food Intake and Spexin Expression in a Fish Model.

Ma A, He M, Bai J, Wong MK, Ko WK, Wong AO.

Endocrinology. 2017 Mar 1;158(3):560-577. doi: 10.1210/en.2016-1534.


TAC1 Gene Products Regulate Pituitary Hormone Secretion and Gene Expression in Prepubertal Grass Carp Pituitary Cells.

Hu G, He M, Ko WKW, Wong AOL.

Endocrinology. 2017 Jun 1;158(6):1776-1797. doi: 10.1210/en.2016-1740.


Tachycardia-bradycardia syndrome: Electrophysiological mechanisms and future therapeutic approaches (Review).

Tse G, Liu T, Li KH, Laxton V, Wong AO, Chan YW, Keung W, Chan CW, Li RA.

Int J Mol Med. 2017 Mar;39(3):519-526. doi: 10.3892/ijmm.2017.2877. Epub 2017 Feb 6. Review.


Mechanisms for PACAP-induced prolactin gene expression in grass carp pituitary cells.

Lin C, Jiang X, He M, Zhao L, Huang T, Bian Z, Wong AO.

J Endocrinol. 2017 Apr;233(1):37-51. doi: 10.1530/JOE-16-0433. Epub 2017 Jan 27.


A Micropatterned Human Pluripotent Stem Cell-Based Ventricular Cardiac Anisotropic Sheet for Visualizing Drug-Induced Arrhythmogenicity.

Shum AM, Che H, Wong AO, Zhang C, Wu H, Chan CW, Costa K, Khine M, Kong CW, Li RA.

Adv Mater. 2017 Jan;29(1). doi: 10.1002/adma.201602448. Epub 2016 Nov 2.


Non-cell autonomous cues for enhanced functionality of human embryonic stem cell-derived cardiomyocytes via maturation of sarcolemmal and mitochondrial KATP channels.

Keung W, Ren L, Sen Li, Wong AO, Chopra A, Kong CW, Tomaselli GF, Chen CS, Li RA.

Sci Rep. 2016 Sep 28;6:34154. doi: 10.1038/srep34154.


Type II SOCS as a feedback repressor for GH-induced Igf1 expression in carp hepatocytes.

Jiang X, Xiao J, He M, Ma A, Wong AO.

J Endocrinol. 2016 May;229(2):171-86. doi: 10.1530/JOE-15-0423.


Pseudomonas moraviensis subsp. stanleyae, a bacterial endophyte of hyperaccumulator Stanleya pinnata, is capable of efficient selenite reduction to elemental selenium under aerobic conditions.

Staicu LC, Ackerson CJ, Cornelis P, Ye L, Berendsen RL, Hunter WJ, Noblitt SD, Henry CS, Cappa JJ, Montenieri RL, Wong AO, Musilova L, Sura-de Jong M, van Hullebusch ED, Lens PN, Reynolds RJ, Pilon-Smits EA.

J Appl Microbiol. 2015 Aug;119(2):400-10. doi: 10.1111/jam.12842. Epub 2015 Jun 24.


Grass carp prolactin: molecular cloning, tissue expression, intrapituitary autoregulation by prolactin and paracrine regulation by growth hormone and luteinizing hormone.

Lin C, Jiang X, Hu G, Ko WK, Wong AO.

Mol Cell Endocrinol. 2015 Jan 5;399:267-83. doi: 10.1016/j.mce.2014.10.010. Epub 2014 Oct 16.


Kisspeptin induction of somatolactin-α release in goldfish pituitary cells: functional role of cAMP/PKA-, PLC/PKC-, and Ca(2+)/calmodulin-dependent cascades.

Jiang Q, He M, Ko WK, Wong AO.

Am J Physiol Endocrinol Metab. 2014 Nov 15;307(10):E872-84. doi: 10.1152/ajpendo.00321.2014. Epub 2014 Sep 2.


Neurokinin B and reproductive functions: "KNDy neuron" model in mammals and the emerging story in fish.

Hu G, Lin C, He M, Wong AO.

Gen Comp Endocrinol. 2014 Nov 1;208:94-108. doi: 10.1016/j.ygcen.2014.08.009. Epub 2014 Aug 27. Review.


Aided cortical response, speech intelligibility, consonant perception and functional performance of young children using conventional amplification or nonlinear frequency compression.

Zhang VW, Ching TY, Van Buynder P, Hou S, Flynn C, Burns L, McGhie K, Wong AO.

Int J Pediatr Otorhinolaryngol. 2014 Oct;78(10):1692-700. doi: 10.1016/j.ijporl.2014.07.022. Epub 2014 Jul 23.


Somatostatin-28 inhibitory action on somatolactin-α and -β gene expression in goldfish.

Jiang Q, Wong AO.

Am J Physiol Regul Integr Comp Physiol. 2014 Sep 15;307(6):R755-68. doi: 10.1152/ajpregu.00193.2014. Epub 2014 Jul 9.


Mechanisms for luteinizing hormone induction of growth hormone gene transcription in fish model: crosstalk of the cAMP/PKA pathway with MAPK-and PI3K-dependent cascades.

Sun C, He M, Ko WK, Wong AO.

Mol Cell Endocrinol. 2014 Feb 15;382(2):835-50. doi: 10.1016/j.mce.2013.10.017. Epub 2013 Oct 23.


Goldfish spexin: solution structure and novel function as a satiety factor in feeding control.

Wong MK, Sze KH, Chen T, Cho CK, Law HC, Chu IK, Wong AO.

Am J Physiol Endocrinol Metab. 2013 Aug 1;305(3):E348-66. doi: 10.1152/ajpendo.00141.2013. Epub 2013 May 28.


Gene expression of luteinizing hormone receptor in carp somatotrophs differentially regulated by local action of gonadotropin and dopamine D1 receptor activation.

Sun C, He M, Ko WK, Wong AO.

Mol Cell Endocrinol. 2013 Jul 15;374(1-2):22-34. doi: 10.1016/j.mce.2013.04.003. Epub 2013 Apr 16.


Signal transduction mechanisms for autocrine/paracrine regulation of somatolactin-α secretion and synthesis in carp pituitary cells by somatolactin-α and -β.

Jiang Q, Wong AO.

Am J Physiol Endocrinol Metab. 2013 Jan 15;304(2):E176-86. doi: 10.1152/ajpendo.00455.2012. Epub 2012 Nov 27.


Kisspeptin-1 directly stimulates LH and GH secretion from goldfish pituitary cells in a Ca(2+)-dependent manner.

Chang JP, Mar A, Wlasichuk M, Wong AO.

Gen Comp Endocrinol. 2012 Oct 1;179(1):38-46. doi: 10.1016/j.ygcen.2012.07.028. Epub 2012 Aug 4.


Insulin-like growth factor as a novel stimulator for somatolactin secretion and synthesis in carp pituitary cells via activation of MAPK cascades.

Jiang Q, Ko WK, Wong AO.

Am J Physiol Endocrinol Metab. 2011 Dec;301(6):E1208-19. doi: 10.1152/ajpendo.00347.2011. Epub 2011 Aug 23.


Preoperative capecitabine and pelvic radiation in locally advanced rectal cancer--is it equivalent to 5-FU infusion plus leucovorin and radiotherapy?

Chan AK, Wong AO, Jenken DA.

Int J Radiat Oncol Biol Phys. 2010 Apr;76(5):1413-9. doi: 10.1016/j.ijrobp.2009.03.048.


International Symposium for Fish Growth and Reproduction.

Wong AO.

Gen Comp Endocrinol. 2010 Jul 1;167(3):339. doi: 10.1016/j.ygcen.2010.03.007. Epub 2010 Mar 16. No abstract available.


Genomic structure and transcriptional regulation of grass carp calmodulin gene.

Huo L, Wong AO.

Biochem Biophys Res Commun. 2009 Dec 18;390(3):827-33. doi: 10.1016/j.bbrc.2009.10.057. Epub 2009 Oct 22.


The secretogranin II-derived peptide secretoneurin stimulates luteinizing hormone secretion from gonadotrophs.

Zhao E, Basak A, Wong AO, Ko W, Chen A, López GC, Grey CL, Canosa LF, Somoza GM, Chang JP, Trudeau VL.

Endocrinology. 2009 May;150(5):2273-82. doi: 10.1210/en.2008-1060. Epub 2008 Dec 23.


Oxaliplatin plus irinotecan compared with irinotecan alone as second-line treatment after single-agent fluoropyrimidine therapy for metastatic colorectal carcinoma.

Haller DG, Rothenberg ML, Wong AO, Koralewski PM, Miller WH Jr, Bodoky G, Habboubi N, Garay C, Olivatto LO.

J Clin Oncol. 2008 Oct 1;26(28):4544-50. doi: 10.1200/JCO.2008.17.1249.


Serotonin interferes with Ca2+ and PKC signaling to reduce gonadotropin-releasing hormone-stimulated GH secretion in goldfish pituitary cells.

Yu Y, Wong AO, Chang JP.

Gen Comp Endocrinol. 2008 Oct;159(1):58-66. doi: 10.1016/j.ygcen.2008.07.021. Epub 2008 Aug 7.


Grass carp somatolactin: I. Evidence for PACAP induction of somatolactin-alpha and -beta gene expression via activation of pituitary PAC-I receptors.

Jiang Q, Ko WK, Lerner EA, Chan KM, Wong AO.

Am J Physiol Endocrinol Metab. 2008 Aug;295(2):E463-76. doi: 10.1152/ajpendo.90385.2008. Epub 2008 Jun 3.


Grass carp somatolactin: II. Pharmacological study on postreceptor signaling mechanisms for PACAP-induced somatolactin-alpha and -beta gene expression.

Jiang Q, He M, Wang X, Wong AO.

Am J Physiol Endocrinol Metab. 2008 Aug;295(2):E477-90. doi: 10.1152/ajpendo.90386.2008. Epub 2008 Jun 3.


Molecular cloning and characterization of the zebrafish (Danio rerio) telomerase catalytic subunit (telomerase reverse transcriptase, TERT).

Lau BW, Wong AO, Tsao GS, So KF, Yip HK.

J Mol Neurosci. 2008;34(1):63-75. Epub 2007 Sep 19.


Signaling mechanisms for alpha2-adrenergic inhibition of PACAP-induced growth hormone secretion and gene expression grass carp pituitary cells.

Wang X, Chu MM, Wong AO.

Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1750-62. Epub 2007 Feb 20.


Discovery of growth hormone-releasing hormones and receptors in nonmammalian vertebrates.

Lee LT, Siu FK, Tam JK, Lau IT, Wong AO, Lin MC, Vaudry H, Chow BK.

Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2133-8. Epub 2007 Feb 5.

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