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Items: 1 to 50 of 141


A comprehensive in vivo and mathematic modeling-based kinetic characterization for aspirin-induced chemoprevention in colorectal cancer.

Shimura T, Toden S, Komarova NL, Boland C, Wodarz D, Goel A.

Carcinogenesis. 2020 Jan 6. pii: bgz195. doi: 10.1093/carcin/bgz195. [Epub ahead of print]


The 2019 mathematical oncology roadmap.

Rockne RC, Hawkins-Daarud A, Swanson KR, Sluka JP, Glazier JA, Macklin P, Hormuth DA, Jarrett AM, Lima EABF, Tinsley Oden J, Biros G, Yankeelov TE, Curtius K, Al Bakir I, Wodarz D, Komarova N, Aparicio L, Bordyuh M, Rabadan R, Finley SD, Enderling H, Caudell J, Moros EG, Anderson ARA, Gatenby RA, Kaznatcheev A, Jeavons P, Krishnan N, Pelesko J, Wadhwa RR, Yoon N, Nichol D, Marusyk A, Hinczewski M, Scott JG.

Phys Biol. 2019 Jun 19;16(4):041005. doi: 10.1088/1478-3975/ab1a09. Review.


Multiple infection of cells changes the dynamics of basic viral evolutionary processes.

Wodarz D, Levy DN, Komarova NL.

Evol Lett. 2018 Dec 31;3(1):104-115. doi: 10.1002/evl3.95. eCollection 2019 Feb.


A call to arms: Unifying the fight against resistance.

Kaushansky A, Hedstrom L, Goldman A, Singh J, Yang PL, Rathod PK, Cynamon M, Wodarz D, Mahadevan D, Tomaras A, Navia MA, Schiffer CA.

Sci Signal. 2018 Oct 23;11(553). pii: eaav0442. doi: 10.1126/scisignal.aav0442.


Virus and CTL dynamics in the extrafollicular and follicular tissue compartments in SIV-infected macaques.

Wodarz D, Skinner PJ, Levy DN, Connick E.

PLoS Comput Biol. 2018 Oct 18;14(10):e1006461. doi: 10.1371/journal.pcbi.1006461. eCollection 2018 Oct.


The role of telomere shortening in carcinogenesis: A hybrid stochastic-deterministic approach.

Rodriguez-Brenes IA, Komarova NL, Wodarz D.

J Theor Biol. 2019 Jan 7;460:144-152. doi: 10.1016/j.jtbi.2018.09.003. Epub 2018 Oct 10.


Passenger mutations can accelerate tumour suppressor gene inactivation in cancer evolution.

Wodarz D, Newell AC, Komarova NL.

J R Soc Interface. 2018 Jun;15(143). pii: 20170967. doi: 10.1098/rsif.2017.0967.


Spatial evolution of regularization in learned behavior of animals.

Harris D, Wodarz D, Komarova NL.

Math Biosci. 2018 May;299:103-116. doi: 10.1016/j.mbs.2018.03.005. Epub 2018 Mar 14.


Effect of cell cycle duration on somatic evolutionary dynamics.

Wodarz D, Goel A, Komarova NL.

Evol Appl. 2017 Oct 12;10(10):1121-1129. doi: 10.1111/eva.12518. eCollection 2017 Dec.


Effect of aspirin on tumour cell colony formation and evolution.

Wodarz D, Goel A, Boland CR, Komarova NL.

J R Soc Interface. 2017 Sep;14(134). pii: 20170374. doi: 10.1098/rsif.2017.0374.


Early Stochastic Dynamics in Human Cytomegalovirus Infection.

Wodarz D, Rodriguez-Brenes I.

J Virol. 2017 Aug 24;91(18). pii: e00949-17. doi: 10.1128/JVI.00949-17. Print 2017 Sep 15. No abstract available.


Pyroptosis, superinfection, and the maintenance of the latent reservoir in HIV-1 infection.

Wodarz D, Levy DN.

Sci Rep. 2017 Jun 19;7(1):3834. doi: 10.1038/s41598-017-04130-9.


Determining the role of inflammation in the selection of JAK2 mutant cells in myeloproliferative neoplasms.

Zhang J, Fleischman AG, Wodarz D, Komarova NL.

J Theor Biol. 2017 Jul 21;425:43-52. doi: 10.1016/j.jtbi.2017.05.012. Epub 2017 May 10.


Cellular Hierarchy as a Determinant of Tumor Sensitivity to Chemotherapy.

Rodriguez-Brenes IA, Kurtova AV, Lin C, Lee YC, Xiao J, Mims M, Chan KS, Wodarz D.

Cancer Res. 2017 May 1;77(9):2231-2241. doi: 10.1158/0008-5472.CAN-16-2434. Epub 2017 Feb 24.


Aspirin-Induced Chemoprevention and Response Kinetics Are Enhanced by PIK3CA Mutations in Colorectal Cancer Cells.

Zumwalt TJ, Wodarz D, Komarova NL, Toden S, Turner J, Cardenas J, Burn J, Chan AT, Boland CR, Goel A.

Cancer Prev Res (Phila). 2017 Mar;10(3):208-218. doi: 10.1158/1940-6207.CAPR-16-0175. Epub 2017 Feb 2.


Leukemia cell proliferation and death in chronic lymphocytic leukemia patients on therapy with the BTK inhibitor ibrutinib.

Burger JA, Li KW, Keating MJ, Sivina M, Amer AM, Garg N, Ferrajoli A, Huang X, Kantarjian H, Wierda WG, O'Brien S, Hellerstein MK, Turner SM, Emson CL, Chen SS, Yan XJ, Wodarz D, Chiorazzi N.

JCI Insight. 2017 Jan 26;2(2):e89904. doi: 10.1172/jci.insight.89904.


Complex Dynamics of Virus Spread from Low Infection Multiplicities: Implications for the Spread of Oncolytic Viruses.

Rodriguez-Brenes IA, Hofacre A, Fan H, Wodarz D.

PLoS Comput Biol. 2017 Jan 20;13(1):e1005241. doi: 10.1371/journal.pcbi.1005241. eCollection 2017 Jan. Erratum in: PLoS Comput Biol. 2017 May 19;13(5):e1005548.


In Vivo HIV-1 Cell-to-Cell Transmission Promotes Multicopy Micro-compartmentalized Infection.

Law KM, Komarova NL, Yewdall AW, Lee RK, Herrera OL, Wodarz D, Chen BK.

Cell Rep. 2016 Jun 21;15(12):2771-83. doi: 10.1016/j.celrep.2016.05.059. Epub 2016 Jun 9.


Computational modeling approaches to the dynamics of oncolytic viruses.

Wodarz D.

Wiley Interdiscip Rev Syst Biol Med. 2016 May;8(3):242-52. doi: 10.1002/wsbm.1332. Epub 2016 Mar 22. Review.


Timing of CD8 T cell effector responses in viral infections.

Stipp SR, Iniguez A, Wan F, Wodarz D.

R Soc Open Sci. 2016 Feb 17;3(2):150661. doi: 10.1098/rsos.150661. eCollection 2016 Feb.


Telomeres open a window on stem cell division.

Rodriguez-Brenes IA, Wodarz D.

Elife. 2016 Jan 25;5:e12481. doi: 10.7554/eLife.12481.


HIV-1 latency and virus production from unintegrated genomes following direct infection of resting CD4 T cells.

Chan CN, Trinité B, Lee CS, Mahajan S, Anand A, Wodarz D, Sabbaj S, Bansal A, Goepfert PA, Levy DN.

Retrovirology. 2016 Jan 5;13:1. doi: 10.1186/s12977-015-0234-9.


Quantifying replicative senescence as a tumor suppressor pathway and a target for cancer therapy.

Rodriguez-Brenes IA, Wodarz D, Komarova NL.

Sci Rep. 2015 Dec 9;5:17660. doi: 10.1038/srep17660.


Characterizing inhibited tumor growth in stem-cell-driven non-spatial cancers.

Rodriguez-Brenes IA, Wodarz D, Komarova NL.

Math Biosci. 2015 Dec;270(Pt A):135-41. doi: 10.1016/j.mbs.2015.08.009. Epub 2015 Sep 4.


Preventing clonal evolutionary processes in cancer: Insights from mathematical models.

Rodriguez-Brenes IA, Wodarz D.

Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):8843-50. doi: 10.1073/pnas.1501730112.


New virus dynamics in the presence of multiple infection.

Asatryan A, Wodarz D, Komarova NL.

J Theor Biol. 2015 Jul 21;377:98-109. doi: 10.1016/j.jtbi.2015.04.014. Epub 2015 Apr 20.


Modeling multiple infection of cells by viruses: Challenges and insights.

Phan D, Wodarz D.

Math Biosci. 2015 Jun;264:21-8. doi: 10.1016/j.mbs.2015.03.001. Epub 2015 Mar 10.


Curcumin mediates chemosensitization to 5-fluorouracil through miRNA-induced suppression of epithelial-to-mesenchymal transition in chemoresistant colorectal cancer.

Toden S, Okugawa Y, Jascur T, Wodarz D, Komarova NL, Buhrmann C, Shakibaei M, Boland CR, Goel A.

Carcinogenesis. 2015 Mar;36(3):355-67. doi: 10.1093/carcin/bgv006. Epub 2015 Feb 4.


Cancer: Risk factors and random chances.

Wodarz D, Zauber AG.

Nature. 2015 Jan 29;517(7536):563-4. doi: 10.1038/517563a. No abstract available.


Contribution of HIV-1 genomes that do not integrate to the basic reproductive ratio of the virus.

Lau JW, Levy DN, Wodarz D.

J Theor Biol. 2015 Feb 21;367:222-229. doi: 10.1016/j.jtbi.2014.12.004. Epub 2014 Dec 12.


Modeling T cell responses to antigenic challenge.

Wodarz D.

J Pharmacokinet Pharmacodyn. 2014 Oct;41(5):415-29. doi: 10.1007/s10928-014-9387-8. Epub 2014 Oct 1. Review.


Evolution of ibrutinib resistance in chronic lymphocytic leukemia (CLL).

Komarova NL, Burger JA, Wodarz D.

Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13906-11. doi: 10.1073/pnas.1409362111. Epub 2014 Sep 8.


On the laws of virus spread through cell populations.

Wodarz D, Chan CN, Trinité B, Komarova NL, Levy DN.

J Virol. 2014 Nov;88(22):13240-8. doi: 10.1128/JVI.02096-14. Epub 2014 Sep 3. Erratum in: J Virol. 2015 Jan 15;89(2):1484.


Mathematical models of HIV replication and pathogenesis.

Wodarz D.

Methods Mol Biol. 2014;1184:563-81. doi: 10.1007/978-1-4939-1115-8_30.


Kinetics of CLL cells in tissues and blood during therapy with the BTK inhibitor ibrutinib.

Wodarz D, Garg N, Komarova NL, Benjamini O, Keating MJ, Wierda WG, Kantarjian H, James D, O'Brien S, Burger JA.

Blood. 2014 Jun 26;123(26):4132-5. doi: 10.1182/blood-2014-02-554220. Epub 2014 May 14.


Dynamics of cellular responses to radiation.

Wodarz D, Sorace R, Komarova NL.

PLoS Comput Biol. 2014 Apr 10;10(4):e1003513. doi: 10.1371/journal.pcbi.1003513. eCollection 2014 Apr.


Complex role of space in the crossing of fitness valleys by asexual populations.

Komarova NL, Shahriyari L, Wodarz D.

J R Soc Interface. 2014 Mar 26;11(95):20140014. doi: 10.1098/rsif.2014.0014. Print 2014 Jun 6.


Cancer-associated mutations in healthy individuals: assessing the risk of carcinogenesis.

Rodriguez-Brenes IA, Komarova NL, Wodarz D.

Cancer Res. 2014 Mar 15;74(6):1661-9. doi: 10.1158/0008-5472.CAN-13-1452. Epub 2014 Jan 22.


Tissue architecture, feedback regulation, and resilience to viral infection.

Roy SM, Wodarz D.

J Theor Biol. 2014 Jan 7;340:131-8. doi: 10.1016/j.jtbi.2013.09.011. Epub 2013 Sep 19.


An HIV-1 replication pathway utilizing reverse transcription products that fail to integrate.

Trinité B, Ohlson EC, Voznesensky I, Rana SP, Chan CN, Mahajan S, Alster J, Burke SA, Wodarz D, Levy DN.

J Virol. 2013 Dec;87(23):12701-20. doi: 10.1128/JVI.01939-13. Epub 2013 Sep 18.


Nearest-neighbor interactions, habitat fragmentation, and the persistence of host-pathogen systems.

Wodarz D, Sun Z, Lau JW, Komarova NL.

Am Nat. 2013 Sep;182(3):E94-E111. doi: 10.1086/671185. Epub 2013 Jul 18.


Dependence of the firearm-related homicide rate on gun availability: a mathematical analysis.

Wodarz D, Komarova NL.

PLoS One. 2013 Jul 26;8(7):e71606. doi: 10.1371/journal.pone.0071606. Print 2013.


Evolutionary dynamics of giant viruses and their virophages.

Wodarz D.

Ecol Evol. 2013 Jul;3(7):2103-15. doi: 10.1002/ece3.600. Epub 2013 Jun 4.


Computational modeling approaches to studying the dynamics of oncolytic viruses.

Wodarz D.

Math Biosci Eng. 2013 Jun;10(3):939-57. doi: 10.3934/mbe.2013.10.939. Review.


Minimizing the risk of cancer: tissue architecture and cellular replication limits.

Rodriguez-Brenes IA, Wodarz D, Komarova NL.

J R Soc Interface. 2013 Jul 3;10(86):20130410. doi: 10.1098/rsif.2013.0410. Print 2013 Sep 6.


Tumor growth dynamics: insights into evolutionary processes.

Rodriguez-Brenes IA, Komarova NL, Wodarz D.

Trends Ecol Evol. 2013 Oct;28(10):597-604. doi: 10.1016/j.tree.2013.05.020. Epub 2013 Jun 28. Review.


Synaptic transmission and the susceptibility of HIV infection to anti-viral drugs.

Komarova NL, Levy DN, Wodarz D.

Sci Rep. 2013;3:2103. doi: 10.1038/srep02103.


Methylation kinetics and CpG-island methylator phenotype status in colorectal cancer cell lines.

Wodarz D, Boland CR, Goel A, Komarova NL.

Biol Direct. 2013 Jun 11;8:14. doi: 10.1186/1745-6150-8-14.


Stem cell control, oscillations, and tissue regeneration in spatial and non-spatial models.

Rodriguez-Brenes IA, Wodarz D, Komarova NL.

Front Oncol. 2013 Apr 15;3:82. doi: 10.3389/fonc.2013.00082. eCollection 2013.

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