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Dynamics and selective remodeling of the DNA-binding domains of RPA.

Pokhrel N, Caldwell CC, Corless EI, Tillison EA, Tibbs J, Jocic N, Tabei SMA, Wold MS, Spies M, Antony E.

Nat Struct Mol Biol. 2019 Feb;26(2):129-136. doi: 10.1038/s41594-018-0181-y. Epub 2019 Feb 4.


A minimal threshold of FANCJ helicase activity is required for its response to replication stress or double-strand break repair.

Bharti SK, Sommers JA, Awate S, Bellani MA, Khan I, Bradley L, King GA, Seol Y, Vidhyasagar V, Wu Y, Abe T, Kobayashi K, Shin-Ya K, Kitao H, Wold MS, Branzei D, Neuman KC, Brosh RM Jr.

Nucleic Acids Res. 2018 Jul 6;46(12):6238-6256. doi: 10.1093/nar/gky403.


Stress-induced acidification may contribute to formation of unusual structures in C9orf72-repeats.

Zamiri B, Mirceta M, Abu-Ghazalah R, Wold MS, Pearson CE, Macgregor RB Jr.

Biochim Biophys Acta Gen Subj. 2018 Jun;1862(6):1482-1491. doi: 10.1016/j.bbagen.2018.03.001. Epub 2018 Mar 15.


Single-Molecule Analysis of Replication Protein A-DNA Interactions.

Bain FE, Fischer LA, Chen R, Wold MS.

Methods Enzymol. 2018;600:439-461. doi: 10.1016/bs.mie.2017.11.016.


Autophagy Receptors and Neurodegenerative Diseases.

Deng Z, Purtell K, Lachance V, Wold MS, Chen S, Yue Z.

Trends Cell Biol. 2017 Jul;27(7):491-504. doi: 10.1016/j.tcb.2017.01.001. Epub 2017 Feb 3. Review.


RPA Interacts with HIRA and Regulates H3.3 Deposition at Gene Regulatory Elements in Mammalian Cells.

Zhang H, Gan H, Wang Z, Lee JH, Zhou H, Ordog T, Wold MS, Ljungman M, Zhang Z.

Mol Cell. 2017 Jan 19;65(2):272-284. doi: 10.1016/j.molcel.2016.11.030.


ULK1-mediated phosphorylation of ATG14 promotes autophagy and is impaired in Huntington's disease models.

Wold MS, Lim J, Lachance V, Deng Z, Yue Z.

Mol Neurodegener. 2016 Dec 9;11(1):76.


Dynamic binding of replication protein a is required for DNA repair.

Chen R, Subramanyam S, Elcock AH, Spies M, Wold MS.

Nucleic Acids Res. 2016 Jul 8;44(12):5758-72. doi: 10.1093/nar/gkw339. Epub 2016 Apr 29.


Single-molecule imaging reveals the mechanism of Exo1 regulation by single-stranded DNA binding proteins.

Myler LR, Gallardo IF, Zhou Y, Gong F, Yang SH, Wold MS, Miller KM, Paull TT, Finkelstein IJ.

Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):E1170-9. doi: 10.1073/pnas.1516674113. Epub 2016 Feb 16.


Beclin 1 is required for neuron viability and regulates endosome pathways via the UVRAG-VPS34 complex.

McKnight NC, Zhong Y, Wold MS, Gong S, Phillips GR, Dou Z, Zhao Y, Heintz N, Zong WX, Yue Z.

PLoS Genet. 2014 Oct 2;10(10):e1004626. doi: 10.1371/journal.pgen.1004626. eCollection 2014 Oct.


Diffusion of human replication protein A along single-stranded DNA.

Nguyen B, Sokoloski J, Galletto R, Elson EL, Wold MS, Lohman TM.

J Mol Biol. 2014 Sep 23;426(19):3246-3261. doi: 10.1016/j.jmb.2014.07.014. Epub 2014 Jul 22.


Novel function of the Fanconi anemia group J or RECQ1 helicase to disrupt protein-DNA complexes in a replication protein A-stimulated manner.

Sommers JA, Banerjee T, Hinds T, Wan B, Wold MS, Lei M, Brosh RM Jr.

J Biol Chem. 2014 Jul 18;289(29):19928-41. doi: 10.1074/jbc.M113.542456. Epub 2014 Jun 3.


Human exonuclease 5 is a novel sliding exonuclease required for genome stability.

Sparks JL, Kumar R, Singh M, Wold MS, Pandita TK, Burgers PM.

J Biol Chem. 2012 Dec 14;287(51):42773-83. doi: 10.1074/jbc.M112.422444. Epub 2012 Oct 24.


Detection of posttranslational modifications of replication protein A.

Hass CS, Chen R, Wold MS.

Methods Mol Biol. 2012;922:193-204. doi: 10.1007/978-1-62703-032-8_15.


In vitro analysis of the role of replication protein A (RPA) and RPA phosphorylation in ATR-mediated checkpoint signaling.

Lindsey-Boltz LA, Reardon JT, Wold MS, Sancar A.

J Biol Chem. 2012 Oct 19;287(43):36123-31. doi: 10.1074/jbc.M112.407825. Epub 2012 Sep 4.


Repair-specific functions of replication protein A.

Hass CS, Lam K, Wold MS.

J Biol Chem. 2012 Feb 3;287(6):3908-18. doi: 10.1074/jbc.M111.287441. Epub 2011 Dec 16.


Inhibition of homologous recombination by DNA-dependent protein kinase requires kinase activity, is titratable, and is modulated by autophosphorylation.

Neal JA, Dang V, Douglas P, Wold MS, Lees-Miller SP, Meek K.

Mol Cell Biol. 2011 Apr;31(8):1719-33. doi: 10.1128/MCB.01298-10. Epub 2011 Feb 7.


Molecular cooperation between the Werner syndrome protein and replication protein A in relation to replication fork blockage.

Machwe A, Lozada E, Wold MS, Li GM, Orren DK.

J Biol Chem. 2011 Feb 4;286(5):3497-508. doi: 10.1074/jbc.M110.105411. Epub 2010 Nov 24.


Reconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling.

Choi JH, Lindsey-Boltz LA, Kemp M, Mason AC, Wold MS, Sancar A.

Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13660-5. doi: 10.1073/pnas.1007856107. Epub 2010 Jun 28.


Functional characterization of a cancer causing mutation in human replication protein A.

Hass CS, Gakhar L, Wold MS.

Mol Cancer Res. 2010 Jul;8(7):1017-26. doi: 10.1158/1541-7786.MCR-10-0161. Epub 2010 Jun 29.


Functions of alternative replication protein A in initiation and elongation.

Mason AC, Roy R, Simmons DT, Wold MS.

Biochemistry. 2010 Jul 20;49(28):5919-28. doi: 10.1021/bi100380n.


An alternative form of replication protein a expressed in normal human tissues supports DNA repair.

Kemp MG, Mason AC, Carreira A, Reardon JT, Haring SJ, Borgstahl GE, Kowalczykowski SC, Sancar A, Wold MS.

J Biol Chem. 2010 Feb 12;285(7):4788-97. doi: 10.1074/jbc.M109.079418. Epub 2009 Dec 7.


A naturally occurring human RPA subunit homolog does not support DNA replication or cell-cycle progression.

Haring SJ, Humphreys TD, Wold MS.

Nucleic Acids Res. 2010 Jan;38(3):846-58. doi: 10.1093/nar/gkp1062. Epub 2009 Nov 26.


FANCJ helicase uniquely senses oxidative base damage in either strand of duplex DNA and is stimulated by replication protein A to unwind the damaged DNA substrate in a strand-specific manner.

Suhasini AN, Sommers JA, Mason AC, Voloshin ON, Camerini-Otero RD, Wold MS, Brosh RM Jr.

J Biol Chem. 2009 Jul 3;284(27):18458-70. doi: 10.1074/jbc.M109.012229. Epub 2009 May 5.


Essential functions of the 32 kDa subunit of yeast replication protein A.

Dickson AM, Krasikova Y, Pestryakov P, Lavrik O, Wold MS.

Nucleic Acids Res. 2009 Apr;37(7):2313-26. doi: 10.1093/nar/gkp090. Epub 2009 Feb 25.


An alternative form of replication protein a prevents viral replication in vitro.

Mason AC, Haring SJ, Pryor JM, Staloch CA, Gan TF, Wold MS.

J Biol Chem. 2009 Feb 20;284(8):5324-31. doi: 10.1074/jbc.M808963200. Epub 2008 Dec 29.


Investigation of the properties of non-gypsy suppressor of hairy-wing-binding sites.

Kuhn-Parnell EJ, Helou C, Marion DJ, Gilmore BL, Parnell TJ, Wold MS, Geyer PK.

Genetics. 2008 Jul;179(3):1263-73. doi: 10.1534/genetics.108.087254. Epub 2008 Jun 18.


Catalysis of strand annealing by replication protein A derives from its strand melting properties.

Bartos JD, Willmott LJ, Binz SK, Wold MS, Bambara RA.

J Biol Chem. 2008 Aug 1;283(31):21758-68. doi: 10.1074/jbc.M800856200. Epub 2008 Jun 3.


Regulatory functions of the N-terminal domain of the 70-kDa subunit of replication protein A (RPA).

Binz SK, Wold MS.

J Biol Chem. 2008 Aug 1;283(31):21559-70. doi: 10.1074/jbc.M802450200. Epub 2008 May 30.


Cellular functions of human RPA1. Multiple roles of domains in replication, repair, and checkpoints.

Haring SJ, Mason AC, Binz SK, Wold MS.

J Biol Chem. 2008 Jul 4;283(27):19095-111. doi: 10.1074/jbc.M800881200. Epub 2008 May 9.


Structure of the full-length human RPA14/32 complex gives insights into the mechanism of DNA binding and complex formation.

Deng X, Habel JE, Kabaleeswaran V, Snell EH, Wold MS, Borgstahl GE.

J Mol Biol. 2007 Dec 7;374(4):865-76. Epub 2007 Oct 2.


Replication protein A prevents accumulation of single-stranded telomeric DNA in cells that use alternative lengthening of telomeres.

Grudic A, Jul-Larsen A, Haring SJ, Wold MS, Lønning PE, Bjerkvig R, Bøe SO.

Nucleic Acids Res. 2007;35(21):7267-78. Epub 2007 Oct 24.


A common means to an end.

Haring SJ, Wold MS.

Nat Struct Mol Biol. 2007 Mar;14(3):176-7. No abstract available.


Identification of genomic sites that bind the Drosophila suppressor of Hairy-wing insulator protein.

Parnell TJ, Kuhn EJ, Gilmore BL, Helou C, Wold MS, Geyer PK.

Mol Cell Biol. 2006 Aug;26(16):5983-93.


Replication protein A directs loading of the DNA damage checkpoint clamp to 5'-DNA junctions.

Majka J, Binz SK, Wold MS, Burgers PM.

J Biol Chem. 2006 Sep 22;281(38):27855-61. Epub 2006 Jul 24.


Functional assays for replication protein A (RPA).

Binz SK, Dickson AM, Haring SJ, Wold MS.

Methods Enzymol. 2006;409:11-38.


Secondary structure and dynamics of an intrinsically unstructured linker domain.

Olson KE, Narayanaswami P, Vise PD, Lowry DF, Wold MS, Daughdrill GW.

J Biomol Struct Dyn. 2005 Oct;23(2):113-24.


Replication protein A phosphorylation and the cellular response to DNA damage.

Binz SK, Sheehan AM, Wold MS.

DNA Repair (Amst). 2004 Aug-Sep;3(8-9):1015-24. Review.


Replication protein A (RPA) phosphorylation prevents RPA association with replication centers.

Vassin VM, Wold MS, Borowiec JA.

Mol Cell Biol. 2004 Mar;24(5):1930-43.


The N-terminal domain of the large subunit of human replication protein A binds to Werner syndrome protein and stimulates helicase activity.

Shen JC, Lao Y, Kamath-Loeb A, Wold MS, Loeb LA.

Mech Ageing Dev. 2003 Aug-Sep;124(8-9):921-30.


Chemical shift changes provide evidence for overlapping single-stranded DNA- and XPA-binding sites on the 70 kDa subunit of human replication protein A.

Daughdrill GW, Buchko GW, Botuyan MV, Arrowsmith C, Wold MS, Kennedy MA, Lowry DF.

Nucleic Acids Res. 2003 Jul 15;31(14):4176-83.


Analysis of the human replication protein A:Rad52 complex: evidence for crosstalk between RPA32, RPA70, Rad52 and DNA.

Jackson D, Dhar K, Wahl JK, Wold MS, Borgstahl GE.

J Mol Biol. 2002 Aug 2;321(1):133-48.


The weak interdomain coupling observed in the 70 kDa subunit of human replication protein A is unaffected by ssDNA binding.

Daughdrill GW, Ackerman J, Isern NG, Botuyan MV, Arrowsmith C, Wold MS, Lowry DF.

Nucleic Acids Res. 2001 Aug 1;29(15):3270-6.


Polarity of human replication protein A binding to DNA.

Kolpashchikov DM, Khodyreva SN, Khlimankov DY, Wold MS, Favre A, Lavrik OI.

Nucleic Acids Res. 2001 Jan 15;29(2):373-9.


RBT1, a novel transcriptional co-activator, binds the second subunit of replication protein A.

Cho JM, Song DJ, Bergeron J, Benlimame N, Wold MS, Alaoui-Jamali MA.

Nucleic Acids Res. 2000 Sep 15;28(18):3478-85.


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