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Randomized Placebo-Controlled Trial Evaluating the Ophthalmic Safety of Single-Dose Tafenoquine in Healthy Volunteers.

Ackert J, Mohamed K, Slakter JS, El-Harazi S, Berni A, Gevorkyan H, Hardaker E, Hussaini A, Jones SW, Koh GCKW, Patel J, Rasmussen S, Kelly DS, Barañano DE, Thompson JT, Warren KA, Sergott RC, Tonkyn J, Wolstenholme A, Coleman H, Yuan A, Duparc S, Green JA.

Drug Saf. 2019 Sep;42(9):1103-1114. doi: 10.1007/s40264-019-00839-w.


Refugia and anthelmintic resistance: Concepts and challenges.

Hodgkinson JE, Kaplan RM, Kenyon F, Morgan ER, Park AW, Paterson S, Babayan SA, Beesley NJ, Britton C, Chaudhry U, Doyle SR, Ezenwa VO, Fenton A, Howell SB, Laing R, Mable BK, Matthews L, McIntyre J, Milne CE, Morrison TA, Prentice JC, Sargison ND, Williams DJL, Wolstenholme AJ, Devaney E.

Int J Parasitol Drugs Drug Resist. 2019 May 17;10:51-57. doi: 10.1016/j.ijpddr.2019.05.001. [Epub ahead of print] Review.


Macrocyclic lactone anthelmintic-induced leukocyte binding to Dirofilaria immitis microfilariae: Influence of the drug resistance status of the parasite.

Berrafato T, Coates R, Reaves BJ, Kulke D, Wolstenholme AJ.

Int J Parasitol Drugs Drug Resist. 2019 Apr 26;10:45-50. doi: 10.1016/j.ijpddr.2019.04.004. [Epub ahead of print]


Efficacy and side effects of doxycycline versus minocycline in the three-dose melarsomine canine adulticidal heartworm treatment protocol.

Savadelis MD, Day KM, Bradner JL, Wolstenholme AJ, Dzimianski MT, Moorhead AR.

Parasit Vectors. 2018 Dec 27;11(1):671. doi: 10.1186/s13071-018-3264-z.


Anthelmintics - From Discovery to Resistance III (Indian Rocks Beach, FL, 2018).

Wolstenholme AJ, Martin RJ.

Int J Parasitol Drugs Drug Resist. 2018 Dec;8(3):494-495. doi: 10.1016/j.ijpddr.2018.11.002. Epub 2018 Nov 5.


Recognition and killing of Brugia malayi microfilariae by human immune cells is dependent on the parasite sample and is not altered by ivermectin treatment.

Reaves BJ, Wallis C, McCoy CJ, Lorenz WW, Rada B, Wolstenholme AJ.

Int J Parasitol Drugs Drug Resist. 2018 Dec;8(3):587-595. doi: 10.1016/j.ijpddr.2018.09.002. Epub 2018 Sep 22.


Bioequivalence of a Fixed-Dose Combination Tablet of the Complete Two-Drug Regimen of Dolutegravir and Rilpivirine for Treatment of HIV-1 Infection.

Mehta R, Wolstenholme A, Di Lullo K, Fu C, Joshi S, Crauwels H, Givens N, Vanveggel S, Wynne B, Adkison K.

Antimicrob Agents Chemother. 2018 Aug 27;62(9). pii: e00748-18. doi: 10.1128/AAC.00748-18. Print 2018 Sep.


Deciphering the molecular determinants of cholinergic anthelmintic sensitivity in nematodes: When novel functional validation approaches highlight major differences between the model Caenorhabditis elegans and parasitic species.

Blanchard A, Guégnard F, Charvet CL, Crisford A, Courtot E, Sauvé C, Harmache A, Duguet T, O'Connor V, Castagnone-Sereno P, Reaves B, Wolstenholme AJ, Beech RN, Holden-Dye L, Neveu C.

PLoS Pathog. 2018 May 2;14(5):e1006996. doi: 10.1371/journal.ppat.1006996. eCollection 2018 May.


Randomized clinical study of safety, pharmacokinetics, and pharmacodynamics of RIPK1 inhibitor GSK2982772 in healthy volunteers.

Weisel K, Scott NE, Tompson DJ, Votta BJ, Madhavan S, Povey K, Wolstenholme A, Simeoni M, Rudo T, Richards-Peterson L, Sahota T, Wang JG, Lich J, Finger J, Verticelli A, Reilly M, Gough PJ, Harris PA, Bertin J, Wang ML.

Pharmacol Res Perspect. 2017 Dec;5(6). doi: 10.1002/prp2.365.


Improving screening and brief intervention activities in primary health care: Secondary analysis of professional accuracy based on the AUDIT-C.

Palacio-Vieira J, Segura L, Anderson P, Wolstenholme A, Drummond C, Bendtsen P, Wojnar M, Kaner E, Keurhorst MN, van Steenkiste B, Kłoda K, Mierzecki A, Parkinson K, Newbury-Birch D, Okulicz-Kozaryn K, Deluca P, Colom J, Gual A.

J Eval Clin Pract. 2018 Apr;24(2):369-374. doi: 10.1111/jep.12854. Epub 2017 Dec 1.


A National Survey of Assertive Outreach Treatment Services for People Who Frequently Attend Hospital due to Alcohol-Related Reasons in England.

Fincham-Campbell S, Kimergård A, Wolstenholme A, Blackwood R, Patton R, Dunne J, Deluca P, Drummond C.

Alcohol Alcohol. 2018 May 1;53(3):277-281. doi: 10.1093/alcalc/agx095.


Effect of Sorbitol on the Pharmacokinetic Profile of Lamivudine Oral Solution in Adults: An Open-Label, Randomized Study.

Adkison K, Wolstenholme A, Lou Y, Zhang Z, Eld A, Perger T, Vangerow H, Hayward K, Shaefer M, McCoig C.

Clin Pharmacol Ther. 2018 Mar;103(3):402-408. doi: 10.1002/cpt.943. Epub 2017 Dec 11.


Does evaluation of in vitro microfilarial motility reflect the resistance status of Dirofilaria immitis isolates to macrocyclic lactones?

Maclean MJ, Savadelis MD, Coates R, Dzimianski MT, Jones C, Benbow C, Storey BE, Kaplan RM, Moorhead AR, Wolstenholme AJ.

Parasit Vectors. 2017 Nov 9;10(Suppl 2):480. doi: 10.1186/s13071-017-2436-6.


Evaluation of the larval migration inhibition assay for detecting macrocyclic lactone resistance in Dirofilaria immitis.

Evans CC, Moorhead AR, Storey BE, Blagburn BL, Wolstenholme AJ, Kaplan RM.

Vet Parasitol. 2017 Nov 15;246:76-81. doi: 10.1016/j.vetpar.2017.09.003. Epub 2017 Sep 8.


Human Leukocytes Kill Brugia malayi Microfilariae Independently of DNA-Based Extracellular Trap Release.

McCoy CJ, Reaves BJ, Giguère S, Coates R, Rada B, Wolstenholme AJ.

PLoS Negl Trop Dis. 2017 Jan 3;11(1):e0005279. doi: 10.1371/journal.pntd.0005279. eCollection 2017 Jan.


Anthelmintics: From discovery to resistance II (San Diego, 2016).

Martin RJ, Wolstenholme AJ, Caffrey CR.

Int J Parasitol Drugs Drug Resist. 2016 Dec;6(3):297-298. doi: 10.1016/j.ijpddr.2016.09.002. Epub 2016 Sep 29.


Impact of primary healthcare providers' initial role security and therapeutic commitment on implementing brief interventions in managing risky alcohol consumption: a cluster randomised factorial trial.

Keurhorst M, Anderson P, Heinen M, Bendtsen P, Baena B, Brzózka K, Colom J, Deluca P, Drummond C, Kaner E, Kłoda K, Mierzecki A, Newbury-Birch D, Okulicz-Kozaryn K, Palacio-Vieira J, Parkinson K, Reynolds J, Ronda G, Segura L, Słodownik L, Spak F, van Steenkiste B, Wallace P, Wolstenholme A, Wojnar M, Gual A, Laurant M, Wensing M.

Implement Sci. 2016 Jul 16;11:96. doi: 10.1186/s13012-016-0468-5.


How do the macrocyclic lactones kill filarial nematode larvae?

Wolstenholme AJ, Maclean MJ, Coates R, McCoy CJ, Reaves BJ.

Invert Neurosci. 2016 Sep;16(3):7. doi: 10.1007/s10158-016-0190-7. Epub 2016 Jun 9. Review.


Improving the delivery of brief interventions for heavy drinking in primary health care: outcome results of the Optimizing Delivery of Health Care Intervention (ODHIN) five-country cluster randomized factorial trial.

Anderson P, Bendtsen P, Spak F, Reynolds J, Drummond C, Segura L, Keurhorst MN, Palacio-Vieira J, Wojnar M, Parkinson K, Colom J, Kłoda K, Deluca P, Baena B, Newbury-Birch D, Wallace P, Heinen M, Wolstenholme A, van Steenkiste B, Mierzecki A, Okulicz-Kozaryn K, Ronda G, Kaner E, Laurant MG, Coulton S, Gual T.

Addiction. 2016 Nov;111(11):1935-1945. doi: 10.1111/add.13476. Epub 2016 Jul 25.


Expression of nicotinic acetylcholine receptor subunits from parasitic nematodes in Caenorhabditis elegans.

Sloan MA, Reaves BJ, Maclean MJ, Storey BE, Wolstenholme AJ.

Mol Biochem Parasitol. 2015 Nov;204(1):44-50. doi: 10.1016/j.molbiopara.2015.12.006. Epub 2015 Dec 30.


Functional Characterization of a Novel Class of Morantel-Sensitive Acetylcholine Receptors in Nematodes.

Courtot E, Charvet CL, Beech RN, Harmache A, Wolstenholme AJ, Holden-Dye L, O'Connor V, Peineau N, Woods DJ, Neveu C.

PLoS Pathog. 2015 Dec 1;11(12):e1005267. doi: 10.1371/journal.ppat.1005267. eCollection 2015 Dec.


Transient effects of levamisole on Brugia malayi microfilariae.

Mostafa E, Storey B, Farghaly AM, Afify HA, Taha AA, Wolstenholme AJ.

Invert Neurosci. 2015 Sep;15(3):5. doi: 10.1007/s10158-015-0181-0. Epub 2015 Jul 18.


The emergence of macrocyclic lactone resistance in the canine heartworm, Dirofilaria immitis.

Wolstenholme AJ, Evans CC, Jimenez PD, Moorhead AR.

Parasitology. 2015 Sep;142(10):1249-59. doi: 10.1017/S003118201500061X. Epub 2015 Jun 4. Review.


Professional's Attitudes Do Not Influence Screening and Brief Interventions Rates for Hazardous and Harmful Drinkers: Results from ODHIN Study.

Bendtsen P, Anderson P, Wojnar M, Newbury-Birch D, Müssener U, Colom J, Karlsson N, Brzózka K, Spak F, Deluca P, Drummond C, Kaner E, Kłoda K, Mierzecki A, Okulicz-Kozaryn K, Parkinson K, Reynolds J, Ronda G, Segura L, Palacio J, Baena B, Slodownik L, van Steenkiste B, Wolstenholme A, Wallace P, Keurhorst MN, Laurant MG, Gual A.

Alcohol Alcohol. 2015 Jul;50(4):430-7. doi: 10.1093/alcalc/agv020. Epub 2015 Mar 18.


Enhanced resolution through thick tissue with structured illumination and adaptive optics.

Thomas B, Wolstenholme A, Chaudhari SN, Kipreos ET, Kner P.

J Biomed Opt. 2015 Feb;20(2):26006. doi: 10.1117/1.JBO.20.2.026006.


Molecular basis for convergent evolution of glutamate recognition by pentameric ligand-gated ion channels.

Lynagh T, Beech RN, Lalande MJ, Keller K, Cromer BA, Wolstenholme AJ, Laube B.

Sci Rep. 2015 Feb 24;5:8558. doi: 10.1038/srep08558.


Characterization of the Ca2+-gated and voltage-dependent K+-channel Slo-1 of nematodes and its interaction with emodepside.

Kulke D, von Samson-Himmelstjerna G, Miltsch SM, Wolstenholme AJ, Jex AR, Gasser RB, Ballesteros C, Geary TG, Keiser J, Townson S, Harder A, Krücken J.

PLoS Negl Trop Dis. 2014 Dec 18;8(12):e3401. doi: 10.1371/journal.pntd.0003401. eCollection 2014 Dec.


Utilization of computer processed high definition video imaging for measuring motility of microscopic nematode stages on a quantitative scale: "The Worminator".

Storey B, Marcellino C, Miller M, Maclean M, Mostafa E, Howell S, Sakanari J, Wolstenholme A, Kaplan R.

Int J Parasitol Drugs Drug Resist. 2014 Aug 28;4(3):233-43. doi: 10.1016/j.ijpddr.2014.08.003. eCollection 2014 Dec.


Anthelmintics - from discovery to resistance.

Wolstenholme AJ, Martin RJ.

Int J Parasitol Drugs Drug Resist. 2014 Nov 22;4(3):218-9. doi: 10.1016/j.ijpddr.2014.10.001. eCollection 2014 Dec.


Recent advances in candidate-gene and whole-genome approaches to the discovery of anthelmintic resistance markers and the description of drug/receptor interactions.

Kotze AC, Hunt PW, Skuce P, von Samson-Himmelstjerna G, Martin RJ, Sager H, Krücken J, Hodgkinson J, Lespine A, Jex AR, Gilleard JS, Beech RN, Wolstenholme AJ, Demeler J, Robertson AP, Charvet CL, Neveu C, Kaminsky R, Rufener L, Alberich M, Menez C, Prichard RK.

Int J Parasitol Drugs Drug Resist. 2014 Aug 13;4(3):164-84. doi: 10.1016/j.ijpddr.2014.07.007. eCollection 2014 Dec. Review.


Ivermectin-dependent attachment of neutrophils and peripheral blood mononuclear cells to Dirofilaria immitis microfilariae in vitro.

Vatta AF, Dzimianski M, Storey BE, Camus MS, Moorhead AR, Kaplan RM, Wolstenholme AJ.

Vet Parasitol. 2014 Nov 15;206(1-2):38-42. doi: 10.1016/j.vetpar.2014.02.004. Epub 2014 Feb 12.


Development of an in vitro bioassay for measuring susceptibility to macrocyclic lactone anthelmintics in Dirofilaria immitis.

Evans CC, Moorhead AR, Storey BE, Wolstenholme AJ, Kaplan RM.

Int J Parasitol Drugs Drug Resist. 2013 Jun 6;3:102-8. doi: 10.1016/j.ijpddr.2013.05.001. eCollection 2013 Dec.


FGT-1 is the major glucose transporter in C. elegans and is central to aging pathways.

Feng Y, Williams BG, Koumanov F, Wolstenholme AJ, Holman GD.

Biochem J. 2013 Dec 1;456(2):219-29. doi: 10.1042/BJ20131101.


The genome and transcriptome of Haemonchus contortus, a key model parasite for drug and vaccine discovery.

Laing R, Kikuchi T, Martinelli A, Tsai IJ, Beech RN, Redman E, Holroyd N, Bartley DJ, Beasley H, Britton C, Curran D, Devaney E, Gilabert A, Hunt M, Jackson F, Johnston SL, Kryukov I, Li K, Morrison AA, Reid AJ, Sargison N, Saunders GI, Wasmuth JD, Wolstenholme A, Berriman M, Gilleard JS, Cotton JA.

Genome Biol. 2013 Aug 28;14(8):R88. doi: 10.1186/gb-2013-14-8-r88.


Glutamate-gated chloride channels.

Wolstenholme AJ.

J Biol Chem. 2012 Nov 23;287(48):40232-8. doi: 10.1074/jbc.R112.406280. Epub 2012 Oct 4. Review.


Xenopus laevis RIC-3 enhances the functional expression of the C. elegans homomeric nicotinic receptor, ACR-16, in Xenopus oocytes.

Bennett HM, Lees K, Harper KM, Jones AK, Sattelle DB, Wonnacott S, Wolstenholme AJ.

J Neurochem. 2012 Dec;123(6):911-8. doi: 10.1111/jnc.12013. Epub 2012 Oct 10.


The genome of the heartworm, Dirofilaria immitis, reveals drug and vaccine targets.

Godel C, Kumar S, Koutsovoulos G, Ludin P, Nilsson D, Comandatore F, Wrobel N, Thompson M, Schmid CD, Goto S, Bringaud F, Wolstenholme A, Bandi C, Epe C, Kaminsky R, Blaxter M, Mäser P.

FASEB J. 2012 Nov;26(11):4650-61. doi: 10.1096/fj.12-205096. Epub 2012 Aug 13.


ACR-26: a novel nicotinic receptor subunit of parasitic nematodes.

Bennett HM, Williamson SM, Walsh TK, Woods DJ, Wolstenholme AJ.

Mol Biochem Parasitol. 2012 Jun;183(2):151-7. doi: 10.1016/j.molbiopara.2012.02.010. Epub 2012 Mar 1.


Evolution. Surviving in a toxic world.

Wolstenholme AJ.

Science. 2012 Feb 3;335(6068):545-6. doi: 10.1126/science.1218166. No abstract available.


Ion channels and receptor as targets for the control of parasitic nematodes.

Wolstenholme AJ.

Int J Parasitol Drugs Drug Resist. 2011 Oct 14;1(1):2-13. doi: 10.1016/j.ijpddr.2011.09.003. eCollection 2011 Dec. Review.


Resistance to macrocyclic lactones.

Wolstenholme AJ, Kaplan RM.

Curr Pharm Biotechnol. 2012 May;13(6):873-87. Review.


Candidate anthelmintic resistance-associated gene expression and sequence polymorphisms in a triple-resistant field isolate of Haemonchus contortus.

Williamson SM, Storey B, Howell S, Harper KM, Kaplan RM, Wolstenholme AJ.

Mol Biochem Parasitol. 2011 Dec;180(2):99-105. doi: 10.1016/j.molbiopara.2011.09.003. Epub 2011 Sep 16.


Glutamate-gated chloride channels of Haemonchus contortus restore drug sensitivity to ivermectin resistant Caenorhabditis elegans.

Glendinning SK, Buckingham SD, Sattelle DB, Wonnacott S, Wolstenholme AJ.

PLoS One. 2011;6(7):e22390. doi: 10.1371/journal.pone.0022390. Epub 2011 Jul 26.


P-glycoproteins of Haemonchus contortus: development of real-time PCR assays for gene expression studies.

Williamson SM, Wolstenholme AJ.

J Helminthol. 2012 Jun;86(2):202-8. doi: 10.1017/S0022149X11000216. Epub 2011 Jun 1.


Altered avr-14B gene transcription patterns in ivermectin-resistant isolates of the cattle parasites, Cooperia oncophora and Ostertagia ostertagi.

El-Abdellati A, De Graef J, Van Zeveren A, Donnan A, Skuce P, Walsh T, Wolstenholme A, Tait A, Vercruysse J, Claerebout E, Geldhof P.

Int J Parasitol. 2011 Aug 1;41(9):951-7. doi: 10.1016/j.ijpara.2011.04.003. Epub 2011 Jun 1.


Identifying the gap between need and intervention for alcohol use disorders in Europe.

Drummond C, Gual A, Goos C, Godfrey C, Deluca P, Von Der Goltz C, Gmel G, Scafato E, Wolstenholme A, Mann K, Coulton S, Kaner E.

Addiction. 2011 Mar;106 Suppl 1:31-6. doi: 10.1111/j.1360-0443.2010.03335.x. Review.


TRP channels in parasites.

Wolstenholme AJ, Williamson SM, Reaves BJ.

Adv Exp Med Biol. 2011;704:359-71. doi: 10.1007/978-94-007-0265-3_20. Review.


Recent progress in understanding the interaction between avermectins and ligand-gated ion channels: putting the pests to sleep.

Wolstenholme AJ.

Invert Neurosci. 2010 Nov;10(1):5-10. doi: 10.1007/s10158-010-0105-y. Epub 2010 Oct 15. Review.


Identification of ion channel genes in the Acyrthosiphon pisum genome.

Dale RP, Jones AK, Tamborindeguy C, Davies TG, Amey JS, Williamson S, Wolstenholme A, Field LM, Williamson MS, Walsh TK, Sattelle DB.

Insect Mol Biol. 2010 Mar;19 Suppl 2:141-53. doi: 10.1111/j.1365-2583.2009.00975.x.


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