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Items: 43

1.

Genetic basis for the cooperative bioactivation of plant lignans by Eggerthella lenta and other human gut bacteria.

Bess EN, Bisanz JE, Yarza F, Bustion A, Rich BE, Li X, Kitamura S, Waligurski E, Ang QY, Alba DL, Spanogiannopoulos P, Nayfach S, Koliwad SK, Wolan DW, Franke AA, Turnbaugh PJ.

Nat Microbiol. 2019 Nov 4. doi: 10.1038/s41564-019-0596-1. [Epub ahead of print]

PMID:
31686027
2.

SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase.

Zheng Q, Woehl JL, Kitamura S, Santos-Martins D, Smedley CJ, Li G, Forli S, Moses JE, Wolan DW, Sharpless KB.

Proc Natl Acad Sci U S A. 2019 Sep 17;116(38):18808-18814. doi: 10.1073/pnas.1909972116. Epub 2019 Sep 4.

PMID:
31484779
3.

N-Terminomics/TAILS Profiling of Proteases and Their Substrates in Ulcerative Colitis.

Gordon MH, Anowai A, Young D, Das N, Campden RI, Sekhon H, Myers Z, Mainoli B, Chopra S, Thuy-Boun PS, Kizhakkedathu J, Bindra G, Jijon HB, Heitman S, Yates R, Wolan DW, Edgington-Mitchell LE, MacNaughton WK, Dufour A.

ACS Chem Biol. 2019 Nov 15;14(11):2471-2483. doi: 10.1021/acschembio.9b00608. Epub 2019 Aug 21.

PMID:
31393699
4.

A glycal-based photoaffinity probe that enriches sialic acid binding proteins.

Thuy-Boun PS, Wolan DW.

Bioorg Med Chem Lett. 2019 Sep 15;29(18):2609-2612. doi: 10.1016/j.bmcl.2019.07.054. Epub 2019 Aug 1.

PMID:
31387789
5.

Selective and Rapid Cell-Permeable Inhibitor of Human Caspase-3.

Solania A, González-Páez GE, Wolan DW.

ACS Chem Biol. 2019 Nov 15;14(11):2463-2470. doi: 10.1021/acschembio.9b00564. Epub 2019 Aug 1.

PMID:
31334631
6.

X-ray structure of an inactive zymogen clostripain-like protease from Parabacteroides distasonis.

González-Páez GE, Roncase EJ, Wolan DW.

Acta Crystallogr D Struct Biol. 2019 Mar 1;75(Pt 3):325-332. doi: 10.1107/S2059798319000809. Epub 2019 Feb 28.

PMID:
30950403
7.

X-ray Structures of Two Bacteroides thetaiotaomicron C11 Proteases in Complex with Peptide-Based Inhibitors.

Roncase EJ, González-Páez GE, Wolan DW.

Biochemistry. 2019 Apr 2;58(13):1728-1737. doi: 10.1021/acs.biochem.9b00098. Epub 2019 Mar 14.

PMID:
30835452
8.

Nanobody-based binding assay for the discovery of potent inhibitors of CFTR inhibitory factor (Cif).

Vasylieva N, Kitamura S, Dong J, Barnych B, Hvorecny KL, Madden DR, Gee SJ, Wolan DW, Morisseau C, Hammock BD.

Anal Chim Acta. 2019 May 30;1057:106-113. doi: 10.1016/j.aca.2018.12.060. Epub 2019 Jan 9.

PMID:
30832908
9.

ComPIL 2.0: An Updated Comprehensive Metaproteomics Database.

Park SKR, Jung T, Thuy-Boun PS, Wang AY, Yates JR 3rd, Wolan DW.

J Proteome Res. 2019 Feb 1;18(2):616-622. doi: 10.1021/acs.jproteome.8b00722. Epub 2019 Jan 14.

PMID:
30525664
10.

Expanding the Use of Spectral Libraries in Proteomics.

Deutsch EW, Perez-Riverol Y, Chalkley RJ, Wilhelm M, Tate S, Sachsenberg T, Walzer M, Käll L, Delanghe B, Böcker S, Schymanski EL, Wilmes P, Dorfer V, Kuster B, Volders PJ, Jehmlich N, Vissers JPC, Wolan DW, Wang AY, Mendoza L, Shofstahl J, Dowsey AW, Griss J, Salek RM, Neumann S, Binz PA, Lam H, Vizcaíno JA, Bandeira N, Röst H.

J Proteome Res. 2018 Dec 7;17(12):4051-4060. doi: 10.1021/acs.jproteome.8b00485. Epub 2018 Oct 11. Review.

11.

A Commensal Dipeptidyl Aminopeptidase with Specificity for N-Terminal Glycine Degrades Human-Produced Antimicrobial Peptides in Vitro.

Xu JH, Jiang Z, Solania A, Chatterjee S, Suzuki B, Lietz CB, Hook VYH, O'Donoghue AJ, Wolan DW.

ACS Chem Biol. 2018 Sep 21;13(9):2513-2521. doi: 10.1021/acschembio.8b00420. Epub 2018 Aug 23.

PMID:
30085657
12.

Announcement of 2019 Keystone Symposia Conference: "Microbiome: Chemical Mechanisms and Biological Consequences".

Balskus EP, Turnbaugh PJ, Wolan DW.

mSystems. 2018 Jul 24;3(4). pii: e00115-18. doi: 10.1128/mSystems.00115-18. eCollection 2018 Jul-Aug.

13.

Triflic Acid Treatment Enables LC-MS/MS Analysis of Insoluble Bacterial Biomass.

Wang AY, Thuy-Boun PS, Stupp GS, Su AI, Wolan DW.

J Proteome Res. 2018 Sep 7;17(9):2978-2986. doi: 10.1021/acs.jproteome.8b00166. Epub 2018 Aug 8.

PMID:
30019906
14.

Probing substrate recognition of bacterial lipoprotein signal peptidase using FRET reporters.

Kitamura S, Wolan DW.

FEBS Lett. 2018 Jul;592(13):2289-2296. doi: 10.1002/1873-3468.13155. Epub 2018 Jun 27.

15.

METLIN: A Technology Platform for Identifying Knowns and Unknowns.

Guijas C, Montenegro-Burke JR, Domingo-Almenara X, Palermo A, Warth B, Hermann G, Koellensperger G, Huan T, Uritboonthai W, Aisporna AE, Wolan DW, Spilker ME, Benton HP, Siuzdak G.

Anal Chem. 2018 Mar 6;90(5):3156-3164. doi: 10.1021/acs.analchem.7b04424. Epub 2018 Feb 9.

16.

Lipoprotein Signal Peptidase Inhibitors with Antibiotic Properties Identified through Design of a Robust In Vitro HT Platform.

Kitamura S, Owensby A, Wall D, Wolan DW.

Cell Chem Biol. 2018 Mar 15;25(3):301-308.e12. doi: 10.1016/j.chembiol.2017.12.011. Epub 2018 Jan 11.

17.

Metaproteomics of Colonic Microbiota Unveils Discrete Protein Functions among Colitic Mice and Control Groups.

Moon C, Stupp GS, Su AI, Wolan DW.

Proteomics. 2018 Feb;18(3-4). doi: 10.1002/pmic.201700391. Epub 2018 Feb 2.

18.

Structure-based optimization and synthesis of antiviral drug Arbidol analogues with significantly improved affinity to influenza hemagglutinin.

Wright ZVF, Wu NC, Kadam RU, Wilson IA, Wolan DW.

Bioorg Med Chem Lett. 2017 Aug 15;27(16):3744-3748. doi: 10.1016/j.bmcl.2017.06.074. Epub 2017 Jun 28.

19.

Substrate Profiling and High Resolution Co-complex Crystal Structure of a Secreted C11 Protease Conserved across Commensal Bacteria.

Roncase EJ, Moon C, Chatterjee S, González-Páez GE, Craik CS, O'Donoghue AJ, Wolan DW.

ACS Chem Biol. 2017 Jun 16;12(6):1556-1565. doi: 10.1021/acschembio.7b00143. Epub 2017 Apr 27.

20.

Quantitative Metaproteomics and Activity-Based Probe Enrichment Reveals Significant Alterations in Protein Expression from a Mouse Model of Inflammatory Bowel Disease.

Mayers MD, Moon C, Stupp GS, Su AI, Wolan DW.

J Proteome Res. 2017 Feb 3;16(2):1014-1026. doi: 10.1021/acs.jproteome.6b00938. Epub 2017 Jan 23.

21.

Data Streaming for Metabolomics: Accelerating Data Processing and Analysis from Days to Minutes.

Montenegro-Burke JR, Aisporna AE, Benton HP, Rinehart D, Fang M, Huan T, Warth B, Forsberg E, Abe BT, Ivanisevic J, Wolan DW, Teyton L, Lairson L, Siuzdak G.

Anal Chem. 2017 Jan 17;89(2):1254-1259. doi: 10.1021/acs.analchem.6b03890. Epub 2017 Jan 3.

22.

A comprehensive and scalable database search system for metaproteomics.

Chatterjee S, Stupp GS, Park SK, Ducom JC, Yates JR 3rd, Su AI, Wolan DW.

BMC Genomics. 2016 Aug 16;17(1):642. doi: 10.1186/s12864-016-2855-3.

23.

Synthesis and Sulfur Electrophilicity of the Nuphar Thiaspirane Pharmacophore.

Tada N, Jansen DJ, Mower MP, Blewett MM, Umotoy JC, Cravatt BF, Wolan DW, Shenvi RA.

ACS Cent Sci. 2016 Jun 22;2(6):401-8. doi: 10.1021/acscentsci.6b00113. Epub 2016 Jun 13.

24.

Proteome-wide covalent ligand discovery in native biological systems.

Backus KM, Correia BE, Lum KM, Forli S, Horning BD, González-Páez GE, Chatterjee S, Lanning BR, Teijaro JR, Olson AJ, Wolan DW, Cravatt BF.

Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.

25.

Identification and Co-complex Structure of a New S. pyogenes SpeB Small Molecule Inhibitor.

Wang AY, González-Páez GE, Wolan DW.

Biochemistry. 2015 Jul 21;54(28):4365-73. doi: 10.1021/acs.biochem.5b00607. Epub 2015 Jul 13.

PMID:
26132413
26.

Acetone-Linked Peptides: A Convergent Approach for Peptide Macrocyclization and Labeling.

Assem N, Ferreira DJ, Wolan DW, Dawson PE.

Angew Chem Int Ed Engl. 2015 Jul 20;54(30):8665-8. doi: 10.1002/anie.201502607. Epub 2015 Jun 11.

27.

Nitrosopurines en route to potently cytotoxic asmarines.

Wan KK, Iwasaki K, Umotoy JC, Wolan DW, Shenvi RA.

Angew Chem Int Ed Engl. 2015 Feb 16;54(8):2410-5. doi: 10.1002/anie.201411493. Epub 2015 Jan 7.

28.

Discovery of a highly selective caspase-3 substrate for imaging live cells.

Vickers CJ, González-Páez GE, Wolan DW.

ACS Chem Biol. 2014 Oct 17;9(10):2199-203. doi: 10.1021/cb500586p. Epub 2014 Aug 20.

PMID:
25133295
29.

Selective inhibition of initiator versus executioner caspases using small peptides containing unnatural amino acids.

Vickers CJ, González-Páez GE, Litwin KM, Umotoy JC, Coutsias EA, Wolan DW.

ACS Chem Biol. 2014 Oct 17;9(10):2194-8. doi: 10.1021/cb5004256. Epub 2014 Aug 5.

PMID:
25079698
30.

Selective detection and inhibition of active caspase-3 in cells with optimized peptides.

Vickers CJ, González-Páez GE, Wolan DW.

J Am Chem Soc. 2013 Aug 28;135(34):12869-76. doi: 10.1021/ja406399r. Epub 2013 Aug 19.

PMID:
23915420
31.

Small-molecule procaspase activators identified using fluorescence polarization.

Vickers CJ, González-Páez GE, Umotoy JC, Cayanan-Garrett C, Brown SJ, Wolan DW.

Chembiochem. 2013 Aug 19;14(12):1419-22. doi: 10.1002/cbic.201300315. Epub 2013 Jul 8.

PMID:
23836614
32.

Selective detection of caspase-3 versus caspase-7 using activity-based probes with key unnatural amino acids.

Vickers CJ, González-Páez GE, Wolan DW.

ACS Chem Biol. 2013 Jul 19;8(7):1558-66. doi: 10.1021/cb400209w. Epub 2013 May 3.

PMID:
23614665
33.

Fibrils colocalize caspase-3 with procaspase-3 to foster maturation.

Zorn JA, Wolan DW, Agard NJ, Wells JA.

J Biol Chem. 2012 Sep 28;287(40):33781-95. Epub 2012 Aug 7.

34.

Ultrahigh and high resolution structures and mutational analysis of monomeric Streptococcus pyogenes SpeB reveal a functional role for the glycine-rich C-terminal loop.

González-Páez GE, Wolan DW.

J Biol Chem. 2012 Jul 13;287(29):24412-26. doi: 10.1074/jbc.M112.361576. Epub 2012 May 29.

35.

Self-assembling small molecules form nanofibrils that bind procaspase-3 to promote activation.

Zorn JA, Wille H, Wolan DW, Wells JA.

J Am Chem Soc. 2011 Dec 14;133(49):19630-3. doi: 10.1021/ja208350u. Epub 2011 Nov 17.

36.

Turning a protein kinase on or off from a single allosteric site via disulfide trapping.

Sadowsky JD, Burlingame MA, Wolan DW, McClendon CL, Jacobson MP, Wells JA.

Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6056-61. doi: 10.1073/pnas.1102376108. Epub 2011 Mar 23.

37.

Small-molecule activators of a proenzyme.

Wolan DW, Zorn JA, Gray DC, Wells JA.

Science. 2009 Nov 6;326(5954):853-8. doi: 10.1126/science.1177585.

39.

Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates.

Cheong CG, Wolan DW, Greasley SE, Horton PA, Beardsley GP, Wilson IA.

J Biol Chem. 2004 Apr 23;279(17):18034-45. Epub 2004 Feb 13.

40.

Structural insights into the human and avian IMP cyclohydrolase mechanism via crystal structures with the bound XMP inhibitor.

Wolan DW, Cheong CG, Greasley SE, Wilson IA.

Biochemistry. 2004 Feb 10;43(5):1171-83.

PMID:
14756553
41.

Structure of avian AICAR transformylase with a multisubstrate adduct inhibitor beta-DADF identifies the folate binding site.

Wolan DW, Greasley SE, Wall MJ, Benkovic SJ, Wilson IA.

Biochemistry. 2003 Sep 23;42(37):10904-14.

PMID:
12974624
42.

Structural insights into the avian AICAR transformylase mechanism.

Wolan DW, Greasley SE, Beardsley GP, Wilson IA.

Biochemistry. 2002 Dec 31;41(52):15505-13.

PMID:
12501179
43.

Crystal structure of the murine NK cell-activating receptor NKG2D at 1.95 A.

Wolan DW, Teyton L, Rudolph MG, Villmow B, Bauer S, Busch DH, Wilson IA.

Nat Immunol. 2001 Mar;2(3):248-54.

PMID:
11224525

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