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Items: 39


Hyperbaric oxygen therapy accelerates wound healing in diabetic mice by decreasing active matrix metalloproteinase-9.

Nguyen TT, Jones JI, Wolter WR, Pérez RL, Schroeder VA, Champion MM, Hesek D, Lee M, Suckow MA, Mobashery S, Chang M.

Wound Repair Regen. 2019 Nov 17. doi: 10.1111/wrr.12782. [Epub ahead of print]


Digitoxin Inhibits Epithelial-to-Mesenchymal-Transition in Hereditary Castration Resistant Prostate Cancer.

Pollard BS, Suckow MA, Wolter WR, Starr JM, Eidelman O, Dalgard CL, Kumar P, Battacharyya S, Srivastava M, Biswas R, Wilkerson MD, Zhang X, Yang Q, Pollard HB.

Front Oncol. 2019 Aug 2;9:630. doi: 10.3389/fonc.2019.00630. eCollection 2019.


The Quinazolinone Allosteric Inhibitor of PBP 2a Synergizes with Piperacillin and Tazobactam against Methicillin-Resistant Staphylococcus aureus.

Janardhanan J, Bouley R, Martínez-Caballero S, Peng Z, Batuecas-Mordillo M, Meisel JE, Ding D, Schroeder VA, Wolter WR, Mahasenan KV, Hermoso JA, Mobashery S, Chang M.

Antimicrob Agents Chemother. 2019 Apr 25;63(5). pii: e02637-18. doi: 10.1128/AAC.02637-18. Print 2019 May.


Validation of Matrix Metalloproteinase-9 (MMP-9) as a Novel Target for Treatment of Diabetic Foot Ulcers in Humans and Discovery of a Potent and Selective Small-Molecule MMP-9 Inhibitor That Accelerates Healing.

Nguyen TT, Ding D, Wolter WR, Pérez RL, Champion MM, Mahasenan KV, Hesek D, Lee M, Schroeder VA, Jones JI, Lastochkin E, Rose MK, Peterson CE, Suckow MA, Mobashery S, Chang M.

J Med Chem. 2018 Oct 11;61(19):8825-8837. doi: 10.1021/acs.jmedchem.8b01005. Epub 2018 Sep 27.


In Search of Selectivity in Inhibition of ADAM10.

Mahasenan KV, Ding D, Gao M, Nguyen TT, Suckow MA, Schroeder VA, Wolter WR, Chang M, Mobashery S.

ACS Med Chem Lett. 2018 Jun 11;9(7):708-713. doi: 10.1021/acsmedchemlett.8b00163. eCollection 2018 Jul 12.


Expression of active matrix metalloproteinase-9 as a likely contributor to the clinical failure of aclerastide in treatment of diabetic foot ulcers.

Nguyen TT, Ding D, Wolter WR, Champion MM, Hesek D, Lee M, Pérez RL, Schroeder VA, Suckow MA, Mobashery S, Chang M.

Eur J Pharmacol. 2018 Sep 5;834:77-83. doi: 10.1016/j.ejphar.2018.07.014. Epub 2018 Jul 19.


The Impact of Environmental Light Intensity on Experimental Tumor Growth.

Suckow MA, Wolter WR, Duffield GE.

Anticancer Res. 2017 Sep;37(9):4967-4971.


Exploitation of Conformational Dynamics in Imparting Selective Inhibition for Related Matrix Metalloproteinases.

Mahasenan KV, Bastian M, Gao M, Frost E, Ding D, Zorina-Lichtenwalter K, Jacobs J, Suckow MA, Schroeder VA, Wolter WR, Chang M, Mobashery S.

ACS Med Chem Lett. 2017 May 1;8(6):654-659. doi: 10.1021/acsmedchemlett.7b00130. eCollection 2017 Jun 8.


Targeted Antibiotic Delivery: Selective Siderophore Conjugation with Daptomycin Confers Potent Activity against Multidrug Resistant Acinetobacter baumannii Both in Vitro and in Vivo.

Ghosh M, Miller PA, Möllmann U, Claypool WD, Schroeder VA, Wolter WR, Suckow M, Yu H, Li S, Huang W, Zajicek J, Miller MJ.

J Med Chem. 2017 Jun 8;60(11):4577-4583. doi: 10.1021/acs.jmedchem.7b00102. Epub 2017 Apr 1.


Selective Inhibition of MMP-2 Does Not Alter Neurological Recovery after Spinal Cord Injury.

Gao M, Zhang H, Trivedi A, Mahasenan KV, Schroeder VA, Wolter WR, Suckow MA, Mobashery S, Noble-Haeusslein LJ, Chang M.

ACS Chem Neurosci. 2016 Nov 16;7(11):1482-1487. Epub 2016 Aug 25.


In Vitro and In Vivo Synergy of the Oxadiazole Class of Antibacterials with β-Lactams.

Janardhanan J, Meisel JE, Ding D, Schroeder VA, Wolter WR, Mobashery S, Chang M.

Antimicrob Agents Chemother. 2016 Aug 22;60(9):5581-8. doi: 10.1128/AAC.00787-16. Print 2016 Sep.


Structure-Activity Relationship for the 4(3H)-Quinazolinone Antibacterials.

Bouley R, Ding D, Peng Z, Bastian M, Lastochkin E, Song W, Suckow MA, Schroeder VA, Wolter WR, Mobashery S, Chang M.

J Med Chem. 2016 May 26;59(10):5011-21. doi: 10.1021/acs.jmedchem.6b00372. Epub 2016 May 5.


Acceleration of diabetic wound healing using a novel protease-anti-protease combination therapy.

Gao M, Nguyen TT, Suckow MA, Wolter WR, Gooyit M, Mobashery S, Chang M.

Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):15226-31. doi: 10.1073/pnas.1517847112. Epub 2015 Nov 23.


Synergistic, collaterally sensitive β-lactam combinations suppress resistance in MRSA.

Gonzales PR, Pesesky MW, Bouley R, Ballard A, Biddy BA, Suckow MA, Wolter WR, Schroeder VA, Burnham CA, Mobashery S, Chang M, Dantas G.

Nat Chem Biol. 2015 Nov;11(11):855-61. doi: 10.1038/nchembio.1911. Epub 2015 Sep 14.


Phenoxide-Bridged Zinc(II)-Bis(dipicolylamine) Probes for Molecular Imaging of Cell Death.

Clear KJ, Harmatys KM, Rice DR, Wolter WR, Suckow MA, Wang Y, Rusckowski M, Smith BD.

Bioconjug Chem. 2016 Feb 17;27(2):363-75. doi: 10.1021/acs.bioconjchem.5b00447. Epub 2015 Sep 11.


Water-Soluble MMP-9 Inhibitor Reduces Lesion Volume after Severe Traumatic Brain Injury.

Lee M, Chen Z, Tomlinson BN, Gooyit M, Hesek D, Juárez MR, Nizam R, Boggess B, Lastochkin E, Schroeder VA, Wolter WR, Suckow MA, Cui J, Mobashery S, Gu Z, Chang M.

ACS Chem Neurosci. 2015 Oct 21;6(10):1658-64. doi: 10.1021/acschemneuro.5b00140. Epub 2015 Aug 14.


Discovery of antibiotic (E)-3-(3-carboxyphenyl)-2-(4-cyanostyryl)quinazolin-4(3H)-one.

Bouley R, Kumarasiri M, Peng Z, Otero LH, Song W, Suckow MA, Schroeder VA, Wolter WR, Lastochkin E, Antunes NT, Pi H, Vakulenko S, Hermoso JA, Chang M, Mobashery S.

J Am Chem Soc. 2015 Feb 11;137(5):1738-41. doi: 10.1021/jacs.5b00056. Epub 2015 Feb 2.


Structure-activity relationship for the oxadiazole class of antibiotics.

Spink E, Ding D, Peng Z, Boudreau MA, Leemans E, Lastochkin E, Song W, Lichtenwalter K, O'Daniel PI, Testero SA, Pi H, Schroeder VA, Wolter WR, Antunes NT, Suckow MA, Vakulenko S, Chang M, Mobashery S.

J Med Chem. 2015 Feb 12;58(3):1380-9. doi: 10.1021/jm501661f. Epub 2015 Jan 30.


Library synthesis, screening, and discovery of modified Zinc(II)-Bis(dipicolylamine) probe for enhanced molecular imaging of cell death.

Plaunt AJ, Harmatys KM, Wolter WR, Suckow MA, Smith BD.

Bioconjug Chem. 2014 Apr 16;25(4):724-37. doi: 10.1021/bc500003x. Epub 2014 Mar 13.


Discovery of a new class of non-β-lactam inhibitors of penicillin-binding proteins with Gram-positive antibacterial activity.

O'Daniel PI, Peng Z, Pi H, Testero SA, Ding D, Spink E, Leemans E, Boudreau MA, Yamaguchi T, Schroeder VA, Wolter WR, Llarrull LI, Song W, Lastochkin E, Kumarasiri M, Antunes NT, Espahbodi M, Lichtenwalter K, Suckow MA, Vakulenko S, Mobashery S, Chang M.

J Am Chem Soc. 2014 Mar 5;136(9):3664-72. doi: 10.1021/ja500053x. Epub 2014 Feb 21.


A chemical biological strategy to facilitate diabetic wound healing.

Gooyit M, Peng Z, Wolter WR, Pi H, Ding D, Hesek D, Lee M, Boggess B, Champion MM, Suckow MA, Mobashery S, Chang M.

ACS Chem Biol. 2014 Jan 17;9(1):105-10. doi: 10.1021/cb4005468. Epub 2013 Sep 26.


O-phenyl carbamate and phenyl urea thiiranes as selective matrix metalloproteinase-2 inhibitors that cross the blood-brain barrier.

Gooyit M, Song W, Mahasenan KV, Lichtenwalter K, Suckow MA, Schroeder VA, Wolter WR, Mobashery S, Chang M.

J Med Chem. 2013 Oct 24;56(20):8139-50. doi: 10.1021/jm401217d. Epub 2013 Oct 8.


Water-soluble mmp-9 inhibitor prodrug generates active metabolites that cross the blood-brain barrier.

Song W, Peng Z, Gooyit M, Suckow MA, Schroeder VA, Wolter WR, Lee M, Ikejiri M, Cui J, Gu Z, Chang M.

ACS Chem Neurosci. 2013 Aug 21;4(8):1168-73. doi: 10.1021/cn400077d. Epub 2013 May 30.


Selective gelatinase inhibitor neuroprotective agents cross the blood-brain barrier.

Gooyit M, Suckow MA, Schroeder VA, Wolter WR, Mobashery S, Chang M.

ACS Chem Neurosci. 2012 Oct 17;3(10):730-6. doi: 10.1021/cn300062w. Epub 2012 Jul 30.


Bupivacaine-enhanced small intestinal submucosa biomaterial as a hernia repair device.

Suckow MA, Wolter WR, Fecteau C, Labadie-Suckow SM, Johnson C.

J Biomater Appl. 2012 Aug;27(2):231-7. doi: 10.1177/0885328211406298. Epub 2011 Jun 16.


Synthesis and evaluation of 5-lipoxygenase translocation inhibitors from acylnitroso hetero-Diels-Alder cycloadducts.

Bolger JK, Tian W, Wolter WR, Cho W, Suckow MA, Miller MJ.

Org Biomol Chem. 2011 Apr 21;9(8):2999-3010. doi: 10.1039/c0ob00714e. Epub 2011 Mar 2.


Pro-inflammatory angiogenesis is mediated by p38 MAP kinase.

Rajashekhar G, Kamocka M, Marin A, Suckow MA, Wolter WR, Badve S, Sanjeevaiah AR, Pumiglia K, Rosen E, Clauss M.

J Cell Physiol. 2011 Mar;226(3):800-8. doi: 10.1002/jcp.22404.


Addition of nimesulide to small intestinal submucosa biomaterial inhibits postsurgical adhesiogenesis in rats.

Suckow MA, Hodde JP, Wolter WR, Wood KV, Hiles MC, Janis AD.

J Biomed Mater Res B Appl Biomater. 2010 Apr;93(1):18-23. doi: 10.1002/jbm.b.31545.


A potent gelatinase inhibitor with anti-tumor-invasive activity and its metabolic disposition.

Lee M, Celenza G, Boggess B, Blase J, Shi Q, Toth M, Bernardo MM, Wolter WR, Suckow MA, Hesek D, Noll BC, Fridman R, Mobashery S, Chang M.

Chem Biol Drug Des. 2009 Feb;73(2):189-202. doi: 10.1111/j.1747-0285.2008.00750.x.


Inhibition of prostate cancer metastasis by administration of a tissue vaccine.

Suckow MA, Wolter WR, Sailes VT.

Clin Exp Metastasis. 2008;25(8):913-8. doi: 10.1007/s10585-008-9213-z. Epub 2008 Sep 28.


Immunization with a tissue vaccine enhances the effect of irradiation on prostate tumors.

Suckow MA, Wheeler J, Wolter WR, Sailes V, Yan M.

In Vivo. 2008 Mar-Apr;22(2):171-7.


Metabolism of (4-phenoxyphenylsulfonyl) methylthiirane, a selective gelatinase inhibitor.

Celenza G, Villegas-Estrada A, Lee M, Boggess B, Forbes C, Wolter WR, Suckow MA, Mobashery S, Chang M.

Chem Biol Drug Des. 2008 Mar;71(3):187-96. doi: 10.1111/j.1747-0277.2008.00632.x.


Repair of experimental Achilles tenotomy with porcine renal capsule material in a rat model.

Suckow MA, Hodde JP, Wolter WR, Hiles MC.

J Mater Sci Mater Med. 2007 Jun;18(6):1105-10. Epub 2007 Feb 1.


Prevention of human PC-346C prostate cancer growth in mice by a xenogeneic tissue vaccine.

Suckow MA, Rosen ED, Wolter WR, Sailes V, Jeffrey R, Tenniswood M.

Cancer Immunol Immunother. 2007 Aug;56(8):1275-83. Epub 2007 Jan 23.


Use of mucosal immunization with porcine zona pellucida (PZP) in mice and rabbits.

Martin BJ, Suckow MA, Wolter WR, Berger T, Turner JW Jr.

Anim Reprod Sci. 2006 Jul;93(3-4):372-8. Epub 2005 Oct 24.


Prevention of de novo prostate cancer by immunization with tumor-derived vaccines.

Suckow MA, Wolter WR, Pollard M.

Cancer Immunol Immunother. 2005 Jun;54(6):571-6. Epub 2005 Feb 1.


Small intestinal submucosa does not promote PAIII tumor growth in Lobund-Wistar rats.

Hodde JP, Suckow MA, Wolter WR, Hiles MC.

J Surg Res. 2004 Aug;120(2):189-94.


The anti-ischemia agent ranolazine promotes the development of intestinal tumors in APC(Min/+) mice.

Suckow MA, Gutierrez LS, Risatti CA, Wolter WR, Taylor RE, Pollard M, Navari RM, Castellino FJ, Paoni NF.

Cancer Lett. 2004 Jun 25;209(2):165-9.


Prostate-seminal vesicle cancers induced in noble rats.

Pollard M, Wolter WR, Sun L.

Prostate. 2000 Apr 1;43(1):71-4.


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