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Items: 1 to 50 of 73

1.

A neuronal role of the Alanine-Serine-Cysteine-1 transporter (SLC7A10, Asc-1) for glycine inhibitory transmission and respiratory pattern.

Mesuret G, Khabbazzadeh S, Bischoff AM, Safory H, Wolosker H, Hülsmann S.

Sci Rep. 2018 Jun 4;8(1):8536. doi: 10.1038/s41598-018-26868-6.

2.

The Neurobiology of d-Serine Signaling.

Wolosker H.

Adv Pharmacol. 2018;82:325-348. doi: 10.1016/bs.apha.2017.08.010. Epub 2017 Nov 8.

PMID:
29413526
3.

Serine Racemase and D-serine in the Amygdala Are Dynamically Involved in Fear Learning.

Balu DT, Presti KT, Huang CCY, Muszynski K, Radzishevsky I, Wolosker H, Guffanti G, Ressler KJ, Coyle JT.

Biol Psychiatry. 2018 Feb 1;83(3):273-283. doi: 10.1016/j.biopsych.2017.08.012. Epub 2017 Aug 26.

PMID:
29025687
4.

Astroglial Versus Neuronal D-Serine: Check Your Controls!

Wolosker H, Balu DT, Coyle JT.

Trends Neurosci. 2017 Sep;40(9):520-522. doi: 10.1016/j.tins.2017.06.010. Epub 2017 Jul 26. No abstract available.

PMID:
28756007
5.

The Rise and Fall of the d-Serine-Mediated Gliotransmission Hypothesis.

Wolosker H, Balu DT, Coyle JT.

Trends Neurosci. 2016 Nov;39(11):712-721. doi: 10.1016/j.tins.2016.09.007. Epub 2016 Oct 11. Review.

6.

Nuclear compartmentalization of serine racemase regulates d-serine production. IMPLICATIONS FOR N-METHYL-d-ASPARTATE (NMDA) RECEPTOR ACTIVATION.

Kolodney G, Dumin E, Safory H, Rosenberg D, Mori H, Radzishevsky I, Wolosker H.

J Biol Chem. 2016 Feb 5;291(6):2630. doi: 10.1074/jbc.A115.699496. No abstract available.

7.

Asc-1 Transporter Regulation of Synaptic Activity via the Tonic Release of d-Serine in the Forebrain.

Sason H, Billard JM, Smith GP, Safory H, Neame S, Kaplan E, Rosenberg D, Zubedat S, Foltyn VN, Christoffersen CT, Bundgaard C, Thomsen C, Avital A, Christensen KV, Wolosker H.

Cereb Cortex. 2017 Feb 1;27(2):1573-1587. doi: 10.1093/cercor/bhv350.

PMID:
26796213
8.

Nuclear Compartmentalization of Serine Racemase Regulates D-Serine Production: IMPLICATIONS FOR N-METHYL-D-ASPARTATE (NMDA) RECEPTOR ACTIVATION.

Kolodney G, Dumin E, Safory H, Rosenberg D, Mori H, Radzishevsky I, Wolosker H.

J Biol Chem. 2015 Dec 25;290(52):31037-50. doi: 10.1074/jbc.M115.699496. Epub 2015 Nov 9. Erratum in: J Biol Chem. 2016 Feb 5;291(6):2630. Radzishevisky, Inna [corrected to Radzishevsky, Inna].

9.

The alanine-serine-cysteine-1 (Asc-1) transporter controls glycine levels in the brain and is required for glycinergic inhibitory transmission.

Safory H, Neame S, Shulman Y, Zubedat S, Radzishevsky I, Rosenberg D, Sason H, Engelender S, Avital A, Hülsmann S, Schiller J, Wolosker H.

EMBO Rep. 2015 May;16(5):590-8. doi: 10.15252/embr.201439561. Epub 2015 Mar 9.

10.

Identity of the NMDA receptor coagonist is synapse specific and developmentally regulated in the hippocampus.

Le Bail M, Martineau M, Sacchi S, Yatsenko N, Radzishevsky I, Conrod S, Ait Ouares K, Wolosker H, Pollegioni L, Billard JM, Mothet JP.

Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):E204-13. doi: 10.1073/pnas.1416668112. Epub 2014 Dec 30.

11.

FBXO22 protein is required for optimal synthesis of the N-methyl-D-aspartate (NMDA) receptor coagonist D-serine.

Dikopoltsev E, Foltyn VN, Zehl M, Jensen ON, Mori H, Radzishevsky I, Wolosker H.

J Biol Chem. 2014 Dec 5;289(49):33904-15. doi: 10.1074/jbc.M114.618405. Epub 2014 Oct 21.

12.

Serine racemase regulated by binding to stargazin and PSD-95: potential N-methyl-D-aspartate-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (NMDA-AMPA) glutamate neurotransmission cross-talk.

Ma TM, Paul BD, Fu C, Hu S, Zhu H, Blackshaw S, Wolosker H, Snyder SH.

J Biol Chem. 2014 Oct 24;289(43):29631-41. doi: 10.1074/jbc.M114.571604. Epub 2014 Aug 27.

13.

Circuit-specific changes in D-serine-dependent activation of the N-methyl-D-aspartate receptor in the aging hippocampus.

Labarrière M, Thomas F, Dutar P, Pollegioni L, Wolosker H, Billard JM.

Age (Dordr). 2014;36(5):9698. doi: 10.1007/s11357-014-9698-0. Epub 2014 Aug 20.

14.

The serine shuttle between glia and neurons: implications for neurotransmission and neurodegeneration.

Wolosker H, Radzishevsky I.

Biochem Soc Trans. 2013 Dec;41(6):1546-50. doi: 10.1042/BST20130220. Review.

PMID:
24256252
15.

D-serine in glia and neurons derives from 3-phosphoglycerate dehydrogenase.

Ehmsen JT, Ma TM, Sason H, Rosenberg D, Ogo T, Furuya S, Snyder SH, Wolosker H.

J Neurosci. 2013 Jul 24;33(30):12464-9. doi: 10.1523/JNEUROSCI.4914-12.2013.

16.

Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss.

Talantova M, Sanz-Blasco S, Zhang X, Xia P, Akhtar MW, Okamoto S, Dziewczapolski G, Nakamura T, Cao G, Pratt AE, Kang YJ, Tu S, Molokanova E, McKercher SR, Hires SA, Sason H, Stouffer DG, Buczynski MW, Solomon JP, Michael S, Powers ET, Kelly JW, Roberts A, Tong G, Fang-Newmeyer T, Parker J, Holland EA, Zhang D, Nakanishi N, Chen HS, Wolosker H, Wang Y, Parsons LH, Ambasudhan R, Masliah E, Heinemann SF, Piña-Crespo JC, Lipton SA.

Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):E2518-27. doi: 10.1073/pnas.1306832110. Epub 2013 Jun 17. Erratum in: Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13691. Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):E3630. Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):E3751-2.

17.

Neuronal D-serine and glycine release via the Asc-1 transporter regulates NMDA receptor-dependent synaptic activity.

Rosenberg D, Artoul S, Segal AC, Kolodney G, Radzishevsky I, Dikopoltsev E, Foltyn VN, Inoue R, Mori H, Billard JM, Wolosker H.

J Neurosci. 2013 Feb 20;33(8):3533-44. doi: 10.1523/JNEUROSCI.3836-12.2013.

18.

AF-6 is a positive modulator of the PINK1/parkin pathway and is deficient in Parkinson's disease.

Haskin J, Szargel R, Shani V, Mekies LN, Rott R, Lim GG, Lim KL, Bandopadhyay R, Wolosker H, Engelender S.

Hum Mol Genet. 2013 May 15;22(10):2083-96. doi: 10.1093/hmg/ddt058. Epub 2013 Feb 7.

19.

D-serine: physiology and pathology.

Radzishevsky I, Sason H, Wolosker H.

Curr Opin Clin Nutr Metab Care. 2013 Jan;16(1):72-5. doi: 10.1097/MCO.0b013e32835a3466. Review.

PMID:
23041616
20.

Serine racemase: an unconventional enzyme for an unconventional transmitter.

Wolosker H, Mori H.

Amino Acids. 2012 Nov;43(5):1895-904. doi: 10.1007/s00726-012-1370-3. Epub 2012 Jul 31. Review.

PMID:
22847782
21.

An enzymatic-HPLC assay to monitor endogenous D-serine release from neuronal cultures.

Radzishevsky I, Wolosker H.

Methods Mol Biol. 2012;794:291-7. doi: 10.1007/978-1-61779-331-8_19.

PMID:
21956571
22.

Serine racemase and the serine shuttle between neurons and astrocytes.

Wolosker H.

Biochim Biophys Acta. 2011 Nov;1814(11):1558-66. doi: 10.1016/j.bbapap.2011.01.001. Epub 2011 Jan 9. Review.

PMID:
21224019
23.

Phosphorylation of mouse serine racemase regulates D-serine synthesis.

Foltyn VN, Zehl M, Dikopoltsev E, Jensen ON, Wolosker H.

FEBS Lett. 2010 Jul 2;584(13):2937-41. doi: 10.1016/j.febslet.2010.05.022. Epub 2010 May 21.

24.

Neuronal release of D-serine: a physiological pathway controlling extracellular D-serine concentration.

Rosenberg D, Kartvelishvily E, Shleper M, Klinker CM, Bowser MT, Wolosker H.

FASEB J. 2010 Aug;24(8):2951-61. doi: 10.1096/fj.09-147967. Epub 2010 Apr 6.

25.

Feedback inactivation of D-serine synthesis by NMDA receptor-elicited translocation of serine racemase to the membrane.

Balan L, Foltyn VN, Zehl M, Dumin E, Dikopoltsev E, Knoh D, Ohno Y, Kihara A, Jensen ON, Radzishevsky IS, Wolosker H.

Proc Natl Acad Sci U S A. 2009 May 5;106(18):7589-94. doi: 10.1073/pnas.0809442106. Epub 2009 Apr 20.

26.

Pilot controlled trial of D-serine for the treatment of post-traumatic stress disorder.

Heresco-Levy U, Vass A, Bloch B, Wolosker H, Dumin E, Balan L, Deutsch L, Kremer I.

Int J Neuropsychopharmacol. 2009 Oct;12(9):1275-82. doi: 10.1017/S1461145709000339. Epub 2009 Apr 15.

PMID:
19366490
27.

Synphilin-1A inhibits seven in absentia homolog (SIAH) and modulates alpha-synuclein monoubiquitylation and inclusion formation.

Szargel R, Rott R, Eyal A, Haskin J, Shani V, Balan L, Wolosker H, Engelender S.

J Biol Chem. 2009 Apr 24;284(17):11706-16. doi: 10.1074/jbc.M805990200. Epub 2009 Feb 17.

28.

D-amino acids in the brain: D-serine in neurotransmission and neurodegeneration.

Wolosker H, Dumin E, Balan L, Foltyn VN.

FEBS J. 2008 Jul;275(14):3514-26. doi: 10.1111/j.1742-4658.2008.06515.x. Review.

29.

Increased brain D-amino acid oxidase (DAAO) activity in schizophrenia.

Madeira C, Freitas ME, Vargas-Lopes C, Wolosker H, Panizzutti R.

Schizophr Res. 2008 Apr;101(1-3):76-83. doi: 10.1016/j.schres.2008.02.002. Epub 2008 Apr 2.

PMID:
18378121
30.

NMDA receptor regulation by D-serine: new findings and perspectives.

Wolosker H.

Mol Neurobiol. 2007 Oct;36(2):152-64. Epub 2007 Sep 12. Review.

PMID:
17952659
31.

Endogenous D-serine contributes to NMDA-receptor-mediated light-evoked responses in the vertebrate retina.

Gustafson EC, Stevens ER, Wolosker H, Miller RF.

J Neurophysiol. 2007 Jul;98(1):122-30. Epub 2007 May 16.

32.

A CSF and postmortem brain study of D-serine metabolic parameters in schizophrenia.

Bendikov I, Nadri C, Amar S, Panizzutti R, De Miranda J, Wolosker H, Agam G.

Schizophr Res. 2007 Feb;90(1-3):41-51. Epub 2006 Dec 6.

PMID:
17156977
33.

D-serine regulation of NMDA receptor activity.

Wolosker H.

Sci STKE. 2006 Oct 10;2006(356):pe41. Review.

PMID:
17033043
34.

Modulation of D-serine levels via ubiquitin-dependent proteasomal degradation of serine racemase.

Dumin E, Bendikov I, Foltyn VN, Misumi Y, Ikehara Y, Kartvelishvily E, Wolosker H.

J Biol Chem. 2006 Jul 21;281(29):20291-302. Epub 2006 May 19.

35.

Slow-binding human serine racemase inhibitors from high-throughput screening of combinatorial libraries.

Dixon SM, Li P, Liu R, Wolosker H, Lam KS, Kurth MJ, Toney MD.

J Med Chem. 2006 Apr 20;49(8):2388-97.

PMID:
16610782
36.

Neuron-derived D-serine release provides a novel means to activate N-methyl-D-aspartate receptors.

Kartvelishvily E, Shleper M, Balan L, Dumin E, Wolosker H.

J Biol Chem. 2006 May 19;281(20):14151-62. Epub 2006 Mar 21.

37.

D-serine is the dominant endogenous coagonist for NMDA receptor neurotoxicity in organotypic hippocampal slices.

Shleper M, Kartvelishvily E, Wolosker H.

J Neurosci. 2005 Oct 12;25(41):9413-7.

38.

Serine racemase modulates intracellular D-serine levels through an alpha,beta-elimination activity.

Foltyn VN, Bendikov I, De Miranda J, Panizzutti R, Dumin E, Shleper M, Li P, Toney MD, Kartvelishvily E, Wolosker H.

J Biol Chem. 2005 Jan 21;280(3):1754-63. Epub 2004 Nov 9.

39.

Cofactors of serine racemase that physiologically stimulate the synthesis of the N-methyl-D-aspartate (NMDA) receptor coagonist D-serine.

De Miranda J, Panizzutti R, Foltyn VN, Wolosker H.

Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14542-7. Epub 2002 Oct 22.

40.

Neurobiology through the looking-glass: D-serine as a new glial-derived transmitter.

Wolosker H, Panizzutti R, De Miranda J.

Neurochem Int. 2002 Nov;41(5):327-32. Review.

PMID:
12176074
41.

Glial transport of the neuromodulator D-serine.

Ribeiro CS, Reis M, Panizzutti R, de Miranda J, Wolosker H.

Brain Res. 2002 Mar 8;929(2):202-9.

PMID:
11864625
42.

Naturally occurring free D-aspartate is a nuclear component of cells in the mammalian hypothalamo-neurohypophyseal system.

Wang H, Wolosker H, Morris JF, Pevsner J, Snyder SH, Selkoe DJ.

Neuroscience. 2002;109(1):1-4.

PMID:
11784695
43.

A new strategy to decrease N-methyl-D-aspartate (NMDA) receptor coactivation: inhibition of D-serine synthesis by converting serine racemase into an eliminase.

Panizzutti R, De Miranda J, Ribeiro CS, Engelender S, Wolosker H.

Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5294-9. Epub 2001 Apr 17.

44.

Amyloid precursor proteins inhibit heme oxygenase activity and augment neurotoxicity in Alzheimer's disease.

Takahashi M, Doré S, Ferris CD, Tomita T, Sawa A, Wolosker H, Borchelt DR, Iwatsubo T, Kim SH, Thinakaran G, Sisodia SS, Snyder SH.

Neuron. 2000 Nov;28(2):461-73.

45.
46.

Human serine racemase: moleular cloning, genomic organization and functional analysis.

De Miranda J, Santoro A, Engelender S, Wolosker H.

Gene. 2000 Oct 3;256(1-2):183-8.

PMID:
11054547
47.

D-aspartate disposition in neuronal and endocrine tissues: ontogeny, biosynthesis and release.

Wolosker H, D'Aniello A, Snyder SH.

Neuroscience. 2000;100(1):183-9.

PMID:
10996468
48.

Chloride-dependent inhibition of vesicular glutamate uptake by alpha-keto acids accumulated in maple syrup urine disease.

Reis M, Farage M, Wolosker H.

Biochim Biophys Acta. 2000 Jul 3;1475(2):114-8.

PMID:
10832024
49.

A mammalian iron ATPase induced by iron.

Barañano DE, Wolosker H, Bae BI, Barrow RK, Snyder SH, Ferris CD.

J Biol Chem. 2000 May 19;275(20):15166-73.

50.

D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor.

Mothet JP, Parent AT, Wolosker H, Brady RO Jr, Linden DJ, Ferris CD, Rogawski MA, Snyder SH.

Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4926-31.

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