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Items: 1 to 50 of 53

1.

Pharmacodynamic Effects, Pharmacokinetics, and Metabolism of the Synthetic Cannabinoid AM-2201 in Male Rats.

Carlier J, Wohlfarth A, Salmeron BD, Scheidweiler KB, Huestis MA, Baumann MH.

J Pharmacol Exp Ther. 2018 Dec;367(3):543-550. doi: 10.1124/jpet.118.250530. Epub 2018 Sep 28.

2.

Fatal Poisonings Associated with New Psychoactive Substances.

Kronstrand R, Guerrieri D, Vikingsson S, Wohlfarth A, Gréen H.

Handb Exp Pharmacol. 2018 Aug 14. doi: 10.1007/164_2018_110. [Epub ahead of print]

PMID:
30105471
3.

Metabolism study for CUMYL-4CN-BINACA in human hepatocytes and authentic urine specimens: Free cyanide is formed during the main metabolic pathway.

Åstrand A, Vikingsson S, Lindstedt D, Thelander G, Gréen H, Kronstrand R, Wohlfarth A.

Drug Test Anal. 2018 Mar 25. doi: 10.1002/dta.2373. [Epub ahead of print]

PMID:
29577658
4.

In Vitro Metabolite Profiling of ADB-FUBINACA, A New Synthetic Cannabinoid.

Carlier J, Diao X, Wohlfarth A, Scheidweiler K, Huestis MA.

Curr Neuropharmacol. 2017 Jul;15(5):682-691. doi: 10.2174/1570159X15666161108123419.

5.

In Vitro and In Vivo Metabolite Identification Studies for the New Synthetic Opioids Acetylfentanyl, Acrylfentanyl, Furanylfentanyl, and 4-Fluoro-Isobutyrylfentanyl.

Watanabe S, Vikingsson S, Roman M, Green H, Kronstrand R, Wohlfarth A.

AAPS J. 2017 Jul;19(4):1102-1122. doi: 10.1208/s12248-017-0070-z. Epub 2017 Apr 5.

6.

Identifying Metabolites of Meclonazepam by High-Resolution Mass Spectrometry Using Human Liver Microsomes, Hepatocytes, a Mouse Model, and Authentic Urine Samples.

Vikingsson S, Wohlfarth A, Andersson M, Gréen H, Roman M, Josefsson M, Kugelberg FC, Kronstrand R.

AAPS J. 2017 May;19(3):736-742. doi: 10.1208/s12248-016-0040-x. Epub 2017 Jan 13.

7.

Looking at flubromazolam metabolism from four different angles: Metabolite profiling in human liver microsomes, human hepatocytes, mice and authentic human urine samples with liquid chromatography high-resolution mass spectrometry.

Wohlfarth A, Vikingsson S, Roman M, Andersson M, Kugelberg FC, Green H, Kronstrand R.

Forensic Sci Int. 2017 May;274:55-63. doi: 10.1016/j.forsciint.2016.10.021. Epub 2016 Nov 5.

PMID:
27863836
8.

In Vitro Metabolite Profiling of ADB-FUBINACA, A New Synthetic Cannabinoid.

Carlier J, Diao X, Wohlfarth A, Scheidweiler K, Huestis MA.

Curr Neuropharmacol. 2016 Nov 8. [Epub ahead of print]

PMID:
27829332
9.

Metabolism of Carfentanil, an Ultra-Potent Opioid, in Human Liver Microsomes and Human Hepatocytes by High-Resolution Mass Spectrometry.

Feasel MG, Wohlfarth A, Nilles JM, Pang S, Kristovich RL, Huestis MA.

AAPS J. 2016 Nov;18(6):1489-1499. Epub 2016 Aug 5.

PMID:
27495118
10.

Untargeted screening of unknown xenobiotics and potential toxins in plasma of poisoned patients using high-resolution mass spectrometry: Generation of xenobiotic fingerprint using background subtraction.

Chen C, Wohlfarth A, Xu H, Su D, Wang X, Jiang H, Feng Y, Zhu M.

Anal Chim Acta. 2016 Nov 9;944:37-43. doi: 10.1016/j.aca.2016.09.034. Epub 2016 Sep 30.

PMID:
27776637
11.

Strategies to distinguish new synthetic cannabinoid FUBIMINA (BIM-2201) intake from its isomer THJ-2201: metabolism of FUBIMINA in human hepatocytes.

Diao X, Scheidweiler KB, Wohlfarth A, Zhu M, Pang S, Huestis MA.

Forensic Toxicol. 2016;34:256-267. Epub 2016 Mar 28.

12.

25C-NBOMe and 25I-NBOMe metabolite studies in human hepatocytes, in vivo mouse and human urine with high-resolution mass spectrometry.

Wohlfarth A, Roman M, Andersson M, Kugelberg FC, Diao X, Carlier J, Eriksson C, Wu X, Konradsson P, Josefsson M, Huestis MA, Kronstrand R.

Drug Test Anal. 2017 May;9(5):680-698. doi: 10.1002/dta.2044. Epub 2016 Aug 12.

PMID:
27448631
13.

Quantification of [1-(5-fluoropentyl)-1H-indol-3-yl](naphthalene-1-yl)methanone (AM-2201) and 13 metabolites in human and rat plasma by liquid chromatography-tandem mass spectrometry.

Carlier J, Scheidweiler KB, Wohlfarth A, Salmeron BD, Baumann MH, Huestis MA.

J Chromatogr A. 2016 Jun 17;1451:97-106. doi: 10.1016/j.chroma.2016.05.020. Epub 2016 May 6.

14.

First metabolic profile of PV8, a novel synthetic cathinone, in human hepatocytes and urine by high-resolution mass spectrometry.

Swortwood MJ, Ellefsen KN, Wohlfarth A, Diao X, Concheiro-Guisan M, Kronstrand R, Huestis MA.

Anal Bioanal Chem. 2016 Jul;408(18):4845-56. doi: 10.1007/s00216-016-9599-4. Epub 2016 May 16.

PMID:
27185540
15.

Metabolic profiling of new synthetic cannabinoids AMB and 5F-AMB by human hepatocyte and liver microsome incubations and high-resolution mass spectrometry.

Andersson M, Diao X, Wohlfarth A, Scheidweiler KB, Huestis MA.

Rapid Commun Mass Spectrom. 2016 Apr 30;30(8):1067-78. doi: 10.1002/rcm.7538.

PMID:
27003044
16.

In Vitro and In Vivo Human Metabolism of Synthetic Cannabinoids FDU-PB-22 and FUB-PB-22.

Diao X, Scheidweiler KB, Wohlfarth A, Pang S, Kronstrand R, Huestis MA.

AAPS J. 2016 Mar;18(2):455-64. doi: 10.1208/s12248-016-9867-4. Epub 2016 Jan 25.

17.

4-Methoxy-α-PVP: in silico prediction, metabolic stability, and metabolite identification by human hepatocyte incubation and high-resolution mass spectrometry.

Ellefsen KN, Wohlfarth A, Swortwood MJ, Diao X, Concheiro M, Huestis MA.

Forensic Toxicol. 2016;34:61-75. Epub 2015 Aug 5.

18.

Prolonged hypoglycemia after a suicidal ingestion of repaglinide with unexpected slow plasma elimination.

Elling R, Spehl MS, Wohlfarth A, Auwaerter V, Hermanns-Clausen M.

Clin Toxicol (Phila). 2016;54(2):158-60. doi: 10.3109/15563650.2015.1122793. Epub 2015 Dec 22.

PMID:
26692235
19.

In vitro, in vivo and in silico metabolic profiling of α-pyrrolidinopentiothiophenone, a novel thiophene stimulant.

Swortwood MJ, Carlier J, Ellefsen KN, Wohlfarth A, Diao X, Concheiro-Guisan M, Kronstrand R, Huestis MA.

Bioanalysis. 2016;8(1):65-82. doi: 10.4155/bio.15.237. Epub 2015 Dec 9.

20.

High-Resolution Mass Spectrometry for Characterizing the Metabolism of Synthetic Cannabinoid THJ-018 and Its 5-Fluoro Analog THJ-2201 after Incubation in Human Hepatocytes.

Diao X, Wohlfarth A, Pang S, Scheidweiler KB, Huestis MA.

Clin Chem. 2016 Jan;62(1):157-69. doi: 10.1373/clinchem.2015.243535. Epub 2015 Oct 1.

21.

Metabolic characterization of AH-7921, a synthetic opioid designer drug: in vitro metabolic stability assessment and metabolite identification, evaluation of in silico prediction, and in vivo confirmation.

Wohlfarth A, Scheidweiler KB, Pang S, Zhu M, Castaneto M, Kronstrand R, Huestis MA.

Drug Test Anal. 2016 Aug;8(8):779-91. doi: 10.1002/dta.1856. Epub 2015 Sep 1.

22.

Synthetic cannabinoids pharmacokinetics and detection methods in biological matrices.

Castaneto MS, Wohlfarth A, Desrosiers NA, Hartman RL, Gorelick DA, Huestis MA.

Drug Metab Rev. 2015 May;47(2):124-74. doi: 10.3109/03602532.2015.1029635. Epub 2015 Apr 8. Review.

PMID:
25853390
23.

Pentylindole/Pentylindazole Synthetic Cannabinoids and Their 5-Fluoro Analogs Produce Different Primary Metabolites: Metabolite Profiling for AB-PINACA and 5F-AB-PINACA.

Wohlfarth A, Castaneto MS, Zhu M, Pang S, Scheidweiler KB, Kronstrand R, Huestis MA.

AAPS J. 2015 May;17(3):660-77. doi: 10.1208/s12248-015-9721-0. Epub 2015 Feb 28.

24.

Urinary prevalence, metabolite detection rates, temporal patterns and evaluation of suitable LC-MS/MS targets to document synthetic cannabinoid intake in US military urine specimens.

Wohlfarth A, Scheidweiler KB, Castaneto M, Gandhi AS, Desrosiers NA, Klette KL, Martin TM, Huestis MA.

Clin Chem Lab Med. 2015 Feb;53(3):423-34. doi: 10.1515/cclm-2014-0612.

PMID:
25263309
25.

Quantitative urine confirmatory testing for synthetic cannabinoids in randomly collected urine specimens.

Castaneto MS, Scheidweiler KB, Gandhi A, Wohlfarth A, Klette KL, Martin TM, Huestis MA.

Drug Test Anal. 2015 Jun;7(6):483-93. doi: 10.1002/dta.1709. Epub 2014 Sep 17.

26.

Metabolite profiling of RCS-4, a novel synthetic cannabinoid designer drug, using human hepatocyte metabolism and TOF-MS.

Gandhi AS, Zhu M, Pang S, Wohlfarth A, Scheidweiler KB, Huestis MA.

Bioanalysis. 2014 Jun;6(11):1471-85. doi: 10.4155/bio.14.13.

27.

Metabolism of RCS-8, a synthetic cannabinoid with cyclohexyl structure, in human hepatocytes by high-resolution MS.

Wohlfarth A, Pang S, Zhu M, Gandhi AS, Scheidweiler KB, Huestis MA.

Bioanalysis. 2014 May;6(9):1187-200. doi: 10.4155/bio.14.1.

29.

Metabolism of synthetic cannabinoids PB-22 and its 5-fluoro analog, 5F-PB-22, by human hepatocyte incubation and high-resolution mass spectrometry.

Wohlfarth A, Gandhi AS, Pang S, Zhu M, Scheidweiler KB, Huestis MA.

Anal Bioanal Chem. 2014 Feb;406(6):1763-80. doi: 10.1007/s00216-014-7668-0. Epub 2014 Feb 12.

PMID:
24518903
30.

First metabolic profile of XLR-11, a novel synthetic cannabinoid, obtained by using human hepatocytes and high-resolution mass spectrometry.

Wohlfarth A, Pang S, Zhu M, Gandhi AS, Scheidweiler KB, Liu HF, Huestis MA.

Clin Chem. 2013 Nov;59(11):1638-48. doi: 10.1373/clinchem.2013.209965. Epub 2013 Sep 6.

31.

First characterization of AKB-48 metabolism, a novel synthetic cannabinoid, using human hepatocytes and high-resolution mass spectrometry.

Gandhi AS, Zhu M, Pang S, Wohlfarth A, Scheidweiler KB, Liu HF, Huestis MA.

AAPS J. 2013 Oct;15(4):1091-8. doi: 10.1208/s12248-013-9516-0. Epub 2013 Aug 3.

32.

Qualitative confirmation of 9 synthetic cannabinoids and 20 metabolites in human urine using LC-MS/MS and library search.

Wohlfarth A, Scheidweiler KB, Chen X, Liu HF, Huestis MA.

Anal Chem. 2013 Apr 2;85(7):3730-8. doi: 10.1021/ac3037365. Epub 2013 Mar 18.

33.

Accidental clozapine intoxication in a toddler: clinical and pharmacokinetic lessons learnt.

Toepfner N, Wohlfarth A, Naue J, Auwärter V, Berner R, Hermanns-Clausen M.

J Clin Pharm Ther. 2013 Apr;38(2):165-8. doi: 10.1111/jcpt.12022. Epub 2012 Nov 20.

PMID:
23167664
34.

A fast and inexpensive procedure for the isolation of synthetic cannabinoids from 'Spice' products using a flash chromatography system.

Moosmann B, Kneisel S, Wohlfarth A, Brecht V, Auwärter V.

Anal Bioanal Chem. 2013 May;405(12):3929-35. doi: 10.1007/s00216-012-6462-0. Epub 2012 Oct 14.

PMID:
23064708
35.

Regioselective synthesis of isotopically labeled Δ9-tetrahydrocannabinolic acid A (THCA-A-D3) by reaction of Δ9-tetrahydrocannabinol-D3 with magnesium methyl carbonate.

Roth N, Wohlfarth A, Müller M, Auwärter V.

Forensic Sci Int. 2012 Oct 10;222(1-3):368-72. doi: 10.1016/j.forsciint.2012.07.019. Epub 2012 Aug 23.

PMID:
22921834
36.

Limits of proton conductivity.

Kreuer KD, Wohlfarth A.

Angew Chem Int Ed Engl. 2012 Oct 15;51(42):10454-6; author reply 10457-8. doi: 10.1002/anie.201203887. Epub 2012 Aug 15.

PMID:
22893584
37.
39.

Rapid isolation procedure for Δ9-tetrahydrocannabinolic acid A (THCA) from Cannabis sativa using two flash chromatography systems.

Wohlfarth A, Mahler H, Auwärter V.

J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Oct 15;879(28):3059-64. doi: 10.1016/j.jchromb.2011.09.012. Epub 2011 Sep 10.

PMID:
21944900
40.

Cocktail approach for in vivo phenotyping of 5 major CYP450 isoenzymes: development of an effective sampling, extraction, and analytical procedure and pilot study with comparative genotyping.

Wohlfarth A, Naue J, Lutz-Bonengel S, Dresen S, Auwärter V.

J Clin Pharmacol. 2012 Aug;52(8):1200-14. doi: 10.1177/0091270011410570. Epub 2011 Sep 1.

PMID:
21885687
41.

Single alkaline-ion (Li(+), Na(+)) conductors by ion exchange of proton-conducting ionomers and polyelectrolytes.

Kreuer KD, Wohlfarth A, de Araujo CC, Fuchs A, Maier J.

Chemphyschem. 2011 Oct 4;12(14):2558-60. doi: 10.1002/cphc.201100506. Epub 2011 Jul 26. No abstract available.

PMID:
21793154
42.

Sensitive quantification of clozapine and its main metabolites norclozapine and clozapine-N-oxide in serum and urine using LC-MS/MS after simple liquid-liquid extraction work-up.

Wohlfarth A, Toepfner N, Hermanns-Clausen M, Auwärter V.

Anal Bioanal Chem. 2011 May;400(3):737-46. doi: 10.1007/s00216-011-4831-8. Epub 2011 Mar 12.

PMID:
21394453
43.

Ethyl sulphate and ethyl glucuronide in vitreous humor as postmortem evidence marker for ethanol consumption prior to death.

Thierauf A, Kempf J, Perdekamp MG, Auwärter V, Gnann H, Wohlfarth A, Weinmann W.

Forensic Sci Int. 2011 Jul 15;210(1-3):63-8. doi: 10.1016/j.forsciint.2011.01.036. Epub 2011 Mar 2.

PMID:
21367549
44.

Outside or inside: role of the subcellular localization of DP4-like enzymes for substrate conversion and inhibitor effects.

Bank U, Heimburg A, Wohlfarth A, Koch G, Nordhoff K, Julius H, Helmuth M, Breyer D, Reinhold D, Täger M, Ansorge S.

Biol Chem. 2011 Mar;392(3):169-87. doi: 10.1515/BC.2011.025.

PMID:
21194378
45.

Bioanalysis of new designer drugs.

Wohlfarth A, Weinmann W.

Bioanalysis. 2010 May;2(5):965-79. doi: 10.4155/bio.10.32. Review.

PMID:
21083227
46.

Urine tested positive for ethyl glucuronide and ethyl sulfate after the consumption of yeast and sugar.

Thierauf A, Wohlfarth A, Auwärter V, Perdekamp MG, Wurst FM, Weinmann W.

Forensic Sci Int. 2010 Oct 10;202(1-3):e45-7. doi: 10.1016/j.forsciint.2010.06.028. Epub 2010 Jul 23.

PMID:
20655676
47.

Urine tested positive for ethyl glucuronide and ethyl sulphate after the consumption of "non-alcoholic" beer.

Thierauf A, Gnann H, Wohlfarth A, Auwärter V, Perdekamp MG, Buttler KJ, Wurst FM, Weinmann W.

Forensic Sci Int. 2010 Oct 10;202(1-3):82-5. doi: 10.1016/j.forsciint.2010.04.031. Epub 2010 May 8.

PMID:
20457499
48.

Hair analysis for Delta9-tetrahydrocannabinolic acid A--new insights into the mechanism of drug incorporation of cannabinoids into hair.

Auwärter V, Wohlfarth A, Traber J, Thieme D, Weinmann W.

Forensic Sci Int. 2010 Mar 20;196(1-3):10-3. doi: 10.1016/j.forsciint.2009.12.023. Epub 2010 Feb 2.

PMID:
20129747
49.

LC-MS/MS screening method for designer amphetamines, tryptamines, and piperazines in serum.

Wohlfarth A, Weinmann W, Dresen S.

Anal Bioanal Chem. 2010 Apr;396(7):2403-14. doi: 10.1007/s00216-009-3394-4. Epub 2010 Jan 13.

PMID:
20069283
50.

Urine tested positive for ethyl glucuronide after trace amounts of ethanol.

Thierauf A, Halter CC, Rana S, Auwaerter V, Wohlfarth A, Wurst FM, Weinmann W.

Addiction. 2009 Dec;104(12):2007-12. doi: 10.1111/j.1360-0443.2009.02722.x.

PMID:
19922567

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