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Items: 1 to 50 of 63

1.

Repurposing the Electron Transfer Reactant Phenazine Methosulfate (PMS) for the Apoptotic Elimination of Malignant Melanoma Cells through Induction of Lethal Oxidative and Mitochondriotoxic Stress.

Hua AB, Justiniano R, Perer J, Park SL, Li H, Cabello CM, Wondrak GT.

Cancers (Basel). 2019 Apr 27;11(5). pii: E590. doi: 10.3390/cancers11050590.

2.

TLR4 in skin cancer: From molecular mechanisms to clinical interventions.

Dickinson SE, Wondrak GT.

Mol Carcinog. 2019 Jul;58(7):1086-1093. doi: 10.1002/mc.23016. Epub 2019 Apr 24.

PMID:
31020719
3.

Sun sensitivity and sun protective behaviors during sun exposure among indoor office workers in the American Midwest.

Jung AM, Dennis LK, Jacobs ET, Wondrak GT.

Photodermatol Photoimmunol Photomed. 2018 Nov;34(6):393-399. doi: 10.1111/phpp.12403. Epub 2018 Jun 25.

PMID:
29888418
4.

Topical Bixin Confers NRF2-Dependent Protection Against Photodamage and Hair Graying in Mouse Skin.

Rojo de la Vega M, Zhang DD, Wondrak GT.

Front Pharmacol. 2018 Mar 27;9:287. doi: 10.3389/fphar.2018.00287. eCollection 2018.

5.

Pharmacological TLR4 Antagonism Using Topical Resatorvid Blocks Solar UV-Induced Skin Tumorigenesis in SKH-1 Mice.

Blohm-Mangone K, Burkett NB, Tahsin S, Myrdal PB, Aodah A, Ho B, Janda J, McComas M, Saboda K, Roe DJ, Dong Z, Bode AM, Petricoin EF 3rd, Calvert VS, Curiel-Lewandrowski C, Alberts DS, Wondrak GT, Dickinson SE.

Cancer Prev Res (Phila). 2018 May;11(5):265-278. doi: 10.1158/1940-6207.CAPR-17-0349. Epub 2018 Feb 1.

6.

Parkinson's Disease Skin Fibroblasts Display Signature Alterations in Growth, Redox Homeostasis, Mitochondrial Function, and Autophagy.

Teves JMY, Bhargava V, Kirwan KR, Corenblum MJ, Justiniano R, Wondrak GT, Anandhan A, Flores AJ, Schipper DA, Khalpey Z, Sligh JE, Curiel-Lewandrowski C, Sherman SJ, Madhavan L.

Front Neurosci. 2018 Jan 12;11:737. doi: 10.3389/fnins.2017.00737. eCollection 2017.

7.

Targeting NRF2 for Improved Skin Barrier Function and Photoprotection: Focus on the Achiote-Derived Apocarotenoid Bixin.

Rojo de la Vega M, Krajisnik A, Zhang DD, Wondrak GT.

Nutrients. 2017 Dec 18;9(12). pii: E1371. doi: 10.3390/nu9121371. Review.

8.

TLR4-directed Molecular Strategies Targeting Skin Photodamage and Carcinogenesis.

Dickinson SE, Wondrak GT.

Curr Med Chem. 2018;25(40):5487-5502. doi: 10.2174/0929867324666170828125328. Review.

PMID:
28847267
9.

A Topical Zinc Ionophore Blocks Tumorigenic Progression in UV-exposed SKH-1 High-risk Mouse Skin.

Justiniano R, Perer J, Hua A, Fazel M, Krajisnik A, Cabello CM, Wondrak GT.

Photochem Photobiol. 2017 Nov;93(6):1472-1482. doi: 10.1111/php.12794. Epub 2017 Jul 21.

10.

The B6 -vitamer Pyridoxal is a Sensitizer of UVA-induced Genotoxic Stress in Human Primary Keratinocytes and Reconstructed Epidermis.

Justiniano R, Williams JD, Perer J, Hua A, Lesson J, Park SL, Wondrak GT.

Photochem Photobiol. 2017 Jul;93(4):990-998. doi: 10.1111/php.12720. Epub 2017 Feb 28.

11.

Resatorvid-based Pharmacological Antagonism of Cutaneous TLR4 Blocks UV-induced NF-κB and AP-1 Signaling in Keratinocytes and Mouse Skin.

Janda J, Burkett NB, Blohm-Mangone K, Huang V, Curiel-Lewandrowski C, Alberts DS, Petricoin EF 3rd, Calvert VS, Einspahr J, Dong Z, Bode AM, Wondrak GT, Dickinson SE.

Photochem Photobiol. 2016 Nov;92(6):816-825. doi: 10.1111/php.12659. Epub 2016 Dec 8.

12.

Bixin protects mice against ventilation-induced lung injury in an NRF2-dependent manner.

Tao S, Rojo de la Vega M, Quijada H, Wondrak GT, Wang T, Garcia JG, Zhang DD.

Sci Rep. 2016 Jan 5;6:18760. doi: 10.1038/srep18760.

13.

An Essential Role of NRF2 in Diabetic Wound Healing.

Long M, Rojo de la Vega M, Wen Q, Bharara M, Jiang T, Zhang R, Zhou S, Wong PK, Wondrak GT, Zheng H, Zhang DD.

Diabetes. 2016 Mar;65(3):780-93. doi: 10.2337/db15-0564. Epub 2015 Dec 30.

14.

Systemic administration of the apocarotenoid bixin protects skin against solar UV-induced damage through activation of NRF2.

Tao S, Park SL, Rojo de la Vega M, Zhang DD, Wondrak GT.

Free Radic Biol Med. 2015 Dec;89:690-700. doi: 10.1016/j.freeradbiomed.2015.08.028. Epub 2015 Nov 4.

15.

Nrf2-dependent suppression of azoxymethane/dextran sulfate sodium-induced colon carcinogenesis by the cinnamon-derived dietary factor cinnamaldehyde.

Long M, Tao S, Rojo de la Vega M, Jiang T, Wen Q, Park SL, Zhang DD, Wondrak GT.

Cancer Prev Res (Phila). 2015 May;8(5):444-54. doi: 10.1158/1940-6207.CAPR-14-0359. Epub 2015 Feb 23.

16.

The quinone methide aurin is a heat shock response inducer that causes proteotoxic stress and Noxa-dependent apoptosis in malignant melanoma cells.

Davis AL, Qiao S, Lesson JL, Rojo de la Vega M, Park SL, Seanez CM, Gokhale V, Cabello CM, Wondrak GT.

J Biol Chem. 2015 Jan 16;290(3):1623-38. doi: 10.1074/jbc.M114.592626. Epub 2014 Dec 4.

17.

The Tryptophan-Derived Endogenous Aryl Hydrocarbon Receptor Ligand 6-Formylindolo[3,2-b]Carbazole Is a Nanomolar UVA Photosensitizer in Epidermal Keratinocytes.

Park SL, Justiniano R, Williams JD, Cabello CM, Qiao S, Wondrak GT.

J Invest Dermatol. 2015 Jun;135(6):1649-1658. doi: 10.1038/jid.2014.503. Epub 2014 Nov 28.

18.

Plant extracts of the family Lauraceae: a potential resource for chemopreventive agents that activate the nuclear factor-erythroid 2-related factor 2/antioxidant response element pathway.

Shen T, Chen XM, Harder B, Long M, Wang XN, Lou HX, Wondrak GT, Ren DM, Zhang DD.

Planta Med. 2014 Mar;80(5):426-34. doi: 10.1055/s-0034-1368197. Epub 2014 Feb 28. Erratum in: Planta Med. 2014 Nov;80(7):1664.

19.

Malondialdehyde-derived epitopes in human skin result from acute exposure to solar UV and occur in nonmelanoma skin cancer tissue.

Williams JD, Bermudez Y, Park SL, Stratton SP, Uchida K, Hurst CA, Wondrak GT.

J Photochem Photobiol B. 2014 Mar 5;132:56-65. doi: 10.1016/j.jphotobiol.2014.01.019. Epub 2014 Feb 12.

20.

The Nrf2-inducers tanshinone I and dihydrotanshinone protect human skin cells and reconstructed human skin against solar simulated UV.

Tao S, Justiniano R, Zhang DD, Wondrak GT.

Redox Biol. 2013 Oct 29;1:532-41. doi: 10.1016/j.redox.2013.10.004. eCollection 2013.

21.

The antimalarial amodiaquine causes autophagic-lysosomal and proliferative blockade sensitizing human melanoma cells to starvation- and chemotherapy-induced cell death.

Qiao S, Tao S, Rojo de la Vega M, Park SL, Vonderfecht AA, Jacobs SL, Zhang DD, Wondrak GT.

Autophagy. 2013 Dec;9(12):2087-102. doi: 10.4161/auto.26506. Epub 2013 Oct 8.

22.

Nrf2 modulates contractile and metabolic properties of skeletal muscle in streptozotocin-induced diabetic atrophy.

Whitman SA, Long M, Wondrak GT, Zheng H, Zhang DD.

Exp Cell Res. 2013 Oct 15;319(17):2673-83. doi: 10.1016/j.yexcr.2013.07.015. Epub 2013 Jul 27.

23.

UVA causes dual inactivation of cathepsin B and L underlying lysosomal dysfunction in human dermal fibroblasts.

Lamore SD, Wondrak GT.

J Photochem Photobiol B. 2013 Jun 5;123:1-12. doi: 10.1016/j.jphotobiol.2013.03.007. Epub 2013 Mar 28.

24.

Phenotypic identification of the redox dye methylene blue as an antagonist of heat shock response gene expression in metastatic melanoma cells.

Davis AL, Cabello CM, Qiao S, Azimian S, Wondrak GT.

Int J Mol Sci. 2013 Feb 19;14(2):4185-202. doi: 10.3390/ijms14024185.

25.

Tanshinone I activates the Nrf2-dependent antioxidant response and protects against As(III)-induced lung inflammation in vitro and in vivo.

Tao S, Zheng Y, Lau A, Jaramillo MC, Chau BT, Lantz RC, Wong PK, Wondrak GT, Zhang DD.

Antioxid Redox Signal. 2013 Nov 10;19(14):1647-61. doi: 10.1089/ars.2012.5117. Epub 2013 Mar 21.

26.

D-Penicillamine targets metastatic melanoma cells with induction of the unfolded protein response (UPR) and Noxa (PMAIP1)-dependent mitochondrial apoptosis.

Qiao S, Cabello CM, Lamore SD, Lesson JL, Wondrak GT.

Apoptosis. 2012 Oct;17(10):1079-94. doi: 10.1007/s10495-012-0746-x.

27.

Thiostrepton is an inducer of oxidative and proteotoxic stress that impairs viability of human melanoma cells but not primary melanocytes.

Qiao S, Lamore SD, Cabello CM, Lesson JL, Muñoz-Rodriguez JL, Wondrak GT.

Biochem Pharmacol. 2012 May 1;83(9):1229-40. doi: 10.1016/j.bcp.2012.01.027. Epub 2012 Feb 1.

28.

Vitamin B6: beyond coenzyme functions.

Wondrak GT, Jacobson EL.

Subcell Biochem. 2012;56:291-300. doi: 10.1007/978-94-007-2199-9_15. Review.

PMID:
22116705
29.

Therapeutic potential of Nrf2 activators in streptozotocin-induced diabetic nephropathy.

Zheng H, Whitman SA, Wu W, Wondrak GT, Wong PK, Fang D, Zhang DD.

Diabetes. 2011 Nov;60(11):3055-66. doi: 10.2337/db11-0807.

30.

Autophagic-lysosomal dysregulation downstream of cathepsin B inactivation in human skin fibroblasts exposed to UVA.

Lamore SD, Wondrak GT.

Photochem Photobiol Sci. 2012 Jan;11(1):163-72. doi: 10.1039/c1pp05131h. Epub 2011 Jul 20.

31.

The redox antimalarial dihydroartemisinin targets human metastatic melanoma cells but not primary melanocytes with induction of NOXA-dependent apoptosis.

Cabello CM, Lamore SD, Bair WB 3rd, Qiao S, Azimian S, Lesson JL, Wondrak GT.

Invest New Drugs. 2012 Aug;30(4):1289-301. doi: 10.1007/s10637-011-9676-7. Epub 2011 May 6.

32.

Zinc pyrithione impairs zinc homeostasis and upregulates stress response gene expression in reconstructed human epidermis.

Lamore SD, Wondrak GT.

Biometals. 2011 Oct;24(5):875-90. doi: 10.1007/s10534-011-9441-6. Epub 2011 Mar 22.

33.

DCPIP (2,6-dichlorophenolindophenol) as a genotype-directed redox chemotherapeutic targeting NQO1*2 breast carcinoma.

Cabello CM, Lamore SD, Bair WB 3rd, Davis AL, Azimian SM, Wondrak GT.

Free Radic Res. 2011 Mar;45(3):276-92. doi: 10.3109/10715762.2010.526766. Epub 2010 Nov 1.

34.

Proteomic identification of cathepsin B and nucleophosmin as novel UVA-targets in human skin fibroblasts.

Lamore SD, Qiao S, Horn D, Wondrak GT.

Photochem Photobiol. 2010 Nov-Dec;86(6):1307-17. doi: 10.1111/j.1751-1097.2010.00818.x. Epub 2010 Oct 14.

35.

The malondialdehyde-derived fluorophore DHP-lysine is a potent sensitizer of UVA-induced photooxidative stress in human skin cells.

Lamore SD, Azimian S, Horn D, Anglin BL, Uchida K, Cabello CM, Wondrak GT.

J Photochem Photobiol B. 2010 Dec 2;101(3):251-64. doi: 10.1016/j.jphotobiol.2010.07.010. Epub 2010 Jul 30.

36.

The cinnamon-derived dietary factor cinnamic aldehyde activates the Nrf2-dependent antioxidant response in human epithelial colon cells.

Wondrak GT, Villeneuve NF, Lamore SD, Bause AS, Jiang T, Zhang DD.

Molecules. 2010 May 7;15(5):3338-55. doi: 10.3390/molecules15053338.

37.

Resveratrol prevents epigenetic silencing of BRCA-1 by the aromatic hydrocarbon receptor in human breast cancer cells.

Papoutsis AJ, Lamore SD, Wondrak GT, Selmin OI, Romagnolo DF.

J Nutr. 2010 Sep;140(9):1607-14. doi: 10.3945/jn.110.123422. Epub 2010 Jul 14.

38.

HMGB1-directed drug discovery targeting cutaneous inflammatory dysregulation.

Lamore SD, Cabello CM, Wondrak GT.

Curr Drug Metab. 2010 Mar;11(3):250-65. Review.

PMID:
20406187
39.

GLO1 overexpression in human malignant melanoma.

Bair WB 3rd, Cabello CM, Uchida K, Bause AS, Wondrak GT.

Melanoma Res. 2010 Apr;20(2):85-96. doi: 10.1097/CMR.0b013e3283364903.

40.

The topical antimicrobial zinc pyrithione is a heat shock response inducer that causes DNA damage and PARP-dependent energy crisis in human skin cells.

Lamore SD, Cabello CM, Wondrak GT.

Cell Stress Chaperones. 2010 May;15(3):309-22. doi: 10.1007/s12192-009-0145-6. Epub 2009 Oct 7.

41.

Redox-directed cancer therapeutics: molecular mechanisms and opportunities.

Wondrak GT.

Antioxid Redox Signal. 2009 Dec;11(12):3013-69. doi: 10.1089/ARS.2009.2541. Review.

42.

Antimelanoma activity of the redox dye DCPIP (2,6-dichlorophenolindophenol) is antagonized by NQO1.

Cabello CM, Bair WB 3rd, Bause AS, Wondrak GT.

Biochem Pharmacol. 2009 Aug 15;78(4):344-54. doi: 10.1016/j.bcp.2009.04.016. Epub 2009 Apr 24.

43.

The experimental chemotherapeutic N6-furfuryladenosine (kinetin-riboside) induces rapid ATP depletion, genotoxic stress, and CDKN1A(p21) upregulation in human cancer cell lines.

Cabello CM, Bair WB 3rd, Ley S, Lamore SD, Azimian S, Wondrak GT.

Biochem Pharmacol. 2009 Apr 1;77(7):1125-38. doi: 10.1016/j.bcp.2008.12.002. Epub 2008 Dec 24.

44.

The cinnamon-derived Michael acceptor cinnamic aldehyde impairs melanoma cell proliferation, invasiveness, and tumor growth.

Cabello CM, Bair WB 3rd, Lamore SD, Ley S, Bause AS, Azimian S, Wondrak GT.

Free Radic Biol Med. 2009 Jan 15;46(2):220-31. doi: 10.1016/j.freeradbiomed.2008.10.025. Epub 2008 Nov 1.

45.

Cinnamoyl-based Nrf2-activators targeting human skin cell photo-oxidative stress.

Wondrak GT, Cabello CM, Villeneuve NF, Zhang S, Ley S, Li Y, Sun Z, Zhang DD.

Free Radic Biol Med. 2008 Aug 15;45(4):385-95. doi: 10.1016/j.freeradbiomed.2008.04.023. Epub 2008 Apr 26.

46.

Reactivity-based drug discovery using vitamin B(6)-derived pharmacophores.

Wondrak GT.

Mini Rev Med Chem. 2008 May;8(5):519-28. Review.

PMID:
18473939
47.

Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2.

Wang XJ, Sun Z, Villeneuve NF, Zhang S, Zhao F, Li Y, Chen W, Yi X, Zheng W, Wondrak GT, Wong PK, Zhang DD.

Carcinogenesis. 2008 Jun;29(6):1235-43. doi: 10.1093/carcin/bgn095. Epub 2008 Apr 15.

48.

Experimental therapeutics: targeting the redox Achilles heel of cancer.

Cabello CM, Bair WB 3rd, Wondrak GT.

Curr Opin Investig Drugs. 2007 Dec;8(12):1022-37. Review.

PMID:
18058573
49.
50.

Let the sun shine in: mechanisms and potential for therapeutics in skin photodamage.

Wondrak GT.

Curr Opin Investig Drugs. 2007 May;8(5):390-400. Review.

PMID:
17520868

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