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Items: 1 to 50 of 66

1.

De novo GRIN variants in NMDA receptor M2 channel pore-forming loop are associated with neurological diseases.

Li J, Zhang J, Tang W, Mizu RK, Kusumoto H, XiangWei W, Xu Y, Chen W, Amin JB, Hu C, Kannan V, Keller SR, Wilcox WR, Lemke JR, Myers SJ, Swanger SA, Wollmuth LP, Petrovski S, Traynelis SF, Yuan H.

Hum Mutat. 2019 Dec;40(12):2393-2413. doi: 10.1002/humu.23895. Epub 2019 Sep 10.

PMID:
31429998
2.

Tracking Newly Released Synaptic Vesicle Proteins at Ribbon Active Zones.

Vaithianathan T, Wollmuth LP, Henry D, Zenisek D, Matthews G.

iScience. 2019 Jul 26;17:10-23. doi: 10.1016/j.isci.2019.06.015. Epub 2019 Jun 13.

3.

Prying open a glutamate receptor gate.

Wollmuth LP.

J Gen Physiol. 2019 Apr 1;151(4):396-399. doi: 10.1085/jgp.201812312. Epub 2019 Feb 28. No abstract available.

4.

An inter-dimer allosteric switch controls NMDA receptor activity.

Esmenjaud JB, Stroebel D, Chan K, Grand T, David M, Wollmuth LP, Taly A, Paoletti P.

EMBO J. 2019 Jan 15;38(2). pii: e99894. doi: 10.15252/embj.201899894. Epub 2018 Nov 5.

PMID:
30396997
5.

Input-specific maturation of NMDAR-mediated transmission onto parvalbumin-expressing interneurons in layers 2/3 of the visual cortex.

Ferrer C, Hsieh H, Wollmuth LP.

J Neurophysiol. 2018 Dec 1;120(6):3063-3076. doi: 10.1152/jn.00495.2018. Epub 2018 Oct 10.

6.

A conserved glycine harboring disease-associated mutations permits NMDA receptor slow deactivation and high Ca2+ permeability.

Amin JB, Leng X, Gochman A, Zhou HX, Wollmuth LP.

Nat Commun. 2018 Sep 14;9(1):3748. doi: 10.1038/s41467-018-06145-w.

7.

Structure, function, and allosteric modulation of NMDA receptors.

Hansen KB, Yi F, Perszyk RE, Furukawa H, Wollmuth LP, Gibb AJ, Traynelis SF.

J Gen Physiol. 2018 Aug 6;150(8):1081-1105. doi: 10.1085/jgp.201812032. Epub 2018 Jul 23. Review.

8.

A Swiss army knife for targeting receptors.

Amin JB, Wollmuth LP.

Elife. 2018 May 24;7. pii: e37413. doi: 10.7554/eLife.37413.

9.

Ion permeation in ionotropic glutamate receptors: Still dynamic after all these years.

Wollmuth LP.

Curr Opin Physiol. 2018 Apr;2:36-41. doi: 10.1016/j.cophys.2017.12.003. Epub 2017 Dec 19.

10.

Divergent roles of a peripheral transmembrane segment in AMPA and NMDA receptors.

Amin JB, Salussolia CL, Chan K, Regan MC, Dai J, Zhou HX, Furukawa H, Bowen ME, Wollmuth LP.

J Gen Physiol. 2017 Jun 5;149(6):661-680. doi: 10.1085/jgp.201711762. Epub 2017 May 15.

11.

Advancing NMDA Receptor Physiology by Integrating Multiple Approaches.

Zhou HX, Wollmuth LP.

Trends Neurosci. 2017 Mar;40(3):129-137. doi: 10.1016/j.tins.2017.01.001. Epub 2017 Feb 8. Review.

12.

A Molecular Determinant of Subtype-Specific Desensitization in Ionotropic Glutamate Receptors.

Alsaloum M, Kazi R, Gan Q, Amin J, Wollmuth LP.

J Neurosci. 2016 Mar 2;36(9):2617-22. doi: 10.1523/JNEUROSCI.2667-15.2016.

13.

The Transmembrane Domain Mediates Tetramerization of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors.

Gan Q, Dai J, Zhou HX, Wollmuth LP.

J Biol Chem. 2016 Mar 18;291(12):6595-606. doi: 10.1074/jbc.M115.686246. Epub 2016 Feb 2.

14.

Is cholesterol good or bad for your brain?--NMDARs have a say.

Wollmuth LP.

J Physiol. 2015 May 15;593(10):2251-2. doi: 10.1113/JP270325. Epub 2015 Apr 2. No abstract available.

15.

Mechanism-Based Mathematical Model for Gating of Ionotropic Glutamate Receptors.

Dai J, Wollmuth LP, Zhou HX.

J Phys Chem B. 2015 Aug 27;119(34):10934-40. doi: 10.1021/acs.jpcb.5b00521. Epub 2015 Apr 1.

16.

Assembly of AMPA receptors: mechanisms and regulation.

Gan Q, Salussolia CL, Wollmuth LP.

J Physiol. 2015 Jan 1;593(1):39-48. doi: 10.1113/jphysiol.2014.273755. Epub 2014 Aug 1. Review.

17.

Mechanical coupling maintains the fidelity of NMDA receptor-mediated currents.

Kazi R, Dai J, Sweeney C, Zhou HX, Wollmuth LP.

Nat Neurosci. 2014 Jul;17(7):914-22. doi: 10.1038/nn.3724. Epub 2014 May 25.

18.

Synapse-associated protein 97 regulates the membrane properties of fast-spiking parvalbumin interneurons in the visual cortex.

Akgul G, Wollmuth LP.

J Neurosci. 2013 Jul 31;33(31):12739-50. doi: 10.1523/JNEUROSCI.0040-13.2013.

19.

Asynchronous movements prior to pore opening in NMDA receptors.

Kazi R, Gan Q, Talukder I, Markowitz M, Salussolia CL, Wollmuth LP.

J Neurosci. 2013 Jul 17;33(29):12052-66. doi: 10.1523/JNEUROSCI.5780-12.2013.

20.

Modulating the intrinsic disorder in the cytoplasmic domain alters the biological activity of the N-methyl-D-aspartate-sensitive glutamate receptor.

Choi UB, Kazi R, Stenzoski N, Wollmuth LP, Uversky VN, Bowen ME.

J Biol Chem. 2013 Aug 2;288(31):22506-15. doi: 10.1074/jbc.M113.477810. Epub 2013 Jun 19.

21.

A eukaryotic specific transmembrane segment is required for tetramerization in AMPA receptors.

Salussolia CL, Gan Q, Kazi R, Singh P, Allopenna J, Furukawa H, Wollmuth LP.

J Neurosci. 2013 Jun 5;33(23):9840-5. doi: 10.1523/JNEUROSCI.2626-12.2013.

22.

Microglia actively regulate the number of functional synapses.

Ji K, Akgul G, Wollmuth LP, Tsirka SE.

PLoS One. 2013;8(2):e56293. doi: 10.1371/journal.pone.0056293. Epub 2013 Feb 5.

23.

Subgroups of parvalbumin-expressing interneurons in layers 2/3 of the visual cortex.

Helm J, Akgul G, Wollmuth LP.

J Neurophysiol. 2013 Mar;109(6):1600-13. doi: 10.1152/jn.00782.2012. Epub 2012 Dec 28.

24.

Flip-flopping to the membrane.

Salussolia CL, Wollmuth LP.

Neuron. 2012 Nov 8;76(3):463-5. doi: 10.1016/j.neuron.2012.10.022. Erratum in: Neuron. 2012 Dec 20;76(6):1238.

25.

GluN1-specific redox effects on the kinetic mechanism of NMDA receptor activation.

Talukder I, Kazi R, Wollmuth LP.

Biophys J. 2011 Nov 16;101(10):2389-98. doi: 10.1016/j.bpj.2011.10.015. Epub 2011 Nov 15.

26.

Interaction of the M4 segment with other transmembrane segments is required for surface expression of mammalian α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors.

Salussolia CL, Corrales A, Talukder I, Kazi R, Akgul G, Bowen M, Wollmuth LP.

J Biol Chem. 2011 Nov 18;286(46):40205-18. doi: 10.1074/jbc.M111.268839. Epub 2011 Sep 19.

27.

Arrangement of subunits in functional NMDA receptors.

Salussolia CL, Prodromou ML, Borker P, Wollmuth LP.

J Neurosci. 2011 Aug 3;31(31):11295-304. doi: 10.1523/JNEUROSCI.5612-10.2011.

28.

Local constraints in either the GluN1 or GluN2 subunit equally impair NMDA receptor pore opening.

Talukder I, Wollmuth LP.

J Gen Physiol. 2011 Aug;138(2):179-94. doi: 10.1085/jgp.201110623. Epub 2011 Jul 11.

29.

Effect of Src kinase phosphorylation on disordered C-terminal domain of N-methyl-D-aspartic acid (NMDA) receptor subunit GluN2B protein.

Choi UB, Xiao S, Wollmuth LP, Bowen ME.

J Biol Chem. 2011 Aug 26;286(34):29904-12. doi: 10.1074/jbc.M111.258897. Epub 2011 Jun 28.

30.

Expression pattern of membrane-associated guanylate kinases in interneurons of the visual cortex.

Akgul G, Wollmuth LP.

J Comp Neurol. 2010 Dec 15;518(24):4842-54. doi: 10.1002/cne.22491.

31.

Specific sites within the ligand-binding domain and ion channel linkers modulate NMDA receptor gating.

Talukder I, Borker P, Wollmuth LP.

J Neurosci. 2010 Sep 1;30(35):11792-804. doi: 10.1523/JNEUROSCI.5382-09.2010.

32.

Glutamate receptor ion channels: structure, regulation, and function.

Traynelis SF, Wollmuth LP, McBain CJ, Menniti FS, Vance KM, Ogden KK, Hansen KB, Yuan H, Myers SJ, Dingledine R.

Pharmacol Rev. 2010 Sep;62(3):405-96. doi: 10.1124/pr.109.002451. Review. Erratum in: Pharmacol Rev. 2014 Oct;66(4):1141.

33.

Gating modes in AMPA receptors.

Prieto ML, Wollmuth LP.

J Neurosci. 2010 Mar 24;30(12):4449-59. doi: 10.1523/JNEUROSCI.5613-09.2010.

34.

Neuroscience: Excitatory view of a receptor.

Wollmuth LP, Traynelis SF.

Nature. 2009 Dec 10;462(7274):729-31. doi: 10.1038/462729a. No abstract available.

35.

Subunit-specific contribution of pore-forming domains to NMDA receptor channel structure and gating.

Sobolevsky AI, Prodromou ML, Yelshansky MV, Wollmuth LP.

J Gen Physiol. 2007 Jun;129(6):509-25. Epub 2007 May 15.

36.

Target-specific regulation of synaptic amplitudes in the neocortex.

Watanabe J, Rozov A, Wollmuth LP.

J Neurosci. 2005 Jan 26;25(4):1024-33.

37.

State-dependent changes in the electrostatic potential in the pore of a GluR channel.

Sobolevsky AI, Yelshansky MV, Wollmuth LP.

Biophys J. 2005 Jan;88(1):235-42. Epub 2004 Oct 29.

38.

Structure and gating of the glutamate receptor ion channel.

Wollmuth LP, Sobolevsky AI.

Trends Neurosci. 2004 Jun;27(6):321-8. Review.

PMID:
15165736
39.

Block of AMPA receptor desensitization by a point mutation outside the ligand-binding domain.

Yelshansky MV, Sobolevsky AI, Jatzke C, Wollmuth LP.

J Neurosci. 2004 May 19;24(20):4728-36.

40.

The outer pore of the glutamate receptor channel has 2-fold rotational symmetry.

Sobolevsky AI, Yelshansky MV, Wollmuth LP.

Neuron. 2004 Feb 5;41(3):367-78.

41.

Different gating mechanisms in glutamate receptor and K+ channels.

Sobolevsky AI, Yelshansky MV, Wollmuth LP.

J Neurosci. 2003 Aug 20;23(20):7559-68.

42.

Extracellular vestibule determinants of Ca2+ influx in Ca2+-permeable AMPA receptor channels.

Jatzke C, Hernandez M, Wollmuth LP.

J Physiol. 2003 Jun 1;549(Pt 2):439-52. Epub 2003 Apr 11.

43.

Staggering of subunits in NMDAR channels.

Sobolevsky AI, Rooney L, Wollmuth LP.

Biophys J. 2002 Dec;83(6):3304-14.

44.

DRPEER: a motif in the extracellular vestibule conferring high Ca2+ flux rates in NMDA receptor channels.

Watanabe J, Beck C, Kuner T, Premkumar LS, Wollmuth LP.

J Neurosci. 2002 Dec 1;22(23):10209-16.

45.

Molecular rearrangements of the extracellular vestibule in NMDAR channels during gating.

Sobolevsky AI, Beck C, Wollmuth LP.

Neuron. 2002 Jan 3;33(1):75-85.

46.
47.

The Lurcher mutation identifies delta 2 as an AMPA/kainate receptor-like channel that is potentiated by Ca(2+).

Wollmuth LP, Kuner T, Jatzke C, Seeburg PH, Heintz N, Zuo J.

J Neurosci. 2000 Aug 15;20(16):5973-80.

48.

NMDAR channel segments forming the extracellular vestibule inferred from the accessibility of substituted cysteines.

Beck C, Wollmuth LP, Seeburg PH, Sakmann B, Kuner T.

Neuron. 1999 Mar;22(3):559-70.

49.
50.

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