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In-Source CID Ramping and Covariant Ion Analysis of Hydrophilic Interaction Chromatography Metabolomics.

Su X, Chiles E, Maimouni S, Wondisford FE, Zong WX, Song C.

Anal Chem. 2020 Apr 7;92(7):4829-4837. doi: 10.1021/acs.analchem.9b04181. Epub 2020 Mar 13.


A Direct Comparison of Thyroid Hormone Receptor Protein Levels in Mice Provides Unexpected Insights into Thyroid Hormone Action.

Minakhina S, Bansal S, Zhang A, Brotherton M, Janodia R, De Oliveira V, Tadepalli S, Wondisford FE.

Thyroid. 2020 Apr 6. doi: 10.1089/thy.2019.0763. [Epub ahead of print]


G protein-coupled kisspeptin receptor induces metabolic reprograming and tumorigenesis in estrogen receptor-negative breast cancer.

Dragan M, Nguyen MU, Guzman S, Goertzen C, Brackstone M, Dhillo WS, Bech PR, Clarke S, Abbara A, Tuck AB, Hess DA, Pine SR, Zong WX, Wondisford FE, Su X, Babwah AV, Bhattacharya M.

Cell Death Dis. 2020 Feb 7;11(2):106. doi: 10.1038/s41419-020-2305-7.


Glycerol not lactate is the major net carbon source for gluconeogenesis in mice during both short and prolonged fasting.

Wang Y, Kwon H, Su X, Wondisford FE.

Mol Metab. 2020 Jan;31:36-44. doi: 10.1016/j.molmet.2019.11.005. Epub 2019 Nov 9.


Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK.

Wang Y, An H, Liu T, Qin C, Sesaki H, Guo S, Radovick S, Hussain M, Maheshwari A, Wondisford FE, O'Rourke B, He L.

Cell Rep. 2019 Nov 5;29(6):1511-1523.e5. doi: 10.1016/j.celrep.2019.09.070.


Glycerol induces G6pc in primary mouse hepatocytes and is the preferred substrate for gluconeogenesis both in vitro and in vivo.

Kalemba KM, Wang Y, Xu H, Chiles E, McMillin SM, Kwon H, Su X, Wondisford FE.

J Biol Chem. 2019 Nov 29;294(48):18017-18028. doi: 10.1074/jbc.RA119.011033. Epub 2019 Oct 23.


Fast LC-MS quantitation of glucose and glycerol via enzymatic derivatization.

Chiles E, Wang Y, Kalemba KM, Kwon H, Wondisford FE, Su X.

Anal Biochem. 2019 Jun 15;575:40-43. doi: 10.1016/j.ab.2019.03.020. Epub 2019 Mar 30.


ElemCor: accurate data analysis and enrichment calculation for high-resolution LC-MS stable isotope labeling experiments.

Du D, Tan L, Wang Y, Peng B, Weinstein JN, Wondisford FE, Su X, Lorenzi PL.

BMC Bioinformatics. 2019 Feb 19;20(1):89. doi: 10.1186/s12859-019-2669-9.


Ectopic expression of aPKC-mediated phosphorylation in p300 modulates hippocampal neurogenesis, CREB binding and fear memory differently with age.

Syal C, Seegobin M, Sarma SN, Gouveia A, Hsu K, Niibori Y, He L, Wondisford FE, Frankland PW, Wang J.

Sci Rep. 2018 Sep 10;8(1):13489. doi: 10.1038/s41598-018-31657-2.


The matrix protein Fibulin-3 promotes KISS1R induced triple negative breast cancer cell invasion.

Noonan MM, Dragan M, Mehta MM, Hess DA, Brackstone M, Tuck AB, Viswakarma N, Rana A, Babwah AV, Wondisford FE, Bhattacharya M.

Oncotarget. 2018 Jul 10;9(53):30034-30052. doi: 10.18632/oncotarget.25682. eCollection 2018 Jul 10.


Impairments in the reproductive axis of female mice lacking estrogen receptor β in GnRH neurons.

Novaira HJ, Negron AL, Graceli JB, Capellino S, Schoeffield A, Hoffman GE, Levine JE, Wolfe A, Wondisford FE, Radovick S.

Am J Physiol Endocrinol Metab. 2018 Nov 1;315(5):E1019-E1033. doi: 10.1152/ajpendo.00173.2018. Epub 2018 Jul 24.


Evaluating the Hypothalamic-Pituitary-Thyroid (HPT) Axis in Mice.

Wondisford FE.

Methods Mol Biol. 2018;1801:155-161. doi: 10.1007/978-1-4939-7902-8_13.


Hyperglucagonemia Mitigates the Effect of Metformin on Glucose Production in Prediabetes.

Konopka AR, Esponda RR, Robinson MM, Johnson ML, Carter RE, Schiavon M, Cobelli C, Wondisford FE, Lanza IR, Nair KS.

Cell Rep. 2018 May 22;23(8):2532. doi: 10.1016/j.celrep.2018.05.027. No abstract available.


Naturally Occurring Amino Acids in Helix 10 of the Thyroid Hormone Receptor Mediate Isoform-Specific TH Gene Regulation.

Pinto VMS, Minakhina S, Qiu S, Sidhaye A, Brotherton MP, Suhotliv A, Wondisford FE.

Endocrinology. 2017 Sep 1;158(9):3067-3078. doi: 10.1210/en.2017-00314.


Thyroid Hormone Signaling Pathways: Time for a More Precise Nomenclature.

Flamant F, Cheng SY, Hollenberg AN, Moeller LC, Samarut J, Wondisford FE, Yen PM, Refetoff S.

Endocrinology. 2017 Jul 1;158(7):2052-2057. doi: 10.1210/en.2017-00250.


Gene expression of T3-regulated genes in a mouse model of the human thyroid hormone resistance.

Santiago LA, Faustino LC, Pereira GF, Imperio GE, Pazos-Moura CC, Wondisford FE, Bloise FF, Ortiga-Carvalho TM.

Life Sci. 2017 Feb 1;170:93-99. doi: 10.1016/j.lfs.2016.11.032. Epub 2016 Dec 2.


The aPKC-CBP Pathway Regulates Adult Hippocampal Neurogenesis in an Age-Dependent Manner.

Gouveia A, Hsu K, Niibori Y, Seegobin M, Cancino GI, He L, Wondisford FE, Bennett S, Lagace D, Frankland PW, Wang J.

Stem Cell Reports. 2016 Oct 11;7(4):719-734. doi: 10.1016/j.stemcr.2016.08.007. Epub 2016 Sep 8.


Hypothalamus-Pituitary-Thyroid Axis.

Ortiga-Carvalho TM, Chiamolera MI, Pazos-Moura CC, Wondisford FE.

Compr Physiol. 2016 Jun 13;6(3):1387-428. doi: 10.1002/cphy.c150027. Review.


Hyperglucagonemia Mitigates the Effect of Metformin on Glucose Production in Prediabetes.

Konopka AR, Esponda RR, Robinson MM, Johnson ML, Carter RE, Schiavon M, Cobelli C, Wondisford FE, Lanza IR, Nair KS.

Cell Rep. 2016 May 17;15(7):1394-1400. doi: 10.1016/j.celrep.2016.04.024. Epub 2016 May 5. Erratum in: Cell Rep. 2018 May 22;23(8):2532.


Activation of the cAMP-PKA pathway Antagonizes Metformin Suppression of Hepatic Glucose Production.

He L, Chang E, Peng J, An H, McMillin SM, Radovick S, Stratakis CA, Wondisford FE.

J Biol Chem. 2016 May 13;291(20):10562-70. doi: 10.1074/jbc.M116.719666. Epub 2016 Mar 21.


Activating Endogenous Neural Precursor Cells Using Metformin Leads to Neural Repair and Functional Recovery in a Model of Childhood Brain Injury.

Dadwal P, Mahmud N, Sinai L, Azimi A, Fatt M, Wondisford FE, Miller FD, Morshead CM.

Stem Cell Reports. 2015 Aug 11;5(2):166-73. doi: 10.1016/j.stemcr.2015.06.011. Epub 2015 Jul 30.


A direct role for thyroid hormone in development of the adrenal cortex.

Wondisford FE.

Endocrinology. 2015 Jun;156(6):1939-40. doi: 10.1210/en.2015-1351. No abstract available.


Metformin action: concentrations matter.

He L, Wondisford FE.

Cell Metab. 2015 Feb 3;21(2):159-162. doi: 10.1016/j.cmet.2015.01.003.


Metformin activates AMP-activated protein kinase by promoting formation of the αβγ heterotrimeric complex.

Meng S, Cao J, He Q, Xiong L, Chang E, Radovick S, Wondisford FE, He L.

J Biol Chem. 2015 Feb 6;290(6):3793-802. doi: 10.1074/jbc.M114.604421. Epub 2014 Dec 23.


Welcome to the 84th annual meeting of the American Thyroid Association.

Tuttle RM, Wondisford FE.

Thyroid. 2014 Oct;24(10):1439-40. doi: 10.1089/thy.2014.0429. No abstract available.


Thyroid hormone receptors and resistance to thyroid hormone disorders.

Ortiga-Carvalho TM, Sidhaye AR, Wondisford FE.

Nat Rev Endocrinol. 2014 Oct;10(10):582-91. doi: 10.1038/nrendo.2014.143. Epub 2014 Aug 19. Review.


Low concentrations of metformin suppress glucose production in hepatocytes through AMP-activated protein kinase (AMPK).

Cao J, Meng S, Chang E, Beckwith-Fickas K, Xiong L, Cole RN, Radovick S, Wondisford FE, He L.

J Biol Chem. 2014 Jul 25;289(30):20435-46.


Circadian regulation of Tshb gene expression by Rev-Erbα (NR1D1) and nuclear corepressor 1 (NCOR1).

Aninye IO, Matsumoto S, Sidhaye AR, Wondisford FE.

J Biol Chem. 2014 Jun 13;289(24):17070-7. doi: 10.1074/jbc.M114.569723. Epub 2014 May 2.


Potential biomarker of metformin action.

He L, Meng S, Germain-Lee EL, Radovick S, Wondisford FE.

J Endocrinol. 2014 Jun;221(3):363-9. doi: 10.1530/JOE-14-0084. Epub 2014 Mar 17.


Activation of basal gluconeogenesis by coactivator p300 maintains hepatic glycogen storage.

He L, Cao J, Meng S, Ma A, Radovick S, Wondisford FE.

Mol Endocrinol. 2013 Aug;27(8):1322-32. doi: 10.1210/me.2012-1413. Epub 2013 Jun 14.


The thyroid axis is regulated by NCoR1 via its actions in the pituitary.

Costa-e-Sousa RH, Astapova I, Ye F, Wondisford FE, Hollenberg AN.

Endocrinology. 2012 Oct;153(10):5049-57. Epub 2012 Aug 9.


Transcriptional co-activator p300 maintains basal hepatic gluconeogenesis.

He L, Naik K, Meng S, Cao J, Sidhaye AR, Ma A, Radovick S, Wondisford FE.

J Biol Chem. 2012 Sep 14;287(38):32069-77. doi: 10.1074/jbc.M112.385864. Epub 2012 Jul 19.


Fundamentally distinct roles of thyroid hormone receptor isoforms in a thyrotroph cell line are due to differential DNA binding.

Chiamolera MI, Sidhaye AR, Matsumoto S, He Q, Hashimoto K, Ortiga-Carvalho TM, Wondisford FE.

Mol Endocrinol. 2012 Jun;26(6):926-39. doi: 10.1210/me.2011-1290. Epub 2012 May 8.


CREB binding protein (CBP) activation is required for luteinizing hormone beta expression and normal fertility in mice.

Miller RS, Wolfe A, He L, Radovick S, Wondisford FE.

Mol Cell Biol. 2012 Jul;32(13):2349-58. doi: 10.1128/MCB.00394-12. Epub 2012 Apr 16.


Complete activation of thyroid hormone receptor β by T3 is essential for normal cochlear function and morphology in mice.

Richter CP, Münscher A, Machado DS, Wondisford FE, Ortiga-Carvalho TM.

Cell Physiol Biochem. 2011;28(5):997-1008. doi: 10.1159/000335812. Epub 2011 Dec 15.


A new medical therapy for Cushing disease?

Wondisford FE.

J Clin Invest. 2011 Dec;121(12):4621-3. doi: 10.1172/JCI61127. Epub 2011 Nov 21.


The Δ337T mutation on the TRβ causes alterations in growth, adiposity, and hepatic glucose homeostasis in mice.

Santiago LA, Santiago DA, Faustino LC, Cordeiro A, Lisboa PC, Wondisford FE, Pazos-Moura CC, Ortiga-Carvalho TM.

J Endocrinol. 2011 Oct;211(1):39-46. doi: 10.1530/JOE-11-0194. Epub 2011 Jul 11.


Deletion of Otx2 in GnRH neurons results in a mouse model of hypogonadotropic hypogonadism.

Diaczok D, DiVall S, Matsuo I, Wondisford FE, Wolfe AM, Radovick S.

Mol Endocrinol. 2011 May;25(5):833-46. doi: 10.1210/me.2010-0271. Epub 2011 Mar 24.


Rescue of obesity-induced infertility in female mice due to a pituitary-specific knockout of the insulin receptor.

Brothers KJ, Wu S, DiVall SA, Messmer MR, Kahn CR, Miller RS, Radovick S, Wondisford FE, Wolfe A.

Cell Metab. 2010 Sep 8;12(3):295-305. doi: 10.1016/j.cmet.2010.06.010.


Thyroid hormone receptor beta mutation causes severe impairment of cerebellar development.

Portella AC, Carvalho F, Faustino L, Wondisford FE, Ortiga-Carvalho TM, Gomes FC.

Mol Cell Neurosci. 2010 May;44(1):68-77. doi: 10.1016/j.mcn.2010.02.004. Epub 2010 Mar 1.


Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein.

He L, Sabet A, Djedjos S, Miller R, Sun X, Hussain MA, Radovick S, Wondisford FE.

Cell. 2009 May 15;137(4):635-46. doi: 10.1016/j.cell.2009.03.016.


Impaired estrogen feedback and infertility in female mice with pituitary-specific deletion of estrogen receptor alpha (ESR1).

Singh SP, Wolfe A, Ng Y, DiVall SA, Buggs C, Levine JE, Wondisford FE, Radovick S.

Biol Reprod. 2009 Sep;81(3):488-96. doi: 10.1095/biolreprod.108.075259. Epub 2009 May 13.


A thyroid hormone receptor mutation that dissociates thyroid hormone regulation of gene expression in vivo.

Machado DS, Sabet A, Santiago LA, Sidhaye AR, Chiamolera MI, Ortiga-Carvalho TM, Wondisford FE.

Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9441-6. doi: 10.1073/pnas.0903227106. Epub 2009 May 13.


In vivo interaction of steroid receptor coactivator (SRC)-1 and the activation function-2 domain of the thyroid hormone receptor (TR) beta in TRbeta E457A knock-in and SRC-1 knockout mice.

Alonso M, Goodwin C, Liao X, Ortiga-Carvalho T, Machado DS, Wondisford FE, Refetoff S, Weiss RE.

Endocrinology. 2009 Aug;150(8):3927-34. doi: 10.1210/en.2009-0093. Epub 2009 Apr 30.


Minireview: Thyrotropin-releasing hormone and the thyroid hormone feedback mechanism.

Chiamolera MI, Wondisford FE.

Endocrinology. 2009 Mar;150(3):1091-6. doi: 10.1210/en.2008-1795. Epub 2009 Jan 29. Review.


Connexin40 messenger ribonucleic acid is positively regulated by thyroid hormone (TH) acting in cardiac atria via the TH receptor.

Almeida NA, Cordeiro A, Machado DS, Souza LL, Ortiga-Carvalho TM, Campos-de-Carvalho AC, Wondisford FE, Pazos-Moura CC.

Endocrinology. 2009 Jan;150(1):546-54. doi: 10.1210/en.2008-0451. Epub 2008 Sep 11.


Exendin-4 stimulation of cyclin A2 in beta-cell proliferation.

Song WJ, Schreiber WE, Zhong E, Liu FF, Kornfeld BD, Wondisford FE, Hussain MA.

Diabetes. 2008 Sep;57(9):2371-81. doi: 10.2337/db07-1541. Epub 2008 Jun 10.


Thyroid hormone action is required for normal cone opsin expression during mouse retinal development.

Pessôa CN, Santiago LA, Santiago DA, Machado DS, Rocha FA, Ventura DF, Hokoç JN, Pazos-Moura CC, Wondisford FE, Gardino PF, Ortiga-Carvalho TM.

Invest Ophthalmol Vis Sci. 2008 May;49(5):2039-45. doi: 10.1167/iovs.07-0908.


An estrogen receptor-alpha knock-in mutation provides evidence of ligand-independent signaling and allows modulation of ligand-induced pathways in vivo.

Sinkevicius KW, Burdette JE, Woloszyn K, Hewitt SC, Hamilton K, Sugg SL, Temple KA, Wondisford FE, Korach KS, Woodruff TK, Greene GL.

Endocrinology. 2008 Jun;149(6):2970-9. doi: 10.1210/en.2007-1526. Epub 2008 Mar 13.


TRH testing in its infancy.

Divall SA, Wondisford FE.

J Clin Endocrinol Metab. 2008 Feb;93(2):378-9. doi: 10.1210/jc.2007-2648. No abstract available.


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