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OCRL Deficiency Impairs Endolysosomal Function in a Humanized Mouse Model for Lowe Syndrome and Dent Disease.

Festa BP, Berquez M, Gassama A, Amrein I, Ismail HM, Samardzija M, Staiano L, Luciani A, Grimm C, Nussbaum RL, De Matteis MA, Dorchies OM, Scapozza L, Wolfer DP, Devuyst O.

Hum Mol Genet. 2018 Dec 26. doi: 10.1093/hmg/ddy449. [Epub ahead of print]


The Anti-amyloid Compound DO1 Decreases Plaque Pathology and Neuroinflammation-Related Expression Changes in 5xFAD Transgenic Mice.

Boeddrich A, Babila JT, Wiglenda T, Diez L, Jacob M, Nietfeld W, Huska MR, Haenig C, Groenke N, Buntru A, Blanc E, Meier JC, Vannoni E, Erck C, Friedrich B, Martens H, Neuendorf N, Schnoegl S, Wolfer DP, Loos M, Beule D, Andrade-Navarro MA, Wanker EE.

Cell Chem Biol. 2019 Jan 17;26(1):109-120.e7. doi: 10.1016/j.chembiol.2018.10.013. Epub 2018 Nov 21.


Mutant MRPS5 affects mitoribosomal accuracy and confers stress-related behavioral alterations.

Akbergenov R, Duscha S, Fritz AK, Juskeviciene R, Oishi N, Schmitt K, Shcherbakov D, Teo Y, Boukari H, Freihofer P, Isnard-Petit P, Oettinghaus B, Frank S, Thiam K, Rehrauer H, Westhof E, Schacht J, Eckert A, Wolfer D, Böttger EC.

EMBO Rep. 2018 Nov;19(11). pii: e46193. doi: 10.15252/embr.201846193. Epub 2018 Sep 20.


Eliminating the VGlut2-Dependent Glutamatergic Transmission of Parvalbumin-Expressing Neurons Leads to Deficits in Locomotion and Vocalization, Decreased Pain Sensitivity, and Increased Dominance.

Roccaro-Waldmeyer DM, Girard F, Milani D, Vannoni E, Prétôt L, Wolfer DP, Celio MR.

Front Behav Neurosci. 2018 Jul 18;12:146. doi: 10.3389/fnbeh.2018.00146. eCollection 2018.


Loss of Nogo-A, encoded by the schizophrenia risk gene Rtn4, reduces mGlu3 expression and causes hyperexcitability in hippocampal CA3 circuits.

Berry S, Weinmann O, Fritz AK, Rust R, Wolfer D, Schwab ME, Gerber U, Ster J.

PLoS One. 2018 Jul 24;13(7):e0200896. doi: 10.1371/journal.pone.0200896. eCollection 2018.


Distinct in vivo roles of secreted APP ectodomain variants APPsα and APPsβ in regulation of spine density, synaptic plasticity, and cognition.

Richter MC, Ludewig S, Winschel A, Abel T, Bold C, Salzburger LR, Klein S, Han K, Weyer SW, Fritz AK, Laube B, Wolfer DP, Buchholz CJ, Korte M, Müller UC.

EMBO J. 2018 Jun 1;37(11). pii: e98335. doi: 10.15252/embj.201798335. Epub 2018 Apr 16.


Disturbed Processing of Contextual Information in HCN3 Channel Deficient Mice.

Stieglitz MS, Fenske S, Hammelmann V, Becirovic E, Schöttle V, Delorme JE, Schöll-Weidinger M, Mader R, Deussing J, Wolfer DP, Seeliger MW, Albrecht U, Wotjak CT, Biel M, Michalakis S, Wahl-Schott C.

Front Mol Neurosci. 2018 Jan 9;10:436. doi: 10.3389/fnmol.2017.00436. eCollection 2017.


Sampling the Mouse Hippocampal Dentate Gyrus.

Basler L, Gerdes S, Wolfer DP, Slomianka L.

Front Neuroanat. 2017 Dec 12;11:123. doi: 10.3389/fnana.2017.00123. eCollection 2017.


Automated dissection of permanent effects of hippocampal or prefrontal lesions on performance at spatial, working memory and circadian timing tasks of C57BL/6 mice in IntelliCage.

Voikar V, Krackow S, Lipp HP, Rau A, Colacicco G, Wolfer DP.

Behav Brain Res. 2018 Oct 15;352:8-22. doi: 10.1016/j.bbr.2017.08.048. Epub 2017 Sep 18.


Similar reliability and equivalent performance of female and male mice in the open field and water-maze place navigation task.

Fritz AK, Amrein I, Wolfer DP.

Am J Med Genet C Semin Med Genet. 2017 Sep;175(3):380-391. doi: 10.1002/ajmg.c.31565. Epub 2017 Jun 27.


Hippocampus-related effects of fluoxetine treatment under stressful vs enriched conditions.

Alboni S, van Dijk M, Poggini S, Milior G, Perrotta ML, Drenth T, Brunello N, Wolfer D, Limatola C, Amrein I, Cirulli F, Maggi L, Branchi I.

Mol Psychiatry. 2017 Apr;22(4):483. doi: 10.1038/mp.2017.69. No abstract available.


Association of Occupational and Leisure-Time Physical Activity with Aerobic Capacity in a Working Population.

Mundwiler J, Schüpbach U, Dieterle T, Leuppi JD, Schmidt-Trucksäss A, Wolfer DP, Miedinger D, Brighenti-Zogg S.

PLoS One. 2017 Jan 3;12(1):e0168683. doi: 10.1371/journal.pone.0168683. eCollection 2017.


Fluoxetine treatment affects the inflammatory response and microglial function according to the quality of the living environment.

Alboni S, Poggini S, Garofalo S, Milior G, El Hajj H, Lecours C, Girard I, Gagnon S, Boisjoly-Villeneuve S, Brunello N, Wolfer DP, Limatola C, Tremblay MÈ, Maggi L, Branchi I.

Brain Behav Immun. 2016 Nov;58:261-271. doi: 10.1016/j.bbi.2016.07.155. Epub 2016 Jul 27.


Physical Workload and Work Capacity across Occupational Groups.

Brighenti-Zogg S, Mundwiler J, Schüpbach U, Dieterle T, Wolfer DP, Leuppi JD, Miedinger D.

PLoS One. 2016 May 2;11(5):e0154073. doi: 10.1371/journal.pone.0154073. eCollection 2016.


The APP Intracellular Domain Is Required for Normal Synaptic Morphology, Synaptic Plasticity, and Hippocampus-Dependent Behavior.

Klevanski M, Herrmann U, Weyer SW, Fol R, Cartier N, Wolfer DP, Caldwell JH, Korte M, Müller UC.

J Neurosci. 2015 Dec 9;35(49):16018-33. doi: 10.1523/JNEUROSCI.2009-15.2015.


Fluoxetine effects on molecular, cellular and behavioral endophenotypes of depression are driven by the living environment.

Alboni S, van Dijk RM, Poggini S, Milior G, Perrotta M, Drenth T, Brunello N, Wolfer DP, Limatola C, Amrein I, Cirulli F, Maggi L, Branchi I.

Mol Psychiatry. 2017 Apr;22(4):552-561. doi: 10.1038/mp.2015.142. Epub 2015 Sep 15. Erratum in: Mol Psychiatry. 2017 Apr;22(4):635.


Fluoxetine effects on molecular, cellular and behavioral endophenotypes of depression are driven by the living environment.

Alboni S, van Dijk RM, Poggini S, Milior G, Perrotta M, Drenth T, Brunello N, Wolfer DP, Limatola C, Amrein I, Cirulli F, Maggi L, Branchi I.

Mol Psychiatry. 2017 Apr;22(4):635. doi: 10.1038/mp.2015.191. Epub 2015 Nov 24. No abstract available.


Mutations in NONO lead to syndromic intellectual disability and inhibitory synaptic defects.

Mircsof D, Langouët M, Rio M, Moutton S, Siquier-Pernet K, Bole-Feysot C, Cagnard N, Nitschke P, Gaspar L, Žnidarič M, Alibeu O, Fritz AK, Wolfer DP, Schröter A, Bosshard G, Rudin M, Koester C, Crestani F, Seebeck P, Boddaert N, Prescott K; DDD Study, Hines R, Moss SJ, Fritschy JM, Munnich A, Amiel J, Brown SA, Tyagarajan SK, Colleaux L.

Nat Neurosci. 2015 Dec;18(12):1731-6. doi: 10.1038/nn.4169. Epub 2015 Nov 16.


Large-scale phenotyping links adult hippocampal neurogenesis to the reaction to novelty.

van Dijk RM, Lazic SE, Slomianka L, Wolfer DP, Amrein I.

Hippocampus. 2016 May;26(5):646-57. doi: 10.1002/hipo.22548. Epub 2015 Nov 25.


Lack of parvalbumin in mice leads to behavioral deficits relevant to all human autism core symptoms and related neural morphofunctional abnormalities.

Wöhr M, Orduz D, Gregory P, Moreno H, Khan U, Vörckel KJ, Wolfer DP, Welzl H, Gall D, Schiffmann SN, Schwaller B.

Transl Psychiatry. 2015 Mar 10;5:e525. doi: 10.1038/tp.2015.19.


Selection for tameness, a key behavioral trait of domestication, increases adult hippocampal neurogenesis in foxes.

Huang S, Slomianka L, Farmer AJ, Kharlamova AV, Gulevich RG, Herbeck YE, Trut LN, Wolfer DP, Amrein I.

Hippocampus. 2015 Aug;25(8):963-75. doi: 10.1002/hipo.22420. Epub 2015 Mar 26.


Erratum to: Acute function of secreted amyloid precursor protein fragment APPsα in synaptic plasticity.

Hick M, Herrmann U, Weyer SW, Mallm JP, Tschäpe JA, Borgers M, Mercken M, Roth FC, Draguhn A, Slomianka L, Wolfer DP, Korte M, Müller UC.

Acta Neuropathol. 2015 Jan;129(1):161-2. doi: 10.1007/s00401-014-1374-z. No abstract available.


Acute function of secreted amyloid precursor protein fragment APPsα in synaptic plasticity.

Hick M, Herrmann U, Weyer SW, Mallm JP, Tschäpe JA, Borgers M, Mercken M, Roth FC, Draguhn A, Slomianka L, Wolfer DP, Korte M, Müller UC.

Acta Neuropathol. 2015 Jan;129(1):21-37. doi: 10.1007/s00401-014-1368-x. Epub 2014 Nov 29. Erratum in: Acta Neuropathol. 2015 Jan;129(1):161-2.


Early life stress in fathers improves behavioural flexibility in their offspring.

Gapp K, Soldado-Magraner S, Alvarez-Sánchez M, Bohacek J, Vernaz G, Shu H, Franklin TB, Wolfer D, Mansuy IM.

Nat Commun. 2014 Nov 18;5:5466. doi: 10.1038/ncomms6466.


Gravity anomalies without geomagnetic disturbances interfere with pigeon homing--a GPS tracking study.

Blaser N, Guskov SI, Entin VA, Wolfer DP, Kanevskyi VA, Lipp HP.

J Exp Biol. 2014 Nov 15;217(Pt 22):4057-67. doi: 10.1242/jeb.108670.


Spontaneous behavior in the social homecage discriminates strains, lesions and mutations in mice.

Vannoni E, Voikar V, Colacicco G, Sánchez MA, Lipp HP, Wolfer DP.

J Neurosci Methods. 2014 Aug 30;234:26-37. doi: 10.1016/j.jneumeth.2014.04.026. Epub 2014 May 1.


Learning and memory with neuropathic pain: impact of old age and progranulin deficiency.

Albuquerque B, Häussler A, Vannoni E, Wolfer DP, Tegeder I.

Front Behav Neurosci. 2013 Nov 22;7:174. doi: 10.3389/fnbeh.2013.00174. eCollection 2013.


Testing cognitive navigation in unknown territories: homing pigeons choose different targets.

Blaser N, Dell'Omo G, Dell'Ariccia G, Wolfer DP, Lipp HP.

J Exp Biol. 2013 Aug 15;216(Pt 16):3123-31. doi: 10.1242/jeb.083246.


Genetic dissection of medial habenula-interpeduncular nucleus pathway function in mice.

Kobayashi Y, Sano Y, Vannoni E, Goto H, Suzuki H, Oba A, Kawasaki H, Kanba S, Lipp HP, Murphy NP, Wolfer DP, Itohara S.

Front Behav Neurosci. 2013 Mar 12;7:17. doi: 10.3389/fnbeh.2013.00017. eCollection 2013.


Epileptiform activity and cognitive deficits in SNAP-25(+/-) mice are normalized by antiepileptic drugs.

Corradini I, Donzelli A, Antonucci F, Welzl H, Loos M, Martucci R, De Astis S, Pattini L, Inverardi F, Wolfer D, Caleo M, Bozzi Y, Verderio C, Frassoni C, Braida D, Clerici M, Lipp HP, Sala M, Matteoli M.

Cereb Cortex. 2014 Feb;24(2):364-76. doi: 10.1093/cercor/bhs316. Epub 2012 Oct 12.


Defective intestinal amino acid absorption in Ace2 null mice.

Singer D, Camargo SM, Ramadan T, Schäfer M, Mariotta L, Herzog B, Huggel K, Wolfer D, Werner S, Penninger JM, Verrey F.

Am J Physiol Gastrointest Liver Physiol. 2012 Sep 15;303(6):G686-95. doi: 10.1152/ajpgi.00140.2012. Epub 2012 Jul 12.


Effects of spatial and cognitive enrichment on activity pattern and learning performance in three strains of mice in the IntelliMaze.

Codita A, Mohammed AH, Willuweit A, Reichelt A, Alleva E, Branchi I, Cirulli F, Colacicco G, Voikar V, Wolfer DP, Buschmann FJ, Lipp HP, Vannoni E, Krackow S.

Behav Genet. 2012 May;42(3):449-60. doi: 10.1007/s10519-011-9512-z. Epub 2011 Dec 21.


Mice Lacking Ras-GRF1 Show Contextual Fear Conditioning but not Spatial Memory Impairments: Convergent Evidence from Two Independently Generated Mouse Mutant Lines.

d'Isa R, Clapcote SJ, Voikar V, Wolfer DP, Giese KP, Brambilla R, Fasano S.

Front Behav Neurosci. 2011 Dec 6;5:78. doi: 10.3389/fnbeh.2011.00078. eCollection 2011.


Dysregulation of Rho GTPases in the αPix/Arhgef6 mouse model of X-linked intellectual disability is paralleled by impaired structural and synaptic plasticity and cognitive deficits.

Ramakers GJ, Wolfer D, Rosenberger G, Kuchenbecker K, Kreienkamp HJ, Prange-Kiel J, Rune G, Richter K, Langnaese K, Masneuf S, Bösl MR, Fischer KD, Krugers HJ, Lipp HP, van Galen E, Kutsche K.

Hum Mol Genet. 2012 Jan 15;21(2):268-86. doi: 10.1093/hmg/ddr457. Epub 2011 Oct 11.


Hippocampal pyramidal cells: the reemergence of cortical lamination.

Slomianka L, Amrein I, Knuesel I, Sørensen JC, Wolfer DP.

Brain Struct Funct. 2011 Nov;216(4):301-17. doi: 10.1007/s00429-011-0322-0. Epub 2011 May 20. Review.


APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP.

Weyer SW, Klevanski M, Delekate A, Voikar V, Aydin D, Hick M, Filippov M, Drost N, Schaller KL, Saar M, Vogt MA, Gass P, Samanta A, Jäschke A, Korte M, Wolfer DP, Caldwell JH, Müller UC.

EMBO J. 2011 Jun 1;30(11):2266-80. doi: 10.1038/emboj.2011.119. Epub 2011 Apr 26. Erratum in: EMBO J. 2011 Jun 1;30(11):2306.


Automated test of behavioral flexibility in mice using a behavioral sequencing task in IntelliCage.

Endo T, Maekawa F, Võikar V, Haijima A, Uemura Y, Zhang Y, Miyazaki W, Suyama S, Shimazaki K, Wolfer DP, Yada T, Tohyama C, Lipp HP, Kakeyama M.

Behav Brain Res. 2011 Aug 1;221(1):172-81. doi: 10.1016/j.bbr.2011.02.037. Epub 2011 Mar 4.


Effect of population heterogenization on the reproducibility of mouse behavior: a multi-laboratory study.

Richter SH, Garner JP, Zipser B, Lewejohann L, Sachser N, Touma C, Schindler B, Chourbaji S, Brandwein C, Gass P, van Stipdonk N, van der Harst J, Spruijt B, Võikar V, Wolfer DP, Würbel H.

PLoS One. 2011 Jan 31;6(1):e16461. doi: 10.1371/journal.pone.0016461.


CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice.

Shimokawa N, Haglund K, Hölter SM, Grabbe C, Kirkin V, Koibuchi N, Schultz C, Rozman J, Hoeller D, Qiu CH, Londoño MB, Ikezawa J, Jedlicka P, Stein B, Schwarzacher SW, Wolfer DP, Ehrhardt N, Heuchel R, Nezis I, Brech A, Schmidt MHH, Fuchs H, Gailus-Durner V, Klingenspor M, Bogler O, Wurst W, Deller T, de Angelis MH, Dikic I.

EMBO J. 2010 Jul 21;29(14):2421-32. doi: 10.1038/emboj.2010.120. Epub 2010 Jun 15.


Consistent behavioral phenotype differences between inbred mouse strains in the IntelliCage.

Krackow S, Vannoni E, Codita A, Mohammed AH, Cirulli F, Branchi I, Alleva E, Reichelt A, Willuweit A, Voikar V, Colacicco G, Wolfer DP, Buschmann JU, Safi K, Lipp HP.

Genes Brain Behav. 2010 Oct;9(7):722-31. doi: 10.1111/j.1601-183X.2010.00606.x. Epub 2010 Jul 7.


Conditioned response suppression in the IntelliCage: assessment of mouse strain differences and effects of hippocampal and striatal lesions on acquisition and retention of memory.

Voikar V, Colacicco G, Gruber O, Vannoni E, Lipp HP, Wolfer DP.

Behav Brain Res. 2010 Dec 1;213(2):304-12. doi: 10.1016/j.bbr.2010.05.019. Epub 2010 May 21.


Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease.

Coomaraswamy J, Kilger E, Wölfing H, Schäfer C, Kaeser SA, Wegenast-Braun BM, Hefendehl JK, Wolburg H, Mazzella M, Ghiso J, Goedert M, Akiyama H, Garcia-Sierra F, Wolfer DP, Mathews PM, Jucker M.

Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7969-74. doi: 10.1073/pnas.1001056107. Epub 2010 Apr 12.


EEG responses to visual landmarks in flying pigeons.

Vyssotski AL, Dell'Omo G, Dell'Ariccia G, Abramchuk AN, Serkov AN, Latanov AV, Loizzo A, Wolfer DP, Lipp HP.

Curr Biol. 2009 Jul 28;19(14):1159-66. doi: 10.1016/j.cub.2009.05.070. Epub 2009 Jun 25.


Neprilysin deficiency-dependent impairment of cognitive functions in a mouse model of amyloidosis.

Mohajeri MH, Wolfer DP.

Neurochem Res. 2009 Apr;34(4):717-26. doi: 10.1007/s11064-009-9919-6. Epub 2009 Feb 6.


Phosphatidylinositide dependent kinase deficiency increases anxiety and decreases GABA and serotonin abundance in the amygdala.

Ackermann TF, Hörtnagl H, Wolfer DP, Colacicco G, Sohr R, Lang F, Hellweg R, Lang UE.

Cell Physiol Biochem. 2008;22(5-6):735-44. doi: 10.1159/000185557. Epub 2008 Dec 9.


Standards for the publication of mouse mutant studies.

Crusio WE, Goldowitz D, Holmes A, Wolfer D.

Genes Brain Behav. 2009 Feb;8(1):1-4. doi: 10.1111/j.1601-183X.2008.00438.x. Epub 2008 Sep 6. No abstract available.


Delayed melatonin administration promotes neuronal survival, neurogenesis and motor recovery, and attenuates hyperactivity and anxiety after mild focal cerebral ischemia in mice.

Kilic E, Kilic U, Bacigaluppi M, Guo Z, Abdallah NB, Wolfer DP, Reiter RJ, Hermann DM, Bassetti CL.

J Pineal Res. 2008 Sep;45(2):142-8. doi: 10.1111/j.1600-079X.2008.00568.x. Epub 2008 Feb 14.


The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice.

Ring S, Weyer SW, Kilian SB, Waldron E, Pietrzik CU, Filippov MA, Herms J, Buchholz C, Eckman CB, Korte M, Wolfer DP, Müller UC.

J Neurosci. 2007 Jul 18;27(29):7817-26.


Transient activation of the CA3 Kappa opioid system in the dorsal hippocampus modulates complex memory processing in mice.

Daumas S, Betourne A, Halley H, Wolfer DP, Lipp HP, Lassalle JM, Francés B.

Neurobiol Learn Mem. 2007 Jul;88(1):94-103. Epub 2007 Mar 19.


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