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Items: 22


Polarization of Macrophages toward M2 Phenotype Is Favored by Reduction in iPLA2β (Group VIA Phospholipase A2).

Ashley JW, Hancock WD, Nelson AJ, Bone RN, Tse HM, Wohltmann M, Turk J, Ramanadham S.

J Biol Chem. 2016 Oct 28;291(44):23268-23281. Epub 2016 Sep 20.


Group VIA phospholipase A2 mitigates palmitate-induced β-cell mitochondrial injury and apoptosis.

Song H, Wohltmann M, Tan M, Ladenson JH, Turk J.

J Biol Chem. 2014 May 16;289(20):14194-210. doi: 10.1074/jbc.M114.561910. Epub 2014 Mar 19.


Genetic modulation of islet β-cell iPLA₂β expression provides evidence for its impact on β-cell apoptosis and autophagy.

Lei X, Bone RN, Ali T, Wohltmann M, Gai Y, Goodwin KJ, Bohrer AE, Turk J, Ramanadham S.

Islets. 2013 Jan-Feb;5(1):29-44. doi: 10.4161/isl.23758. Epub 2013 Jan 1.


Group VIB Phospholipase A(2) promotes proliferation of INS-1 insulinoma cells and attenuates lipid peroxidation and apoptosis induced by inflammatory cytokines and oxidant agents.

Bao S, Song H, Tan M, Wohltmann M, Ladenson JH, Turk J.

Oxid Med Cell Longev. 2012;2012:989372. doi: 10.1155/2012/989372. Epub 2012 Nov 11.


Disturbed brain phospholipid and docosahexaenoic acid metabolism in calcium-independent phospholipase A(2)-VIA (iPLA(2)β)-knockout mice.

Cheon Y, Kim HW, Igarashi M, Modi HR, Chang L, Ma K, Greenstein D, Wohltmann M, Turk J, Rapoport SI, Taha AY.

Biochim Biophys Acta. 2012 Sep;1821(9):1278-86. doi: 10.1016/j.bbalip.2012.02.003. Epub 2012 Feb 10.


Group VIA PLA2 (iPLA2β) is activated upstream of p38 mitogen-activated protein kinase (MAPK) in pancreatic islet β-cell signaling.

Song H, Wohltmann M, Tan M, Bao S, Ladenson JH, Turk J.

J Biol Chem. 2012 Feb 17;287(8):5528-41. doi: 10.1074/jbc.M111.285114. Epub 2011 Dec 22.


Effects of endoplasmic reticulum stress on group VIA phospholipase A2 in beta cells include tyrosine phosphorylation and increased association with calnexin.

Song H, Rohrs H, Tan M, Wohltmann M, Ladenson JH, Turk J.

J Biol Chem. 2010 Oct 29;285(44):33843-57. doi: 10.1074/jbc.M110.153197. Epub 2010 Aug 23.


Imaging decreased brain docosahexaenoic acid metabolism and signaling in iPLA(2)β (VIA)-deficient mice.

Basselin M, Rosa AO, Ramadan E, Cheon Y, Chang L, Chen M, Greenstein D, Wohltmann M, Turk J, Rapoport SI.

J Lipid Res. 2010 Nov;51(11):3166-73. doi: 10.1194/jlr.M008334. Epub 2010 Aug 4.


Mice deficient in group VIB phospholipase A2 (iPLA2gamma) exhibit relative resistance to obesity and metabolic abnormalities induced by a Western diet.

Song H, Wohltmann M, Bao S, Ladenson JH, Semenkovich CF, Turk J.

Am J Physiol Endocrinol Metab. 2010 Jun;298(6):E1097-114. doi: 10.1152/ajpendo.00780.2009. Epub 2010 Feb 23.


Age-related changes in bone morphology are accelerated in group VIA phospholipase A2 (iPLA2beta)-null mice.

Ramanadham S, Yarasheski KE, Silva MJ, Wohltmann M, Novack DV, Christiansen B, Tu X, Zhang S, Lei X, Turk J.

Am J Pathol. 2008 Apr;172(4):868-81. doi: 10.2353/ajpath.2008.070756. Epub 2008 Mar 18.


Disrupted membrane homeostasis and accumulation of ubiquitinated proteins in a mouse model of infantile neuroaxonal dystrophy caused by PLA2G6 mutations.

Malik I, Turk J, Mancuso DJ, Montier L, Wohltmann M, Wozniak DF, Schmidt RE, Gross RW, Kotzbauer PT.

Am J Pathol. 2008 Feb;172(2):406-16. doi: 10.2353/ajpath.2008.070823. Epub 2008 Jan 17.


Glucose homeostasis, insulin secretion, and islet phospholipids in mice that overexpress iPLA2beta in pancreatic beta-cells and in iPLA2beta-null mice.

Bao S, Jacobson DA, Wohltmann M, Bohrer A, Jin W, Philipson LH, Turk J.

Am J Physiol Endocrinol Metab. 2008 Feb;294(2):E217-29. Epub 2007 Sep 25.


Attenuated free cholesterol loading-induced apoptosis but preserved phospholipid composition of peritoneal macrophages from mice that do not express group VIA phospholipase A2.

Bao S, Li Y, Lei X, Wohltmann M, Jin W, Bohrer A, Semenkovich CF, Ramanadham S, Tabas I, Turk J.

J Biol Chem. 2007 Sep 14;282(37):27100-14. Epub 2007 Jul 12.


Genetic and pharmacologic evidence that calcium-independent phospholipase A2beta regulates virus-induced inducible nitric-oxide synthase expression by macrophages.

Moran JM, Buller RM, McHowat J, Turk J, Wohltmann M, Gross RW, Corbett JA.

J Biol Chem. 2005 Jul 29;280(30):28162-8. Epub 2005 Jun 8.


Male mice that do not express group VIA phospholipase A2 produce spermatozoa with impaired motility and have greatly reduced fertility.

Bao S, Miller DJ, Ma Z, Wohltmann M, Eng G, Ramanadham S, Moley K, Turk J.

J Biol Chem. 2004 Sep 10;279(37):38194-200. Epub 2004 Jul 12.


Delta6-, Stearoyl CoA-, and Delta5-desaturase enzymes are expressed in beta-cells and are altered by increases in exogenous PUFA concentrations.

Ramanadham S, Zhang S, Ma Z, Wohltmann M, Bohrer A, Hsu FF, Turk J.

Biochim Biophys Acta. 2002 Jan 30;1580(1):40-56.


Differential postnatal development of mu and delta opiate receptors.

Wohltmann M, Roth BL, Coscia CJ.

Brain Res. 1982 Apr;255(4):679-84.


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