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Items: 41

1.

BRCA1 promoter methylation in peripheral blood is associated with the risk of triple-negative breast cancer.

Prajzendanc K, Domagała P, Hybiak J, Ryś J, Huzarski T, Szwiec M, Tomiczek-Szwiec J, Redelbach W, Sejda A, Gronwald J, Kluz T, Wiśniowski R, Cybulski C, Łukomska A, Białkowska K, Sukiennicki G, Kulczycka K, Narod SA, Wojdacz TK, Lubiński J, Jakubowska A.

Int J Cancer. 2020 Mar 1;146(5):1293-1298. doi: 10.1002/ijc.32655. Epub 2019 Sep 29.

PMID:
31469414
2.

Clinical significance of DNA methylation in chronic lymphocytic leukemia patients: results from 3 UK clinical trials.

Wojdacz TK, Amarasinghe HE, Kadalayil L, Beattie A, Forster J, Blakemore SJ, Parker H, Bryant D, Larrayoz M, Clifford R, Robbe P, Davis ZA, Else M, Howard DR, Stamatopoulos B, Steele AJ, Rosenquist R, Collins A, Pettitt AR, Hillmen P, Plass C, Schuh A, Catovsky D, Oscier DG, Rose-Zerilli MJJ, Oakes CC, Strefford JC.

Blood Adv. 2019 Aug 27;3(16):2474-2481. doi: 10.1182/bloodadvances.2019000237.

3.

Methylation biomarker development in the context of the EU regulations for clinical use of in-vitro diagnostic devices.

Wojdacz TK.

Expert Rev Mol Diagn. 2019 Jun;19(6):439-441. doi: 10.1080/14737159.2019.1618188. Epub 2019 May 17. No abstract available.

PMID:
31092067
4.

Chronic lymphocytic leukemia patients with heterogeneously or fully methylated LPL promotor display longer time to treatment.

Daugaard I, Hussmann D, Kristensen L, Kristensen T, Kjeldsen TE, Nyvold CG, Larsen TS, Møller MB, Hansen LL, Wojdacz TK.

Epigenomics. 2018 Sep;10(9):1155-1166. doi: 10.2217/epi-2018-0020. Epub 2018 Sep 5.

PMID:
30182737
5.

A pilot investigation on DNA methylation modifications associated with complex posttraumatic symptoms in elderly traumatized in childhood.

Marinova Z, Maercker A, Grünblatt E, Wojdacz TK, Walitza S.

BMC Res Notes. 2017 Dec 19;10(1):752. doi: 10.1186/s13104-017-3082-y.

6.

Combining genetic and epigenetic parameters of the serotonin transporter gene in obsessive-compulsive disorder.

Grünblatt E, Marinova Z, Roth A, Gardini E, Ball J, Geissler J, Wojdacz TK, Romanos M, Walitza S.

J Psychiatr Res. 2018 Jan;96:209-217. doi: 10.1016/j.jpsychires.2017.10.010. Epub 2017 Oct 16.

PMID:
29102815
7.

Lamin B1 regulates somatic mutations and progression of B-cell malignancies.

Klymenko T, Bloehdorn J, Bahlo J, Robrecht S, Akylzhanova G, Cox K, Estenfelder S, Wang J, Edelmann J, Strefford JC, Wojdacz TK, Fischer K, Hallek M, Stilgenbauer S, Cragg M, Gribben J, Braun A.

Leukemia. 2018 Feb;32(2):364-375. doi: 10.1038/leu.2017.255. Epub 2017 Aug 14.

8.

DNA methylation profiles of elderly individuals subjected to indentured childhood labor and trauma.

Marinova Z, Maercker A, Küffer A, Robinson MD, Wojdacz TK, Walitza S, Grünblatt E, Burri A.

BMC Med Genet. 2017 Feb 27;18(1):21. doi: 10.1186/s12881-017-0370-2.

9.

Gene silencing of Nox4 by CpG island methylation during hepatocarcinogenesis in rats.

López-Álvarez GS, Wojdacz TK, García-Cuellar CM, Monroy-Ramírez HC, Rodríguez-Segura MA, Pacheco-Rivera RA, Valencia-Antúnez CA, Cervantes-Anaya N, Soto-Reyes E, Vásquez-Garzón VR, Sánchez-Pérez Y, Villa-Treviño S.

Biol Open. 2017 Jan 15;6(1):59-70. doi: 10.1242/bio.020370.

10.

Transcriptomics and methylomics of CD4-positive T cells in arsenic-exposed women.

Engström K, Wojdacz TK, Marabita F, Ewels P, Käller M, Vezzi F, Prezza N, Gruselius J, Vahter M, Broberg K.

Arch Toxicol. 2017 May;91(5):2067-2078. doi: 10.1007/s00204-016-1879-4. Epub 2016 Nov 12.

11.

Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukaemia.

Parker H, Rose-Zerilli MJ, Larrayoz M, Clifford R, Edelmann J, Blakemore S, Gibson J, Wang J, Ljungström V, Wojdacz TK, Chaplin T, Roghanian A, Davis Z, Parker A, Tausch E, Ntoufa S, Ramos S, Robbe P, Alsolami R, Steele AJ, Packham G, Rodríguez-Vicente AE, Brown L, McNicholl F, Forconi F, Pettitt A, Hillmen P, Dyer M, Cragg MS, Chelala C, Oakes CC, Rosenquist R, Stamatopoulos K, Stilgenbauer S, Knight S, Schuh A, Oscier DG, Strefford JC.

Leukemia. 2016 Nov;30(11):2179-2186. doi: 10.1038/leu.2016.134. Epub 2016 May 20.

12.

Identification and validation of candidate epigenetic biomarkers in lung adenocarcinoma.

Daugaard I, Dominguez D, Kjeldsen TE, Kristensen LS, Hager H, Wojdacz TK, Hansen LL.

Sci Rep. 2016 Oct 26;6:35807. doi: 10.1038/srep35807.

13.

The transcriptional coregulator MAML1 affects DNA methylation and gene expression patterns in human embryonic kidney cells.

Putnik M, Brodin D, Wojdacz TK, Fagerström-Billai F, Dahlman-Wright K, Wallberg AE.

Mol Biol Rep. 2016 Mar;43(3):141-50. doi: 10.1007/s11033-016-3946-6. Epub 2016 Feb 8.

PMID:
26857655
14.

Alterations of telomere length and DNA methylation in hairdressers: A cross-sectional study.

Li H, Åkerman G, Lidén C, Alhamdow A, Wojdacz TK, Broberg K, Albin M.

Environ Mol Mutagen. 2016 Mar;57(2):159-67. doi: 10.1002/em.21991. Epub 2015 Dec 6.

PMID:
26637967
15.

Biological and methodological aspects of assessment of locus specific de novo methylation in blood.

Wojdacz TK.

Biomark Med. 2015;9(12):1291-9. doi: 10.2217/bmm.15.83. Epub 2015 Nov 19.

PMID:
26612587
16.

Prenatal lead exposure is associated with decreased cord blood DNA methylation of the glycoprotein VI gene involved in platelet activation and thrombus formation.

Engström K, Rydbeck F, Kippler M, Wojdacz TK, Arifeen S, Vahter M, Broberg K.

Environ Epigenet. 2015 Nov 27;1(1):dvv007. doi: 10.1093/eep/dvv007. eCollection 2015.

17.

The influence of DNA degradation in formalin-fixed, paraffin-embedded (FFPE) tissue on locus-specific methylation assessment by MS-HRM.

Daugaard I, Kjeldsen TE, Hager H, Hansen LL, Wojdacz TK.

Exp Mol Pathol. 2015 Dec;99(3):632-40. doi: 10.1016/j.yexmp.2015.11.007. Epub 2015 Nov 6.

PMID:
26551081
18.

Discordant pattern of BRCA1 gene epimutation in blood between mothers and daughters.

Wojdacz TK, Harari F, Vahter M, Broberg K.

J Clin Pathol. 2015 Jul;68(7):575-7. doi: 10.1136/jclinpath-2015-202982. Epub 2015 Apr 15.

PMID:
25878326
19.

MS-HRM assay identifies high levels of epigenetic heterogeneity in human immortalized cell lines.

Putnik M, Wojdacz TK, Pournara A, Vahter M, Wallberg AE.

Gene. 2015 Apr 15;560(2):165-72. doi: 10.1016/j.gene.2015.01.063. Epub 2015 Jan 31.

PMID:
25644772
20.

Methylation of the BRCA1 promoter in peripheral blood DNA is associated with triple-negative and medullary breast cancer.

Gupta S, Jaworska-Bieniek K, Narod SA, Lubinski J, Wojdacz TK, Jakubowska A.

Breast Cancer Res Treat. 2014 Dec;148(3):615-22. doi: 10.1007/s10549-014-3179-0. Epub 2014 Nov 7.

PMID:
25376744
21.

Exposure to arsenic and intra-chromosomal instability in blood.

Wojdacz TK, Bottai M, Vahter M, Broberg K.

Metallomics. 2014 Aug;6(8):1387-9. doi: 10.1039/c4mt00128a.

PMID:
25025787
22.

Identification and characterization of locus-specific methylation patterns within novel loci undergoing hypermethylation during breast cancer pathogenesis.

Wojdacz TK, Windeløv JA, Thestrup BB, Damsgaard TE, Overgaard J, Hansen L.

Breast Cancer Res. 2014 Feb 3;16(1):R17. doi: 10.1186/bcr3612.

23.

ChAMP: 450k Chip Analysis Methylation Pipeline.

Morris TJ, Butcher LM, Feber A, Teschendorff AE, Chakravarthy AR, Wojdacz TK, Beck S.

Bioinformatics. 2014 Feb 1;30(3):428-30. doi: 10.1093/bioinformatics/btt684. Epub 2013 Dec 12.

24.

Challenges for the application of DNA methylation biomarkers in molecular diagnostic testing for cancer.

Jain S, Wojdacz TK, Su YH.

Expert Rev Mol Diagn. 2013 Apr;13(3):283-94. doi: 10.1586/erm.13.9. Review. Erratum in: Expert Rev Mol Diagn. 2013 Jun;13(5):510.

PMID:
23570406
25.

The limitations of locus specific methylation qualification and quantification in clinical material.

Wojdacz TK.

Front Genet. 2012 Feb 28;3:21. doi: 10.3389/fgene.2012.00021. eCollection 2012.

26.
27.

Methylation of cancer related genes in tumor and peripheral blood DNA from the same breast cancer patient as two independent events.

Wojdacz TK, Thestrup BB, Overgaard J, Hansen LL.

Diagn Pathol. 2011 Nov 30;6:116. doi: 10.1186/1746-1596-6-116.

28.

No difference in the frequency of locus-specific methylation in the peripheral blood DNA of women diagnosed with breast cancer and age-matched controls.

Wojdacz TK, Thestrup BB, Cold S, Overgaard J, Hansen LL.

Future Oncol. 2011 Dec;7(12):1451-5. doi: 10.2217/fon.11.123.

PMID:
22112320
29.

Comprehensive genome methylation analysis in bladder cancer: identification and validation of novel methylated genes and application of these as urinary tumor markers.

Reinert T, Modin C, Castano FM, Lamy P, Wojdacz TK, Hansen LL, Wiuf C, Borre M, Dyrskjøt L, Orntoft TF.

Clin Cancer Res. 2011 Sep 1;17(17):5582-92. doi: 10.1158/1078-0432.CCR-10-2659. Epub 2011 Jul 25.

30.

Identification and validation of highly frequent CpG island hypermethylation in colorectal adenomas and carcinomas.

Oster B, Thorsen K, Lamy P, Wojdacz TK, Hansen LL, Birkenkamp-Demtröder K, Sørensen KD, Laurberg S, Orntoft TF, Andersen CL.

Int J Cancer. 2011 Dec 15;129(12):2855-66. doi: 10.1002/ijc.25951. Epub 2011 Apr 1.

31.

Limitations and advantages of MS-HRM and bisulfite sequencing for single locus methylation studies.

Wojdacz TK, Møller TH, Thestrup BB, Kristensen LS, Hansen LL.

Expert Rev Mol Diagn. 2010 Jul;10(5):575-80. doi: 10.1586/erm.10.46. Review.

PMID:
20629507
32.

Quality assessment of DNA derived from up to 30 years old formalin fixed paraffin embedded (FFPE) tissue for PCR-based methylation analysis using SMART-MSP and MS-HRM.

Kristensen LS, Wojdacz TK, Thestrup BB, Wiuf C, Hager H, Hansen LL.

BMC Cancer. 2009 Dec 21;9:453. doi: 10.1186/1471-2407-9-453.

33.

Current methylation screening methods.

Wojdacz TK.

Epigenomics. 2009 Dec;1(2):223-6. doi: 10.2217/epi.09.32. No abstract available.

34.

Primer design versus PCR bias in methylation independent PCR amplifications.

Wojdacz TK, Borgbo T, Hansen LL.

Epigenetics. 2009 May 16;4(4):231-4. Epub 2009 May 14.

PMID:
19483476
35.

Methylation-sensitive high-resolution melting.

Wojdacz TK, Dobrovic A, Hansen LL.

Nat Protoc. 2008;3(12):1903-8. doi: 10.1038/nprot.2008.191.

PMID:
19180074
36.

Melting curve assays for DNA methylation analysis.

Wojdacz TK, Dobrovic A.

Methods Mol Biol. 2009;507:229-40. doi: 10.1007/978-1-59745-522-0_17.

PMID:
18987818
37.

A new approach to primer design for the control of PCR bias in methylation studies.

Wojdacz TK, Hansen LL, Dobrovic A.

BMC Res Notes. 2008 Jul 28;1:54. doi: 10.1186/1756-0500-1-54.

38.

Rapid detection of methylation change at H19 in human imprinting disorders using methylation-sensitive high-resolution melting.

Wojdacz TK, Dobrovic A, Algar EM.

Hum Mutat. 2008 Oct;29(10):1255-60. doi: 10.1002/humu.20779.

PMID:
18473334
39.
40.

Reversal of PCR bias for improved sensitivity of the DNA methylation melting curve assay.

Wojdacz TK, Hansen LL.

Biotechniques. 2006 Sep;41(3):274, 276, 278. No abstract available.

41.

Techniques used in studies of age-related DNA methylation changes.

Wojdacz TK, Hansen LL.

Ann N Y Acad Sci. 2006 May;1067:479-87. Review.

PMID:
16804030

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