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Items: 1 to 50 of 57

1.

Disease risk and GVHD biomarkers can stratify patients for risk of relapse and nonrelapse mortality post hematopoietic cell transplant.

Aziz MD, Shah J, Kapoor U, Dimopoulos C, Anand S, Augustine A, Ayuk F, Chaudhry M, Chen YB, Choe HK, Etra A, Gergoudis S, Hartwell MJ, Hexner EO, Hogan WJ, Kitko CL, Kowalyk S, Kröger N, Merli P, Morales G, Nakamura R, Ordemann R, Pulsipher MA, Qayed M, Reshef R, Rösler W, Schechter T, Schreiner E, Srinagesh H, Wölfl M, Wudhikarn K, Yanik G, Young R, Özbek U, Ferrara JLM, Levine JE.

Leukemia. 2020 Feb 4. doi: 10.1038/s41375-020-0726-z. [Epub ahead of print]

PMID:
32020045
2.

Viral reactivations following hematopoietic stem cell transplantation in pediatric patients - A single center 11-year analysis.

Düver F, Weißbrich B, Eyrich M, Wölfl M, Schlegel PG, Wiegering V.

PLoS One. 2020 Feb 4;15(2):e0228451. doi: 10.1371/journal.pone.0228451. eCollection 2020.

3.

The MAGIC algorithm probability is a validated response biomarker of treatment of acute graft-versus-host disease.

Srinagesh HK, Özbek U, Kapoor U, Ayuk F, Aziz M, Ben-David K, Choe HK, DeFilipp Z, Etra A, Grupp SA, Hartwell MJ, Hexner EO, Hogan WJ, Karol AB, Kasikis S, Kitko CL, Kowalyk S, Lin JY, Major-Monfried H, Mielke S, Merli P, Morales G, Ordemann R, Pulsipher MA, Qayed M, Reddy P, Reshef R, Rösler W, Sandhu KS, Schechter T, Shah J, Sigel K, Weber D, Wölfl M, Wudhikarn K, Young R, Levine JE, Ferrara JLM.

Blood Adv. 2019 Dec 10;3(23):4034-4042. doi: 10.1182/bloodadvances.2019000791.

4.

On-target restoration of a split T cell-engaging antibody for precision immunotherapy.

Banaszek A, Bumm TGP, Nowotny B, Geis M, Jacob K, Wölfl M, Trebing J, Kucka K, Kouhestani D, Gogishvili T, Krenz B, Lutz J, Rasche L, Hönemann D, Neuweiler H, Heiby JC, Bargou RC, Wajant H, Einsele H, Riethmüller G, Stuhler G.

Nat Commun. 2019 Nov 26;10(1):5387. doi: 10.1038/s41467-019-13196-0.

5.

Re-expression of CD14 in Response to a Combined IL-10/TLR Stimulus Defines Monocyte-Derived Cells With an Immunoregulatory Phenotype.

Krakow S, Crescimone ML, Bartels C, Wiegering V, Eyrich M, Schlegel PG, Wölfl M.

Front Immunol. 2019 Jun 28;10:1484. doi: 10.3389/fimmu.2019.01484. eCollection 2019.

6.

Role of B cells in chronic graft-versus-host disease after allogeneic stem cell transplantation in children and adolescents.

Wiegering V, Keupp A, Frietsch M, Fiessler C, Haas K, Haubitz I, Beyersdorf N, Wölfl M, Schlegel PG, Eyrich M.

Br J Haematol. 2019 Sep;186(5):e133-e137. doi: 10.1111/bjh.15977. Epub 2019 May 28. No abstract available.

PMID:
31134622
7.

Cognate Nonlytic Interactions between CD8+ T Cells and Breast Cancer Cells Induce Cancer Stem Cell-like Properties.

Stein RG, Ebert S, Schlahsa L, Scholz CJ, Braun M, Hauck P, Horn E, Monoranu CM, Thiemann VJ, Wustrow MP, Häusler SF, Montalbán Del Barrio I, Stüber TN, Wölfl M, Dietl J, Rosenwald A, Diessner JE, Wöckel A, Wischhusen J.

Cancer Res. 2019 Apr 1;79(7):1507-1519. doi: 10.1158/0008-5472.CAN-18-0387. Epub 2019 Jan 28.

PMID:
30692216
8.

Stem cell transplantation for congenital dyserythropoietic anemia: an analysis from the European Society for Blood and Marrow Transplantation.

Miano M, Eikema DJ, Aljurf M, Van't Veer PJ, Öztürk G, Wölfl M, Smiers F, Schulz A, Socié G, Vettenranta K, de Heredia CD, Zecca M, Maertens J, Rovira M, Sierra J, Uckan-Cetinkaya D, Skorobogatova E, Antmen AB, Dalle JH, Markiewicz M, Hamladji RM, Kitra-Roussou V, La Nasa G, Kriván G, Al-Seiraihy A, Giardino S, Risitano AM, de Latour RP, Dufour C.

Haematologica. 2019 Aug;104(8):e335-e339. doi: 10.3324/haematol.2018.206623. Epub 2019 Jan 24. No abstract available.

9.

Early and late complications following hematopoietic stem cell transplantation in pediatric patients - A retrospective analysis over 11 years.

Hierlmeier S, Eyrich M, Wölfl M, Schlegel PG, Wiegering V.

PLoS One. 2018 Oct 16;13(10):e0204914. doi: 10.1371/journal.pone.0204914. eCollection 2018.

10.

An early-biomarker algorithm predicts lethal graft-versus-host disease and survival.

Hartwell MJ, Özbek U, Holler E, Renteria AS, Major-Monfried H, Reddy P, Aziz M, Hogan WJ, Ayuk F, Efebera YA, Hexner EO, Bunworasate U, Qayed M, Ordemann R, Wölfl M, Mielke S, Pawarode A, Chen YB, Devine S, Harris AC, Jagasia M, Kitko CL, Litzow MR, Kröger N, Locatelli F, Morales G, Nakamura R, Reshef R, Rösler W, Weber D, Wudhikarn K, Yanik GA, Levine JE, Ferrara JL.

JCI Insight. 2018 Aug 23;3(16). pii: 124015. doi: 10.1172/jci.insight.124015. eCollection 2018 Aug 23. No abstract available.

11.

High-grade glioma associated immunosuppression does not prevent immune responses induced by therapeutic vaccines in combination with Treg depletion.

Löhr M, Freitag B, Technau A, Krauss J, Monoranu CM, Rachor J, Lutz MB, Hagemann C, Kessler AF, Linsenmann T, Wölfl M, Ernestus RI, Engelhardt S, Gelbrich G, Schlegel PG, Eyrich M.

Cancer Immunol Immunother. 2018 Oct;67(10):1545-1558. doi: 10.1007/s00262-018-2214-0. Epub 2018 Jul 27.

12.

Spontaneous reversion of a lineage switch following an initial blinatumomab-induced ALL-to-AML switch in MLL-rearranged infant ALL.

Wölfl M, Rasche M, Eyrich M, Schmid R, Reinhardt D, Schlegel PG.

Blood Adv. 2018 Jun 26;2(12):1382-1385. doi: 10.1182/bloodadvances.2018018093. No abstract available.

13.

Extension of the International Atomic Energy Agency phantom study in image quantification: results of multicentre evaluation in Croatia.

Grošev D, Gregov M, Wolfl MR, Krstonošić B, Debeljuh DD.

Nucl Med Commun. 2018 Aug;39(8):797-802. doi: 10.1097/MNM.0000000000000877.

PMID:
29889160
14.

MAGIC biomarkers predict long-term outcomes for steroid-resistant acute GVHD.

Major-Monfried H, Renteria AS, Pawarode A, Reddy P, Ayuk F, Holler E, Efebera YA, Hogan WJ, Wölfl M, Qayed M, Hexner EO, Wudhikarn K, Ordemann R, Young R, Shah J, Hartwell MJ, Chaudhry MS, Aziz M, Etra A, Yanik GA, Kröger N, Weber D, Chen YB, Nakamura R, Rösler W, Kitko CL, Harris AC, Pulsipher M, Reshef R, Kowalyk S, Morales G, Torres I, Özbek U, Ferrara JLM, Levine JE.

Blood. 2018 Jun 21;131(25):2846-2855. doi: 10.1182/blood-2018-01-822957. Epub 2018 Mar 15.

15.

Characterization of a novel OTX2-driven stem cell program in Group 3 and Group 4 medulloblastoma.

Stromecki M, Tatari N, Morrison LC, Kaur R, Zagozewski J, Palidwor G, Ramaswamy V, Skowron P, Wölfl M, Milde T, Del Bigio MR, Taylor MD, Werbowetski-Ogilvie TE.

Mol Oncol. 2018 Apr;12(4):495-513. doi: 10.1002/1878-0261.12177. Epub 2018 Mar 1.

16.

Double Peripheral Venous and Arterial Cannulation for Extracorporeal Membrane Oxygenation in Combined Septic and Cardiogenic Shock.

Kredel M, Kunzmann S, Schlegel PG, Wölfl M, Nordbeck P, Bühler C, Lotz C, Lepper PM, Wirbelauer J, Roewer N, Muellenbach RM.

Am J Case Rep. 2017 Jun 28;18:723-727.

17.

An early-biomarker algorithm predicts lethal graft-versus-host disease and survival.

Hartwell MJ, Özbek U, Holler E, Renteria AS, Major-Monfried H, Reddy P, Aziz M, Hogan WJ, Ayuk F, Efebera YA, Hexner EO, Bunworasate U, Qayed M, Ordemann R, Wölfl M, Mielke S, Pawarode A, Chen YB, Devine S, Harris AC, Jagasia M, Kitko CL, Litzow MR, Kröger N, Locatelli F, Morales G, Nakamura R, Reshef R, Rösler W, Weber D, Wudhikarn K, Yanik GA, Levine JE, Ferrara JL.

JCI Insight. 2017 Feb 9;2(3):e89798. doi: 10.1172/jci.insight.89798. Erratum in: JCI Insight. 2018 Aug 23;3(16):.

18.

Prospective Biomarker Screening for Diagnosis of Invasive Aspergillosis in High-Risk Pediatric Patients.

Loeffler J, Hafner J, Mengoli C, Wirth C, Heussel CP, Löffler C, White PL, Ullmann AJ, Michel D, Wiegering V, Wölfl M, Schlegel PG, Einsele H, Springer J, Eyrich M.

J Clin Microbiol. 2016 Dec 28;55(1):101-109. doi: 10.1128/JCM.01682-16. Print 2017 Jan.

19.

IL12-mediated sensitizing of T-cell receptor-dependent and -independent tumor cell killing.

Braun M, Ress ML, Yoo YE, Scholz CJ, Eyrich M, Schlegel PG, Wölfl M.

Oncoimmunology. 2016 May 19;5(7):e1188245. doi: 10.1080/2162402X.2016.1188245. eCollection 2016 Jul.

20.

Pillars Article: Induction of Tolerance by IL-10-Treated Dendritic Cells. J. Immunol. 1997. 159: 4772-4780.

Steinbrink K, Wölfl M, Jonuleit H, Knop J, Enk AH.

J Immunol. 2016 Sep 1;197(5):1547-55. No abstract available.

21.

MB3W1 is an orthotopic xenograft model for anaplastic medulloblastoma displaying cancer stem cell- and Group 3-properties.

Dietl S, Schwinn S, Dietl S, Riedel S, Deinlein F, Rutkowski S, von Bueren AO, Krauss J, Schweitzer T, Vince GH, Picard D, Eyrich M, Rosenwald A, Ramaswamy V, Taylor MD, Remke M, Monoranu CM, Beilhack A, Schlegel PG, Wölfl M.

BMC Cancer. 2016 Feb 17;16:115. doi: 10.1186/s12885-016-2170-z.

22.

Dermatom und Diffusion--Diagnostik und Therapiekontrolle eines undifferenzierten embryonalen Sarkoms der Leber.

Neubauer H, Wölfl M, Ernestus K.

Rofo. 2016 Apr;188(4):389-91. doi: 10.1055/s-0041-107202. Epub 2015 Nov 3. German. No abstract available.

PMID:
26529268
23.

International, Multicenter Standardization of Acute Graft-versus-Host Disease Clinical Data Collection: A Report from the Mount Sinai Acute GVHD International Consortium.

Harris AC, Young R, Devine S, Hogan WJ, Ayuk F, Bunworasate U, Chanswangphuwana C, Efebera YA, Holler E, Litzow M, Ordemann R, Qayed M, Renteria AS, Reshef R, Wölfl M, Chen YB, Goldstein S, Jagasia M, Locatelli F, Mielke S, Porter D, Schechter T, Shekhovtsova Z, Ferrara JL, Levine JE.

Biol Blood Marrow Transplant. 2016 Jan;22(1):4-10. doi: 10.1016/j.bbmt.2015.09.001. Epub 2015 Sep 16.

24.

Fulminant skin GvHD with a cytokine pattern resemblant of cytokine release syndrome successfully treated with multimodal immunosuppression including tocilizumab.

Hellwig Y, Yoo YE, Reß ML, Andres O, Braun M, Schlegel PG, Wölfl M.

Pediatr Blood Cancer. 2015 Nov;62(11):2033-5. doi: 10.1002/pbc.25595. Epub 2015 Jul 7.

PMID:
26153219
25.

MRI demyelination pattern and clinical course in a child with cerebral X-linked adrenoleukodystrophy (X-ALD).

Nowak J, Löbel U, Wölfl M, Schlegel PG, Warmuth-Metz M.

Acta Radiol Open. 2015 Apr 1;4(4):2047981615573655. doi: 10.1177/2047981615573655. eCollection 2015 Apr.

26.

Recovery of large carnivores in Europe's modern human-dominated landscapes.

Chapron G, Kaczensky P, Linnell JD, von Arx M, Huber D, Andrén H, López-Bao JV, Adamec M, Álvares F, Anders O, Balčiauskas L, Balys V, Bedő P, Bego F, Blanco JC, Breitenmoser U, Brøseth H, Bufka L, Bunikyte R, Ciucci P, Dutsov A, Engleder T, Fuxjäger C, Groff C, Holmala K, Hoxha B, Iliopoulos Y, Ionescu O, Jeremić J, Jerina K, Kluth G, Knauer F, Kojola I, Kos I, Krofel M, Kubala J, Kunovac S, Kusak J, Kutal M, Liberg O, Majić A, Männil P, Manz R, Marboutin E, Marucco F, Melovski D, Mersini K, Mertzanis Y, Mysłajek RW, Nowak S, Odden J, Ozolins J, Palomero G, Paunović M, Persson J, Potočnik H, Quenette PY, Rauer G, Reinhardt I, Rigg R, Ryser A, Salvatori V, Skrbinšek T, Stojanov A, Swenson JE, Szemethy L, Trajçe A, Tsingarska-Sedefcheva E, Váňa M, Veeroja R, Wabakken P, Wölfl M, Wölfl S, Zimmermann F, Zlatanova D, Boitani L.

Science. 2014 Dec 19;346(6216):1517-9. doi: 10.1126/science.1257553.

PMID:
25525247
27.

The TGF-β-inducible miR-23a cluster attenuates IFN-γ levels and antigen-specific cytotoxicity in human CD8⁺ T cells.

Chandran PA, Keller A, Weinmann L, Seida AA, Braun M, Andreev K, Fischer B, Horn E, Schwinn S, Junker M, Houben R, Dombrowski Y, Dietl J, Finotto S, Wölfl M, Meister G, Wischhusen J.

J Leukoc Biol. 2014 Oct;96(4):633-45. doi: 10.1189/jlb.3A0114-025R. Epub 2014 Jul 16.

PMID:
25030422
28.

Impact of sequence variation in a dominant HLA-A*02-restricted epitope in hepatitis C virus on priming and cross-reactivity of CD8+ T cells.

Ziegler S, Skibbe K, Walker A, Ke X, Heinemann FM, Heinold A, Mok JY, van Esch WJ, Yang D, Wölfl M, Timm J.

J Virol. 2014 Oct;88(19):11080-90. doi: 10.1128/JVI.01590-14. Epub 2014 Jul 9.

29.

Development and validation of a fully GMP-compliant production process of autologous, tumor-lysate-pulsed dendritic cells.

Eyrich M, Schreiber SC, Rachor J, Krauss J, Pauwels F, Hain J, Wölfl M, Lutz MB, de Vleeschouwer S, Schlegel PG, Van Gool SW.

Cytotherapy. 2014 Jul;16(7):946-64. doi: 10.1016/j.jcyt.2014.02.017. Epub 2014 May 13.

PMID:
24831836
30.

Antigen-specific activation and cytokine-facilitated expansion of naive, human CD8+ T cells.

Wölfl M, Greenberg PD.

Nat Protoc. 2014 Apr;9(4):950-66. doi: 10.1038/nprot.2014.064. Epub 2014 Mar 27.

31.

Dendritic cell vaccination in pediatric gliomas: lessons learnt and future perspectives.

Eyrich M, Rachor J, Schreiber SC, Wölfl M, Schlegel PG.

Front Pediatr. 2013 Jun 10;1:12. doi: 10.3389/fped.2013.00012. Review.

32.

Successful treatment of an infant with CDA type II by intrauterine transfusions and postnatal stem cell transplantation.

Braun M, Wölfl M, Wiegering V, Winkler B, Ertan K, Bald R, Schwarz K, Heimpel H, Eyrich M, Schlegel PG.

Pediatr Blood Cancer. 2014 Apr;61(4):743-5. doi: 10.1002/pbc.24786. Epub 2013 Oct 3.

PMID:
24123799
33.

Src-kinase inhibitors sensitize human cells of myeloid origin to Toll-like-receptor-induced interleukin 12 synthesis.

Wölfl M, Schwinn S, Yoo YE, Reß ML, Braun M, Chopra M, Schreiber SC, Ayala VI, Ohlen C, Eyrich M, Beilhack A, Schlegel PG.

Blood. 2013 Aug 15;122(7):1203-13. doi: 10.1182/blood-2013-03-488072. Epub 2013 Jul 8.

34.

Transferred WT1-reactive CD8+ T cells can mediate antileukemic activity and persist in post-transplant patients.

Chapuis AG, Ragnarsson GB, Nguyen HN, Chaney CN, Pufnock JS, Schmitt TM, Duerkopp N, Roberts IM, Pogosov GL, Ho WY, Ochsenreither S, Wölfl M, Bar M, Radich JP, Yee C, Greenberg PD.

Sci Transl Med. 2013 Feb 27;5(174):174ra27. doi: 10.1126/scitranslmed.3004916.

35.

Dasatinib medication causing profound immunosuppression in a patient after haploidentical SCT: functional assays from whole blood as diagnostic clues.

Wölfl M, Langhammer F, Wiegering V, Eyrich M, Schlegel PG.

Bone Marrow Transplant. 2013 Jun;48(6):875-7. doi: 10.1038/bmt.2012.246. Epub 2012 Dec 10. No abstract available.

PMID:
23222377
36.

Lower TGFß serum levels and higher frequency of IFNγ-producing T cells during early immune reconstitution in surviving children after allogeneic stem cell transplantation.

Wiegering V, Winkler B, Haubitz I, Wölfl M, Schlegel PG, Eyrich M.

Pediatr Blood Cancer. 2013 Jan;60(1):121-8. doi: 10.1002/pbc.24208. Epub 2012 May 23.

PMID:
22623061
37.

Improving T-cell immunotherapy for melanoma through a mathematically motivated strategy: efficacy in numbers?

Kronik N, Kogan Y, Schlegel PG, Wölfl M.

J Immunother. 2012 Feb-Mar;35(2):116-24. doi: 10.1097/CJI.0b013e318236054c. Erratum in: J Immunother. 2012 Apr;35(3):292.

PMID:
22306899
38.

Pre-differentiated human committed T-lymphoid progenitors promote peripheral T-cell re-constitution after stem cell transplantation in immunodeficient mice.

Eyrich M, Schreiber SC, Wollny G, Ziegler H, Schlenker R, Koch-Büttner K, Wölfl M, Schlegel PG, Schilbach K.

Eur J Immunol. 2011 Dec;41(12):3596-603. doi: 10.1002/eji.201141561. Epub 2011 Oct 24.

39.

Allogeneic hematopoietic stem cell transplantation in Glanzmann thrombasthenia complicated by platelet alloimmunization.

Wiegering V, Winkler B, Langhammer F, Wölfl M, Wirbelauer J, Sauer K, Kobsar A, Meyer T, Strauss A, Bakchoul T, Eyrich M, Schlegel PG.

Klin Padiatr. 2011 May;223(3):173-5. doi: 10.1055/s-0031-1273726. Epub 2011 May 12.

PMID:
21567370
40.

Priming CD8+ T cells with dendritic cells matured using TLR4 and TLR7/8 ligands together enhances generation of CD8+ T cells retaining CD28.

Pufnock JS, Cigal M, Rolczynski LS, Andersen-Nissen E, Wolfl M, McElrath MJ, Greenberg PD.

Blood. 2011 Jun 16;117(24):6542-51. doi: 10.1182/blood-2010-11-317966. Epub 2011 Apr 14.

41.

TH1 predominance is associated with improved survival in pediatric medulloblastoma patients.

Wiegering V, Eyrich M, Rutkowski S, Wölfl M, Schlegel PG, Winkler B.

Cancer Immunol Immunother. 2011 May;60(5):693-703. doi: 10.1007/s00262-011-0981-y. Epub 2011 Feb 16.

PMID:
21327638
42.

Primed tumor-reactive multifunctional CD62L+ human CD8+ T cells for immunotherapy.

Wölfl M, Merker K, Morbach H, Van Gool SW, Eyrich M, Greenberg PD, Schlegel PG.

Cancer Immunol Immunother. 2011 Feb;60(2):173-86. doi: 10.1007/s00262-010-0928-8. Epub 2010 Oct 24.

43.

Immunological response after therapeutic vaccination with WT1 mRNA-loaded dendritic cells in end-stage endometrial carcinoma.

Coosemans A, Wölfl M, Berneman ZN, Van Tendeloo V, Vergote I, Amant F, Van Gool SW.

Anticancer Res. 2010 Sep;30(9):3709-14.

PMID:
20944158
44.

Transient loss of consciousness in pediatric recipients of dimethylsulfoxide (DMSO)-cryopreserved peripheral blood stem cells independent of morphine co-medication.

Schlegel PG, Wölfl M, Schick J, Winkler B, Eyrich M.

Haematologica. 2009 Oct;94(10):1473-5. doi: 10.3324/haematol.2009.009860. Epub 2009 Jul 16. No abstract available.

45.

Rituximab treatment before reduced-intensity conditioning transplantation associates with a decreased incidence of extensive chronic GVHD.

van Dorp S, Pietersma F, Wölfl M, Verdonck LF, Petersen EJ, Lokhorst HM, Martens E, Theobald M, van Baarle D, Meijer E, Kuball J.

Biol Blood Marrow Transplant. 2009 Jun;15(6):671-8. doi: 10.1016/j.bbmt.2009.02.005. Epub 2009 Apr 16.

46.

Increasing functional avidity of TCR-redirected T cells by removing defined N-glycosylation sites in the TCR constant domain.

Kuball J, Hauptrock B, Malina V, Antunes E, Voss RH, Wolfl M, Strong R, Theobald M, Greenberg PD.

J Exp Med. 2009 Feb 16;206(2):463-75. doi: 10.1084/jem.20082487. Epub 2009 Jan 26.

47.

Hepatitis C virus immune escape via exploitation of a hole in the T cell repertoire.

Wölfl M, Rutebemberwa A, Mosbruger T, Mao Q, Li HM, Netski D, Ray SC, Pardoll D, Sidney J, Sette A, Allen T, Kuntzen T, Kavanagh DG, Kuball J, Greenberg PD, Cox AL.

J Immunol. 2008 Nov 1;181(9):6435-46.

48.

Use of CD137 to study the full repertoire of CD8+ T cells without the need to know epitope specificities.

Wölfl M, Kuball J, Eyrich M, Schlegel PG, Greenberg PD.

Cytometry A. 2008 Nov;73(11):1043-9. doi: 10.1002/cyto.a.20594. Review.

49.
50.

T-cells in stem cell transplants: dissecting the good, the bad and the ugly.

Wolfl M, Eyrich M, Schlegel P, Greenberg P.

J Stem Cells Regen Med. 2007 May 16;2(1):26. eCollection 2007. No abstract available.

PMID:
24692886

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