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Tracking Newly Released Synaptic Vesicle Proteins at Ribbon Active Zones.

Vaithianathan T, Wollmuth LP, Henry D, Zenisek D, Matthews G.

iScience. 2019 Jul 26;17:10-23. doi: 10.1016/j.isci.2019.06.015. Epub 2019 Jun 13.


Prying open a glutamate receptor gate.

Wollmuth LP.

J Gen Physiol. 2019 Apr 1;151(4):396-399. doi: 10.1085/jgp.201812312. Epub 2019 Feb 28. No abstract available.


An inter-dimer allosteric switch controls NMDA receptor activity.

Esmenjaud JB, Stroebel D, Chan K, Grand T, David M, Wollmuth LP, Taly A, Paoletti P.

EMBO J. 2019 Jan 15;38(2). pii: e99894. doi: 10.15252/embj.201899894. Epub 2018 Nov 5.


Input-specific maturation of NMDAR-mediated transmission onto parvalbumin-expressing interneurons in layers 2/3 of the visual cortex.

Ferrer C, Hsieh H, Wollmuth LP.

J Neurophysiol. 2018 Dec 1;120(6):3063-3076. doi: 10.1152/jn.00495.2018. Epub 2018 Oct 10.


A conserved glycine harboring disease-associated mutations permits NMDA receptor slow deactivation and high Ca2+ permeability.

Amin JB, Leng X, Gochman A, Zhou HX, Wollmuth LP.

Nat Commun. 2018 Sep 14;9(1):3748. doi: 10.1038/s41467-018-06145-w.


Structure, function, and allosteric modulation of NMDA receptors.

Hansen KB, Yi F, Perszyk RE, Furukawa H, Wollmuth LP, Gibb AJ, Traynelis SF.

J Gen Physiol. 2018 Aug 6;150(8):1081-1105. doi: 10.1085/jgp.201812032. Epub 2018 Jul 23. Review.


A Swiss army knife for targeting receptors.

Amin JB, Wollmuth LP.

Elife. 2018 May 24;7. pii: e37413. doi: 10.7554/eLife.37413.


Ion permeation in ionotropic glutamate receptors: Still dynamic after all these years.

Wollmuth LP.

Curr Opin Physiol. 2018 Apr;2:36-41. doi: 10.1016/j.cophys.2017.12.003. Epub 2017 Dec 19.


Divergent roles of a peripheral transmembrane segment in AMPA and NMDA receptors.

Amin JB, Salussolia CL, Chan K, Regan MC, Dai J, Zhou HX, Furukawa H, Bowen ME, Wollmuth LP.

J Gen Physiol. 2017 Jun 5;149(6):661-680. doi: 10.1085/jgp.201711762. Epub 2017 May 15.


Advancing NMDA Receptor Physiology by Integrating Multiple Approaches.

Zhou HX, Wollmuth LP.

Trends Neurosci. 2017 Mar;40(3):129-137. doi: 10.1016/j.tins.2017.01.001. Epub 2017 Feb 8. Review.


A Molecular Determinant of Subtype-Specific Desensitization in Ionotropic Glutamate Receptors.

Alsaloum M, Kazi R, Gan Q, Amin J, Wollmuth LP.

J Neurosci. 2016 Mar 2;36(9):2617-22. doi: 10.1523/JNEUROSCI.2667-15.2016.


The Transmembrane Domain Mediates Tetramerization of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors.

Gan Q, Dai J, Zhou HX, Wollmuth LP.

J Biol Chem. 2016 Mar 18;291(12):6595-606. doi: 10.1074/jbc.M115.686246. Epub 2016 Feb 2.


Is cholesterol good or bad for your brain?--NMDARs have a say.

Wollmuth LP.

J Physiol. 2015 May 15;593(10):2251-2. doi: 10.1113/JP270325. Epub 2015 Apr 2. No abstract available.


Mechanism-Based Mathematical Model for Gating of Ionotropic Glutamate Receptors.

Dai J, Wollmuth LP, Zhou HX.

J Phys Chem B. 2015 Aug 27;119(34):10934-40. doi: 10.1021/acs.jpcb.5b00521. Epub 2015 Apr 1.


Assembly of AMPA receptors: mechanisms and regulation.

Gan Q, Salussolia CL, Wollmuth LP.

J Physiol. 2015 Jan 1;593(1):39-48. doi: 10.1113/jphysiol.2014.273755. Epub 2014 Aug 1. Review.


Mechanical coupling maintains the fidelity of NMDA receptor-mediated currents.

Kazi R, Dai J, Sweeney C, Zhou HX, Wollmuth LP.

Nat Neurosci. 2014 Jul;17(7):914-22. doi: 10.1038/nn.3724. Epub 2014 May 25.


Synapse-associated protein 97 regulates the membrane properties of fast-spiking parvalbumin interneurons in the visual cortex.

Akgul G, Wollmuth LP.

J Neurosci. 2013 Jul 31;33(31):12739-50. doi: 10.1523/JNEUROSCI.0040-13.2013.


Asynchronous movements prior to pore opening in NMDA receptors.

Kazi R, Gan Q, Talukder I, Markowitz M, Salussolia CL, Wollmuth LP.

J Neurosci. 2013 Jul 17;33(29):12052-66. doi: 10.1523/JNEUROSCI.5780-12.2013.


Modulating the intrinsic disorder in the cytoplasmic domain alters the biological activity of the N-methyl-D-aspartate-sensitive glutamate receptor.

Choi UB, Kazi R, Stenzoski N, Wollmuth LP, Uversky VN, Bowen ME.

J Biol Chem. 2013 Aug 2;288(31):22506-15. doi: 10.1074/jbc.M113.477810. Epub 2013 Jun 19.


A eukaryotic specific transmembrane segment is required for tetramerization in AMPA receptors.

Salussolia CL, Gan Q, Kazi R, Singh P, Allopenna J, Furukawa H, Wollmuth LP.

J Neurosci. 2013 Jun 5;33(23):9840-5. doi: 10.1523/JNEUROSCI.2626-12.2013.


Microglia actively regulate the number of functional synapses.

Ji K, Akgul G, Wollmuth LP, Tsirka SE.

PLoS One. 2013;8(2):e56293. doi: 10.1371/journal.pone.0056293. Epub 2013 Feb 5.


Subgroups of parvalbumin-expressing interneurons in layers 2/3 of the visual cortex.

Helm J, Akgul G, Wollmuth LP.

J Neurophysiol. 2013 Mar;109(6):1600-13. doi: 10.1152/jn.00782.2012. Epub 2012 Dec 28.


Flip-flopping to the membrane.

Salussolia CL, Wollmuth LP.

Neuron. 2012 Nov 8;76(3):463-5. doi: 10.1016/j.neuron.2012.10.022. Erratum in: Neuron. 2012 Dec 20;76(6):1238.


GluN1-specific redox effects on the kinetic mechanism of NMDA receptor activation.

Talukder I, Kazi R, Wollmuth LP.

Biophys J. 2011 Nov 16;101(10):2389-98. doi: 10.1016/j.bpj.2011.10.015. Epub 2011 Nov 15.


Interaction of the M4 segment with other transmembrane segments is required for surface expression of mammalian α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors.

Salussolia CL, Corrales A, Talukder I, Kazi R, Akgul G, Bowen M, Wollmuth LP.

J Biol Chem. 2011 Nov 18;286(46):40205-18. doi: 10.1074/jbc.M111.268839. Epub 2011 Sep 19.


Arrangement of subunits in functional NMDA receptors.

Salussolia CL, Prodromou ML, Borker P, Wollmuth LP.

J Neurosci. 2011 Aug 3;31(31):11295-304. doi: 10.1523/JNEUROSCI.5612-10.2011.


Local constraints in either the GluN1 or GluN2 subunit equally impair NMDA receptor pore opening.

Talukder I, Wollmuth LP.

J Gen Physiol. 2011 Aug;138(2):179-94. doi: 10.1085/jgp.201110623. Epub 2011 Jul 11.


Effect of Src kinase phosphorylation on disordered C-terminal domain of N-methyl-D-aspartic acid (NMDA) receptor subunit GluN2B protein.

Choi UB, Xiao S, Wollmuth LP, Bowen ME.

J Biol Chem. 2011 Aug 26;286(34):29904-12. doi: 10.1074/jbc.M111.258897. Epub 2011 Jun 28.


Expression pattern of membrane-associated guanylate kinases in interneurons of the visual cortex.

Akgul G, Wollmuth LP.

J Comp Neurol. 2010 Dec 15;518(24):4842-54. doi: 10.1002/cne.22491.


Specific sites within the ligand-binding domain and ion channel linkers modulate NMDA receptor gating.

Talukder I, Borker P, Wollmuth LP.

J Neurosci. 2010 Sep 1;30(35):11792-804. doi: 10.1523/JNEUROSCI.5382-09.2010.


Glutamate receptor ion channels: structure, regulation, and function.

Traynelis SF, Wollmuth LP, McBain CJ, Menniti FS, Vance KM, Ogden KK, Hansen KB, Yuan H, Myers SJ, Dingledine R.

Pharmacol Rev. 2010 Sep;62(3):405-96. doi: 10.1124/pr.109.002451. Review. Erratum in: Pharmacol Rev. 2014 Oct;66(4):1141.


Gating modes in AMPA receptors.

Prieto ML, Wollmuth LP.

J Neurosci. 2010 Mar 24;30(12):4449-59. doi: 10.1523/JNEUROSCI.5613-09.2010.


Neuroscience: Excitatory view of a receptor.

Wollmuth LP, Traynelis SF.

Nature. 2009 Dec 10;462(7274):729-31. doi: 10.1038/462729a. No abstract available.


Subunit-specific contribution of pore-forming domains to NMDA receptor channel structure and gating.

Sobolevsky AI, Prodromou ML, Yelshansky MV, Wollmuth LP.

J Gen Physiol. 2007 Jun;129(6):509-25. Epub 2007 May 15.


Target-specific regulation of synaptic amplitudes in the neocortex.

Watanabe J, Rozov A, Wollmuth LP.

J Neurosci. 2005 Jan 26;25(4):1024-33.


State-dependent changes in the electrostatic potential in the pore of a GluR channel.

Sobolevsky AI, Yelshansky MV, Wollmuth LP.

Biophys J. 2005 Jan;88(1):235-42. Epub 2004 Oct 29.


Structure and gating of the glutamate receptor ion channel.

Wollmuth LP, Sobolevsky AI.

Trends Neurosci. 2004 Jun;27(6):321-8. Review.


Block of AMPA receptor desensitization by a point mutation outside the ligand-binding domain.

Yelshansky MV, Sobolevsky AI, Jatzke C, Wollmuth LP.

J Neurosci. 2004 May 19;24(20):4728-36.


The outer pore of the glutamate receptor channel has 2-fold rotational symmetry.

Sobolevsky AI, Yelshansky MV, Wollmuth LP.

Neuron. 2004 Feb 5;41(3):367-78.


Different gating mechanisms in glutamate receptor and K+ channels.

Sobolevsky AI, Yelshansky MV, Wollmuth LP.

J Neurosci. 2003 Aug 20;23(20):7559-68.


Extracellular vestibule determinants of Ca2+ influx in Ca2+-permeable AMPA receptor channels.

Jatzke C, Hernandez M, Wollmuth LP.

J Physiol. 2003 Jun 1;549(Pt 2):439-52. Epub 2003 Apr 11.


Staggering of subunits in NMDAR channels.

Sobolevsky AI, Rooney L, Wollmuth LP.

Biophys J. 2002 Dec;83(6):3304-14.


DRPEER: a motif in the extracellular vestibule conferring high Ca2+ flux rates in NMDA receptor channels.

Watanabe J, Beck C, Kuner T, Premkumar LS, Wollmuth LP.

J Neurosci. 2002 Dec 1;22(23):10209-16.


Molecular rearrangements of the extracellular vestibule in NMDAR channels during gating.

Sobolevsky AI, Beck C, Wollmuth LP.

Neuron. 2002 Jan 3;33(1):75-85.


The Lurcher mutation identifies delta 2 as an AMPA/kainate receptor-like channel that is potentiated by Ca(2+).

Wollmuth LP, Kuner T, Jatzke C, Seeburg PH, Heintz N, Zuo J.

J Neurosci. 2000 Aug 15;20(16):5973-80.


NMDAR channel segments forming the extracellular vestibule inferred from the accessibility of substituted cysteines.

Beck C, Wollmuth LP, Seeburg PH, Sakmann B, Kuner T.

Neuron. 1999 Mar;22(3):559-70.


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