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Mucus accumulation in the lungs precedes structural changes and infection in children with cystic fibrosis.

Esther CR Jr, Muhlebach MS, Ehre C, Hill DB, Wolfgang MC, Kesimer M, Ramsey KA, Markovetz MR, Garbarine IC, Forest MG, Seim I, Zorn B, Morrison CB, Delion MF, Thelin WR, Villalon D, Sabater JR, Turkovic L, Ranganathan S, Stick SM, Boucher RC.

Sci Transl Med. 2019 Apr 3;11(486). pii: eaav3488. doi: 10.1126/scitranslmed.aav3488.


One-hit wonder: Late after burn injury, granulocytes can clear one bacterial infection but cannot control a subsequent infection.

Kartchner LB, Gode CJ, Dunn JLM, Glenn LI, Duncan DN, Wolfgang MC, Cairns BA, Maile R.

Burns. 2019 May;45(3):627-640. doi: 10.1016/j.burns.2018.08.019. Epub 2019 Mar 2.


Mechanisms of reduced susceptibility and genotypic prediction of antibiotic resistance in Prevotella isolated from cystic fibrosis (CF) and non-CF patients.

Sherrard LJ, Schaible B, Graham KA, McGrath SJ, McIlreavey L, Hatch J, Wolfgang MC, Muhlebach MS, Gilpin DF, Schneiders T, Stuart Elborn J, Tunney MM.

J Antimicrob Chemother. 2018 Nov 1;73(11):3218. doi: 10.1093/jac/dky313. No abstract available.


Anaerobic bacteria cultured from cystic fibrosis airways correlate to milder disease: a multisite study.

Muhlebach MS, Hatch JE, Einarsson GG, McGrath SJ, Gilipin DF, Lavelle G, Mirkovic B, Murray MA, McNally P, Gotman N, Davis Thomas S, Wolfgang MC, Gilligan PH, McElvaney NG, Elborn JS, Boucher RC, Tunney MM.

Eur Respir J. 2018 Jul 11;52(1). pii: 1800242. doi: 10.1183/13993003.00242-2018. Print 2018 Jul.


RsmV, a Small Noncoding Regulatory RNA in Pseudomonas aeruginosa That Sequesters RsmA and RsmF from Target mRNAs.

Janssen KH, Diaz MR, Gode CJ, Wolfgang MC, Yahr TL.

J Bacteriol. 2018 Jul 25;200(16). pii: e00277-18. doi: 10.1128/JB.00277-18. Print 2018 Aug 15.


Evaluation of e-liquid toxicity using an open-source high-throughput screening assay.

Sassano MF, Davis ES, Keating JE, Zorn BT, Kochar TK, Wolfgang MC, Glish GL, Tarran R.

PLoS Biol. 2018 Mar 27;16(3):e2003904. doi: 10.1371/journal.pbio.2003904. eCollection 2018 Mar.


Functional Analyses of the RsmY and RsmZ Small Noncoding Regulatory RNAs in Pseudomonas aeruginosa.

Janssen KH, Diaz MR, Golden M, Graham JW, Sanders W, Wolfgang MC, Yahr TL.

J Bacteriol. 2018 May 9;200(11). pii: e00736-17. doi: 10.1128/JB.00736-17. Print 2018 Jun 1.


Initial acquisition and succession of the cystic fibrosis lung microbiome is associated with disease progression in infants and preschool children.

Muhlebach MS, Zorn BT, Esther CR, Hatch JE, Murray CP, Turkovic L, Ranganathan SC, Boucher RC, Stick SM, Wolfgang MC.

PLoS Pathog. 2018 Jan 18;14(1):e1006798. doi: 10.1371/journal.ppat.1006798. eCollection 2018 Jan.


Pseudomonas aeruginosa exoproducts determine antibiotic efficacy against Staphylococcus aureus.

Radlinski L, Rowe SE, Kartchner LB, Maile R, Cairns BA, Vitko NP, Gode CJ, Lachiewicz AM, Wolfgang MC, Conlon BP.

PLoS Biol. 2017 Nov 27;15(11):e2003981. doi: 10.1371/journal.pbio.2003981. eCollection 2017 Nov.


Primary and Secondary Sequence Structure Requirements for Recognition and Discrimination of Target RNAs by Pseudomonas aeruginosa RsmA and RsmF.

Schulmeyer KH, Diaz MR, Bair TB, Sanders W, Gode CJ, Laederach A, Wolfgang MC, Yahr TL.

J Bacteriol. 2016 Aug 25;198(18):2458-69. doi: 10.1128/JB.00343-16. Print 2016 Sep 15.


Phosphoryl Group Flow within the Pseudomonas aeruginosa Pil-Chp Chemosensory System: DIFFERENTIAL FUNCTION OF THE EIGHT PHOSPHOTRANSFERASE AND THREE RECEIVER DOMAINS.

Silversmith RE, Wang B, Fulcher NB, Wolfgang MC, Bourret RB.

J Biol Chem. 2016 Aug 19;291(34):17677-91. doi: 10.1074/jbc.M116.737528. Epub 2016 Jun 27.


Vfr Directly Activates exsA Transcription To Regulate Expression of the Pseudomonas aeruginosa Type III Secretion System.

Marsden AE, Intile PJ, Schulmeyer KH, Simmons-Patterson ER, Urbanowski ML, Wolfgang MC, Yahr TL.

J Bacteriol. 2016 Apr 14;198(9):1442-50. doi: 10.1128/JB.00049-16. Print 2016 May.


Production of extended-spectrum β-lactamases and the potential indirect pathogenic role of Prevotella isolates from the cystic fibrosis respiratory microbiota.

Sherrard LJ, McGrath SJ, McIlreavey L, Hatch J, Wolfgang MC, Muhlebach MS, Gilpin DF, Elborn JS, Tunney MM.

Int J Antimicrob Agents. 2016 Feb;47(2):140-5. doi: 10.1016/j.ijantimicag.2015.12.004. Epub 2015 Dec 29.


The RNA Helicase DeaD Stimulates ExsA Translation To Promote Expression of the Pseudomonas aeruginosa Type III Secretion System.

Intile PJ, Balzer GJ, Wolfgang MC, Yahr TL.

J Bacteriol. 2015 Aug;197(16):2664-74. doi: 10.1128/JB.00231-15. Epub 2015 Jun 8.


A hierarchical cascade of second messengers regulates Pseudomonas aeruginosa surface behaviors.

Luo Y, Zhao K, Baker AE, Kuchma SL, Coggan KA, Wolfgang MC, Wong GC, O'Toole GA.

MBio. 2015 Jan 27;6(1). pii: e02456-14. doi: 10.1128/mBio.02456-14.


Mechanisms of reduced susceptibility and genotypic prediction of antibiotic resistance in Prevotella isolated from cystic fibrosis (CF) and non-CF patients.

Sherrard LJ, Schaible B, Graham KA, McGrath SJ, McIlreavey L, Hatch J, Wolfgang MC, Muhlebach MS, Gilpin DF, Schneiders T, Elborn JS, Tunney MM.

J Antimicrob Chemother. 2014 Oct;69(10):2690-8. doi: 10.1093/jac/dku192. Epub 2014 Jun 10.


Flagellin treatment prevents increased susceptibility to systemic bacterial infection after injury by inhibiting anti-inflammatory IL-10+ IL-12- neutrophil polarization.

Neely CJ, Kartchner LB, Mendoza AE, Linz BM, Frelinger JA, Wolfgang MC, Maile R, Cairns BA.

PLoS One. 2014 Jan 15;9(1):e85623. doi: 10.1371/journal.pone.0085623. eCollection 2014.


The AlgZR two-component system recalibrates the RsmAYZ posttranscriptional regulatory system to inhibit expression of the Pseudomonas aeruginosa type III secretion system.

Intile PJ, Diaz MR, Urbanowski ML, Wolfgang MC, Yahr TL.

J Bacteriol. 2014 Jan;196(2):357-66. doi: 10.1128/JB.01199-13. Epub 2013 Nov 1.


An unusual CsrA family member operates in series with RsmA to amplify posttranscriptional responses in Pseudomonas aeruginosa.

Marden JN, Diaz MR, Walton WG, Gode CJ, Betts L, Urbanowski ML, Redinbo MR, Yahr TL, Wolfgang MC.

Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):15055-60. doi: 10.1073/pnas.1307217110. Epub 2013 Aug 26.


Antibiotic resistance in Prevotella species isolated from patients with cystic fibrosis.

Sherrard LJ, Graham KA, McGrath SJ, McIlreavey L, Hatch J, Muhlebach MS, Wolfgang MC, Gilpin DF, Elborn JS, Schneiders T, Tunney MM.

J Antimicrob Chemother. 2013 Oct;68(10):2369-74. doi: 10.1093/jac/dkt191. Epub 2013 May 21.


Lung microbiota and bacterial abundance in patients with bronchiectasis when clinically stable and during exacerbation.

Tunney MM, Einarsson GG, Wei L, Drain M, Klem ER, Cardwell C, Ennis M, Boucher RC, Wolfgang MC, Elborn JS.

Am J Respir Crit Care Med. 2013 May 15;187(10):1118-26. doi: 10.1164/rccm.201210-1937OC.


The adult cystic fibrosis airway microbiota is stable over time and infection type, and highly resilient to antibiotic treatment of exacerbations.

Fodor AA, Klem ER, Gilpin DF, Elborn JS, Boucher RC, Tunney MM, Wolfgang MC.

PLoS One. 2012;7(9):e45001. doi: 10.1371/journal.pone.0045001. Epub 2012 Sep 26.


Mucus clearance, MyD88-dependent and MyD88-independent immunity modulate lung susceptibility to spontaneous bacterial infection and inflammation.

Livraghi-Butrico A, Kelly EJ, Klem ER, Dang H, Wolfgang MC, Boucher RC, Randell SH, O'Neal WK.

Mucosal Immunol. 2012 Jul;5(4):397-408. doi: 10.1038/mi.2012.17. Epub 2012 Mar 14.


Global regulatory pathways and cross-talk control pseudomonas aeruginosa environmental lifestyle and virulence phenotype.

Coggan KA, Wolfgang MC.

Curr Issues Mol Biol. 2012;14(2):47-70. Epub 2012 Feb 22. Review.


Significance of the microbiome in obstructive lung disease.

Han MK, Huang YJ, Lipuma JJ, Boushey HA, Boucher RC, Cookson WO, Curtis JL, Erb-Downward J, Lynch SV, Sethi S, Toews GB, Young VB, Wolfgang MC, Huffnagle GB, Martinez FJ.

Thorax. 2012 May;67(5):456-63. doi: 10.1136/thoraxjnl-2011-201183. Epub 2012 Feb 8. Review.


Pseudomonas aeruginosa PilY1 binds integrin in an RGD- and calcium-dependent manner.

Johnson MD, Garrett CK, Bond JE, Coggan KA, Wolfgang MC, Redinbo MR.

PLoS One. 2011;6(12):e29629. doi: 10.1371/journal.pone.0029629. Epub 2011 Dec 29.


Crystal structure and regulation mechanisms of the CyaB adenylyl cyclase from the human pathogen Pseudomonas aeruginosa.

Topal H, Fulcher NB, Bitterman J, Salazar E, Buck J, Levin LR, Cann MJ, Wolfgang MC, Steegborn C.

J Mol Biol. 2012 Feb 17;416(2):271-86. doi: 10.1016/j.jmb.2011.12.045. Epub 2011 Dec 28.


Use of culture and molecular analysis to determine the effect of antibiotic treatment on microbial community diversity and abundance during exacerbation in patients with cystic fibrosis.

Tunney MM, Klem ER, Fodor AA, Gilpin DF, Moriarty TF, McGrath SJ, Muhlebach MS, Boucher RC, Cardwell C, Doering G, Elborn JS, Wolfgang MC.

Thorax. 2011 Jul;66(7):579-84. doi: 10.1136/thx.2010.137281. Epub 2011 Jan 26.


Analysis of the bacterial communities present in lungs of patients with cystic fibrosis from American and British centers.

Stressmann FA, Rogers GB, Klem ER, Lilley AK, Donaldson SH, Daniels TW, Carroll MP, Patel N, Forbes B, Boucher RC, Wolfgang MC, Bruce KD.

J Clin Microbiol. 2011 Jan;49(1):281-91. doi: 10.1128/JCM.01650-10. Epub 2010 Nov 10.


Activation of the Pseudomonas aeruginosa AlgU regulon through mucA mutation inhibits cyclic AMP/Vfr signaling.

Jones AK, Fulcher NB, Balzer GJ, Urbanowski ML, Pritchett CL, Schurr MJ, Yahr TL, Wolfgang MC.

J Bacteriol. 2010 Nov;192(21):5709-17. doi: 10.1128/JB.00526-10. Epub 2010 Sep 3.


The development of ciprofloxacin resistance in Pseudomonas aeruginosa involves multiple response stages and multiple proteins.

Su HC, Ramkissoon K, Doolittle J, Clark M, Khatun J, Secrest A, Wolfgang MC, Giddings MC.

Antimicrob Agents Chemother. 2010 Nov;54(11):4626-35. doi: 10.1128/AAC.00762-10. Epub 2010 Aug 9.


The Pseudomonas aeruginosa Vfr regulator controls global virulence factor expression through cyclic AMP-dependent and -independent mechanisms.

Fuchs EL, Brutinel ED, Jones AK, Fulcher NB, Urbanowski ML, Yahr TL, Wolfgang MC.

J Bacteriol. 2010 Jul;192(14):3553-64. doi: 10.1128/JB.00363-10. Epub 2010 May 21.


In vitro and in vivo characterization of the Pseudomonas aeruginosa cyclic AMP (cAMP) phosphodiesterase CpdA, required for cAMP homeostasis and virulence factor regulation.

Fuchs EL, Brutinel ED, Klem ER, Fehr AR, Yahr TL, Wolfgang MC.

J Bacteriol. 2010 Jun;192(11):2779-90. doi: 10.1128/JB.00168-10. Epub 2010 Mar 26.


The Pseudomonas aeruginosa Chp chemosensory system regulates intracellular cAMP levels by modulating adenylate cyclase activity.

Fulcher NB, Holliday PM, Klem E, Cann MJ, Wolfgang MC.

Mol Microbiol. 2010 May;76(4):889-904. doi: 10.1111/j.1365-2958.2010.07135.x. Epub 2010 Mar 16.


Infection of human mucosal tissue by Pseudomonas aeruginosa requires sequential and mutually dependent virulence factors and a novel pilus-associated adhesin.

Heiniger RW, Winther-Larsen HC, Pickles RJ, Koomey M, Wolfgang MC.

Cell Microbiol. 2010 Aug;12(8):1158-73. doi: 10.1111/j.1462-5822.2010.01461.x. Epub 2010 Mar 12.


Crystal structure analysis reveals Pseudomonas PilY1 as an essential calcium-dependent regulator of bacterial surface motility.

Orans J, Johnson MD, Coggan KA, Sperlazza JR, Heiniger RW, Wolfgang MC, Redinbo MR.

Proc Natl Acad Sci U S A. 2010 Jan 19;107(3):1065-70. doi: 10.1073/pnas.0911616107. Epub 2009 Dec 28. Erratum in: Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5260.


Airway epithelial inflammation-induced endoplasmic reticulum Ca2+ store expansion is mediated by X-box binding protein-1.

Martino ME, Olsen JC, Fulcher NB, Wolfgang MC, O'Neal WK, Ribeiro CM.

J Biol Chem. 2009 May 29;284(22):14904-13. doi: 10.1074/jbc.M809180200. Epub 2009 Mar 25.


Pseudomonas aeruginosa AlgR controls cyanide production in an AlgZ-dependent manner.

Cody WL, Pritchett CL, Jones AK, Carterson AJ, Jackson D, Frisk A, Wolfgang MC, Schurr MJ.

J Bacteriol. 2009 May;191(9):2993-3002. doi: 10.1128/JB.01156-08. Epub 2009 Mar 6.


Detection of anaerobic bacteria in high numbers in sputum from patients with cystic fibrosis.

Tunney MM, Field TR, Moriarty TF, Patrick S, Doering G, Muhlebach MS, Wolfgang MC, Boucher R, Gilpin DF, McDowell A, Elborn JS.

Am J Respir Crit Care Med. 2008 May 1;177(9):995-1001. doi: 10.1164/rccm.200708-1151OC. Epub 2008 Feb 8.


Genetic and functional analyses of PptA, a phospho-form transferase targeting type IV pili in Neisseria gonorrhoeae.

Naessan CL, Egge-Jacobsen W, Heiniger RW, Wolfgang MC, Aas FE, Røhr A, Winther-Larsen HC, Koomey M.

J Bacteriol. 2008 Jan;190(1):387-400. Epub 2007 Oct 19.


Pseudomonas aeruginosa Type IV pilus expression in Neisseria gonorrhoeae: effects of pilin subunit composition on function and organelle dynamics.

Winther-Larsen HC, Wolfgang MC, van Putten JP, Roos N, Aas FE, Egge-Jacobsen WM, Maier B, Koomey M.

J Bacteriol. 2007 Sep;189(18):6676-85. Epub 2007 Jun 15.


Transcriptional regulation of the Pseudomonas aeruginosa type III secretion system.

Yahr TL, Wolfgang MC.

Mol Microbiol. 2006 Nov;62(3):631-40. Epub 2006 Sep 21. Review.


Bacterial neuraminidase facilitates mucosal infection by participating in biofilm production.

Soong G, Muir A, Gomez MI, Waks J, Reddy B, Planet P, Singh PK, Kaneko Y, Wolfgang MC, Hsiao YS, Tong L, Prince A.

J Clin Invest. 2006 Aug;116(8):2297-2305. Erratum in: J Clin Invest. 2006 Oct;116(10):2828. Kanetko, Yukihiro [corrected to Kaneko, Yukihiro].


Acquisition and evolution of the exoU locus in Pseudomonas aeruginosa.

Kulasekara BR, Kulasekara HD, Wolfgang MC, Stevens L, Frank DW, Lory S.

J Bacteriol. 2006 Jun;188(11):4037-50.


Genome-wide analysis of host responses to the Pseudomonas aeruginosa type III secretion system yields synergistic effects.

Ichikawa JK, English SB, Wolfgang MC, Jackson R, Butte AJ, Lory S.

Cell Microbiol. 2005 Nov;7(11):1635-46.


A novel anti-anti-activator mechanism regulates expression of the Pseudomonas aeruginosa type III secretion system.

Dasgupta N, Lykken GL, Wolfgang MC, Yahr TL.

Mol Microbiol. 2004 Jul;53(1):297-308.


Pseudomonas aeruginosa regulates flagellin expression as part of a global response to airway fluid from cystic fibrosis patients.

Wolfgang MC, Jyot J, Goodman AL, Ramphal R, Lory S.

Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6664-8. Epub 2004 Apr 14.


Sequence polymorphism in the glycosylation island and flagellins of Pseudomonas aeruginosa.

Arora SK, Wolfgang MC, Lory S, Ramphal R.

J Bacteriol. 2004 Apr;186(7):2115-22.

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