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Chemoenzymatic synthesis of the oligosaccharide moiety of the tumor-associated antigen disialosyl globopentaosylceramide.

't Hart IME, Li T, Wolfert MA, Wang S, Moremen KW, Boons GJ.

Org Biomol Chem. 2019 Aug 7;17(31):7304-7308. doi: 10.1039/c9ob01368g.


N-Glycolylneuraminic Acid as a Receptor for Influenza A Viruses.

Broszeit F, Tzarum N, Zhu X, Nemanichvili N, Eggink D, Leenders T, Li Z, Liu L, Wolfert MA, Papanikolaou A, Martínez-Romero C, Gagarinov IA, Yu W, García-Sastre A, Wennekes T, Okamatsu M, Verheije MH, Wilson IA, Boons GJ, de Vries RP.

Cell Rep. 2019 Jun 11;27(11):3284-3294.e6. doi: 10.1016/j.celrep.2019.05.048.


Protecting-Group-Controlled Enzymatic Glycosylation of Oligo-N-Acetyllactosamine Derivatives.

Gagarinov IA, Li T, Wei N, Sastre Toraño J, de Vries RP, Wolfert MA, Boons GJ.

Angew Chem Int Ed Engl. 2019 Jul 29;58(31):10547-10552. doi: 10.1002/anie.201903140. Epub 2019 Jul 1.


Synthesis and Immunological Evaluation of a Multicomponent Cancer Vaccine Candidate Containing a Long MUC1 Glycopeptide.

Supekar NT, Lakshminarayanan V, Capicciotti CJ, Sirohiwal A, Madsen CS, Wolfert MA, Cohen PA, Gendler SJ, Boons GJ.

Chembiochem. 2018 Jan 18;19(2):121-125. doi: 10.1002/cbic.201700424. Epub 2017 Nov 30.


Heparan Sulfate Microarray Reveals That Heparan Sulfate-Protein Binding Exhibits Different Ligand Requirements.

Zong C, Venot A, Li X, Lu W, Xiao W, Wilkes JL, Salanga CL, Handel TM, Wang L, Wolfert MA, Boons GJ.

J Am Chem Soc. 2017 Jul 19;139(28):9534-9543. doi: 10.1021/jacs.7b01399. Epub 2017 Jul 7.


Synthesis of asymmetrical multiantennary human milk oligosaccharides.

Prudden AR, Liu L, Capicciotti CJ, Wolfert MA, Wang S, Gao Z, Meng L, Moremen KW, Boons GJ.

Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):6954-6959. doi: 10.1073/pnas.1701785114. Epub 2017 Jun 19.


Mucin architecture behind the immune response: design, evaluation and conformational analysis of an antitumor vaccine derived from an unnatural MUC1 fragment.

Martínez-Sáez N, Supekar NT, Wolfert MA, Bermejo IA, Hurtado-Guerrero R, Asensio JL, Jiménez-Barbero J, Busto JH, Avenoza A, Boons GJ, Peregrina JM, Corzana F.

Chem Sci. 2016 Mar 1;7(3):2294-2301. doi: 10.1039/c5sc04039f. Epub 2015 Dec 15.


MUC1 Vaccines, Comprised of Glycosylated or Non-Glycosylated Peptides or Tumor-Derived MUC1, Can Circumvent Immunoediting to Control Tumor Growth in MUC1 Transgenic Mice.

Lakshminarayanan V, Supekar NT, Wei J, McCurry DB, Dueck AC, Kosiorek HE, Trivedi PP, Bradley JM, Madsen CS, Pathangey LB, Hoelzinger DB, Wolfert MA, Boons GJ, Cohen PA, Gendler SJ.

PLoS One. 2016 Jan 20;11(1):e0145920. doi: 10.1371/journal.pone.0145920. eCollection 2016.


Controlled Multi-functionalization Facilitates Targeted Delivery of Nanoparticles to Cancer Cells.

Hudlikar MS, Li X, Gagarinov IA, Kolishetti N, Wolfert MA, Boons GJ.

Chemistry. 2016 Jan 22;22(4):1415-23. doi: 10.1002/chem.201503999. Epub 2015 Dec 18.


Linear synthesis and immunological properties of a fully synthetic vaccine candidate containing a sialylated MUC1 glycopeptide.

Thompson P, Lakshminarayanan V, Supekar NT, Bradley JM, Cohen PA, Wolfert MA, Gendler SJ, Boons GJ.

Chem Commun (Camb). 2015 Jun 25;51(50):10214-7. doi: 10.1039/c5cc02199e. Epub 2015 May 29.


Immune and anticancer responses elicited by fully synthetic aberrantly glycosylated MUC1 tripartite vaccines modified by a TLR2 or TLR9 agonist.

Abdel-Aal AB, Lakshminarayanan V, Thompson P, Supekar N, Bradley JM, Wolfert MA, Cohen PA, Gendler SJ, Boons GJ.

Chembiochem. 2014 Jul 7;15(10):1508-13. doi: 10.1002/cbic.201402077. Epub 2014 May 30.


A multifunctional anomeric linker for the chemoenzymatic synthesis of complex oligosaccharides.

Prudden AR, Chinoy ZS, Wolfert MA, Boons GJ.

Chem Commun (Camb). 2014 Jul 11;50(54):7132-5. doi: 10.1039/c4cc02222j.


Adaptive immune activation: glycosylation does matter.

Wolfert MA, Boons GJ.

Nat Chem Biol. 2013 Dec;9(12):776-84. doi: 10.1038/nchembio.1403.


Selective exo-enzymatic labeling of N-glycans on the surface of living cells by recombinant ST6Gal I.

Mbua NE, Li X, Flanagan-Steet HR, Meng L, Aoki K, Moremen KW, Wolfert MA, Steet R, Boons GJ.

Angew Chem Int Ed Engl. 2013 Dec 2;52(49):13012-5. doi: 10.1002/anie.201307095. Epub 2013 Oct 15.


Abnormal accumulation and recycling of glycoproteins visualized in Niemann-Pick type C cells using the chemical reporter strategy.

Mbua NE, Flanagan-Steet H, Johnson S, Wolfert MA, Boons GJ, Steet R.

Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):10207-12. doi: 10.1073/pnas.1221105110. Epub 2013 Jun 3.


Chemical synthesis and immunological evaluation of the inner core oligosaccharide of Francisella tularensis.

Boltje TJ, Zhong W, Park J, Wolfert MA, Chen W, Boons GJ.

J Am Chem Soc. 2012 Aug 29;134(34):14255-62. doi: 10.1021/ja306274v. Epub 2012 Aug 16.


Polar dibenzocyclooctynes for selective labeling of extracellular glycoconjugates of living cells.

Friscourt F, Ledin PA, Mbua NE, Flanagan-Steet HR, Wolfert MA, Steet R, Boons GJ.

J Am Chem Soc. 2012 Mar 21;134(11):5381-9. doi: 10.1021/ja3002666. Epub 2012 Mar 9.


Immune recognition of tumor-associated mucin MUC1 is achieved by a fully synthetic aberrantly glycosylated MUC1 tripartite vaccine.

Lakshminarayanan V, Thompson P, Wolfert MA, Buskas T, Bradley JM, Pathangey LB, Madsen CS, Cohen PA, Gendler SJ, Boons GJ.

Proc Natl Acad Sci U S A. 2012 Jan 3;109(1):261-6. doi: 10.1073/pnas.1115166109. Epub 2011 Dec 14.


Morphological changes in diabetic kidney are associated with increased O-GlcNAcylation of cytoskeletal proteins including α-actinin 4.

Akimoto Y, Miura Y, Toda T, Wolfert MA, Wells L, Boons GJ, Hart GW, Endo T, Kawakami H.

Clin Proteomics. 2011 Sep 21;8(1):15. doi: 10.1186/1559-0275-8-15.


Multifunctional surface modification of gold-stabilized nanoparticles by bioorthogonal reactions.

Li X, Guo J, Asong J, Wolfert MA, Boons GJ.

J Am Chem Soc. 2011 Jul 27;133(29):11147-53. doi: 10.1021/ja2012164. Epub 2011 Jun 30.


Strain-promoted alkyne-azide cycloadditions (SPAAC) reveal new features of glycoconjugate biosynthesis.

Mbua NE, Guo J, Wolfert MA, Steet R, Boons GJ.

Chembiochem. 2011 Aug 16;12(12):1912-21. doi: 10.1002/cbic.201100117. Epub 2011 Jun 9.


Surface modification of polymeric micelles by strain-promoted alkyne-azide cycloadditions.

Guo J, Chen G, Ning X, Wolfert MA, Li X, Xu B, Boons GJ.

Chemistry. 2010 Dec 3;16(45):13360-6. doi: 10.1002/chem.201002532.


Surface functionalization using catalyst-free azide-alkyne cycloaddition.

Kuzmin A, Poloukhtine A, Wolfert MA, Popik VV.

Bioconjug Chem. 2010 Nov 17;21(11):2076-85. doi: 10.1021/bc100306u. Epub 2010 Oct 21.


Differential induction of innate immune responses by synthetic lipid a derivatives.

Gaekwad J, Zhang Y, Zhang W, Reeves J, Wolfert MA, Boons GJ.

J Biol Chem. 2010 Sep 17;285(38):29375-86. doi: 10.1074/jbc.M110.115204. Epub 2010 Jul 15.


Protein modification by strain-promoted alkyne-nitrone cycloaddition.

Ning X, Temming RP, Dommerholt J, Guo J, Ania DB, Debets MF, Wolfert MA, Boons GJ, van Delft FL.

Angew Chem Int Ed Engl. 2010 Apr 12;49(17):3065-8. doi: 10.1002/anie.201000408. No abstract available.


Glycopeptide-specific monoclonal antibodies suggest new roles for O-GlcNAc.

Teo CF, Ingale S, Wolfert MA, Elsayed GA, Nöt LG, Chatham JC, Wells L, Boons GJ.

Nat Chem Biol. 2010 May;6(5):338-43. doi: 10.1038/nchembio.338. Epub 2010 Mar 21.


Chemical synthesis and proinflammatory responses of monophosphoryl lipid A adjuvant candidates.

Maiti KK, Decastro M, El-Sayed AB, Foote MI, Wolfert MA, Boons GJ.

European J Org Chem. 2010 Jan 1;2010(1):80-91.


Selective labeling of living cells by a photo-triggered click reaction.

Poloukhtine AA, Mbua NE, Wolfert MA, Boons GJ, Popik VV.

J Am Chem Soc. 2009 Nov 4;131(43):15769-76. doi: 10.1021/ja9054096.


Innate immune responses of primary murine macrophage-lineage cells and RAW 264.7 cells to ligands of Toll-like receptors 2, 3, and 4.

Berghaus LJ, Moore JN, Hurley DJ, Vandenplas ML, Fortes BP, Wolfert MA, Boons GJ.

Comp Immunol Microbiol Infect Dis. 2010 Sep;33(5):443-54. doi: 10.1016/j.cimid.2009.07.001. Epub 2009 Sep 3.


Binding and Cellular Activation Studies Reveal That Toll-like Receptor 2 Can Differentially Recognize Peptidoglycan from Gram-positive and Gram-negative Bacteria.

Asong J, Wolfert MA, Maiti KK, Miller D, Boons GJ.

J Biol Chem. 2009 Mar 27;284(13):8643-53. doi: 10.1074/jbc.M806633200. Epub 2009 Jan 21.


Increasing the antigenicity of synthetic tumor-associated carbohydrate antigens by targeting Toll-like receptors.

Ingale S, Wolfert MA, Buskas T, Boons GJ.

Chembiochem. 2009 Feb 13;10(3):455-63. doi: 10.1002/cbic.200800596.


Synthetic tetra-acylated derivatives of lipid A from Porphyromonas gingivalis are antagonists of human TLR4.

Zhang Y, Gaekwad J, Wolfert MA, Boons GJ.

Org Biomol Chem. 2008 Sep 21;6(18):3371-81. doi: 10.1039/b809090d. Epub 2008 Jul 25.


Chemical synthesis and immunological properties of oligosaccharides derived from the vegetative cell wall of Bacillus anthracis.

Vasan M, Rauvolfova J, Wolfert MA, Leoff C, Kannenberg EL, Quinn CP, Carlson RW, Boons GJ.

Chembiochem. 2008 Jul 21;9(11):1716-20. doi: 10.1002/cbic.200800210. No abstract available.


Visualizing metabolically labeled glycoconjugates of living cells by copper-free and fast huisgen cycloadditions.

Ning X, Guo J, Wolfert MA, Boons GJ.

Angew Chem Int Ed Engl. 2008;47(12):2253-5. doi: 10.1002/anie.200705456. No abstract available.


Innate immune responses of synthetic lipid A derivatives of Neisseria meningitidis.

Zhang Y, Gaekwad J, Wolfert MA, Boons GJ.

Chemistry. 2008;14(2):558-69.


Robust immune responses elicited by a fully synthetic three-component vaccine.

Ingale S, Wolfert MA, Gaekwad J, Buskas T, Boons GJ.

Nat Chem Biol. 2007 Oct;3(10):663-7. Epub 2007 Sep 2.


Agonistic and antagonistic properties of a Rhizobium sin-1 lipid A modified by an ether-linked lipid.

Vasan M, Wolfert MA, Boons GJ.

Org Biomol Chem. 2007 Jul 7;5(13):2087-97. Epub 2007 May 29.


The influence of the long chain fatty acid on the antagonistic activities of Rhizobium sin-1 lipid A.

Zhang Y, Wolfert MA, Boons GJ.

Bioorg Med Chem. 2007 Jul 15;15(14):4800-12. Epub 2007 May 6.


Modulation of innate immune responses with synthetic lipid A derivatives.

Zhang Y, Gaekwad J, Wolfert MA, Boons GJ.

J Am Chem Soc. 2007 Apr 25;129(16):5200-16. Epub 2007 Mar 29.


The 2-aminogluconate isomer of rhizobium sin-1 lipid A can antagonize TNF-alpha production induced by enteric LPS.

Lee HS, Wolfert MA, Zhang Y, Boons GJ.

Chembiochem. 2006 Jan;7(1):140-8.


Synthesis and proinflammatory properties of muramyl tripeptides containing lysine and diaminopimelic acid moieties.

Roychowdhury A, Wolfert MA, Boons GJ.

Chembiochem. 2005 Nov;6(11):2088-97.


Synthesis and biological evaluation of a lipid A derivative that contains an aminogluconate moiety.

Santhanam B, Wolfert MA, Moore JN, Boons GJ.

Chemistry. 2004 Oct 4;10(19):4798-807.


Synthesis and biological evaluation of Rhizobium sin-1 lipid A derivatives.

Demchenko AV, Wolfert MA, Santhanam B, Moore JN, Boons GJ.

J Am Chem Soc. 2003 May 21;125(20):6103-12.


The origin of the synergistic effect of muramyl dipeptide with endotoxin and peptidoglycan.

Wolfert MA, Murray TF, Boons GJ, Moore JN.

J Biol Chem. 2002 Oct 18;277(42):39179-86. Epub 2002 Jul 31.


Synthesis and proinflammatory effects of peptidoglycan-derived neoglycopeptide polymers.

Siriwardena A, Jørgensen MR, Wolfert MA, Vandenplas ML, Moore JN, Boons GJ.

J Am Chem Soc. 2001 Aug 22;123(33):8145-6. No abstract available.


DNA delivery systems based on complexes of DNA with synthetic polycations and their copolymers.

Oupický D, Konák C, Ulbrich K, Wolfert MA, Seymour LW.

J Control Release. 2000 Mar 1;65(1-2):149-71.


Sources of Escherichia coli in a coastal subtropical environment.

Solo-Gabriele HM, Wolfert MA, Desmarais TR, Palmer CJ.

Appl Environ Microbiol. 2000 Jan;66(1):230-7.


Polyelectrolyte vectors for gene delivery: influence of cationic polymer on biophysical properties of complexes formed with DNA.

Wolfert MA, Dash PR, Nazarova O, Oupicky D, Seymour LW, Smart S, Strohalm J, Ulbrich K.

Bioconjug Chem. 1999 Nov-Dec;10(6):993-1004.


Factors affecting blood clearance and in vivo distribution of polyelectrolyte complexes for gene delivery.

Dash PR, Read ML, Barrett LB, Wolfert MA, Seymour LW.

Gene Ther. 1999 Apr;6(4):643-50.

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