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Items: 44


The role of FHL2 in wound healing and inflammation.

Wixler V.

FASEB J. 2019 Jul;33(7):7799-7809. doi: 10.1096/fj.201802765RR. Epub 2019 Apr 2.


Deficiency of Fhl2 leads to delayed neuronal cell migration and premature astrocyte differentiation.

Kim SY, Völkl S, Ludwig S, Schneider H, Wixler V, Park J.

J Cell Sci. 2019 Mar 18;132(6). pii: jcs228940. doi: 10.1242/jcs.228940.


The transcription factor CREM drives an inflammatory phenotype of T cells in oligoarticular juvenile idiopathic arthritis.

Ohl K, Nickel H, Moncrieffe H, Klemm P, Scheufen A, Föll D, Wixler V, Schippers A, Wagner N, Wedderburn LR, Tenbrock K.

Pediatr Rheumatol Online J. 2018 Jun 20;16(1):39. doi: 10.1186/s12969-018-0253-x.


Oncolytic influenza virus infection restores immunocompetence of lung tumor-associated alveolar macrophages.

Masemann D, Köther K, Kuhlencord M, Varga G, Roth J, Lichty BD, Rapp UR, Wixler V, Ludwig S.

Oncoimmunology. 2018 Feb 12;7(5):e1423171. doi: 10.1080/2162402X.2017.1423171. eCollection 2018.


Autoinhibitory regulation of S100A8/S100A9 alarmin activity locally restricts sterile inflammation.

Vogl T, Stratis A, Wixler V, Völler T, Thurainayagam S, Jorch SK, Zenker S, Dreiling A, Chakraborty D, Fröhling M, Paruzel P, Wehmeyer C, Hermann S, Papantonopoulou O, Geyer C, Loser K, Schäfers M, Ludwig S, Stoll M, Leanderson T, Schultze JL, König S, Pap T, Roth J.

J Clin Invest. 2018 May 1;128(5):1852-1866. doi: 10.1172/JCI89867. Epub 2018 Apr 3.


The Four-and-a-Half LIM Domain Protein 2 Supports Influenza A Virus-Induced Lung Inflammation by Restricting the Host Adaptive Immune Response.

Masemann D, Leite Dantas R, Sitnik S, Schied T, Nordhoff C, Ludwig S, Wixler V.

Am J Pathol. 2018 May;188(5):1236-1245. doi: 10.1016/j.ajpath.2018.02.004. Epub 2018 Feb 17.


Inflammatory Cytokines Stabilize SOXC Transcription Factors to Mediate the Transformation of Fibroblast-Like Synoviocytes in Arthritic Disease.

Bhattaram P, Muschler G, Wixler V, Lefebvre V.

Arthritis Rheumatol. 2018 Mar;70(3):371-382. doi: 10.1002/art.40386. Epub 2018 Feb 6.


The LIM-Only Protein Four and a Half LIM Domain Protein 2 Attenuates Development of Psoriatic Arthritis by Blocking Adam17-Mediated Tumor Necrosis Factor Release.

Leite Dantas R, Brachvogel B, Schied T, Bergmeier V, Skryabin B, Vogl T, Ludwig S, Wixler V.

Am J Pathol. 2017 Nov;187(11):2388-2398. doi: 10.1016/j.ajpath.2017.07.015. Epub 2017 Aug 18.


Influenza A virus NS1 protein-induced JNK activation and apoptosis are not functionally linked.

Nacken W, Wixler V, Ehrhardt C, Ludwig S.

Cell Microbiol. 2017 Jul;19(7). doi: 10.1111/cmi.12721. Epub 2017 Jan 27.


Macrophage-mediated psoriasis can be suppressed by regulatory T lymphocytes.

Leite Dantas R, Masemann D, Schied T, Bergmeier V, Vogl T, Loser K, Brachvogel B, Varga G, Ludwig S, Wixler V.

J Pathol. 2016 Nov;240(3):366-377. doi: 10.1002/path.4786.


Phosphorylation of influenza A virus NS1 protein at threonine 49 suppresses its interferon antagonistic activity.

Kathum OA, Schräder T, Anhlan D, Nordhoff C, Liedmann S, Pande A, Mellmann A, Ehrhardt C, Wixler V, Ludwig S.

Cell Microbiol. 2016 Jun;18(6):784-91. doi: 10.1111/cmi.12559. Epub 2016 Jan 27.


In vitro and in vivo antitumor activity of a novel semisynthetic derivative of cucurbitacin B.

Silva IT, Carvalho A, Lang KL, Dudek SE, Masemann D, Durán FJ, Caro MS, Rapp UR, Wixler V, Schenkel EP, Simões CM, Ludwig S.

PLoS One. 2015 Feb 12;10(2):e0117794. doi: 10.1371/journal.pone.0117794. eCollection 2015.


FHL2 regulates the resolution of tissue damage in chronic inflammatory arthritis.

Wixler V, Cromme C, Retser E, Meyer LH, Smyth N, Mühlenberg K, Korb-Pap A, Koers-Wunrau C, Sotsios Y, Bassel-Duby R, Baeten D, Tak PP, Niederreiter B, Redlich K, Bertrand J, Skryabin BV, Ludwig S, Pap T.

Ann Rheum Dis. 2015 Dec;74(12):2216-23. doi: 10.1136/annrheumdis-2013-205061. Epub 2014 Aug 14.


MAPKAP kinase 3 suppresses Ifng gene expression and attenuates NK cell cytotoxicity and Th1 CD4 T-cell development upon influenza A virus infection.

Köther K, Nordhoff C, Masemann D, Varga G, Bream JH, Gaestel M, Wixler V, Ludwig S.

FASEB J. 2014 Oct;28(10):4235-46. doi: 10.1096/fj.14-249599. Epub 2014 Jun 16.


β-catenin promotes the type I IFN synthesis and the IFN-dependent signaling response but is suppressed by influenza A virus-induced RIG-I/NF-κB signaling.

Hillesheim A, Nordhoff C, Boergeling Y, Ludwig S, Wixler V.

Cell Commun Signal. 2014 Apr 26;12:29. doi: 10.1186/1478-811X-12-29.


The LIM-only protein FHL2 attenuates lung inflammation during bleomycin-induced fibrosis.

Alnajar A, Nordhoff C, Schied T, Chiquet-Ehrismann R, Loser K, Vogl T, Ludwig S, Wixler V.

PLoS One. 2013 Nov 18;8(11):e81356. doi: 10.1371/journal.pone.0081356. eCollection 2013.


Doxycycline-induced expression of transgenic human tumor necrosis factor α in adult mice results in psoriasis-like arthritis.

Retser E, Schied T, Skryabin BV, Vogl T, Kanczler JM, Hamann N, Niehoff A, Hermann S, Eisenblätter M, Wachsmuth L, Pap T, van Lent PL, Loser K, Roth J, Zaucke F, Ludwig S, Wixler V.

Arthritis Rheum. 2013 Sep;65(9):2290-300. doi: 10.1002/art.38026.


Mss4 protein is a regulator of stress response and apoptosis.

Walter BM, Nordhoff C, Varga G, Goncharenko G, Schneider SW, Ludwig S, Wixler V.

Cell Death Dis. 2012 Apr 12;3:e297. doi: 10.1038/cddis.2012.37.


The adaptor protein FHL2 enhances the cellular innate immune response to influenza A virus infection.

Nordhoff C, Hillesheim A, Walter BM, Haasbach E, Planz O, Ehrhardt C, Ludwig S, Wixler V.

Cell Microbiol. 2012 Jul;14(7):1135-47. doi: 10.1111/j.1462-5822.2012.01787.x. Epub 2012 Apr 12.


A new splice variant of the human guanylate-binding protein 3 mediates anti-influenza activity through inhibition of viral transcription and replication.

Nordmann A, Wixler L, Boergeling Y, Wixler V, Ludwig S.

FASEB J. 2012 Mar;26(3):1290-300. doi: 10.1096/fj.11-189886. Epub 2011 Nov 21.


The influenza virus PB1-F2 protein has interferon antagonistic activity.

Dudek SE, Wixler L, Nordhoff C, Nordmann A, Anhlan D, Wixler V, Ludwig S.

Biol Chem. 2011 Dec;392(12):1135-44. doi: 10.1515/BC.2011.174.


Phosphatidylinositol-3-kinase (PI3K) is activated by influenza virus vRNA via the pathogen pattern receptor Rig-I to promote efficient type I interferon production.

Hrincius ER, Dierkes R, Anhlan D, Wixler V, Ludwig S, Ehrhardt C.

Cell Microbiol. 2011 Dec;13(12):1907-19. doi: 10.1111/j.1462-5822.2011.01680.x. Epub 2011 Oct 11.


Identification and characterisation of novel Mss4-binding Rab GTPases.

Wixler V, Wixler L, Altenfeld A, Ludwig S, Goody RS, Itzen A.

Biol Chem. 2011 Mar;392(3):239-48. doi: 10.1515/BC.2011.022.


Monoclonal antibodies against the PB1-F2 protein of H1N1 influenza A virus.

Nordmann A, Wixler L, Ludwig S, Wixler V.

Hybridoma (Larchmt). 2010 Aug;29(4):321-6. doi: 10.1089/hyb.2010.0010.


MAP kinase-activated protein kinases 2 and 3 are required for influenza A virus propagation and act via inhibition of PKR.

Luig C, Köther K, Dudek SE, Gaestel M, Hiscott J, Wixler V, Ludwig S.

FASEB J. 2010 Oct;24(10):4068-77. doi: 10.1096/fj.10-158766. Epub 2010 May 19.


CRK adaptor protein expression is required for efficient replication of avian influenza A viruses and controls JNK-mediated apoptotic responses.

Hrincius ER, Wixler V, Wolff T, Wagner R, Ludwig S, Ehrhardt C.

Cell Microbiol. 2010 Jun;12(6):831-43. doi: 10.1111/j.1462-5822.2010.01436.x. Epub 2010 Jan 29.


MEK5/ERK5 signaling modulates endothelial cell migration and focal contact turnover.

Spiering D, Schmolke M, Ohnesorge N, Schmidt M, Goebeler M, Wegener J, Wixler V, Ludwig S.

J Biol Chem. 2009 Sep 11;284(37):24972-80. doi: 10.1074/jbc.M109.042911. Epub 2009 Jul 15.


Umbilical cord blood stem cells: induction of differentiation into mesenchymal lineages by cell-cell contacts with various mesenchymal cells.

Park J, Setter V, Wixler V, Schneider H.

Tissue Eng Part A. 2009 Feb;15(2):397-406. doi: 10.1089/ten.tea.2007.0379.


Deficiency in the LIM-only protein FHL2 impairs assembly of extracellular matrix proteins.

Park J, Will C, Martin B, Gullotti L, Friedrichs N, Buettner R, Schneider H, Ludwig S, Wixler V.

FASEB J. 2008 Jul;22(7):2508-20. doi: 10.1096/fj.07-095521. Epub 2008 Mar 20.


FHL2 regulates cell cycle-dependent and doxorubicin-induced p21Cip1/Waf1 expression in breast cancer cells.

Martin BT, Kleiber K, Wixler V, Raab M, Zimmer B, Kaufmann M, Strebhardt K.

Cell Cycle. 2007 Jul 15;6(14):1779-88.


Deficiency in the LIM-only protein Fhl2 impairs skin wound healing.

Wixler V, Hirner S, Müller JM, Gullotti L, Will C, Kirfel J, Günther T, Schneider H, Bosserhoff A, Schorle H, Park J, Schüle R, Buettner R.

J Cell Biol. 2007 Apr 9;177(1):163-72.


Def-6, a guanine nucleotide exchange factor for Rac1, interacts with the skeletal muscle integrin chain alpha7A and influences myoblast differentiation.

Samson T, Will C, Knoblauch A, Sharek L, von der Mark K, Burridge K, Wixler V.

J Biol Chem. 2007 May 25;282(21):15730-42. Epub 2007 Apr 2.


The binding of Mss4 to alpha-integrin subunits regulates matrix metalloproteinase activation and fibronectin remodeling.

Knoblauch A, Will C, Goncharenko G, Ludwig S, Wixler V.

FASEB J. 2007 Feb;21(2):497-510. Epub 2006 Dec 16.


The LIM-only proteins FHL2 and FHL3 interact with alpha- and beta-subunits of the muscle alpha7beta1 integrin receptor.

Samson T, Smyth N, Janetzky S, Wendler O, Müller JM, Schüle R, von der Mark H, von der Mark K, Wixler V.

J Biol Chem. 2004 Jul 2;279(27):28641-52. Epub 2004 Apr 26.


The LIM-only protein FHL2 interacts with beta-catenin and promotes differentiation of mouse myoblasts.

Martin B, Schneider R, Janetzky S, Waibler Z, Pandur P, Kühl M, Behrens J, von der Mark K, Starzinski-Powitz A, Wixler V.

J Cell Biol. 2002 Oct 14;159(1):113-22. Epub 2002 Oct 7.


The PDZ domain of TIP-2/GIPC interacts with the C-terminus of the integrin alpha5 and alpha6 subunits.

El Mourabit H, Poinat P, Koster J, Sondermann H, Wixler V, Wegener E, Laplantine E, Geerts D, Georges-Labouesse E, Sonnenberg A, Aumailley M.

Matrix Biol. 2002 Mar;21(2):207-14.


The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes.

Wixler V, Geerts D, Laplantine E, Westhoff D, Smyth N, Aumailley M, Sonnenberg A, Paulsson M.

J Biol Chem. 2000 Oct 27;275(43):33669-78.


Identification of novel interaction partners for the conserved membrane proximal region of alpha-integrin cytoplasmic domains.

Wixler V, Laplantine E, Geerts D, Sonnenberg A, Petersohn D, Eckes B, Paulsson M, Aumailley M.

FEBS Lett. 1999 Feb 26;445(2-3):351-5.


The regulatory subunit of protein kinase CK2 is a specific A-Raf activator.

Hagemann C, Kalmes A, Wixler V, Wixler L, Schuster T, Rapp UR.

FEBS Lett. 1997 Feb 17;403(2):200-2.


Role of diacylglycerol-regulated protein kinase C isotypes in growth factor activation of the Raf-1 protein kinase.

Cai H, Smola U, Wixler V, Eisenmann-Tappe I, Diaz-Meco MT, Moscat J, Rapp U, Cooper GM.

Mol Cell Biol. 1997 Feb;17(2):732-41.


3pK, a new mitogen-activated protein kinase-activated protein kinase located in the small cell lung cancer tumor suppressor gene region.

Sithanandam G, Latif F, Duh FM, Bernal R, Smola U, Li H, Kuzmin I, Wixler V, Geil L, Shrestha S.

Mol Cell Biol. 1996 Mar;16(3):868-76. Erratum in: Mol Cell Biol 1996 Apr;16(4):1880.


Mutant frequency at the H-2K class 1 and HPRT genes in T lymphocytes from the X-ray-exposed mouse.

Klarmann B, Wixler V, Lorenz R, Hempel K.

Int J Radiat Biol. 1995 Apr;67(4):421-30.


Isolation and quantification of class 1 MHC gene mutants in mouse T cells by immunoselection with a magnetic cell sorter (MACS).

Wixler V, Klarmann B, Begemann U, Gahn G, Lorenz R, Hempel K.

J Immunol Methods. 1994 May 2;171(1):121-30.


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