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Items: 1 to 50 of 92

1.

Health-Relevant Phenotypes in the Offspring of Mice Given CAR Activators Prior to Pregnancy.

Dietrich K, Baumgart J, Eshkind L, Reuter L, Gödtel-Armbrust U, Butt E, Musheev M, Marini F, More P, Grosser T, Niehrs C, Wojnowski L, Mathäs M.

Drug Metab Dispos. 2018 Nov;46(11):1827-1835. doi: 10.1124/dmd.118.082925. Epub 2018 Aug 28.

PMID:
30154105
2.

The SGLT2 inhibitor empagliflozin improves the primary diabetic complications in ZDF rats.

Steven S, Oelze M, Hanf A, Kröller-Schön S, Kashani F, Roohani S, Welschof P, Kopp M, Gödtel-Armbrust U, Xia N, Li H, Schulz E, Lackner KJ, Wojnowski L, Bottari SP, Wenzel P, Mayoux E, Münzel T, Daiber A.

Redox Biol. 2017 Oct;13:370-385. doi: 10.1016/j.redox.2017.06.009. Epub 2017 Jun 22.

3.

Correction: Structural and Functional Similarity of Amphibian Constitutive Androstane Receptor with Mammalian Pregnane X Receptor.

Mathäs M, Nusshag C, Burk O, Gödtel-Armbrust U, Herlyn H, Wojnowski L, Windshügel B.

PLoS One. 2016 Feb 1;11(2):e0148703. doi: 10.1371/journal.pone.0148703. eCollection 2016. No abstract available.

4.

Association of NADPH oxidase polymorphisms with anthracycline-induced cardiotoxicity in the RICOVER-60 trial of patients with aggressive CD20(+) B-cell lymphoma.

Reichwagen A, Ziepert M, Kreuz M, Gödtel-Armbrust U, Rixecker T, Poeschel V, Reza Toliat M, Nürnberg P, Tzvetkov M, Deng S, Trümper L, Hasenfuss G, Pfreundschuh M, Wojnowski L.

Pharmacogenomics. 2015;16(4):361-72. doi: 10.2217/pgs.14.179.

PMID:
25823784
5.

The catalytic topoisomerase II inhibitor dexrazoxane induces DNA breaks, ATF3 and the DNA damage response in cancer cells.

Deng S, Yan T, Nikolova T, Fuhrmann D, Nemecek A, Gödtel-Armbrust U, Kaina B, Wojnowski L.

Br J Pharmacol. 2015 May;172(9):2246-57. doi: 10.1111/bph.13046. Epub 2015 Feb 27.

6.

Dexrazoxane may prevent doxorubicin-induced DNA damage via depleting both topoisomerase II isoforms.

Deng S, Yan T, Jendrny C, Nemecek A, Vincetic M, Gödtel-Armbrust U, Wojnowski L.

BMC Cancer. 2014 Nov 18;14:842. doi: 10.1186/1471-2407-14-842.

7.

Accuracy and completeness of drug information in Wikipedia: a comparison with standard textbooks of pharmacology.

Kräenbring J, Monzon Penza T, Gutmann J, Muehlich S, Zolk O, Wojnowski L, Maas R, Engelhardt S, Sarikas A.

PLoS One. 2014 Sep 24;9(9):e106930. doi: 10.1371/journal.pone.0106930. eCollection 2014.

8.

Role of nitric oxide synthase isoforms for ophthalmic artery reactivity in mice.

Laspas P, Goloborodko E, Sniatecki JJ, Kordasz ML, Manicam C, Wojnowski L, Li H, Patzak A, Pfeiffer N, Gericke A.

Exp Eye Res. 2014 Oct;127:1-8. doi: 10.1016/j.exer.2014.06.018. Epub 2014 Jul 10.

PMID:
25017185
9.

Report on the international colloquium on cardio-oncology (rome, 12-14 march 2014).

Ewer M, Gianni L, Pane F, Sandri MT, Steiner RK, Wojnowski L, Yeh ET, Carver JR, Lipshultz SE, Minotti G, Armstrong GT, Cardinale D, Colan SD, Darby SC, Force TL, Kremer LC, Lenihan DJ, Sallan SE, Sawyer DB, Suter TM, Swain SM, van Leeuwen FE.

Ecancermedicalscience. 2014 May 29;8:433. doi: 10.3332/ecancer.2014.433. eCollection 2014.

10.

Structural and functional similarity of amphibian constitutive androstane receptor with mammalian pregnane X receptor.

Mathäs M, Nusshag C, Burk O, Gödtel-Armbrust U, Herlyn H, Wojnowski L, Windshügel B.

PLoS One. 2014 May 5;9(5):e96263. doi: 10.1371/journal.pone.0096263. eCollection 2014. Erratum in: PLoS One. 2014;9(7):e104594. PLoS One. 2016;11(2):e0148703. Nuβhag, Christian [corrected to Nusshag, Christian].

11.

Reduction of nevirapine-driven HIV mutations by carbamazepine is modulated by CYP3A activity.

Baranyai D, Muro E, Gödtel-Armbrust U, Schirmer MA, Kisanga E, Diczfalusy U, Fillekes Q, Schuurman R, Burger D, Wojnowski L.

J Antimicrob Chemother. 2014 Jul;69(7):1933-7. doi: 10.1093/jac/dku086. Epub 2014 Apr 2.

PMID:
24695353
12.

Lineage-specific duplications of Muroidea Faim and Spag6 genes and atypical accelerated evolution of the parental Spag6 gene.

Qiu H, Gołas A, Grzmil P, Wojnowski L.

J Mol Evol. 2013 Sep;77(3):119-29. doi: 10.1007/s00239-013-9585-9. Epub 2013 Sep 27.

PMID:
24071998
13.

Contribution of nitric oxide synthase isoforms to cholinergic vasodilation in murine retinal arterioles.

Gericke A, Goloborodko E, Sniatecki JJ, Steege A, Wojnowski L, Pfeiffer N.

Exp Eye Res. 2013 Apr;109:60-6. doi: 10.1016/j.exer.2013.01.012. Epub 2013 Feb 19.

PMID:
23434456
14.

PI3K inhibition enhances doxorubicin-induced apoptosis in sarcoma cells.

Marklein D, Graab U, Naumann I, Yan T, Ridzewski R, Nitzki F, Rosenberger A, Dittmann K, Wienands J, Wojnowski L, Fulda S, Hahn H.

PLoS One. 2012;7(12):e52898. doi: 10.1371/journal.pone.0052898. Epub 2012 Dec 31.

15.

Inactivation of Patched1 in mice leads to development of gastrointestinal stromal-like tumors that express Pdgfrα but not kit.

Pelczar P, Zibat A, van Dop WA, Heijmans J, Bleckmann A, Gruber W, Nitzki F, Uhmann A, Guijarro MV, Hernando E, Dittmann K, Wienands J, Dressel R, Wojnowski L, Binder C, Taguchi T, Beissbarth T, Hogendoorn PC, Antonescu CR, Rubin BP, Schulz-Schaeffer W, Aberger F, van den Brink GR, Hahn H.

Gastroenterology. 2013 Jan;144(1):134-144.e6. doi: 10.1053/j.gastro.2012.09.061. Epub 2012 Oct 3.

16.

Nitric oxide production and endothelium-dependent vasorelaxation ameliorated by N1-methylnicotinamide in human blood vessels.

Domagala TB, Szeffler A, Dobrucki LW, Dropinski J, Polanski S, Leszczynska-Wiloch M, Kotula-Horowitz K, Wojciechowski J, Wojnowski L, Szczeklik A, Kalinowski L.

Hypertension. 2012 Apr;59(4):825-32. doi: 10.1161/HYPERTENSIONAHA.111.183210. Epub 2012 Feb 21.

PMID:
22353616
17.

Pregnane X receptor and yin yang 1 contribute to the differential tissue expression and induction of CYP3A5 and CYP3A4.

Nem D, Baranyai D, Qiu H, Gödtel-Armbrust U, Nestler S, Wojnowski L.

PLoS One. 2012;7(1):e30895. doi: 10.1371/journal.pone.0030895. Epub 2012 Jan 23.

18.

Functional characterization of protein variants of the human multidrug transporter ABCC2 by a novel targeted expression system in fibrosarcoma cells.

Arlanov R, Porter A, Strand D, Brough R, Karpova D, Kerb R, Wojnowski L, Schwab M, Lang T.

Hum Mutat. 2012 Apr;33(4):750-62. doi: 10.1002/humu.22041. Epub 2012 Feb 28.

PMID:
22290738
19.

Evolutionary history and functional characterization of the amphibian xenosensor CAR.

Mathäs M, Burk O, Qiu H, Nusshag C, Gödtel-Armbrust U, Baranyai D, Deng S, Römer K, Nem D, Windshügel B, Wojnowski L.

Mol Endocrinol. 2012 Jan;26(1):14-26. doi: 10.1210/me.2011-1235. Epub 2011 Nov 10.

20.

A functional polymorphism in the NAD(P)H oxidase subunit CYBA is related to gene expression, enzyme activity, and outcome in non-Hodgkin lymphoma.

Hoffmann M, Schirmer MA, Tzvetkov MV, Kreuz M, Ziepert M, Wojnowski L, Kube D, Pfreundschuh M, Trümper L, Loeffler M, Brockmöller J; German Study Group for High-Grade Non-Hodgkin Lymphoma.

Cancer Res. 2010 Mar 15;70(6):2328-38. doi: 10.1158/0008-5472.CAN-09-2388. Epub 2010 Mar 9.

21.

The unique complexity of the CYP3A4 upstream region suggests a nongenetic explanation of its expression variability.

Qiu H, Mathäs M, Nestler S, Bengel C, Nem D, Gödtel-Armbrust U, Lang T, Taudien S, Burk O, Wojnowski L.

Pharmacogenet Genomics. 2010 Mar;20(3):167-78. doi: 10.1097/FPC.0b013e328336bbeb.

PMID:
20147837
22.
23.

Topoisomerase II{alpha}-dependent and -independent apoptotic effects of dexrazoxane and doxorubicin.

Yan T, Deng S, Metzger A, Gödtel-Armbrust U, Porter AC, Wojnowski L.

Mol Cancer Ther. 2009 May;8(5):1075-85. doi: 10.1158/1535-7163.MCT-09-0139. Epub 2009 May 5.

24.

Time-point and dosage of gene inactivation determine the tumor spectrum in conditional Ptch knockouts.

Zibat A, Uhmann A, Nitzki F, Wijgerde M, Frommhold A, Heller T, Armstrong V, Wojnowski L, Quintanilla-Martinez L, Reifenberger J, Schulz-Schaeffer W, Hahn H.

Carcinogenesis. 2009 Jun;30(6):918-26. doi: 10.1093/carcin/bgp068. Epub 2009 Mar 25.

PMID:
19321799
25.

Differential roles of nitric oxide synthase isozymes in cardiotoxicity and mortality following chronic doxorubicin treatment in mice.

Deng S, Kruger A, Schmidt A, Metzger A, Yan T, Gödtel-Armbrust U, Hasenfuss G, Brunner F, Wojnowski L.

Naunyn Schmiedebergs Arch Pharmacol. 2009 Jul;380(1):25-34. doi: 10.1007/s00210-009-0407-y. Epub 2009 Mar 24.

26.

Ligand diversity of human and chimpanzee CYP3A4: activation of human CYP3A4 by lithocholic acid results from positive selection.

Kumar S, Qiu H, Oezguen N, Herlyn H, Halpert JR, Wojnowski L.

Drug Metab Dispos. 2009 Jun;37(6):1328-33. doi: 10.1124/dmd.108.024372. Epub 2009 Mar 19.

27.

Antitumor effects of a combined 5-aza-2'deoxycytidine and valproic acid treatment on rhabdomyosarcoma and medulloblastoma in Ptch mutant mice.

Ecke I, Petry F, Rosenberger A, Tauber S, Mönkemeyer S, Hess I, Dullin C, Kimmina S, Pirngruber J, Johnsen SA, Uhmann A, Nitzki F, Wojnowski L, Schulz-Schaeffer W, Witt O, Hahn H.

Cancer Res. 2009 Feb 1;69(3):887-95. doi: 10.1158/0008-5472.CAN-08-0946. Epub 2009 Jan 20.

28.

GSEA-SNP: applying gene set enrichment analysis to SNP data from genome-wide association studies.

Holden M, Deng S, Wojnowski L, Kulle B.

Bioinformatics. 2008 Dec 1;24(23):2784-5. doi: 10.1093/bioinformatics/btn516. Epub 2008 Oct 14.

PMID:
18854360
29.

Carbonyl reductase 1 is a predominant doxorubicin reductase in the human liver.

Kassner N, Huse K, Martin HJ, Gödtel-Armbrust U, Metzger A, Meineke I, Brockmöller J, Klein K, Zanger UM, Maser E, Wojnowski L.

Drug Metab Dispos. 2008 Oct;36(10):2113-20. doi: 10.1124/dmd.108.022251. Epub 2008 Jul 17.

PMID:
18635746
30.

6-mercaptopurine and 9-(2-phosphonyl-methoxyethyl) adenine (PMEA) transport altered by two missense mutations in the drug transporter gene ABCC4.

Janke D, Mehralivand S, Strand D, Gödtel-Armbrust U, Habermeier A, Gradhand U, Fischer C, Toliat MR, Fritz P, Zanger UM, Schwab M, Fromm MF, Nürnberg P, Wojnowski L, Closs EI, Lang T.

Hum Mutat. 2008 May;29(5):659-69. doi: 10.1002/humu.20694.

PMID:
18300232
31.

B-Raf-mediated signaling pathway regulates T cell development.

Tsukamoto H, Irie A, Senju S, Hatzopoulos AK, Wojnowski L, Nishimura Y.

Eur J Immunol. 2008 Feb;38(2):518-27. doi: 10.1002/eji.200737430.

32.

CYP3 phylogenomics: evidence for positive selection of CYP3A4 and CYP3A7.

Qiu H, Taudien S, Herlyn H, Schmitz J, Zhou Y, Chen G, Roberto R, Rocchi M, Platzer M, Wojnowski L.

Pharmacogenet Genomics. 2008 Jan;18(1):53-66. doi: 10.1097/FPC.0b013e3282f313f8.

PMID:
18216722
33.

ALDH-2 deficiency increases cardiovascular oxidative stress--evidence for indirect antioxidative properties.

Wenzel P, Müller J, Zurmeyer S, Schuhmacher S, Schulz E, Oelze M, Pautz A, Kawamoto T, Wojnowski L, Kleinert H, Münzel T, Daiber A.

Biochem Biophys Res Commun. 2008 Feb 29;367(1):137-43. Epub 2007 Dec 26.

PMID:
18157936
34.

Accounting for haplotype phase uncertainty in linkage disequilibrium estimation.

Kulle B, Frigessi A, Edvardsen H, Kristensen V, Wojnowski L.

Genet Epidemiol. 2008 Feb;32(2):168-78. Erratum in: Genet Epidemiol. 2008 Sep;32(6):586-7.

PMID:
17968987
35.

Dystrophin-deficiency increases the susceptibility to doxorubicin-induced cardiotoxicity.

Deng S, Kulle B, Hosseini M, Schlüter G, Hasenfuss G, Wojnowski L, Schmidt A.

Eur J Heart Fail. 2007 Oct;9(10):986-94. Epub 2007 Sep 20.

36.

Genotyping the risk of anthracycline-induced cardiotoxicity.

Deng S, Wojnowski L.

Cardiovasc Toxicol. 2007;7(2):129-34. Review.

PMID:
17652817
37.

[Chemotherapeutics-induced heart failure].

Paulides M, Wojnowski L.

Med Klin (Munich). 2007 Jul 15;102(7):574-8. Review. German.

PMID:
17634876
38.

Variability in PXR-mediated induction of CYP3A4 by commercial preparations and dry extracts of St. John's wort.

Gödtel-Armbrust U, Metzger A, Kroll U, Kelber O, Wojnowski L.

Naunyn Schmiedebergs Arch Pharmacol. 2007 Aug;375(6):377-82. Epub 2007 Jun 26.

PMID:
17593354
39.

Sex-dependent genetic markers of CYP3A4 expression and activity in human liver microsomes.

Schirmer M, Rosenberger A, Klein K, Kulle B, Toliat MR, Nürnberg P, Zanger UM, Wojnowski L.

Pharmacogenomics. 2007 May;8(5):443-53.

PMID:
17465708
40.

Identification of a genetic contamination in a commercial mouse strain using two panels of polymorphic markers.

Nitzki F, Kruger A, Reifenberg K, Wojnowski L, Hahn H.

Lab Anim. 2007 Apr;41(2):218-28.

PMID:
17430621
41.

Gp91phox-containing NAD(P)H oxidase increases superoxide formation by doxorubicin and NADPH.

Deng S, Kruger A, Kleschyov AL, Kalinowski L, Daiber A, Wojnowski L.

Free Radic Biol Med. 2007 Feb 15;42(4):466-73. Epub 2006 Nov 15.

PMID:
17275678
42.

The interleukin-10 gene promoter polymorphism -1087AG does not correlate with clinical outcome in non-Hodgkin's lymphoma.

Kube D, Hua TD, Klöss M, Kulle B, Brockmöller J, Wojnowski L, Löffler M, Pfreundschuh M, Trümper L.

Genes Immun. 2007 Mar;8(2):164-7. Epub 2007 Jan 11.

PMID:
17215862
43.

Marmoset CYP3A21, a model for human CYP3A4: protein expression and functional characterization of the promoter.

Koehler SC, Von Ahsen N, Schlumbohm C, Asif AR, Goedtel-Armbrust U, Oellerich M, Wojnowski L, Armstrong VW.

Xenobiotica. 2006 Dec;36(12):1210-26.

PMID:
17162468
44.

Association of genetic polymorphism in ABCC2 with hepatic multidrug resistance-associated protein 2 expression and pravastatin pharmacokinetics.

Niemi M, Arnold KA, Backman JT, Pasanen MK, Gödtel-Armbrust U, Wojnowski L, Zanger UM, Neuvonen PJ, Eichelbaum M, Kivistö KT, Lang T.

Pharmacogenet Genomics. 2006 Nov;16(11):801-8.

PMID:
17047488
45.

Topoisomerase II beta expression level correlates with doxorubicin-induced apoptosis in peripheral blood cells.

Kersting G, Tzvetkov MV, Huse K, Kulle B, Hafner V, Brockmöller J, Wojnowski L.

Naunyn Schmiedebergs Arch Pharmacol. 2006 Oct;374(1):21-30. Epub 2006 Sep 7.

PMID:
16957942
46.

Clinical implications of CYP3A polymorphisms.

Wojnowski L, Kamdem LK.

Expert Opin Drug Metab Toxicol. 2006 Apr;2(2):171-82. Review.

PMID:
16866606
47.

ADHD drugs and cardiovascular risk.

Wojnowski L.

N Engl J Med. 2006 May 25;354(21):2296-8; author reply 2296-8. No abstract available.

PMID:
16729376
48.

Dominant contribution of P450 3A4 to the hepatic carcinogenic activation of aflatoxin B1.

Kamdem LK, Meineke I, Gödtel-Armbrust U, Brockmöller J, Wojnowski L.

Chem Res Toxicol. 2006 Apr;19(4):577-86.

PMID:
16608170
49.

Genetic signature consistent with selection against the CYP3A4*1B allele in non-African populations.

Schirmer M, Toliat MR, Haberl M, Suk A, Kamdem LK, Klein K, Brockmöller J, Nürnberg P, Zanger UM, Wojnowski L.

Pharmacogenet Genomics. 2006 Jan;16(1):59-71.

PMID:
16344723
50.

NAD(P)H oxidase and multidrug resistance protein genetic polymorphisms are associated with doxorubicin-induced cardiotoxicity.

Wojnowski L, Kulle B, Schirmer M, Schlüter G, Schmidt A, Rosenberger A, Vonhof S, Bickeböller H, Toliat MR, Suk EK, Tzvetkov M, Kruger A, Seifert S, Kloess M, Hahn H, Loeffler M, Nürnberg P, Pfreundschuh M, Trümper L, Brockmöller J, Hasenfuss G.

Circulation. 2005 Dec 13;112(24):3754-62. Epub 2005 Dec 5.

PMID:
16330681

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