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A cellular complex of BACE1 and γ-secretase sequentially generates Aβ from its full-length precursor.

Liu L, Ding L, Rovere M, Wolfe MS, Selkoe DJ.

J Cell Biol. 2019 Jan 9. pii: jcb.201806205. doi: 10.1083/jcb.201806205. [Epub ahead of print]


Expanding the Concept of Translational Research: Making a Place for Environmental Health Sciences.

Pettibone KG, Balshaw DM, Dilworth C, Drew CH, Hall JE, Heacock M, Latoni AR, McAllister KA, O'Fallon LR, Thompson C, Walker NJ, Wolfe MS, Wright DS, Collman GW.

Environ Health Perspect. 2018 Jul 16;126(7):074501. doi: 10.1289/EHP3657. eCollection 2018 Jul.


Dysfunctional γ-Secretase in Familial Alzheimer's Disease.

Wolfe MS.

Neurochem Res. 2018 Apr 4. doi: 10.1007/s11064-018-2511-1. [Epub ahead of print]


Disruption of amyloid precursor protein ubiquitination selectively increases amyloid β (Aβ) 40 levels via presenilin 2-mediated cleavage.

Williamson RL, Laulagnier K, Miranda AM, Fernandez MA, Wolfe MS, Sadoul R, Di Paolo G.

J Biol Chem. 2017 Dec 1;292(48):19873-19889. doi: 10.1074/jbc.M117.818138. Epub 2017 Oct 11.


Evaluation of 4-methylcyclohexanemethanol (MCHM) in a combined irritancy and Local Lymph Node Assay (LLNA) in mice.

Johnson VJ, Auerbach SS, Luster MI, Waidyanatha S, Masten SA, Wolfe MS, Burleson FG, Burleson GR, Germolec DR.

Food Chem Toxicol. 2017 Jul;105:99-105. doi: 10.1016/j.fct.2017.03.034. Epub 2017 Mar 22.


Enzymatic Assays for Studying Intramembrane Proteolysis.

Bolduc DM, Selkoe DJ, Wolfe MS.

Methods Enzymol. 2017;584:295-308. doi: 10.1016/bs.mie.2016.10.026. Epub 2016 Dec 24.


Transmembrane Substrate Determinants for γ-Secretase Processing of APP CTFβ.

Fernandez MA, Biette KM, Dolios G, Seth D, Wang R, Wolfe MS.

Biochemistry. 2016 Oct 11;55(40):5675-5688. Epub 2016 Sep 30.


The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase.

Bolduc DM, Montagna DR, Seghers MC, Wolfe MS, Selkoe DJ.

Elife. 2016 Aug 31;5. pii: e17578. doi: 10.7554/eLife.17578.


Evaluating the Impact of the U.S. National Toxicology Program: A Case Study on Hexavalent Chromium.

Xie Y, Holmgren S, Andrews DM, Wolfe MS.

Environ Health Perspect. 2017 Feb;125(2):181-188. doi: 10.1289/EHP21. Epub 2016 Aug 2.


Sorting Out Presenilins in Alzheimer's Disease.

Wolfe MS, Yankner BA.

Cell. 2016 Jun 30;166(1):13-5. doi: 10.1016/j.cell.2016.06.034.


Part 3: Notch-sparing γ-secretase inhibitors: SAR studies of 2-substituted aminopyridopyrimidinones.

Zhang J, Lu D, Wei HX, Gu Y, Selkoe DJ, Wolfe MS, Augelli-Szafran CE.

Bioorg Med Chem Lett. 2016 May 1;26(9):2138-41. doi: 10.1016/j.bmcl.2016.03.077. Epub 2016 Mar 23.


Part 2. Notch-sparing γ-secretase inhibitors: The study of novel γ-amino naphthyl alcohols.

Wei HX, Lu D, Sun V, Zhang J, Gu Y, Osenkowski P, Ye W, Selkoe DJ, Wolfe MS, Augelli-Szafran CE.

Bioorg Med Chem Lett. 2016 May 1;26(9):2133-7. doi: 10.1016/j.bmcl.2016.03.042. Epub 2016 Mar 15.


Part 1: Notch-sparing γ-secretase inhibitors: The identification of novel naphthyl and benzofuranyl amide analogs.

Lu D, Wei HX, Zhang J, Gu Y, Osenkowski P, Ye W, Selkoe DJ, Wolfe MS, Augelli-Szafran CE.

Bioorg Med Chem Lett. 2016 May 1;26(9):2129-32. doi: 10.1016/j.bmcl.2016.03.040. Epub 2016 Mar 12.


GRADE: Assessing the quality of evidence in environmental and occupational health.

Morgan RL, Thayer KA, Bero L, Bruce N, Falck-Ytter Y, Ghersi D, Guyatt G, Hooijmans C, Langendam M, Mandrioli D, Mustafa RA, Rehfuess EA, Rooney AA, Shea B, Silbergeld EK, Sutton P, Wolfe MS, Woodruff TJ, Verbeek JH, Holloway AC, Santesso N, Schünemann HJ.

Environ Int. 2016 Jul-Aug;92-93:611-6. doi: 10.1016/j.envint.2016.01.004. Epub 2016 Jan 27.


Nicastrin functions to sterically hinder γ-secretase-substrate interactions driven by substrate transmembrane domain.

Bolduc DM, Montagna DR, Gu Y, Selkoe DJ, Wolfe MS.

Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):E509-18. doi: 10.1073/pnas.1512952113. Epub 2015 Dec 22.


Cutting to the chase: How pathogenic mutations cause Alzheimer's.

Wolfe MS.

J Exp Med. 2015 Nov 16;212(12):1991. doi: 10.1084/jem.21212insight4. No abstract available.


A Tribute to Ronald T. Borchardt--Teacher, Mentor, Scientist, Colleague, Leader, Friend, and Family Man.

Schowen KB, Schowen RL, Borchardt SE, Borchardt PM, Artursson P, Audus KL, Augustijns P, Nicolazzo JA, Raub TJ, Schöneich C, Siahaan TJ, Takakura Y, Thakker DR, Wolfe MS.

J Pharm Sci. 2016 Feb;105(2):370-385. doi: 10.1002/jps.24687. Epub 2016 Jan 29. No abstract available.


Cutting in on a secretase pas de deux.

Wolfe MS.

Cell Res. 2015 Oct;25(10):1091-2. doi: 10.1038/cr.2015.106. Epub 2015 Sep 11.


The stress response neuropeptide CRF increases amyloid-β production by regulating γ-secretase activity.

Park HJ, Ran Y, Jung JI, Holmes O, Price AR, Smithson L, Ceballos-Diaz C, Han C, Wolfe MS, Daaka Y, Ryabinin AE, Kim SH, Hauger RL, Golde TE, Felsenstein KM.

EMBO J. 2015 Jun 12;34(12):1674-86. doi: 10.15252/embj.201488795. Epub 2015 May 11.


Photoinduced aggregation of a model antibody-drug conjugate.

Cockrell GM, Wolfe MS, Wolfe JL, Schöneich C.

Mol Pharm. 2015 Jun 1;12(6):1784-97. doi: 10.1021/mp5006799. Epub 2015 May 1.


Structure of nicastrin unveils secrets of γ-secretase.

Bolduc DM, Wolfe MS.

Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14643-4. doi: 10.1073/pnas.1416637111. Epub 2014 Sep 29. No abstract available.


Alzheimer presenilin-1 mutations dramatically reduce trimming of long amyloid β-peptides (Aβ) by γ-secretase to increase 42-to-40-residue Aβ.

Fernandez MA, Klutkowski JA, Freret T, Wolfe MS.

J Biol Chem. 2014 Nov 7;289(45):31043-52. doi: 10.1074/jbc.M114.581165. Epub 2014 Sep 19.


γ-Secretase: a horseshoe structure brings good luck.

Wolfe MS, Selkoe DJ.

Cell. 2014 Jul 17;158(2):247-249. doi: 10.1016/j.cell.2014.06.043.


Intersection of systematic review methodology with the NIH reproducibility initiative.

Thayer KA, Wolfe MS, Rooney AA, Boyles AL, Bucher JR, Birnbaum LS.

Environ Health Perspect. 2014 Jul;122(7):A176-7. doi: 10.1289/ehp.1408671. No abstract available.


Pen-2 is essential for γ-secretase complex stability and trafficking but partially dispensable for endoproteolysis.

Holmes O, Paturi S, Selkoe DJ, Wolfe MS.

Biochemistry. 2014 Jul 15;53(27):4393-406. doi: 10.1021/bi500489j. Epub 2014 Jun 30.


Targeting mRNA for Alzheimer's and related dementias.

Wolfe MS.

Scientifica (Cairo). 2014;2014:757549. doi: 10.1155/2014/757549. Epub 2014 Apr 27. Review.


Functional analysis and purification of a Pen-2 fusion protein for γ-secretase structural studies.

Holmes O, Paturi S, Wolfe MS, Selkoe DJ.

J Neurochem. 2014 Oct;131(1):94-100. doi: 10.1111/jnc.12772. Epub 2014 Jun 18.


Systematic review and evidence integration for literature-based environmental health science assessments.

Rooney AA, Boyles AL, Wolfe MS, Bucher JR, Thayer KA.

Environ Health Perspect. 2014 Jul;122(7):711-8. doi: 10.1289/ehp.1307972. Epub 2014 Apr 22.


Template-directed synthesis of a small molecule-antisense conjugate targeting an mRNA structure.

Liu Y, Rodriguez L, Wolfe MS.

Bioorg Chem. 2014 Jun;54:7-11. doi: 10.1016/j.bioorg.2014.03.001. Epub 2014 Mar 13.


Resilience as a universal criterion of health.

Döring TF, Vieweger A, Pautasso M, Vaarst M, Finckh MR, Wolfe MS.

J Sci Food Agric. 2015 Feb;95(3):455-65. doi: 10.1002/jsfa.6539. Epub 2014 Feb 6. Review.


Toward the structure of presenilin/γ-secretase and presenilin homologs.

Wolfe MS.

Biochim Biophys Acta. 2013 Dec;1828(12):2886-97. doi: 10.1016/j.bbamem.2013.04.015. Review.


Alternative polyadenylation and miR-34 family members regulate tau expression.

Dickson JR, Kruse C, Montagna DR, Finsen B, Wolfe MS.

J Neurochem. 2013 Dec;127(6):739-49. doi: 10.1111/jnc.12437. Epub 2013 Sep 18.


Implementing systematic review at the National Toxicology Program: status and next steps.

Birnbaum LS, Thayer KA, Bucher JR, Wolfe MS.

Environ Health Perspect. 2013 Apr;121(4):A108-9. doi: 10.1289/ehp.1306711. No abstract available.


Alzheimer's γ-secretase under arrestin.

Wolfe MS.

Nat Med. 2013 Jan;19(1):22-4. doi: 10.1038/nm.3053. No abstract available.


Structural biology: Membrane enzyme cuts a fine figure.

Wolfe MS.

Nature. 2013 Jan 3;493(7430):34-5. doi: 10.1038/nature11768. Epub 2012 Dec 19. No abstract available.


Introduction to special issue on Alzheimer's disease.

Wolfe MS.

J Med Chem. 2012 Nov 8;55(21):8977-8. doi: 10.1021/jm301426y. Epub 2012 Oct 5. No abstract available.


Processive proteolysis by γ-secretase and the mechanism of Alzheimer's disease.

Wolfe MS.

Biol Chem. 2012 Sep;393(9):899-905. doi: 10.1515/hsz-2012-0140. Review.


Targeting a pre-mRNA structure with bipartite antisense molecules modulates tau alternative splicing.

Peacey E, Rodriguez L, Liu Y, Wolfe MS.

Nucleic Acids Res. 2012 Oct;40(19):9836-49. doi: 10.1093/nar/gks710. Epub 2012 Jul 25.


γ-Secretase as a target for Alzheimer's disease.

Wolfe MS.

Adv Pharmacol. 2012;64:127-53. doi: 10.1016/B978-0-12-394816-8.00004-0. Review.


Effects of membrane lipids on the activity and processivity of purified γ-secretase.

Holmes O, Paturi S, Ye W, Wolfe MS, Selkoe DJ.

Biochemistry. 2012 May 1;51(17):3565-75. doi: 10.1021/bi300303g. Epub 2012 Apr 19.


Presenilins and γ-secretase: structure, function, and role in Alzheimer Disease.

De Strooper B, Iwatsubo T, Wolfe MS.

Cold Spring Harb Perspect Med. 2012 Jan;2(1):a006304. doi: 10.1101/cshperspect.a006304. Review.


A G-rich element forms a G-quadruplex and regulates BACE1 mRNA alternative splicing.

Fisette JF, Montagna DR, Mihailescu MR, Wolfe MS.

J Neurochem. 2012 Jun;121(5):763-73. doi: 10.1111/j.1471-4159.2012.07680.x. Epub 2012 Mar 13.


The role of tau in neurodegenerative diseases and its potential as a therapeutic target.

Wolfe MS.

Scientifica (Cairo). 2012;2012:796024. doi: 10.6064/2012/796024. Epub 2012 Dec 19. Review.


γ-Secretase inhibitors and modulators for Alzheimer's disease.

Wolfe MS.

J Neurochem. 2012 Jan;120 Suppl 1:89-98. doi: 10.1111/j.1471-4159.2011.07501.x. Epub 2011 Nov 28. Review.


Molecular characterization of disrupted in schizophrenia-1 risk variant S704C reveals the formation of altered oligomeric assembly.

Narayanan S, Arthanari H, Wolfe MS, Wagner G.

J Biol Chem. 2011 Dec 23;286(51):44266-76. doi: 10.1074/jbc.M111.271593. Epub 2011 Oct 13.


Dissociation between the processivity and total activity of γ-secretase: implications for the mechanism of Alzheimer's disease-causing presenilin mutations.

Quintero-Monzon O, Martin MM, Fernandez MA, Cappello CA, Krzysiak AJ, Osenkowski P, Wolfe MS.

Biochemistry. 2011 Oct 25;50(42):9023-35. doi: 10.1021/bi2007146. Epub 2011 Sep 30.


γ-Secretase-mediated growth hormone receptor proteolysis: mapping of the intramembranous cleavage site.

Wang X, Cowan JW, Gerhart M, Zelickson BR, Jiang J, He K, Wolfe MS, Black RA, Frank SJ.

Biochem Biophys Res Commun. 2011 May 13;408(3):432-6. doi: 10.1016/j.bbrc.2011.04.041. Epub 2011 Apr 13.


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