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Items: 41

1.

An activatable PET imaging radioprobe is a dynamic reporter of myeloperoxidase activity in vivo.

Wang C, Keliher E, Zeller MWG, Wojtkiewicz GR, Aguirre AD, Buckbinder L, Kim HY, Chen J, Maresca K, Ahmed MS, Motlagh NJ, Nahrendorf M, Chen JW.

Proc Natl Acad Sci U S A. 2019 Jun 11;116(24):11966-11971. doi: 10.1073/pnas.1818434116. Epub 2019 May 23.

PMID:
31123149
2.

The Dual PI3K/mTOR Pathway Inhibitor GDC-0084 Achieves Antitumor Activity in PIK3CA-Mutant Breast Cancer Brain Metastases.

Ippen FM, Alvarez-Breckenridge CA, Kuter BM, Fink AL, Bihun IV, Lastrapes M, Penson T, Schmidt SP, Wojtkiewicz GR, Ning J, Subramanian M, Giobbie-Hurder A, Martinez-Lage M, Carter SL, Cahill DP, Wakimoto H, Brastianos PK.

Clin Cancer Res. 2019 Jun 1;25(11):3374-3383. doi: 10.1158/1078-0432.CCR-18-3049. Epub 2019 Feb 22.

PMID:
30796030
3.

Gut intraepithelial T cells calibrate metabolism and accelerate cardiovascular disease.

He S, Kahles F, Rattik S, Nairz M, McAlpine CS, Anzai A, Selgrade D, Fenn AM, Chan CT, Mindur JE, Valet C, Poller WC, Halle L, Rotllan N, Iwamoto Y, Wojtkiewicz GR, Weissleder R, Libby P, Fernández-Hernando C, Drucker DJ, Nahrendorf M, Swirski FK.

Nature. 2019 Feb;566(7742):115-119. doi: 10.1038/s41586-018-0849-9. Epub 2019 Jan 30.

PMID:
30700910
4.

Ultrasmall superparamagnetic iron oxide nanoparticle uptake as noninvasive marker of aortic wall inflammation on MRI: proof of concept study.

Hedgire S, Krebill C, Wojtkiewicz GR, Oliveira I, Ghoshhajra BB, Hoffmann U, Harisinghani MG.

Br J Radiol. 2018 Dec;91(1092):20180461. doi: 10.1259/bjr.20180461. Epub 2018 Sep 12.

PMID:
30160173
5.

Direct vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration.

Herisson F, Frodermann V, Courties G, Rohde D, Sun Y, Vandoorne K, Wojtkiewicz GR, Masson GS, Vinegoni C, Kim J, Kim DE, Weissleder R, Swirski FK, Moskowitz MA, Nahrendorf M.

Nat Neurosci. 2018 Sep;21(9):1209-1217. doi: 10.1038/s41593-018-0213-2. Epub 2018 Aug 27.

6.

Genotype-targeted local therapy of glioma.

Shankar GM, Kirtane AR, Miller JJ, Mazdiyasni H, Rogner J, Tai T, Williams EA, Higuchi F, Juratli TA, Tateishi K, Koerner MVA, Tummala SS, Fink AL, Penson T, Schmidt SP, Wojtkiewicz GR, Baig A, Francis JM, Rinne ML, Batten JM, Batchelor TT, Brastianos PK, Curry WT Jr, Barker FG 2nd, Jordan JT, Iafrate AJ, Chi AS, Lennerz JK, Meyerson M, Langer R, Wakimoto H, Traverso G, Cahill DP.

Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):E8388-E8394. doi: 10.1073/pnas.1805751115. Epub 2018 Aug 6.

7.

Multimodal Molecular Imaging Demonstrates Myeloperoxidase Regulation of Matrix Metalloproteinase Activity in Neuroinflammation.

Zhang Y, Dong H, Seeburg DP, Wojtkiewicz GR, Waterman P, Pulli B, Forghani R, Ali M, Iwamoto Y, Swirski FK, Chen JW.

Mol Neurobiol. 2019 Feb;56(2):954-962. doi: 10.1007/s12035-018-1137-2. Epub 2018 May 28.

PMID:
29808380
8.

Reducing myeloperoxidase activity decreases inflammation and increases cellular protection in ischemic stroke.

Kim HJ, Wei Y, Wojtkiewicz GR, Lee JY, Moskowitz MA, Chen JW.

J Cereb Blood Flow Metab. 2018 Apr 20:271678X18771978. doi: 10.1177/0271678X18771978. [Epub ahead of print]

PMID:
29673284
9.

Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils.

Engblom C, Pfirschke C, Zilionis R, Da Silva Martins J, Bos SA, Courties G, Rickelt S, Severe N, Baryawno N, Faget J, Savova V, Zemmour D, Kline J, Siwicki M, Garris C, Pucci F, Liao HW, Lin YJ, Newton A, Yaghi OK, Iwamoto Y, Tricot B, Wojtkiewicz GR, Nahrendorf M, Cortez-Retamozo V, Meylan E, Hynes RO, Demay M, Klein A, Bredella MA, Scadden DT, Weissleder R, Pittet MJ.

Science. 2017 Dec 1;358(6367). pii: eaal5081. doi: 10.1126/science.aal5081.

10.

Bioengineering of functional human induced pluripotent stem cell-derived intestinal grafts.

Kitano K, Schwartz DM, Zhou H, Gilpin SE, Wojtkiewicz GR, Ren X, Sommer CA, Capilla AV, Mathisen DJ, Goldstein AM, Mostoslavsky G, Ott HC.

Nat Commun. 2017 Oct 10;8(1):765. doi: 10.1038/s41467-017-00779-y.

11.

The infarcted myocardium solicits GM-CSF for the detrimental oversupply of inflammatory leukocytes.

Anzai A, Choi JL, He S, Fenn AM, Nairz M, Rattik S, McAlpine CS, Mindur JE, Chan CT, Iwamoto Y, Tricot B, Wojtkiewicz GR, Weissleder R, Libby P, Nahrendorf M, Stone JR, Becher B, Swirski FK.

J Exp Med. 2017 Nov 6;214(11):3293-3310. doi: 10.1084/jem.20170689. Epub 2017 Oct 4.

12.

Myeloperoxidase Nuclear Imaging for Epileptogenesis.

Zhang Y, Seeburg DP, Pulli B, Wojtkiewicz GR, Bure L, Atkinson W, Schob S, Iwamoto Y, Ali M, Zhang W, Rodriguez E, Milewski A, Keliher EJ, Wang C, Pan Y, Swirski FK, Chen JW.

Radiology. 2017 Feb;282(2):614. doi: 10.1148/radiol.2017164044. No abstract available.

PMID:
28099101
13.

Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease.

Keliher EJ, Ye YX, Wojtkiewicz GR, Aguirre AD, Tricot B, Senders ML, Groenen H, Fay F, Perez-Medina C, Calcagno C, Carlucci G, Reiner T, Sun Y, Courties G, Iwamoto Y, Kim HY, Wang C, Chen JW, Swirski FK, Wey HY, Hooker J, Fayad ZA, Mulder WJ, Weissleder R, Nahrendorf M.

Nat Commun. 2017 Jan 16;8:14064. doi: 10.1038/ncomms14064.

14.

Endotracheal Tubes Cleaned With a Novel Mechanism for Secretion Removal: A Randomized Controlled Clinical Study.

Pinciroli R, Mietto C, Piriyapatsom A, Chenelle CT, Thomas JG, Pirrone M, Bry L, Wojtkiewicz GR, Nahrendorf MP, Kacmarek RM, Berra L.

Respir Care. 2016 Nov;61(11):1431-1439. Epub 2016 Jul 26.

15.

Surface biotinylation of cytotoxic T lymphocytes for in vivo tracking of tumor immunotherapy in murine models.

Li A, Wu Y, Linnoila J, Pulli B, Wang C, Zeller M, Ali M, Lewandrowski GK, Li J, Tricot B, Keliher E, Wojtkiewicz GR, Fulci G, Feng X, Tannous BA, Yao Z, Chen JW.

Cancer Immunol Immunother. 2016 Dec;65(12):1545-1554. Epub 2016 Oct 8.

16.

RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction.

Sager HB, Dutta P, Dahlman JE, Hulsmans M, Courties G, Sun Y, Heidt T, Vinegoni C, Borodovsky A, Fitzgerald K, Wojtkiewicz GR, Iwamoto Y, Tricot B, Khan OF, Kauffman KJ, Xing Y, Shaw TE, Libby P, Langer R, Weissleder R, Swirski FK, Anderson DG, Nahrendorf M.

Sci Transl Med. 2016 Jun 8;8(342):342ra80. doi: 10.1126/scitranslmed.aaf1435.

17.

The use of 18F-2-fluorodeoxyglucose (FDG) to label antibody fragments for immuno-PET of pancreatic cancer.

Rashidian M, Keliher E, Dougan M, Juras PK, Cavallari M, Wojtkiewicz GR, Jacobsen J, Edens JG, Tas JM, Victora G, Weissleder R, Ploegh H.

ACS Cent Sci. 2015 Jun 24;1(3):142-147. Epub 2015 Jun 3.

18.

Sensory and autonomic deficits in a new humanized mouse model of familial dysautonomia.

Morini E, Dietrich P, Salani M, Downs HM, Wojtkiewicz GR, Alli S, Brenner A, Nilbratt M, LeClair JW, Oaklander AL, Slaugenhaupt SA, Dragatsis I.

Hum Mol Genet. 2016 Mar 15;25(6):1116-28. doi: 10.1093/hmg/ddv634. Epub 2016 Jan 13.

19.

Myeloperoxidase Nuclear Imaging for Epileptogenesis.

Zhang Y, Seeburg DP, Pulli B, Wojtkiewicz GR, Bure L, Atkinson W, Schob S, Iwamoto Y, Ali M, Zhang W, Rodriguez E, Milewski A, Keliher EJ, Wang C, Pan Y, Swirski FK, Chen JW.

Radiology. 2016 Mar;278(3):822-30. doi: 10.1148/radiol.2015141922. Epub 2015 Sep 23. Erratum in: Radiology. 2017 Feb;282(2):614.

20.

Imaging Macrophage and Hematopoietic Progenitor Proliferation in Atherosclerosis.

Ye YX, Calcagno C, Binderup T, Courties G, Keliher EJ, Wojtkiewicz GR, Iwamoto Y, Tang J, Pérez-Medina C, Mani V, Ishino S, Johnbeck CB, Knigge U, Fayad ZA, Libby P, Weissleder R, Tawakol A, Dubey S, Belanger AP, Di Carli MF, Swirski FK, Kjaer A, Mulder WJ, Nahrendorf M.

Circ Res. 2015 Oct 23;117(10):835-45. doi: 10.1161/CIRCRESAHA.115.307024. Epub 2015 Sep 22.

21.

Targeting Interleukin-1β Reduces Leukocyte Production After Acute Myocardial Infarction.

Sager HB, Heidt T, Hulsmans M, Dutta P, Courties G, Sebas M, Wojtkiewicz GR, Tricot B, Iwamoto Y, Sun Y, Weissleder R, Libby P, Swirski FK, Nahrendorf M.

Circulation. 2015 Nov 17;132(20):1880-90. doi: 10.1161/CIRCULATIONAHA.115.016160. Epub 2015 Sep 10.

22.

Response to Letter Regarding Article, "18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Enables the Detection of Recurrent Same-Site Deep Vein Thrombosis by Illuminating Recently Formed, Neutrophil-Rich Thrombus".

Tawakol A, Hara T, Truelove J, Wojtkiewicz GR, Hucker WJ, MacNabb MH, Brownell AL, Jokivarsi K, Kessinger CW, Jaff MR, Henke PK, Weissleder R, Jaffer FA.

Circulation. 2015 Jun 16;131(24):e531-2. doi: 10.1161/CIRCULATIONAHA.115.014802. No abstract available.

PMID:
26078375
23.

Noninvasive imaging of immune responses.

Rashidian M, Keliher EJ, Bilate AM, Duarte JN, Wojtkiewicz GR, Jacobsen JT, Cragnolini J, Swee LK, Victora GD, Weissleder R, Ploegh HL.

Proc Natl Acad Sci U S A. 2015 May 12;112(19):6146-51. doi: 10.1073/pnas.1502609112. Epub 2015 Apr 20. Erratum in: Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6387.

24.

Noninvasive mapping of pancreatic inflammation in recent-onset type-1 diabetes patients.

Gaglia JL, Harisinghani M, Aganj I, Wojtkiewicz GR, Hedgire S, Benoist C, Mathis D, Weissleder R.

Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):2139-44. doi: 10.1073/pnas.1424993112. Epub 2015 Feb 3.

25.

Myeloperoxidase propagates damage and is a potential therapeutic target for subacute stroke.

Forghani R, Kim HJ, Wojtkiewicz GR, Bure L, Wu Y, Hayase M, Wei Y, Zheng Y, Moskowitz MA, Chen JW.

J Cereb Blood Flow Metab. 2015 Mar;35(3):485-93. doi: 10.1038/jcbfm.2014.222. Epub 2014 Dec 17.

26.

Multiple sclerosis: myeloperoxidase immunoradiology improves detection of acute and chronic disease in experimental model.

Pulli B, Bure L, Wojtkiewicz GR, Iwamoto Y, Ali M, Li D, Schob S, Hsieh KL, Jacobs AH, Chen JW.

Radiology. 2015 May;275(2):480-9. doi: 10.1148/radiol.14141495. Epub 2014 Dec 10.

27.

Combined MEK and PI3K inhibition in a mouse model of pancreatic cancer.

Alagesan B, Contino G, Guimaraes AR, Corcoran RB, Deshpande V, Wojtkiewicz GR, Hezel AF, Wong KK, Loda M, Weissleder R, Benes CH, Engelman J, Bardeesy N.

Clin Cancer Res. 2015 Jan 15;21(2):396-404. doi: 10.1158/1078-0432.CCR-14-1591. Epub 2014 Oct 27.

28.

Tracheal tube obstruction in mechanically ventilated patients assessed by high-resolution computed tomography.

Mietto C, Pinciroli R, Piriyapatsom A, Thomas JG, Bry L, Delaney ML, Du Bois A, Truelove J, Ackman JB, Wojtkiewicz GR, Nahrendorf M, Kacmarek RM, Berra L.

Anesthesiology. 2014 Dec;121(6):1226-35. doi: 10.1097/ALN.0000000000000455.

PMID:
25254903
29.

18F-fluorodeoxyglucose positron emission tomography/computed tomography enables the detection of recurrent same-site deep vein thrombosis by illuminating recently formed, neutrophil-rich thrombus.

Hara T, Truelove J, Tawakol A, Wojtkiewicz GR, Hucker WJ, MacNabb MH, Brownell AL, Jokivarsi K, Kessinger CW, Jaff MR, Henke PK, Weissleder R, Jaffer FA.

Circulation. 2014 Sep 23;130(13):1044-52. doi: 10.1161/CIRCULATIONAHA.114.008902. Epub 2014 Jul 28.

30.

Evaluation of renal quantitative T2* changes on MRI following administration of ferumoxytol as a T2* contrast agent.

Hedgire SS, McDermott S, Wojtkiewicz GR, Abtahi SM, Harisinghani M, Gaglia JL.

Int J Nanomedicine. 2014 Apr 28;9:2101-7. doi: 10.2147/IJN.S61460. eCollection 2014.

31.

Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors.

Katsimpardi L, Litterman NK, Schein PA, Miller CM, Loffredo FS, Wojtkiewicz GR, Chen JW, Lee RT, Wagers AJ, Rubin LL.

Science. 2014 May 9;344(6184):630-4. doi: 10.1126/science.1251141. Epub 2014 May 5.

32.

Identification of small compound biomarkers of pituitary adenoma: a bilateral inferior petrosal sinus sampling study.

Oklu R, Deipolyi AR, Wicky S, Ergul E, Deik AA, Chen JW, Hirsch JA, Wojtkiewicz GR, Clish CB.

J Neurointerv Surg. 2014 Sep;6(7):541-6. doi: 10.1136/neurintsurg-2013-010821. Epub 2013 Sep 4.

PMID:
24005126
33.

Stochastic model of Tsc1 lesions in mouse brain.

Prabhakar S, Goto J, Zhang X, Sena-Esteves M, Bronson R, Brockmann J, Gianni D, Wojtkiewicz GR, Chen JW, Stemmer-Rachamimov A, Kwiatkowski DJ, Breakefield XO.

PLoS One. 2013 May 16;8(5):e64224. doi: 10.1371/journal.pone.0064224. Print 2013. Erratum in: PLoS One. 2013;8(11). doi:10.1371/annotation/6a5b0a50-27e4-49bc-b82a-9267dd63af53. Zuang, Xuan [corrected to Zhang, Xuan].

34.

Selective factor XIIa inhibition attenuates silent brain ischemia: application of molecular imaging targeting coagulation pathway.

Chen JW, Figueiredo JL, Wojtkiewicz GR, Siegel C, Iwamoto Y, Kim DE, Nolte MW, Dickneite G, Weissleder R, Nahrendorf M.

JACC Cardiovasc Imaging. 2012 Nov;5(11):1127-38. doi: 10.1016/j.jcmg.2012.01.025.

35.

Tracking mesenchymal stem cells with iron oxide nanoparticle loaded poly(lactide-co-glycolide) microparticles.

Xu C, Miranda-Nieves D, Ankrum JA, Matthiesen ME, Phillips JA, Roes I, Wojtkiewicz GR, Juneja V, Kultima JR, Zhao W, Vemula PK, Lin CP, Nahrendorf M, Karp JM.

Nano Lett. 2012 Aug 8;12(8):4131-9. doi: 10.1021/nl301658q. Epub 2012 Jul 12.

36.

Ligation of the jugular veins does not result in brain inflammation or demyelination in mice.

Atkinson W, Forghani R, Wojtkiewicz GR, Pulli B, Iwamoto Y, Ueno T, Waterman P, Truelove J, Oklu R, Chen JW.

PLoS One. 2012;7(3):e33671. doi: 10.1371/journal.pone.0033671. Epub 2012 Mar 21.

37.

Demyelinating diseases: myeloperoxidase as an imaging biomarker and therapeutic target.

Forghani R, Wojtkiewicz GR, Zhang Y, Seeburg D, Bautz BR, Pulli B, Milewski AR, Atkinson WL, Iwamoto Y, Zhang ER, Etzrodt M, Rodriguez E, Robbins CS, Swirski FK, Weissleder R, Chen JW.

Radiology. 2012 May;263(2):451-60. doi: 10.1148/radiol.12111593. Epub 2012 Mar 21.

38.

Bevacizumab with angiostatin-armed oHSV increases antiangiogenesis and decreases bevacizumab-induced invasion in U87 glioma.

Zhang W, Fulci G, Buhrman JS, Stemmer-Rachamimov AO, Chen JW, Wojtkiewicz GR, Weissleder R, Rabkin SD, Martuza RL.

Mol Ther. 2012 Jan;20(1):37-45. doi: 10.1038/mt.2011.187. Epub 2011 Sep 13.

39.

Distinguishing inflammation from tumor and peritumoral edema by myeloperoxidase magnetic resonance imaging.

Kleijn A, Chen JW, Buhrman JS, Wojtkiewicz GR, Iwamoto Y, Lamfers ML, Stemmer-Rachamimov AO, Rabkin SD, Weissleder R, Martuza RL, Fulci G.

Clin Cancer Res. 2011 Jul 1;17(13):4484-93. doi: 10.1158/1078-0432.CCR-11-0575. Epub 2011 May 10.

40.

Imaging primary lung cancers in mice to study radiation biology.

Kirsch DG, Grimm J, Guimaraes AR, Wojtkiewicz GR, Perez BA, Santiago PM, Anthony NK, Forbes T, Doppke K, Weissleder R, Jacks T.

Int J Radiat Oncol Biol Phys. 2010 Mar 15;76(4):973-7. doi: 10.1016/j.ijrobp.2009.11.038.

41.

Oligomerization of CXCL10 is necessary for endothelial cell presentation and in vivo activity.

Campanella GS, Grimm J, Manice LA, Colvin RA, Medoff BD, Wojtkiewicz GR, Weissleder R, Luster AD.

J Immunol. 2006 Nov 15;177(10):6991-8.

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