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Glycolysis Is an Intrinsic Factor for Optimal Replication of a Norovirus.

Passalacqua KD, Lu J, Goodfellow I, Kolawole AO, Arche JR, Maddox RJ, Carnahan KE, O'Riordan MXD, Wobus CE.

MBio. 2019 Mar 12;10(2). pii: e02175-18. doi: 10.1128/mBio.02175-18.


Intestinal non-canonical NFκB signaling shapes the local and systemic immune response.

Ramakrishnan SK, Zhang H, Ma X, Jung I, Schwartz AJ, Triner D, Devenport SN, Das NK, Xue X, Zeng MY, Hu Y, Mortensen RM, Greenson JK, Cascalho M, Wobus CE, Colacino JA, Nunez G, Rui L, Shah YM.

Nat Commun. 2019 Feb 8;10(1):660. doi: 10.1038/s41467-019-08581-8.


Natural Secretory Immunoglobulins Promote Enteric Viral Infections.

Turula H, Bragazzi Cunha J, Mainou BA, Ramakrishnan SK, Wilke CA, Gonzalez-Hernandez MB, Pry A, Fava J, Bassis CM, Edelman J, Shah YM, Corthesy B, Moore BB, Wobus CE.

J Virol. 2018 Nov 12;92(23). pii: e00826-18. doi: 10.1128/JVI.00826-18. Print 2018 Dec 1.


All Aboard! Enteric Viruses Travel Together.

Mirabelli C, Wobus CE.

Cell Host Microbe. 2018 Aug 8;24(2):183-185. doi: 10.1016/j.chom.2018.07.012.


Evolution on the Biophysical Fitness Landscape of an RNA Virus.

Rotem A, Serohijos AWR, Chang CB, Wolfe JT, Fischer AE, Mehoke TS, Zhang H, Tao Y, Lloyd Ung W, Choi JM, Rodrigues JV, Kolawole AO, Koehler SA, Wu S, Thielen PM, Cui N, Demirev PA, Giacobbi NS, Julian TR, Schwab K, Lin JS, Smith TJ, Pipas JM, Wobus CE, Feldman AB, Weitz DA, Shakhnovich EI.

Mol Biol Evol. 2018 Oct 1;35(10):2390-2400. doi: 10.1093/molbev/msy131.


The Dual Tropism of Noroviruses.

Wobus CE.

J Virol. 2018 Jul 31;92(16). pii: e01010-17. doi: 10.1128/JVI.01010-17. Print 2018 Aug 15. Review.


The Role of the Polymeric Immunoglobulin Receptor and Secretory Immunoglobulins during Mucosal Infection and Immunity.

Turula H, Wobus CE.

Viruses. 2018 May 3;10(5). pii: E237. doi: 10.3390/v10050237. Review.


Norovirus Escape from Broadly Neutralizing Antibodies Is Limited to Allostery-Like Mechanisms.

Kolawole AO, Smith HQ, Svoboda SA, Lewis MS, Sherman MB, Lynch GC, Pettitt BM, Smith TJ, Wobus CE.

mSphere. 2017 Oct 18;2(5). pii: e00334-17. doi: 10.1128/mSphere.00334-17. eCollection 2017 Sep-Oct.


Recent advances in understanding noroviruses.

Bartnicki E, Cunha JB, Kolawole AO, Wobus CE.

F1000Res. 2017 Jan 26;6:79. doi: 10.12688/f1000research.10081.1. eCollection 2017. Review.


Norovirus Regulation by Host and Microbe.

Baldridge MT, Turula H, Wobus CE.

Trends Mol Med. 2016 Dec;22(12):1047-1059. doi: 10.1016/j.molmed.2016.10.003. Epub 2016 Nov 22. Review.


Prevalence of human norovirus and Clostridium difficile coinfections in adult hospitalized patients.

Stokely JN, Niendorf S, Taube S, Hoehne M, Young VB, Rogers MA, Wobus CE.

Clin Epidemiol. 2016 Jun 28;8:253-60. doi: 10.2147/CLEP.S106495. eCollection 2016.


Select membrane proteins modulate MNV-1 infection of macrophages and dendritic cells in a cell type-specific manner.

Bragazzi Cunha J, Wobus CE.

Virus Res. 2016 Aug 15;222:64-70. doi: 10.1016/j.virusres.2016.06.001. Epub 2016 Jun 2.


Post-exposure antiviral treatment of norovirus infections effectively protects against diarrhea and reduces virus shedding in the stool in a mortality mouse model.

Rocha-Pereira J, Kolawole AO, Verbeken E, Wobus CE, Neyts J.

Antiviral Res. 2016 Aug;132:76-84. doi: 10.1016/j.antiviral.2016.05.022. Epub 2016 May 29.


Inhibition of human norovirus by a viral polymerase inhibitor in the B cell culture system and in the mouse model.

Kolawole AO, Rocha-Pereira J, Elftman MD, Neyts J, Wobus CE.

Antiviral Res. 2016 Aug;132:46-9. doi: 10.1016/j.antiviral.2016.05.011. Epub 2016 May 17.


Anti-infective Activity of 2-Cyano-3-Acrylamide Inhibitors with Improved Drug-Like Properties against Two Intracellular Pathogens.

Passalacqua KD, Charbonneau ME, Donato NJ, Showalter HD, Sun D, Wen B, He M, Sun H, O'Riordan MX, Wobus CE.

Antimicrob Agents Chemother. 2016 Jun 20;60(7):4183-96. doi: 10.1128/AAC.03021-15. Print 2016 Jul.


Viruses in Rodent Colonies: Lessons Learned from Murine Noroviruses.

Karst SM, Wobus CE.

Annu Rev Virol. 2015 Nov;2(1):525-48. doi: 10.1146/annurev-virology-100114-055204. Epub 2015 Jul 2. Review.


Oral Norovirus Infection Is Blocked in Mice Lacking Peyer's Patches and Mature M Cells.

Kolawole AO, Gonzalez-Hernandez MB, Turula H, Yu C, Elftman MD, Wobus CE.

J Virol. 2015 Nov 18;90(3):1499-506. doi: 10.1128/JVI.02872-15. Print 2016 Feb 1.


Human norovirus culture in B cells.

Jones MK, Grau KR, Costantini V, Kolawole AO, de Graaf M, Freiden P, Graves CL, Koopmans M, Wallet SM, Tibbetts SA, Schultz-Cherry S, Wobus CE, Vinjé J, Karst SM.

Nat Protoc. 2015 Dec;10(12):1939-47. doi: 10.1038/nprot.2015.121. Epub 2015 Oct 29.


Murine norovirus (MNV-1) exposure in vitro to the purine nucleoside analog Ribavirin increases quasispecies diversity.

Julian TR, Baugher JD, Rippinger CM, Pinekenstein R, Kolawole AO, Mehoke TS, Wobus CE, Feldman AB, Pineda FJ, Schwab KJ.

Virus Res. 2016 Jan 4;211:165-73. doi: 10.1016/j.virusres.2015.10.016. Epub 2015 Oct 19.


Rapid, targeted and culture-free viral infectivity assay in drop-based microfluidics.

Tao Y, Rotem A, Zhang H, Chang CB, Basu A, Kolawole AO, Koehler SA, Ren Y, Lin JS, Pipas JM, Feldman AB, Wobus CE, Weitz DA.

Lab Chip. 2015 Oct 7;15(19):3934-40. doi: 10.1039/c5lc00556f.


Artifact-Free Quantification and Sequencing of Rare Recombinant Viruses by Using Drop-Based Microfluidics.

Tao Y, Rotem A, Zhang H, Cockrell SK, Koehler SA, Chang CB, Ung LW, Cantalupo PG, Ren Y, Lin JS, Feldman AB, Wobus CE, Pipas JM, Weitz DA.

Chembiochem. 2015 Oct 12;16(15):2167-71. doi: 10.1002/cbic.201500384. Epub 2015 Sep 7.


Repurposing of rutin for the inhibition of norovirus replication.

Chéron N, Yu C, Kolawole AO, Shakhnovich EI, Wobus CE.

Arch Virol. 2015 Sep;160(9):2353-8. doi: 10.1007/s00705-015-2495-y. Epub 2015 Jun 26.


Isolation and Analysis of Rare Norovirus Recombinants from Coinfected Mice Using Drop-Based Microfluidics.

Zhang H, Cockrell SK, Kolawole AO, Rotem A, Serohijos AW, Chang CB, Tao Y, Mehoke TS, Han Y, Lin JS, Giacobbi NS, Feldman AB, Shakhnovich E, Weitz DA, Wobus CE, Pipas JM.

J Virol. 2015 Aug;89(15):7722-34. doi: 10.1128/JVI.01137-15. Epub 2015 May 13.


Molecular chaperone Hsp90 is a therapeutic target for noroviruses.

Vashist S, Urena L, Gonzalez-Hernandez MB, Choi J, de Rougemont A, Rocha-Pereira J, Neyts J, Hwang S, Wobus CE, Goodfellow I.

J Virol. 2015 Jun;89(12):6352-63. doi: 10.1128/JVI.00315-15. Epub 2015 Apr 8.


A working model of how noroviruses infect the intestine.

Karst SM, Wobus CE.

PLoS Pathog. 2015 Feb 27;11(2):e1004626. doi: 10.1371/journal.ppat.1004626. eCollection 2015 Feb. No abstract available.


A high-throughput drop microfluidic system for virus culture and analysis.

Fischer AE, Wu SK, Proescher JB, Rotem A, Chang CB, Zhang H, Tao Y, Mehoke TS, Thielen PM, Kolawole AO, Smith TJ, Wobus CE, Weitz DA, Lin JS, Feldman AB, Wolfe JT.

J Virol Methods. 2015 Mar;213:111-7. doi: 10.1016/j.jviromet.2014.12.003. Epub 2014 Dec 16.


A novel reverse genetics system for human norovirus.

Taube S, Wobus CE.

Trends Microbiol. 2014 Nov;22(11):604-6. doi: 10.1016/j.tim.2014.10.001. Epub 2014 Oct 16.


Enteric bacteria promote human and mouse norovirus infection of B cells.

Jones MK, Watanabe M, Zhu S, Graves CL, Keyes LR, Grau KR, Gonzalez-Hernandez MB, Iovine NM, Wobus CE, Vinjé J, Tibbetts SA, Wallet SM, Karst SM.

Science. 2014 Nov 7;346(6210):755-9. doi: 10.1126/science.1257147.


Small molecule deubiquitinase inhibitors promote macrophage anti-infective capacity.

Charbonneau ME, Gonzalez-Hernandez MJ, Showalter HD, Donato NJ, Wobus CE, O'Riordan MX.

PLoS One. 2014 Aug 5;9(8):e104096. doi: 10.1371/journal.pone.0104096. eCollection 2014.


Advances in norovirus biology.

Karst SM, Wobus CE, Goodfellow IG, Green KY, Virgin HW.

Cell Host Microbe. 2014 Jun 11;15(6):668-80. doi: 10.1016/j.chom.2014.05.015. Review.


Newly isolated mAbs broaden the neutralizing epitope in murine norovirus.

Kolawole AO, Xia C, Li M, Gamez M, Yu C, Rippinger CM, Yucha RE, Smith TJ, Wobus CE.

J Gen Virol. 2014 Sep;95(Pt 9):1958-68. doi: 10.1099/vir.0.066753-0. Epub 2014 Jun 4.


Murine norovirus: propagation, quantification, and genetic manipulation.

Hwang S, Alhatlani B, Arias A, Caddy SL, Christodoulou C, Cunha JB, Emmott E, Gonzalez-Hernandez M, Kolawole A, Lu J, Rippinger C, Sorgeloos F, Thorne L, Vashist S, Goodfellow I, Wobus CE.

Curr Protoc Microbiol. 2014 May 1;33:15K.2.1-61. doi: 10.1002/9780471729259.mc15k02s33.


Chemical derivatives of a small molecule deubiquitinase inhibitor have antiviral activity against several RNA viruses.

Gonzalez-Hernandez MJ, Pal A, Gyan KE, Charbonneau ME, Showalter HD, Donato NJ, O'Riordan M, Wobus CE.

PLoS One. 2014 Apr 10;9(4):e94491. doi: 10.1371/journal.pone.0094491. eCollection 2014.


Efficient norovirus and reovirus replication in the mouse intestine requires microfold (M) cells.

Gonzalez-Hernandez MB, Liu T, Payne HC, Stencel-Baerenwald JE, Ikizler M, Yagita H, Dermody TS, Williams IR, Wobus CE.

J Virol. 2014 Jun;88(12):6934-43. doi: 10.1128/JVI.00204-14. Epub 2014 Apr 2.


Flexibility in surface-exposed loops in a virus capsid mediates escape from antibody neutralization.

Kolawole AO, Li M, Xia C, Fischer AE, Giacobbi NS, Rippinger CM, Proescher JB, Wu SK, Bessling SL, Gamez M, Yu C, Zhang R, Mehoke TS, Pipas JM, Wolfe JT, Lin JS, Feldman AB, Smith TJ, Wobus CE.

J Virol. 2014 Apr;88(8):4543-57. doi: 10.1128/JVI.03685-13. Epub 2014 Feb 5.


Murine norovirus infection does not cause major disruptions in the murine intestinal microbiota.

Nelson AM, Elftman MD, Pinto AK, Baldridge M, Hooper P, Kuczynski J, Petrosino JF, Young VB, Wobus CE.

Microbiome. 2013 Feb 18;1(1):7. doi: 10.1186/2049-2618-1-7.


Murine norovirus transcytosis across an in vitro polarized murine intestinal epithelial monolayer is mediated by M-like cells.

Gonzalez-Hernandez MB, Liu T, Blanco LP, Auble H, Payne HC, Wobus CE.

J Virol. 2013 Dec;87(23):12685-93. doi: 10.1128/JVI.02378-13. Epub 2013 Sep 18.


A mouse model for human norovirus.

Taube S, Kolawole AO, Höhne M, Wilkinson JE, Handley SA, Perry JW, Thackray LB, Akkina R, Wobus CE.

MBio. 2013 Jul 16;4(4). pii: e00450-13. doi: 10.1128/mBio.00450-13.


Multiple effects of dendritic cell depletion on murine norovirus infection.

Elftman MD, Gonzalez-Hernandez MB, Kamada N, Perkins C, Henderson KS, Núñez G, Wobus CE.

J Gen Virol. 2013 Aug;94(Pt 8):1761-8. doi: 10.1099/vir.0.052134-0. Epub 2013 May 1.


Neutral Red Assay for Murine Norovirus Replication and Detection in a Mouse.

González-Hernández MB, Perry JW, Wobus CE.

Bio Protoc. 2013 Apr 5;3(7). pii: e415.


Disruption of the human gut microbiota following Norovirus infection.

Nelson AM, Walk ST, Taube S, Taniuchi M, Houpt ER, Wobus CE, Young VB.

PLoS One. 2012;7(10):e48224. doi: 10.1371/journal.pone.0048224. Epub 2012 Oct 30.


Plaque assay for murine norovirus.

Gonzalez-Hernandez MB, Bragazzi Cunha J, Wobus CE.

J Vis Exp. 2012 Aug 22;(66):e4297. doi: 10.3791/4297.


Antiviral activity of a small molecule deubiquitinase inhibitor occurs via induction of the unfolded protein response.

Perry JW, Ahmed M, Chang KO, Donato NJ, Showalter HD, Wobus CE.

PLoS Pathog. 2012;8(7):e1002783. doi: 10.1371/journal.ppat.1002783. Epub 2012 Jul 5.


Viruses are everywhere-what do we do?

Wobus CE, Nguyen TH.

Curr Opin Virol. 2012 Feb;2(1):60-2. doi: 10.1016/j.coviro.2011.12.006. Epub 2011 Dec 29. No abstract available.


Murine noroviruses bind glycolipid and glycoprotein attachment receptors in a strain-dependent manner.

Taube S, Perry JW, McGreevy E, Yetming K, Perkins C, Henderson K, Wobus CE.

J Virol. 2012 May;86(10):5584-93. doi: 10.1128/JVI.06854-11. Epub 2012 Mar 21.


A small molecule deubiquitinase inhibitor increases localization of inducible nitric oxide synthase to the macrophage phagosome and enhances bacterial killing.

Burkholder KM, Perry JW, Wobus CE, Donato NJ, Showalter HD, Kapuria V, O'Riordan MX.

Infect Immun. 2011 Dec;79(12):4850-7. doi: 10.1128/IAI.05456-11. Epub 2011 Sep 12.


Transient or persistent norovirus infection does not alter the pathology of Salmonella typhimurium induced intestinal inflammation and fibrosis in mice.

Higgins PD, Johnson LA, Sauder K, Moons D, Blanco L, Taube S, Wobus CE.

Comp Immunol Microbiol Infect Dis. 2011 May;34(3):247-57. doi: 10.1016/j.cimid.2010.12.002. Epub 2011 Jan 14.


Endocytosis of murine norovirus 1 into murine macrophages is dependent on dynamin II and cholesterol.

Perry JW, Wobus CE.

J Virol. 2010 Jun;84(12):6163-76. doi: 10.1128/JVI.00331-10. Epub 2010 Apr 7.


Glycosphingolipids as receptors for non-enveloped viruses.

Taube S, Jiang M, Wobus CE.

Viruses. 2010 Apr;2(4):1011-49. doi: 10.3390/v2041011. Epub 2010 Apr 15.


High-resolution cryo-electron microscopy structures of murine norovirus 1 and rabbit hemorrhagic disease virus reveal marked flexibility in the receptor binding domains.

Katpally U, Voss NR, Cavazza T, Taube S, Rubin JR, Young VL, Stuckey J, Ward VK, Virgin HW 4th, Wobus CE, Smith TJ.

J Virol. 2010 Jun;84(11):5836-41. doi: 10.1128/JVI.00314-10. Epub 2010 Mar 24.

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