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Items: 39


Peripheral and systemic antigens elicit an expandable pool of resident memory CD8+ T cells in the bone marrow.

Pascutti MF, Geerman S, Collins N, Brasser G, Nota B, Stark R, Behr F, Oja A, Slot E, Panagioti E, Prier JE, Hickson S, Wolkers MC, Heemskerk MHM, Hombrink P, Arens R, Mackay LK, van Gisbergen KPJM, Nolte MA.

Eur J Immunol. 2019 Jun;49(6):853-872. doi: 10.1002/eji.201848003. Epub 2019 Apr 2.


Critical role of post-transcriptional regulation for IFN-γ in tumor-infiltrating T cells.

Salerno F, Guislain A, Freen-Van Heeren JJ, Nicolet BP, Young HA, Wolkers MC.

Oncoimmunology. 2018 Oct 22;8(2):e1532762. doi: 10.1080/2162402X.2018.1532762. eCollection 2019.


Costimulation through TLR2 Drives Polyfunctional CD8+ T Cell Responses.

Salerno F, Freen-van Heeren JJ, Guislain A, Nicolet BP, Wolkers MC.

J Immunol. 2019 Feb 1;202(3):714-723. doi: 10.4049/jimmunol.1801026. Epub 2018 Dec 21.


Circular RNA expression in human hematopoietic cells is widespread and cell-type specific.

Nicolet BP, Engels S, Aglialoro F, van den Akker E, von Lindern M, Wolkers MC.

Nucleic Acids Res. 2018 Sep 19;46(16):8168-8180. doi: 10.1093/nar/gky721.


Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids.

Dijkstra KK, Cattaneo CM, Weeber F, Chalabi M, van de Haar J, Fanchi LF, Slagter M, van der Velden DL, Kaing S, Kelderman S, van Rooij N, van Leerdam ME, Depla A, Smit EF, Hartemink KJ, de Groot R, Wolkers MC, Sachs N, Snaebjornsson P, Monkhorst K, Haanen J, Clevers H, Schumacher TN, Voest EE.

Cell. 2018 Sep 6;174(6):1586-1598.e12. doi: 10.1016/j.cell.2018.07.009. Epub 2018 Aug 9.


Translational repression of pre-formed cytokine-encoding mRNA prevents chronic activation of memory T cells.

Salerno F, Engels S, van den Biggelaar M, van Alphen FPJ, Guislain A, Zhao W, Hodge DL, Bell SE, Medema JP, von Lindern M, Turner M, Young HA, Wolkers MC.

Nat Immunol. 2018 Aug;19(8):828-837. doi: 10.1038/s41590-018-0155-6. Epub 2018 Jul 9.


Measuring T Cell Responses by Flow Cytometry-Based Fluorescence In Situ Hybridization.

Freen-van Heeren JJ, Nicolet BP, Wolkers MC.

Crit Rev Immunol. 2018;38(2):131-143. doi: 10.1615/CritRevImmunol.2018025938. Review.


Interferon-Gamma Impairs Maintenance and Alters Hematopoietic Support of Bone Marrow Mesenchymal Stromal Cells.

Goedhart M, Cornelissen AS, Kuijk C, Geerman S, Kleijer M, van Buul JD, Huveneers S, Raaijmakers MHGP, Young HA, Wolkers MC, Voermans C, Nolte MA.

Stem Cells Dev. 2018 May 1;27(9):579-589. doi: 10.1089/scd.2017.0196. Epub 2018 Apr 16.


Memory CD8+ T cells support the maintenance of hematopoietic stem cells in the bone marrow.

Geerman S, Brasser G, Bhushal S, Salerno F, Kragten NA, Hoogenboezem M, de Haan G, Wolkers MC, Pascutti MF, Nolte MA.

Haematologica. 2018 Jun;103(6):e230-e233. doi: 10.3324/haematol.2017.169516. Epub 2018 Feb 22. No abstract available.


Distinct PKC-mediated posttranscriptional events set cytokine production kinetics in CD8+ T cells.

Salerno F, Paolini NA, Stark R, von Lindern M, Wolkers MC.

Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):9677-9682. doi: 10.1073/pnas.1704227114. Epub 2017 Aug 23.


Visualizing the life of mRNA in T cells.

Nicolet BP, Salerno F, Wolkers MC.

Biochem Soc Trans. 2017 Apr 15;45(2):563-570. doi: 10.1042/BST20170003. Review.


Combined Single-Cell Measurement of Cytokine mRNA and Protein Identifies T Cells with Persistent Effector Function.

Nicolet BP, Guislain A, Wolkers MC.

J Immunol. 2017 Jan 15;198(2):962-970. doi: 10.4049/jimmunol.1601531. Epub 2016 Dec 7.


GATA1-Deficient Dendritic Cells Display Impaired CCL21-Dependent Migration toward Lymph Nodes Due to Reduced Levels of Polysialic Acid.

Scheenstra MR, De Cuyper IM, Branco-Madeira F, de Bleser P, Kool M, Meinders M, Hoogenboezem M, Mul E, Wolkers MC, Salerno F, Nota B, Saeys Y, Klarenbeek S, van IJcken WF, Hammad H, Philipsen S, van den Berg TK, Kuijpers TW, Lambrecht BN, Gutiérrez L.

J Immunol. 2016 Dec 1;197(11):4312-4324. Epub 2016 Nov 4.


TLR-Mediated Innate Production of IFN-γ by CD8+ T Cells Is Independent of Glycolysis.

Salerno F, Guislain A, Cansever D, Wolkers MC.

J Immunol. 2016 May 1;196(9):3695-705. doi: 10.4049/jimmunol.1501997. Epub 2016 Mar 25.


T-cells require post-transcriptional regulation for accurate immune responses.

Salerno F, Wolkers MC.

Biochem Soc Trans. 2015 Dec;43(6):1201-7. doi: 10.1042/BST20150154. Review.


Enhanced CD8 T cell responses through GITR-mediated costimulation resolve chronic viral infection.

Pascutti MF, Geerman S, Slot E, van Gisbergen KP, Boon L, Arens R, van Lier RA, Wolkers MC, Nolte MA.

PLoS Pathog. 2015 Mar 4;11(3):e1004675. doi: 10.1371/journal.ppat.1004675. eCollection 2015 Mar.


Better safe than sorry: TOB1 employs multiple parallel regulatory pathways to keep Th17 cells quiet.

Salerno F, van Lier RA, Wolkers MC.

Eur J Immunol. 2014 Mar;44(3):646-9. doi: 10.1002/eji.201444465. Epub 2014 Feb 19.


Adrenergic β2 receptor activation stimulates anti-inflammatory properties of dendritic cells in vitro.

Nijhuis LE, Olivier BJ, Dhawan S, Hilbers FW, Boon L, Wolkers MC, Samsom JN, de Jonge WJ.

PLoS One. 2014 Jan 22;9(1):e85086. doi: 10.1371/journal.pone.0085086. eCollection 2014.


NAB2 and EGR-1 exert opposite roles in regulating TRAIL expression in human Natural Killer cells.

Balzarolo M, Watzl C, Medema JP, Wolkers MC.

Immunol Lett. 2013 Mar;151(1-2):61-7. doi: 10.1016/j.imlet.2013.02.001. Epub 2013 Feb 14.


IL-21-stimulated human plasmacytoid dendritic cells secrete granzyme B, which impairs their capacity to induce T-cell proliferation.

Karrich JJ, Jachimowski LC, Nagasawa M, Kamp A, Balzarolo M, Wolkers MC, Uittenbogaart CH, Marieke van Ham S, Blom B.

Blood. 2013 Apr 18;121(16):3103-11. doi: 10.1182/blood-2012-08-452995. Epub 2013 Feb 13.


The transcriptional regulator NAB2 reveals a two-step induction of TRAIL in activated plasmacytoid DCs.

Balzarolo M, Karrich JJ, Engels S, Blom B, Medema JP, Wolkers MC.

Eur J Immunol. 2012 Nov;42(11):3019-27. doi: 10.1002/eji.201242385. Epub 2012 Sep 12.


The transcription factor Spi-B regulates human plasmacytoid dendritic cell survival through direct induction of the antiapoptotic gene BCL2-A1.

Karrich JJ, Balzarolo M, Schmidlin H, Libouban M, Nagasawa M, Gentek R, Kamihira S, Maeda T, Amsen D, Wolkers MC, Blom B.

Blood. 2012 May 31;119(22):5191-200. doi: 10.1182/blood-2011-07-370239. Epub 2012 Apr 17.


Nab2 regulates secondary CD8+ T-cell responses through control of TRAIL expression.

Wolkers MC, Gerlach C, Arens R, Janssen EM, Fitzgerald P, Schumacher TN, Medema JP, Green DR, Schoenberger SP.

Blood. 2012 Jan 19;119(3):798-804. doi: 10.1182/blood-2011-08-373910. Epub 2011 Nov 29.


Interleukin-2 rescues helpless effector CD8+ T cells by diminishing the susceptibility to TRAIL mediated death.

Wolkers MC, Bensinger SJ, Green DR, Schoenberger SP, Janssen EM.

Immunol Lett. 2011 Sep 30;139(1-2):25-32. doi: 10.1016/j.imlet.2011.04.011. Epub 2011 May 20.


Selective expansion of merocytic dendritic cells and CD8DCs confers anti-tumour effect of Fms-like tyrosine kinase 3-ligand treatment in vivo.

Hennies CM, Reboulet RA, Garcia Z, Nierkens S, Wolkers MC, Janssen EM.

Clin Exp Immunol. 2011 Mar;163(3):381-91. doi: 10.1111/j.1365-2249.2010.04305.x. Epub 2011 Jan 14.


In vivo antigen stability affects DNA vaccine immunogenicity.

Bins AD, Wolkers MC, van den Boom MD, Haanen JB, Schumacher TN.

J Immunol. 2007 Aug 15;179(4):2126-33.


Effective graft depletion of MiHAg T-cell specificities and consequences for graft-versus-host disease.

de Witte MA, Toebes M, Song JY, Wolkers MC, Schumacher TN.

Blood. 2007 May 1;109(9):3830-8. Epub 2007 Jan 3.


Targeting self-antigens through allogeneic TCR gene transfer.

de Witte MA, Coccoris M, Wolkers MC, van den Boom MD, Mesman EM, Song JY, van der Valk M, Haanen JB, Schumacher TN.

Blood. 2006 Aug 1;108(3):870-7.


The generation of protective memory-like CD8+ T cells during homeostatic proliferation requires CD4+ T cells.

Hamilton SE, Wolkers MC, Schoenberger SP, Jameson SC.

Nat Immunol. 2006 May;7(5):475-81. Epub 2006 Apr 9.


A rapid and potent DNA vaccination strategy defined by in vivo monitoring of antigen expression.

Bins AD, Jorritsma A, Wolkers MC, Hung CF, Wu TC, Schumacher TN, Haanen JB.

Nat Med. 2005 Aug;11(8):899-904. Epub 2005 Jun 19.


Gene transfer of MHC-restricted receptors.

Kessels HW, Wolkers MC, Schumacher TN.

Methods Mol Med. 2005;109:201-14.


Antigen bias in T cell cross-priming.

Wolkers MC, Brouwenstijn N, Bakker AH, Toebes M, Schumacher TN.

Science. 2004 May 28;304(5675):1314-7. Erratum in: Science. 2004 Sep 24;305(5692):1912.


Adoptive transfer of T-cell immunity.

Kessels HW, Wolkers MC, Schumacher TN.

Trends Immunol. 2002 May;23(5):264-9. Review. No abstract available.


Optimizing the efficacy of epitope-directed DNA vaccination.

Wolkers MC, Toebes M, Okabe M, Haanen JB, Schumacher TN.

J Immunol. 2002 May 15;168(10):4998-5004.


Immunotherapy through TCR gene transfer.

Kessels HW, Wolkers MC, van den Boom MD, van der Valk MA, Schumacher TN.

Nat Immunol. 2001 Oct;2(10):957-61.


Redundancy of direct priming and cross-priming in tumor-specific CD8+ T cell responses.

Wolkers MC, Stoetter G, Vyth-Dreese FA, Schumacher TN.

J Immunol. 2001 Oct 1;167(7):3577-84.


Selective expansion of cross-reactive CD8(+) memory T cells by viral variants.

Haanen JB, Wolkers MC, Kruisbeek AM, Schumacher TN.

J Exp Med. 1999 Nov 1;190(9):1319-28.


Systemic T cell expansion during localized viral infection.

Haanen JB, Toebes M, Cordaro TA, Wolkers MC, Kruisbeek AM, Schumacher TN.

Eur J Immunol. 1999 Apr;29(4):1168-74.


Detection of human papillomavirus DNA in plucked hairs from renal transplant recipients and healthy volunteers.

Boxman IL, Berkhout RJ, Mulder LH, Wolkers MC, Bouwes Bavinck JN, Vermeer BJ, ter Schegget J.

J Invest Dermatol. 1997 May;108(5):712-5.

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