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Items: 1 to 50 of 113

1.

Semisynthesis of ubiquitinated histone H2B with a native or nonhydrolyzable linkage.

Morgan M, Jbara M, Brik A, Wolberger C.

Methods Enzymol. 2019;618:1-27. doi: 10.1016/bs.mie.2019.01.003. Epub 2019 Feb 26.

PMID:
30850047
2.

Mechanism of Cross-talk between H2B Ubiquitination and H3 Methylation by Dot1L.

Worden EJ, Hoffmann NA, Hicks CW, Wolberger C.

Cell. 2019 Mar 7;176(6):1490-1501.e12. doi: 10.1016/j.cell.2019.02.002. Epub 2019 Feb 11.

PMID:
30765112
3.

FACT and Ubp10 collaborate to modulate H2B deubiquitination and nucleosome dynamics.

Nune M, Morgan MT, Connell Z, McCullough L, Jbara M, Sun H, Brik A, Formosa T, Wolberger C.

Elife. 2019 Jan 25;8. pii: e40988. doi: 10.7554/eLife.40988.

4.

OTUB1 non-catalytically stabilizes the E2 ubiquitin-conjugating enzyme UBE2E1 by preventing its autoubiquitination.

Pasupala N, Morrow ME, Que LT, Malynn BA, Ma A, Wolberger C.

J Biol Chem. 2018 Nov 23;293(47):18285-18295. doi: 10.1074/jbc.RA118.004677. Epub 2018 Oct 3.

5.

Competition Assay for Measuring Deubiquitinating Enzyme Substrate Affinity.

Morgan MT, Wolberger C.

Methods Mol Biol. 2018;1844:59-70. doi: 10.1007/978-1-4939-8706-1_5.

PMID:
30242703
6.

Active site alanine mutations convert deubiquitinases into high-affinity ubiquitin-binding proteins.

Morrow ME, Morgan MT, Clerici M, Growkova K, Yan M, Komander D, Sixma TK, Simicek M, Wolberger C.

EMBO Rep. 2018 Oct;19(10). pii: e45680. doi: 10.15252/embr.201745680. Epub 2018 Aug 27.

7.

Palladium prompted on-demand cysteine chemistry for the synthesis of challenging and uniquely modified proteins.

Jbara M, Laps S, Morgan M, Kamnesky G, Mann G, Wolberger C, Brik A.

Nat Commun. 2018 Aug 8;9(1):3154. doi: 10.1038/s41467-018-05628-0.

8.

Hydrazide Mimics for Protein Lysine Acylation To Assess Nucleosome Dynamics and Deubiquitinase Action.

Bhat S, Hwang Y, Gibson MD, Morgan MT, Taverna SD, Zhao Y, Wolberger C, Poirier MG, Cole PA.

J Am Chem Soc. 2018 Aug 1;140(30):9478-9485. doi: 10.1021/jacs.8b03572. Epub 2018 Jul 24.

PMID:
29991262
9.

A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair.

Brickner JR, Soll JM, Lombardi PM, Vågbø CB, Mudge MC, Oyeniran C, Rabe R, Jackson J, Sullender ME, Blazosky E, Byrum AK, Zhao Y, Corbett MA, Gécz J, Field M, Vindigni A, Slupphaug G, Wolberger C, Mosammaparast N.

Nature. 2017 Nov 16;551(7680):389-393. doi: 10.1038/nature24484. Epub 2017 Nov 8.

10.

Not just Salk.

Greider C, Hopkins N, Steitz J, Amon A, Asai D, Barres B, Bass B, Bassler B, Birgeneau R, Bjorkman P, Botchan M, Brugge J, Cech T, Colwell R, Craig N, deLange T, Eisen M, Gottesman S, Green R, Handelsman J, Kimble J, King MC, Lehmann R, Marder E, Mullins D, O'Shea E, Schmid S, Seydoux G, Spradling A, Storz G, Szostak J, Telesnitsky A, Tilghman S, Tjian R, Vale R, Wolberger C, Zakian V.

Science. 2017 Sep 15;357(6356):1105-1106. doi: 10.1126/science.aao6221. No abstract available.

PMID:
28912235
11.

RAP80, ubiquitin and SUMO in the DNA damage response.

Lombardi PM, Matunis MJ, Wolberger C.

J Mol Med (Berl). 2017 Aug;95(8):799-807. doi: 10.1007/s00109-017-1561-1. Epub 2017 Jul 5. Review.

12.

Total chemical synthesis of SUMO-2-Lys63-linked diubiquitin hybrid chains assisted by removable solubilizing tags.

Bondalapati S, Eid E, Mali SM, Wolberger C, Brik A.

Chem Sci. 2017 May 1;8(5):4027-4034. doi: 10.1039/c7sc00488e. Epub 2017 Apr 5.

13.

A Tunable Brake for HECT Ubiquitin Ligases.

Chen Z, Jiang H, Xu W, Li X, Dempsey DR, Zhang X, Devreotes P, Wolberger C, Amzel LM, Gabelli SB, Cole PA.

Mol Cell. 2017 May 4;66(3):345-357.e6. doi: 10.1016/j.molcel.2017.03.020.

14.

Mutations that Allow SIR2 Orthologs to Function in a NAD+-Depleted Environment.

Ondracek CR, Frappier V, Ringel AE, Wolberger C, Guarente L.

Cell Rep. 2017 Mar 7;18(10):2310-2319. doi: 10.1016/j.celrep.2017.02.031.

15.

Recognition of ubiquitinated nucleosomes.

Morgan MT, Wolberger C.

Curr Opin Struct Biol. 2017 Feb;42:75-82. doi: 10.1016/j.sbi.2016.11.016. Epub 2016 Dec 4. Review.

16.

Role of E2-RING Interactions in Governing RNF4-Mediated Substrate Ubiquitination.

DiBello A, Datta AB, Zhang X, Wolberger C.

J Mol Biol. 2016 Nov 20;428(23):4639-4650. doi: 10.1016/j.jmb.2016.09.018. Epub 2016 Sep 24.

17.

Structural basis for acyl-group discrimination by human Gcn5L2.

Ringel AE, Wolberger C.

Acta Crystallogr D Struct Biol. 2016 Jul;72(Pt 7):841-8. doi: 10.1107/S2059798316007907. Epub 2016 Jun 23.

18.

Enzymatic Analysis of PTEN Ubiquitylation by WWP2 and NEDD4-1 E3 Ligases.

Chen Z, Thomas SN, Bolduc DM, Jiang X, Zhang X, Wolberger C, Cole PA.

Biochemistry. 2016 Jul 5;55(26):3658-66. doi: 10.1021/acs.biochem.6b00448. Epub 2016 Jun 22.

19.

SCIENTIFIC COMMUNITY. Preprints for the life sciences.

Berg JM, Bhalla N, Bourne PE, Chalfie M, Drubin DG, Fraser JS, Greider CW, Hendricks M, Jones C, Kiley R, King S, Kirschner MW, Krumholz HM, Lehmann R, Leptin M, Pulverer B, Rosenzweig B, Spiro JE, Stebbins M, Strasser C, Swaminathan S, Turner P, Vale RD, VijayRaghavan K, Wolberger C.

Science. 2016 May 20;352(6288):899-901. doi: 10.1126/science.aaf9133. No abstract available.

PMID:
27199406
20.

The Substrate Specificity of Sirtuins.

Bheda P, Jing H, Wolberger C, Lin H.

Annu Rev Biochem. 2016 Jun 2;85:405-29. doi: 10.1146/annurev-biochem-060815-014537. Epub 2016 Apr 18. Review.

PMID:
27088879
21.

Chemical Synthesis of Phosphorylated Histone H2A at Tyr57 Reveals Insight into the Inhibition Mode of the SAGA Deubiquitinating Module.

Jbara M, Maity SK, Morgan M, Wolberger C, Brik A.

Angew Chem Int Ed Engl. 2016 Apr 11;55(16):4972-6. doi: 10.1002/anie.201600638. Epub 2016 Mar 9.

22.

Structural basis for histone H2B deubiquitination by the SAGA DUB module.

Morgan MT, Haj-Yahya M, Ringel AE, Bandi P, Brik A, Wolberger C.

Science. 2016 Feb 12;351(6274):725-8. doi: 10.1126/science.aac5681.

23.

Nucleosome competition reveals processive acetylation by the SAGA HAT module.

Ringel AE, Cieniewicz AM, Taverna SD, Wolberger C.

Proc Natl Acad Sci U S A. 2015 Oct 6;112(40):E5461-70. doi: 10.1073/pnas.1508449112. Epub 2015 Sep 23.

24.

Role of a non-canonical surface of Rad6 in ubiquitin conjugating activity.

Kumar P, Magala P, Geiger-Schuller KR, Majumdar A, Tolman JR, Wolberger C.

Nucleic Acids Res. 2015 Oct 15;43(18):9039-50. doi: 10.1093/nar/gkv845. Epub 2015 Aug 18.

25.

A multilaboratory comparison of calibration accuracy and the performance of external references in analytical ultracentrifugation.

Zhao H, Ghirlando R, Alfonso C, Arisaka F, Attali I, Bain DL, Bakhtina MM, Becker DF, Bedwell GJ, Bekdemir A, Besong TM, Birck C, Brautigam CA, Brennerman W, Byron O, Bzowska A, Chaires JB, Chaton CT, Cölfen H, Connaghan KD, Crowley KA, Curth U, Daviter T, Dean WL, Díez AI, Ebel C, Eckert DM, Eisele LE, Eisenstein E, England P, Escalante C, Fagan JA, Fairman R, Finn RM, Fischle W, de la Torre JG, Gor J, Gustafsson H, Hall D, Harding SE, Cifre JG, Herr AB, Howell EE, Isaac RS, Jao SC, Jose D, Kim SJ, Kokona B, Kornblatt JA, Kosek D, Krayukhina E, Krzizike D, Kusznir EA, Kwon H, Larson A, Laue TM, Le Roy A, Leech AP, Lilie H, Luger K, Luque-Ortega JR, Ma J, May CA, Maynard EL, Modrak-Wojcik A, Mok YF, Mücke N, Nagel-Steger L, Narlikar GJ, Noda M, Nourse A, Obsil T, Park CK, Park JK, Pawelek PD, Perdue EE, Perkins SJ, Perugini MA, Peterson CL, Peverelli MG, Piszczek G, Prag G, Prevelige PE, Raynal BD, Rezabkova L, Richter K, Ringel AE, Rosenberg R, Rowe AJ, Rufer AC, Scott DJ, Seravalli JG, Solovyova AS, Song R, Staunton D, Stoddard C, Stott K, Strauss HM, Streicher WW, Sumida JP, Swygert SG, Szczepanowski RH, Tessmer I, Toth RT 4th, Tripathy A, Uchiyama S, Uebel SF, Unzai S, Gruber AV, von Hippel PH, Wandrey C, Wang SH, Weitzel SE, Wielgus-Kutrowska B, Wolberger C, Wolff M, Wright E, Wu YS, Wubben JM, Schuck P.

PLoS One. 2015 May 21;10(5):e0126420. doi: 10.1371/journal.pone.0126420. eCollection 2015.

26.

Structure of the yeast Bre1 RING domain.

Kumar P, Wolberger C.

Proteins. 2015 Jun;83(6):1185-90. doi: 10.1002/prot.24812. Epub 2015 Apr 29.

27.

Uncovering the role of Sgf73 in maintaining SAGA deubiquitinating module structure and activity.

Yan M, Wolberger C.

J Mol Biol. 2015 Apr 24;427(8):1765-78. doi: 10.1016/j.jmb.2014.12.004. Epub 2014 Dec 17.

28.

Extracellular nicotinamide phosphoribosyltransferase (NAMPT) promotes M2 macrophage polarization in chronic lymphocytic leukemia.

Audrito V, Serra S, Brusa D, Mazzola F, Arruga F, Vaisitti T, Coscia M, Maffei R, Rossi D, Wang T, Inghirami G, Rizzi M, Gaidano G, Garcia JG, Wolberger C, Raffaelli N, Deaglio S.

Blood. 2015 Jan 1;125(1):111-23. doi: 10.1182/blood-2014-07-589069. Epub 2014 Nov 3.

29.

Alternate deacylating specificities of the archaeal sirtuins Sir2Af1 and Sir2Af2.

Ringel AE, Roman C, Wolberger C.

Protein Sci. 2014 Dec;23(12):1686-97. doi: 10.1002/pro.2546. Epub 2014 Oct 1.

30.

Characterization of the SUMO-binding activity of the myeloproliferative and mental retardation (MYM)-type zinc fingers in ZNF261 and ZNF198.

Guzzo CM, Ringel A, Cox E, Uzoma I, Zhu H, Blackshaw S, Wolberger C, Matunis MJ.

PLoS One. 2014 Aug 18;9(8):e105271. doi: 10.1371/journal.pone.0105271. eCollection 2014.

31.

The bromodomain of Gcn5 regulates site specificity of lysine acetylation on histone H3.

Cieniewicz AM, Moreland L, Ringel AE, Mackintosh SG, Raman A, Gilbert TM, Wolberger C, Tackett AJ, Taverna SD.

Mol Cell Proteomics. 2014 Nov;13(11):2896-910. doi: 10.1074/mcp.M114.038174. Epub 2014 Aug 8.

32.

New insights into ubiquitin E3 ligase mechanism.

Berndsen CE, Wolberger C.

Nat Struct Mol Biol. 2014 Apr;21(4):301-7. doi: 10.1038/nsmb.2780. Review.

PMID:
24699078
33.

Mechanisms for regulating deubiquitinating enzymes.

Wolberger C.

Protein Sci. 2014 Apr;23(4):344-53. doi: 10.1002/pro.2415. Epub 2014 Feb 12. Review.

34.

Architectural organization of the metabolic regulatory enzyme ghrelin O-acyltransferase.

Taylor MS, Ruch TR, Hsiao PY, Hwang Y, Zhang P, Dai L, Huang CR, Berndsen CE, Kim MS, Pandey A, Wolberger C, Marmorstein R, Machamer C, Boeke JD, Cole PA.

J Biol Chem. 2013 Nov 8;288(45):32211-28. doi: 10.1074/jbc.M113.510313. Epub 2013 Sep 17.

35.

A new RING tossed into an old HAT.

Ringel AE, Wolberger C.

Structure. 2013 Sep 3;21(9):1479-81. doi: 10.1016/j.str.2013.08.011.

36.

E2 ubiquitin-conjugating enzymes regulate the deubiquitinating activity of OTUB1.

Wiener R, DiBello AT, Lombardi PM, Guzzo CM, Zhang X, Matunis MJ, Wolberger C.

Nat Struct Mol Biol. 2013 Sep;20(9):1033-9. doi: 10.1038/nsmb.2655. Epub 2013 Aug 18.

37.

A new DUB makes linear ubiquitin a party to its own destruction.

Wiener R, Wolberger C.

Cell. 2013 Jun 6;153(6):1189-91. doi: 10.1016/j.cell.2013.05.018.

38.

A quantitative analysis of histone methylation and acetylation isoforms from their deuteroacetylated derivatives: application to a series of knockout mutants.

Fiedler KL, Bheda P, Dai J, Boeke JD, Wolberger C, Cotter RJ.

J Mass Spectrom. 2013 May;48(5):608-15. doi: 10.1002/jms.3198.

39.

Biochemistry: Sirtuin on a high-fat diet.

Bheda P, Wolberger C.

Nature. 2013 Apr 4;496(7443):41-2. doi: 10.1038/496041a. No abstract available.

PMID:
23552941
40.

A conserved asparagine has a structural role in ubiquitin-conjugating enzymes.

Berndsen CE, Wiener R, Yu IW, Ringel AE, Wolberger C.

Nat Chem Biol. 2013 Mar;9(3):154-6. doi: 10.1038/nchembio.1159. Epub 2013 Jan 6.

41.

RNF4-dependent hybrid SUMO-ubiquitin chains are signals for RAP80 and thereby mediate the recruitment of BRCA1 to sites of DNA damage.

Guzzo CM, Berndsen CE, Zhu J, Gupta V, Datta A, Greenberg RA, Wolberger C, Matunis MJ.

Sci Signal. 2012 Dec 4;5(253):ra88. doi: 10.1126/scisignal.2003485.

42.

A role for intersubunit interactions in maintaining SAGA deubiquitinating module structure and activity.

Samara NL, Ringel AE, Wolberger C.

Structure. 2012 Aug 8;20(8):1414-24. doi: 10.1016/j.str.2012.05.015. Epub 2012 Jul 5.

43.

Biotinylation of lysine method identifies acetylated histone H3 lysine 79 in Saccharomyces cerevisiae as a substrate for Sir2.

Bheda P, Swatkoski S, Fiedler KL, Boeke JD, Cotter RJ, Wolberger C.

Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):E916-25. doi: 10.1073/pnas.1121471109. Epub 2012 Apr 2.

44.

The mechanism of OTUB1-mediated inhibition of ubiquitination.

Wiener R, Zhang X, Wang T, Wolberger C.

Nature. 2012 Feb 22;483(7391):618-22. doi: 10.1038/nature10911.

45.

Proteins: histones and chromatin.

Cramer P, Wolberger C.

Curr Opin Struct Biol. 2011 Dec;21(6):695-7. doi: 10.1016/j.sbi.2011.10.006. Epub 2011 Nov 11. No abstract available.

46.

A new chapter in the transcription SAGA.

Samara NL, Wolberger C.

Curr Opin Struct Biol. 2011 Dec;21(6):767-74. doi: 10.1016/j.sbi.2011.09.004. Epub 2011 Oct 18. Review.

47.

A spectrophotometric assay for conjugation of ubiquitin and ubiquitin-like proteins.

Berndsen CE, Wolberger C.

Anal Biochem. 2011 Nov 1;418(1):102-10. doi: 10.1016/j.ab.2011.06.034. Epub 2011 Jul 2.

48.

Structure of Sir2Tm bound to a propionylated peptide.

Bheda P, Wang JT, Escalante-Semerena JC, Wolberger C.

Protein Sci. 2011 Jan;20(1):131-9. doi: 10.1002/pro.544.

49.

Structural insights into the assembly and function of the SAGA deubiquitinating module.

Samara NL, Datta AB, Berndsen CE, Zhang X, Yao T, Cohen RE, Wolberger C.

Science. 2010 May 21;328(5981):1025-9. doi: 10.1126/science.1190049. Epub 2010 Apr 15.

50.

Side chain specificity of ADP-ribosylation by a sirtuin.

Fahie K, Hu P, Swatkoski S, Cotter RJ, Zhang Y, Wolberger C.

FEBS J. 2009 Dec;276(23):7159-76. doi: 10.1111/j.1742-4658.2009.07427.x. Epub 2009 Nov 6.

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