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Items: 32


Feedback regulation between atypical E2Fs and APC/CCdh1 coordinates cell cycle progression.

Boekhout M, Yuan R, Wondergem AP, Segeren HA, van Liere EA, Awol N, Jansen I, Wolthuis RM, de Bruin A, Westendorp B.

EMBO Rep. 2016 Mar;17(3):414-27. doi: 10.15252/embr.201540984. Epub 2016 Feb 5.


Defective sister chromatid cohesion is synthetically lethal with impaired APC/C function.

de Lange J, Faramarz A, Oostra AB, de Menezes RX, van der Meulen IH, Rooimans MA, Rockx DA, Brakenhoff RH, van Beusechem VW, King RW, de Winter JP, Wolthuis RM.

Nat Commun. 2015 Oct 1;6:8399. doi: 10.1038/ncomms9399.


Inefficient degradation of cyclin B1 re-activates the spindle checkpoint right after sister chromatid disjunction.

Clijsters L, van Zon W, Riet BT, Voets E, Boekhout M, Ogink J, Rumpf-Kienzl C, Wolthuis RM.

Cell Cycle. 2014;13(15):2370-8. doi: 10.4161/cc.29336.


Stable government of mitosis by Greatwall: the emperor's best servant.

Voets E, Wolthuis RM.

Mol Cell Biol. 2012 Apr;32(8):1334-6. doi: 10.1128/MCB.00213-12. Epub 2012 Mar 5. No abstract available.


MASTL is the human orthologue of Greatwall kinase that facilitates mitotic entry, anaphase and cytokinesis.

Voets E, Wolthuis RM.

Cell Cycle. 2010 Sep 1;9(17):3591-601. Epub 2010 Sep 29.


The APC/C recruits cyclin B1-Cdk1-Cks in prometaphase before D box recognition to control mitotic exit.

van Zon W, Ogink J, ter Riet B, Medema RH, te Riele H, Wolthuis RM.

J Cell Biol. 2010 Aug 23;190(4):587-602. doi: 10.1083/jcb.200912084.


Cyclin A and Nek2A: APC/C-Cdc20 substrates invisible to the mitotic spindle checkpoint.

van Zon W, Wolthuis RM.

Biochem Soc Trans. 2010 Feb;38(Pt 1):72-7. doi: 10.1042/BST0380072. Review.


Cdc20 is required for the post-anaphase, KEN-dependent degradation of centromere protein F.

Gurden MD, Holland AJ, van Zon W, Tighe A, Vergnolle MA, Andres DA, Spielmann HP, Malumbres M, Wolthuis RM, Cleveland DW, Taylor SS.

J Cell Sci. 2010 Feb 1;123(Pt 3):321-30. doi: 10.1242/jcs.062075. Epub 2010 Jan 5.


The cellular phenotype of Roberts syndrome fibroblasts as revealed by ectopic expression of ESCO2.

van der Lelij P, Godthelp BC, van Zon W, van Gosliga D, Oostra AB, Steltenpool J, de Groot J, Scheper RJ, Wolthuis RM, Waisfisz Q, Darroudi F, Joenje H, de Winter JP.

PLoS One. 2009 Sep 7;4(9):e6936. doi: 10.1371/journal.pone.0006936.


Polo-like kinase-1 controls Aurora A destruction by activating APC/C-Cdh1.

van Leuken R, Clijsters L, van Zon W, Lim D, Yao X, Wolthuis RM, Yaffe MB, Medema RH, van Vugt MA.

PLoS One. 2009;4(4):e5282. doi: 10.1371/journal.pone.0005282. Epub 2009 Apr 23.


Usp39 is essential for mitotic spindle checkpoint integrity and controls mRNA-levels of aurora B.

van Leuken RJ, Luna-Vargas MP, Sixma TK, Wolthuis RM, Medema RH.

Cell Cycle. 2008 Sep 1;7(17):2710-9. Epub 2008 Sep 3.


Cyclin B1-Cdk1 activation continues after centrosome separation to control mitotic progression.

Lindqvist A, van Zon W, Karlsson Rosenthal C, Wolthuis RM.

PLoS Biol. 2007 May;5(5):e123.


Mitogen requirement for cell cycle progression in the absence of pocket protein activity.

Foijer F, Wolthuis RM, Doodeman V, Medema RH, te Riele H.

Cancer Cell. 2005 Dec;8(6):455-66. Erratum in: Cancer Cell. 2006 Jan;9(1):71.


Uncoupling anaphase-promoting complex/cyclosome activity from spindle assembly checkpoint control by deregulating polo-like kinase 1.

van de Weerdt BC, van Vugt MA, Lindon C, Kauw JJ, Rozendaal MJ, Klompmaker R, Wolthuis RM, Medema RH.

Mol Cell Biol. 2005 Mar;25(5):2031-44.


Polo-like kinase-1 is required for bipolar spindle formation but is dispensable for anaphase promoting complex/Cdc20 activation and initiation of cytokinesis.

van Vugt MA, van de Weerdt BC, Vader G, Janssen H, Calafat J, Klompmaker R, Wolthuis RM, Medema RH.

J Biol Chem. 2004 Aug 27;279(35):36841-54. Epub 2004 Jun 21.


Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension.

Lens SM, Wolthuis RM, Klompmaker R, Kauw J, Agami R, Brummelkamp T, Kops G, Medema RH.

EMBO J. 2003 Jun 16;22(12):2934-47.


Guanine nucleotide exchange factor-like factor (Rlf) induces gene expression and potentiates alpha 1-adrenergic receptor-induced transcriptional responses in neonatal rat ventricular myocytes.

Post GR, Swiderski C, Waldrop BA, Salty L, Glembotski CC, Wolthuis RM, Mochizuki N.

J Biol Chem. 2002 May 3;277(18):15286-92. Epub 2002 Feb 14.


Ras-dependent regulation of c-Jun phosphorylation is mediated by the Ral guanine nucleotide exchange factor-Ral pathway.

de Ruiter ND, Wolthuis RM, van Dam H, Burgering BM, Bos JL.

Mol Cell Biol. 2000 Nov;20(22):8480-8.


RalGEF2, a pleckstrin homology domain containing guanine nucleotide exchange factor for Ral.

de Bruyn KM, de Rooij J, Wolthuis RM, Rehmann H, Wesenbeek J, Cool RH, Wittinghofer AH, Bos JL.

J Biol Chem. 2000 Sep 22;275(38):29761-6.


The small GTPase, Rap1, mediates CD31-induced integrin adhesion.

Reedquist KA, Ross E, Koop EA, Wolthuis RM, Zwartkruis FJ, van Kooyk Y, Salmon M, Buckley CD, Bos JL.

J Cell Biol. 2000 Mar 20;148(6):1151-8.


Interdependent action of RalGEF and Erk in Ras-induced primitive endoderm differentiation of F9 embryonal carcinoma cells.

Verheijen MH, Wolthuis RM, Defize LH, den Hertog J, Bos JL.

Oncogene. 1999 Aug 5;18(31):4435-9.


Differential fMet-Leu-Phe- and platelet-activating factor-induced signaling toward Ral activation in primary human neutrophils.

M'Rabet L, Coffer PJ, Wolthuis RM, Zwartkruis F, Koenderman L, Bos JL.

J Biol Chem. 1999 Jul 30;274(31):21847-52.


Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2.

Nancy V, Wolthuis RM, de Tand MF, Janoueix-Lerosey I, Bos JL, de Gunzburg J.

J Biol Chem. 1999 Mar 26;274(13):8737-45.


Ras caught in another affair: the exchange factors for Ral.

Wolthuis RM, Bos JL.

Curr Opin Genet Dev. 1999 Feb;9(1):112-7. Review.


Extracellular signal-regulated activation of Rap1 fails to interfere in Ras effector signalling.

Zwartkruis FJ, Wolthuis RM, Nabben NM, Franke B, Bos JL.

EMBO J. 1998 Oct 15;17(20):5905-12.


Structure determination of the Ras-binding domain of the Ral-specific guanine nucleotide exchange factor Rlf.

Esser D, Bauer B, Wolthuis RM, Wittinghofer A, Cool RH, Bayer P.

Biochemistry. 1998 Sep 29;37(39):13453-62.


Ras-dependent activation of the small GTPase Ral.

Wolthuis RM, Zwartkruis F, Moen TC, Bos JL.

Curr Biol. 1998 Apr 9;8(8):471-4.


Activation of the small GTPase Ral in platelets.

Wolthuis RM, Franke B, van Triest M, Bauer B, Cool RH, Camonis JH, Akkerman JW, Bos JL.

Mol Cell Biol. 1998 May;18(5):2486-91.


Stimulation of gene induction and cell growth by the Ras effector Rlf.

Wolthuis RM, de Ruiter ND, Cool RH, Bos JL.

EMBO J. 1997 Nov 17;16(22):6748-61.


RalGDS-like factor (Rlf) is a novel Ras and Rap 1A-associating protein.

Wolthuis RM, Bauer B, van 't Veer LJ, de Vries-Smits AM, Cool RH, Spaargaren M, Wittinghofer A, Burgering BM, Bos JL.

Oncogene. 1996 Jul 18;13(2):353-62.


Epidermal growth factor stimulates phosphorylation of eukaryotic initiation factor 4B, independently of protein kinase C.

Wolthuis RM, Cremers AF, Kasperaitis MA, van der Mast C, Voorma HO, Boonstra J.

Biochim Biophys Acta. 1993 Jun 6;1177(2):160-6.


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