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Items: 20


Broadly protective human antibodies that target the active site of influenza virus neuraminidase.

Stadlbauer D, Zhu X, McMahon M, Turner JS, Wohlbold TJ, Schmitz AJ, Strohmeier S, Yu W, Nachbagauer R, Mudd PA, Wilson IA, Ellebedy AH, Krammer F.

Science. 2019 Oct 25;366(6464):499-504. doi: 10.1126/science.aay0678.


Immunogenicity of chimeric haemagglutinin-based, universal influenza virus vaccine candidates: interim results of a randomised, placebo-controlled, phase 1 clinical trial.

Bernstein DI, Guptill J, Naficy A, Nachbagauer R, Berlanda-Scorza F, Feser J, Wilson PC, Solórzano A, Van der Wielen M, Walter EB, Albrecht RA, Buschle KN, Chen YQ, Claeys C, Dickey M, Dugan HL, Ermler ME, Freeman D, Gao M, Gast C, Guthmiller JJ, Hai R, Henry C, Lan LY, McNeal M, Palm AE, Shaw DG, Stamper CT, Sun W, Sutton V, Tepora ME, Wahid R, Wenzel H, Wohlbold TJ, Innis BL, García-Sastre A, Palese P, Krammer F.

Lancet Infect Dis. 2019 Oct 17. pii: S1473-3099(19)30393-7. doi: 10.1016/S1473-3099(19)30393-7. [Epub ahead of print]


Prolonged evolution of the memory B cell response induced by a replicating adenovirus-influenza H5 vaccine.

Matsuda K, Huang J, Zhou T, Sheng Z, Kang BH, Ishida E, Griesman T, Stuccio S, Bolkhovitinov L, Wohlbold TJ, Chromikova V, Cagigi A, Leung K, Andrews S, Cheung CSF, Pullano AA, Plyler J, Soto C, Zhang B, Yang Y, Joyce MG, Tsybovsky Y, Wheatley A, Narpala SR, Guo Y, Darko S, Bailer RT, Poole A, Liang CJ, Smith J, Alexander J, Gurwith M, Migueles SA, Koup RA, Golding H, Khurana S, McDermott AB, Shapiro L, Krammer F, Kwong PD, Connors M.

Sci Immunol. 2019 Apr 19;4(34). pii: eaau2710. doi: 10.1126/sciimmunol.aau2710.


Broadly Cross-Reactive, Nonneutralizing Antibodies against Influenza B Virus Hemagglutinin Demonstrate Effector Function-Dependent Protection against Lethal Viral Challenge in Mice.

Asthagiri Arunkumar G, Ioannou A, Wohlbold TJ, Meade P, Aslam S, Amanat F, Ayllon J, García-Sastre A, Krammer F.

J Virol. 2019 Mar 5;93(6). pii: e01696-18. doi: 10.1128/JVI.01696-18. Print 2019 Mar 15.


Influenza Infection in Humans Induces Broadly Cross-Reactive and Protective Neuraminidase-Reactive Antibodies.

Chen YQ, Wohlbold TJ, Zheng NY, Huang M, Huang Y, Neu KE, Lee J, Wan H, Rojas KT, Kirkpatrick E, Henry C, Palm AE, Stamper CT, Lan LY, Topham DJ, Treanor J, Wrammert J, Ahmed R, Eichelberger MC, Georgiou G, Krammer F, Wilson PC.

Cell. 2018 Apr 5;173(2):417-429.e10. doi: 10.1016/j.cell.2018.03.030.


An immuno-assay to quantify influenza virus hemagglutinin with correctly folded stalk domains in vaccine preparations.

Rajendran M, Sun W, Comella P, Nachbagauer R, Wohlbold TJ, Amanat F, Kirkpatrick E, Palese P, Krammer F.

PLoS One. 2018 Apr 4;13(4):e0194830. doi: 10.1371/journal.pone.0194830. eCollection 2018.


A universal influenza virus vaccine candidate confers protection against pandemic H1N1 infection in preclinical ferret studies.

Nachbagauer R, Liu WC, Choi A, Wohlbold TJ, Atlas T, Rajendran M, Solórzano A, Berlanda-Scorza F, García-Sastre A, Palese P, Albrecht RA, Krammer F.

NPJ Vaccines. 2017 Sep 14;2:26. doi: 10.1038/s41541-017-0026-4. eCollection 2017.


Generation of Escape Variants of Neutralizing Influenza Virus Monoclonal Antibodies.

Leon PE, Wohlbold TJ, He W, Bailey MJ, Henry CJ, Wilson PC, Krammer F, Tan GS.

J Vis Exp. 2017 Aug 29;(126). doi: 10.3791/56067.


Broadly protective murine monoclonal antibodies against influenza B virus target highly conserved neuraminidase epitopes.

Wohlbold TJ, Podolsky KA, Chromikova V, Kirkpatrick E, Falconieri V, Meade P, Amanat F, Tan J, tenOever BR, Tan GS, Subramaniam S, Palese P, Krammer F.

Nat Microbiol. 2017 Oct;2(10):1415-1424. doi: 10.1038/s41564-017-0011-8. Epub 2017 Aug 21.


A cross-clade H5N1 influenza A virus neutralizing monoclonal antibody binds to a novel epitope within the vestigial esterase domain of hemagglutinin.

Paul SS, Mok CK, Mak TM, Ng OW, Aboagye JO, Wohlbold TJ, Krammer F, Tan YJ.

Antiviral Res. 2017 Aug;144:299-310. doi: 10.1016/j.antiviral.2017.06.012. Epub 2017 Jun 19.


Novel Cross-Reactive Monoclonal Antibodies against Ebolavirus Glycoproteins Show Protection in a Murine Challenge Model.

Duehr J, Wohlbold TJ, Oestereich L, Chromikova V, Amanat F, Rajendran M, Gomez-Medina S, Mena I, tenOever BR, García-Sastre A, Basler CF, Munoz-Fontela C, Krammer F.

J Virol. 2017 Jul 27;91(16). pii: e00652-17. doi: 10.1128/JVI.00652-17. Print 2017 Aug 15.


Globular Head-Displayed Conserved Influenza H1 Hemagglutinin Stalk Epitopes Confer Protection against Heterologous H1N1 Virus.

Klausberger M, Tscheliessnig R, Neff S, Nachbagauer R, Wohlbold TJ, Wilde M, Palmberger D, Krammer F, Jungbauer A, Grabherr R.

PLoS One. 2016 Apr 18;11(4):e0153579. doi: 10.1371/journal.pone.0153579. eCollection 2016.


Cryo-electron Microscopy Structures of Chimeric Hemagglutinin Displayed on a Universal Influenza Vaccine Candidate.

Tran EE, Podolsky KA, Bartesaghi A, Kuybeda O, Grandinetti G, Wohlbold TJ, Tan GS, Nachbagauer R, Palese P, Krammer F, Subramaniam S.

MBio. 2016 Mar 22;7(2):e00257. doi: 10.1128/mBio.00257-16.


Hemagglutinin Stalk- and Neuraminidase-Specific Monoclonal Antibodies Protect against Lethal H10N8 Influenza Virus Infection in Mice.

Wohlbold TJ, Chromikova V, Tan GS, Meade P, Amanat F, Comella P, Hirsh A, Krammer F.

J Virol. 2015 Oct 28;90(2):851-61. doi: 10.1128/JVI.02275-15. Print 2016 Jan 15.


Hemagglutinin Receptor Binding of a Human Isolate of Influenza A(H10N8) Virus.

Ramos I, Mansour M, Wohlbold TJ, Ermler ME, Hirsh A, Runstadler JA, Fernandez-Sesma A, Krammer F.

Emerg Infect Dis. 2015 Jul;21(7):1197-201. doi: 10.3201/eid2107.141755.


Vaccination with soluble headless hemagglutinin protects mice from challenge with divergent influenza viruses.

Wohlbold TJ, Nachbagauer R, Margine I, Tan GS, Hirsh A, Krammer F.

Vaccine. 2015 Jun 26;33(29):3314-21. doi: 10.1016/j.vaccine.2015.05.038. Epub 2015 May 28.


Vaccination with adjuvanted recombinant neuraminidase induces broad heterologous, but not heterosubtypic, cross-protection against influenza virus infection in mice.

Wohlbold TJ, Nachbagauer R, Xu H, Tan GS, Hirsh A, Brokstad KA, Cox RJ, Palese P, Krammer F.

MBio. 2015 Mar 10;6(2):e02556. doi: 10.1128/mBio.02556-14.


An H10N8 influenza virus vaccine strain and mouse challenge model based on the human isolate A/Jiangxi-Donghu/346/13.

Wohlbold TJ, Hirsh A, Krammer F.

Vaccine. 2015 Feb 25;33(9):1102-6. doi: 10.1016/j.vaccine.2015.01.026. Epub 2015 Jan 17.


Induction of broadly reactive anti-hemagglutinin stalk antibodies by an H5N1 vaccine in humans.

Nachbagauer R, Wohlbold TJ, Hirsh A, Hai R, Sjursen H, Palese P, Cox RJ, Krammer F.

J Virol. 2014 Nov;88(22):13260-8. doi: 10.1128/JVI.02133-14. Epub 2014 Sep 10.


In the shadow of hemagglutinin: a growing interest in influenza viral neuraminidase and its role as a vaccine antigen.

Wohlbold TJ, Krammer F.

Viruses. 2014 Jun 23;6(6):2465-94. doi: 10.3390/v6062465. Review.

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