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Non-redundant roles in sister chromatid cohesion of the DNA helicase DDX11 and the SMC3 acetyl transferases ESCO1 and ESCO2.

Faramarz A, Balk JA, van Schie JJM, Oostra AB, Ghandour CA, Rooimans MA, Wolthuis RMF, de Lange J.

PLoS One. 2020 Jan 14;15(1):e0220348. doi: 10.1371/journal.pone.0220348. eCollection 2020.


No evidence for increased prevalence of colorectal carcinoma in 399 Dutch patients with Birt-Hogg-Dubé syndrome.

van de Beek I, Glykofridis IE, Wolthuis RMF, Gille HJJP, Johannesma PC, Meijers-Heijboer HEJ, Moorselaar RJAV, Houweling AC.

Br J Cancer. 2019 Dec 20. doi: 10.1038/s41416-019-0693-1. [Epub ahead of print]


PHF6 promotes non-homologous end joining and G2 checkpoint recovery.

Warmerdam DO, Alonso-de Vega I, Wiegant WW, van den Broek B, Rother MB, Wolthuis RM, Freire R, van Attikum H, Medema RH, Smits VA.

EMBO Rep. 2020 Jan 7;21(1):e48460. doi: 10.15252/embr.201948460. Epub 2019 Nov 29.


Characterization of a head and neck cancer-derived cell line panel confirms the distinct TP53-proficient copy number-silent subclass.

van Harten AM, Poell JB, Buijze M, Brink A, Wells SI, René Leemans C, Wolthuis RMF, Brakenhoff RH.

Oral Oncol. 2019 Nov;98:53-61. doi: 10.1016/j.oraloncology.2019.09.004. Epub 2019 Sep 18.


Targeting the cell cycle in head and neck cancer by Chk1 inhibition: a novel concept of bimodal cell death.

van Harten AM, Buijze M, van der Mast R, Rooimans MA, Martens-de Kemp SR, Bachas C, Brink A, Stigter-van Walsum M, Wolthuis RMF, Brakenhoff RH.

Oncogenesis. 2019 Jun 17;8(7):38. doi: 10.1038/s41389-019-0147-x.


Effective CRISPR/Cas9-mediated correction of a Fanconi anemia defect by error-prone end joining or templated repair.

van de Vrugt HJ, Harmsen T, Riepsaame J, Alexantya G, van Mil SE, de Vries Y, Bin Ali R, Huijbers IJ, Dorsman JC, Wolthuis RMF, Te Riele H.

Sci Rep. 2019 Jan 25;9(1):768. doi: 10.1038/s41598-018-36506-w.


Keeping ribosomal DNA intact: a repeating challenge.

Warmerdam DO, Wolthuis RMF.

Chromosome Res. 2019 Mar;27(1-2):57-72. doi: 10.1007/s10577-018-9594-z. Epub 2018 Dec 17. Review.


Rscreenorm: normalization of CRISPR and siRNA screen data for more reproducible hit selection.

Bachas C, Hodzic J, van der Mijn JC, Stoepker C, Verheul HMW, Wolthuis RMF, Felley-Bosco E, van Wieringen WN, van Beusechem VW, Brakenhoff RH, de Menezes RX.

BMC Bioinformatics. 2018 Aug 20;19(1):301. doi: 10.1186/s12859-018-2306-z.


[CRISPR/Cas: technique to repair DNA errors: is a clinical breakthrough near?]

van de Vrugt HJ, Cornel MC, Wolthuis RMF.

Ned Tijdschr Geneeskd. 2018 Jun 29;162. pii: D2461. Dutch.


Feedback regulation between atypical E2Fs and APC/CCdh1 coordinates cell cycle progression.

Boekhout M, Yuan R, Wondergem AP, Segeren HA, van Liere EA, Awol N, Jansen I, Wolthuis RM, de Bruin A, Westendorp B.

EMBO Rep. 2016 Mar;17(3):414-27. doi: 10.15252/embr.201540984. Epub 2016 Feb 5.


The lethal response to Cdk1 inhibition depends on sister chromatid alignment errors generated by KIF4 and isoform 1 of PRC1.

Voets E, Marsman J, Demmers J, Beijersbergen R, Wolthuis R.

Sci Rep. 2015 Oct 1;5:14798. doi: 10.1038/srep14798.


Defective sister chromatid cohesion is synthetically lethal with impaired APC/C function.

de Lange J, Faramarz A, Oostra AB, de Menezes RX, van der Meulen IH, Rooimans MA, Rockx DA, Brakenhoff RH, van Beusechem VW, King RW, de Winter JP, Wolthuis RMF.

Nat Commun. 2015 Oct 1;6:8399. doi: 10.1038/ncomms9399.


MASTL promotes cyclin B1 destruction by enforcing Cdc20-independent binding of cyclin B1 to the APC/C.

Voets E, Wolthuis R.

Biol Open. 2015 Mar 6;4(4):484-95. doi: 10.1242/bio.201410793.


Nek2A destruction marks APC/C activation at the prophase-to-prometaphase transition by spindle-checkpoint-restricted Cdc20.

Boekhout M, Wolthuis R.

J Cell Sci. 2015 Apr 15;128(8):1639-53. doi: 10.1242/jcs.163279. Epub 2015 Feb 11.


Inefficient degradation of cyclin B1 re-activates the spindle checkpoint right after sister chromatid disjunction.

Clijsters L, van Zon W, Riet BT, Voets E, Boekhout M, Ogink J, Rumpf-Kienzl C, Wolthuis RM.

Cell Cycle. 2014;13(15):2370-8. doi: 10.4161/cc.29336.


PIP-box-mediated degradation prohibits re-accumulation of Cdc6 during S phase.

Clijsters L, Wolthuis R.

J Cell Sci. 2014 Mar 15;127(Pt 6):1336-45. doi: 10.1242/jcs.145862. Epub 2014 Jan 16.


The spindle checkpoint, APC/C(Cdc20), and APC/C(Cdh1) play distinct roles in connecting mitosis to S phase.

Clijsters L, Ogink J, Wolthuis R.

J Cell Biol. 2013 Jun 24;201(7):1013-26. doi: 10.1083/jcb.201211019. Epub 2013 Jun 17.


Stable government of mitosis by Greatwall: the emperor's best servant.

Voets E, Wolthuis RM.

Mol Cell Biol. 2012 Apr;32(8):1334-6. doi: 10.1128/MCB.00213-12. Epub 2012 Mar 5. No abstract available.


MASTL is the human orthologue of Greatwall kinase that facilitates mitotic entry, anaphase and cytokinesis.

Voets E, Wolthuis RM.

Cell Cycle. 2010 Sep 1;9(17):3591-601. Epub 2010 Sep 29.


The APC/C recruits cyclin B1-Cdk1-Cks in prometaphase before D box recognition to control mitotic exit.

van Zon W, Ogink J, ter Riet B, Medema RH, te Riele H, Wolthuis RM.

J Cell Biol. 2010 Aug 23;190(4):587-602. doi: 10.1083/jcb.200912084.


IR spectral imaging of secreted mucus: a promising new tool for the histopathological recognition of human colonic adenocarcinomas.

Travo A, Piot O, Wolthuis R, Gobinet C, Manfait M, Bara J, Forgue-Lafitte ME, Jeannesson P.

Histopathology. 2010 Jun;56(7):921-31. doi: 10.1111/j.1365-2559.2010.03563.x. Epub 2010 May 25.


Cyclin A and Nek2A: APC/C-Cdc20 substrates invisible to the mitotic spindle checkpoint.

van Zon W, Wolthuis RM.

Biochem Soc Trans. 2010 Feb;38(Pt 1):72-7. doi: 10.1042/BST0380072. Review.


Cdc20 is required for the post-anaphase, KEN-dependent degradation of centromere protein F.

Gurden MD, Holland AJ, van Zon W, Tighe A, Vergnolle MA, Andres DA, Spielmann HP, Malumbres M, Wolthuis RM, Cleveland DW, Taylor SS.

J Cell Sci. 2010 Feb 1;123(Pt 3):321-30. doi: 10.1242/jcs.062075. Epub 2010 Jan 5.


The cellular phenotype of Roberts syndrome fibroblasts as revealed by ectopic expression of ESCO2.

van der Lelij P, Godthelp BC, van Zon W, van Gosliga D, Oostra AB, Steltenpool J, de Groot J, Scheper RJ, Wolthuis RM, Waisfisz Q, Darroudi F, Joenje H, de Winter JP.

PLoS One. 2009 Sep 7;4(9):e6936. doi: 10.1371/journal.pone.0006936.


Polo-like kinase-1 controls Aurora A destruction by activating APC/C-Cdh1.

van Leuken R, Clijsters L, van Zon W, Lim D, Yao X, Wolthuis RM, Yaffe MB, Medema RH, van Vugt MA.

PLoS One. 2009;4(4):e5282. doi: 10.1371/journal.pone.0005282. Epub 2009 Apr 23.


IR spectral imaging for histopathological characterization of xenografted human colon carcinomas.

Wolthuis R, Travo A, Nicolet C, Neuville A, Gaub MP, Guenot D, Ly E, Manfait M, Jeannesson P, Piot O.

Anal Chem. 2008 Nov 15;80(22):8461-9. doi: 10.1021/ac801191x. Epub 2008 Oct 11.


Usp39 is essential for mitotic spindle checkpoint integrity and controls mRNA-levels of aurora B.

van Leuken RJ, Luna-Vargas MP, Sixma TK, Wolthuis RM, Medema RH.

Cell Cycle. 2008 Sep 1;7(17):2710-9. Epub 2008 Sep 3.


To cell cycle, swing the APC/C.

van Leuken R, Clijsters L, Wolthuis R.

Biochim Biophys Acta. 2008 Sep;1786(1):49-59. doi: 10.1016/j.bbcan.2008.05.002. Epub 2008 May 21. Review.


Cdc20 and Cks direct the spindle checkpoint-independent destruction of cyclin A.

Wolthuis R, Clay-Farrace L, van Zon W, Yekezare M, Koop L, Ogink J, Medema R, Pines J.

Mol Cell. 2008 May 9;30(3):290-302. doi: 10.1016/j.molcel.2008.02.027.


Combination of FTIR spectral imaging and chemometrics for tumour detection from paraffin-embedded biopsies.

Ly E, Piot O, Wolthuis R, Durlach A, Bernard P, Manfait M.

Analyst. 2008 Feb;133(2):197-205. doi: 10.1039/b715924b. Epub 2007 Dec 20.


Cyclin B1-Cdk1 activation continues after centrosome separation to control mitotic progression.

Lindqvist A, van Zon W, Karlsson Rosenthal C, Wolthuis RM.

PLoS Biol. 2007 May;5(5):e123.


Raman spectroscopic characterization of porcine brain tissue using a single fiber-optic probe.

Koljenović S, Schut TC, Wolthuis R, Vincent AJ, Hendriks-Hagevi G, Santos L, Kros JM, Puppels GJ.

Anal Chem. 2007 Jan 15;79(2):557-64.


Mitogen requirement for cell cycle progression in the absence of pocket protein activity.

Foijer F, Wolthuis RM, Doodeman V, Medema RH, te Riele H.

Cancer Cell. 2005 Dec;8(6):455-66. Erratum in: Cancer Cell. 2006 Jan;9(1):71.


Tissue characterization using high wave number Raman spectroscopy.

Koljenović S, Bakker Schut TC, Wolthuis R, de Jong B, Santos L, Caspers PJ, Kros JM, Puppels GJ.

J Biomed Opt. 2005 May-Jun;10(3):031116.


Fiber-optic probes for in vivo Raman spectroscopy in the high-wavenumber region.

Santos LF, Wolthuis R, Koljenović S, Almeida RM, Puppels GJ.

Anal Chem. 2005 Oct 15;77(20):6747-52.


Uncoupling anaphase-promoting complex/cyclosome activity from spindle assembly checkpoint control by deregulating polo-like kinase 1.

van de Weerdt BC, van Vugt MA, Lindon C, Kauw JJ, Rozendaal MJ, Klompmaker R, Wolthuis RM, Medema RH.

Mol Cell Biol. 2005 Mar;25(5):2031-44.


Polo-like kinase-1 is required for bipolar spindle formation but is dispensable for anaphase promoting complex/Cdc20 activation and initiation of cytokinesis.

van Vugt MA, van de Weerdt BC, Vader G, Janssen H, Calafat J, Klompmaker R, Wolthuis RM, Medema RH.

J Biol Chem. 2004 Aug 27;279(35):36841-54. Epub 2004 Jun 21.


Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension.

Lens SM, Wolthuis RM, Klompmaker R, Kauw J, Agami R, Brummelkamp T, Kops G, Medema RH.

EMBO J. 2003 Jun 16;22(12):2934-47.


A new intracoronary measurement catheter, MetriCath, compared to intravascular ultrasound and quantitative coronary angiography in a stented porcine coronary model.

van der Giessen WJ, Carlier SG, Regar E, van Beusekom HM, Foley DP, de Feyter PJ, Verdouw PD, Boersma E, Wolthuis R, Serruys PW.

Catheter Cardiovasc Interv. 2002 Sep;57(1):2-9; discussion 10-1.


Guanine nucleotide exchange factor-like factor (Rlf) induces gene expression and potentiates alpha 1-adrenergic receptor-induced transcriptional responses in neonatal rat ventricular myocytes.

Post GR, Swiderski C, Waldrop BA, Salty L, Glembotski CC, Wolthuis RM, Mochizuki N.

J Biol Chem. 2002 May 3;277(18):15286-92. Epub 2002 Feb 14.


Determination of water concentration in brain tissue by Raman spectroscopy.

Wolthuis R, van Aken M, Fountas K, Robinson JS Jr, Bruining HA, Puppels GJ.

Anal Chem. 2001 Aug 15;73(16):3915-20.


Ras-dependent regulation of c-Jun phosphorylation is mediated by the Ral guanine nucleotide exchange factor-Ral pathway.

de Ruiter ND, Wolthuis RM, van Dam H, Burgering BM, Bos JL.

Mol Cell Biol. 2000 Nov;20(22):8480-8.


RalGEF2, a pleckstrin homology domain containing guanine nucleotide exchange factor for Ral.

de Bruyn KM, de Rooij J, Wolthuis RM, Rehmann H, Wesenbeek J, Cool RH, Wittinghofer AH, Bos JL.

J Biol Chem. 2000 Sep 22;275(38):29761-6.


The small GTPase, Rap1, mediates CD31-induced integrin adhesion.

Reedquist KA, Ross E, Koop EA, Wolthuis RM, Zwartkruis FJ, van Kooyk Y, Salmon M, Buckley CD, Bos JL.

J Cell Biol. 2000 Mar 20;148(6):1151-8.


Interdependent action of RalGEF and Erk in Ras-induced primitive endoderm differentiation of F9 embryonal carcinoma cells.

Verheijen MH, Wolthuis RM, Defize LH, den Hertog J, Bos JL.

Oncogene. 1999 Aug 5;18(31):4435-9.


Differential fMet-Leu-Phe- and platelet-activating factor-induced signaling toward Ral activation in primary human neutrophils.

M'Rabet L, Coffer PJ, Wolthuis RM, Zwartkruis F, Koenderman L, Bos JL.

J Biol Chem. 1999 Jul 30;274(31):21847-52.


Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2.

Nancy V, Wolthuis RM, de Tand MF, Janoueix-Lerosey I, Bos JL, de Gunzburg J.

J Biol Chem. 1999 Mar 26;274(13):8737-45.


Ras caught in another affair: the exchange factors for Ral.

Wolthuis RM, Bos JL.

Curr Opin Genet Dev. 1999 Feb;9(1):112-7. Review.


Raman spectroscopy for quantifying cholesterol in intact coronary artery wall.

Römer TJ, Brennan JF 3rd, Schut TC, Wolthuis R, van den Hoogen RC, Emeis JJ, van der Laarse A, Bruschke AV, Puppels GJ.

Atherosclerosis. 1998 Nov;141(1):117-24.


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