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Circulating uromodulin inhibits systemic oxidative stress by inactivating the TRPM2 channel.

LaFavers KA, Macedo E, Garimella PS, Lima C, Khan S, Myslinski J, McClintick J, Witzmann FA, Winfree S, Phillips CL, Hato T, Dagher PC, Wu XR, El-Achkar TM, Micanovic R.

Sci Transl Med. 2019 Oct 2;11(512). pii: eaaw3639. doi: 10.1126/scitranslmed.aaw3639.


Editorial: A Possible Chemo-biodescriptor Framework for the Prediction of Toxicity of Nanosubstances: An Integrated Computational Approach.

Vracko M, Witzmann FA, Basak SC.

Curr Comput Aided Drug Des. 2018;14(1):2-4. doi: 10.2174/157340991401180321111721. No abstract available.


Exogenous Gene Transmission of Isocitrate Dehydrogenase 2 Mimics Ischemic Preconditioning Protection.

Kolb AL, Corridon PR, Zhang S, Xu W, Witzmann FA, Collett JA, Rhodes GJ, Winfree S, Bready D, Pfeffenberger ZJ, Pomerantz JM, Hato T, Nagami GT, Molitoris BA, Basile DP, Atkinson SJ, Bacallao RL.

J Am Soc Nephrol. 2018 Apr;29(4):1154-1164. doi: 10.1681/ASN.2017060675. Epub 2018 Jan 25.



Basak SC, Vrac Ko M, Witzmann FA.

Curr Comput Aided Drug Des. 2016;12(4):253-254. No abstract available.


Cancer and Chemotherapy Contribute to Muscle Loss by Activating Common Signaling Pathways.

Barreto R, Mandili G, Witzmann FA, Novelli F, Zimmers TA, Bonetto A.

Front Physiol. 2016 Oct 19;7:472. eCollection 2016.


Delineation of Molecular Pathways Involved in Cardiomyopathies Caused by Troponin T Mutations.

Gilda JE, Lai X, Witzmann FA, Gomes AV.

Mol Cell Proteomics. 2016 Jun;15(6):1962-81. doi: 10.1074/mcp.M115.057380. Epub 2016 Mar 28.


Label-free proteomic methodology for the analysis of human kidney stone matrix composition.

Witzmann FA, Evan AP, Coe FL, Worcester EM, Lingeman JE, Williams JC Jr.

Proteome Sci. 2016 Feb 27;14:4. doi: 10.1186/s12953-016-0093-x. eCollection 2016.


Excess TGF-β mediates muscle weakness associated with bone metastases in mice.

Waning DL, Mohammad KS, Reiken S, Xie W, Andersson DC, John S, Chiechi A, Wright LE, Umanskaya A, Niewolna M, Trivedi T, Charkhzarrin S, Khatiwada P, Wronska A, Haynes A, Benassi MS, Witzmann FA, Zhen G, Wang X, Cao X, Roodman GD, Marks AR, Guise TA.

Nat Med. 2015 Nov;21(11):1262-1271. doi: 10.1038/nm.3961. Epub 2015 Oct 12.


Distinctive and pervasive alterations in aqueous humor protein composition following different types of glaucoma surgery.

Rosenfeld C, Price MO, Lai X, Witzmann FA, Price FW Jr.

Mol Vis. 2015 Aug 25;21:911-8. eCollection 2015.


Proximal Tubules Have the Capacity to Regulate Uptake of Albumin.

Wagner MC, Campos-Bilderback SB, Chowdhury M, Flores B, Lai X, Myslinski J, Pandit S, Sandoval RM, Wean SE, Wei Y, Satlin LM, Wiggins RC, Witzmann FA, Molitoris BA.

J Am Soc Nephrol. 2016 Feb;27(2):482-94. doi: 10.1681/ASN.2014111107. Epub 2015 Jun 8.


Proteomic profiling of human sera for discovery of potential biomarkers to monitor abstinence from alcohol abuse.

Lai X, Liangpunsakul S, Li K, Witzmann FA.

Electrophoresis. 2015 Feb;36(4):556-63. doi: 10.1002/elps.201400319. Epub 2015 Jan 22.


Increasing serum pre-adipocyte factor-1 (Pref-1) correlates with decreased body fat, increased free fatty acids, and level of recent alcohol consumption in excessive alcohol drinkers.

Liangpunsakul S, Bennett R, Westerhold C, Ross RA, Crabb DW, Lai X, Witzmann FA.

Alcohol. 2014 Dec;48(8):795-800. doi: 10.1016/j.alcohol.2014.07.013. Epub 2014 Sep 28.


Bioinformatic Analysis of Differential Protein Expression in Calu-3 Cells Exposed to Carbon Nanotubes.

Li P, Lai X, Witzmann FA, Blazer-Yost BL.

Proteomes. 2013 Oct 14;1(3):219-239.


Protein expression profiles of intestinal epithelial co-cultures: effect of functionalised carbon nanotube exposure.

Lai X, Blazer-Yost BL, Clack JW, Fears SL, Mitra S, Ntim SA, Ringham HN, Witzmann FA.

Int J Biomed Nanosci Nanotechnol. 2013;3(1-2). doi: 10.1504/IJBNN.2013.054508.


Nanoparticle toxicity by the gastrointestinal route: evidence and knowledge gaps.

Bergin IL, Witzmann FA.

Int J Biomed Nanosci Nanotechnol. 2013;3(1-2). doi: 10.1504/IJBNN.2013.054515.


Silver nanoparticle protein corona composition in cell culture media.

Shannahan JH, Lai X, Ke PC, Podila R, Brown JM, Witzmann FA.

PLoS One. 2013 Sep 9;8(9):e74001. doi: 10.1371/journal.pone.0074001. eCollection 2013.


Loss of FHL1 induces an age-dependent skeletal muscle myopathy associated with myofibrillar and intermyofibrillar disorganization in mice.

Domenighetti AA, Chu PH, Wu T, Sheikh F, Gokhin DS, Guo LT, Cui Z, Peter AK, Christodoulou DC, Parfenov MG, Gorham JM, Li DY, Banerjee I, Lai X, Witzmann FA, Seidman CE, Seidman JG, Gomes AV, Shelton GD, Lieber RL, Chen J.

Hum Mol Genet. 2014 Jan 1;23(1):209-25. doi: 10.1093/hmg/ddt412. Epub 2013 Aug 23.


LHX3 interacts with inhibitor of histone acetyltransferase complex subunits LANP and TAF-1β to modulate pituitary gene regulation.

Hunter CS, Malik RE, Witzmann FA, Rhodes SJ.

PLoS One. 2013 Jul 4;8(7):e68898. doi: 10.1371/journal.pone.0068898. Print 2013.


Proteomic analysis of hearts from Akita mice suggests that increases in soluble epoxide hydrolase and antioxidative programming are key changes in early stages of diabetic cardiomyopathy.

Dewey S, Lai X, Witzmann FA, Sohal M, Gomes AV.

J Proteome Res. 2013 Sep 6;12(9):3920-33. doi: 10.1021/pr4004739. Epub 2013 Aug 2.


Perivascular adipose tissue potentiates contraction of coronary vascular smooth muscle: influence of obesity.

Owen MK, Witzmann FA, McKenney ML, Lai X, Berwick ZC, Moberly SP, Alloosh M, Sturek M, Tune JD.

Circulation. 2013 Jul 2;128(1):9-18. doi: 10.1161/CIRCULATIONAHA.112.001238. Epub 2013 May 17.


Three human cell types respond to multi-walled carbon nanotubes and titanium dioxide nanobelts with cell-specific transcriptomic and proteomic expression patterns.

Tilton SC, Karin NJ, Tolic A, Xie Y, Lai X, Hamilton RF Jr, Waters KM, Holian A, Witzmann FA, Orr G.

Nanotoxicology. 2014 Aug;8(5):533-48. doi: 10.3109/17435390.2013.803624. Epub 2013 Jun 7.


Interlaboratory evaluation of in vitro cytotoxicity and inflammatory responses to engineered nanomaterials: the NIEHS Nano GO Consortium.

Xia T, Hamilton RF, Bonner JC, Crandall ED, Elder A, Fazlollahi F, Girtsman TA, Kim K, Mitra S, Ntim SA, Orr G, Tagmount M, Taylor AJ, Telesca D, Tolic A, Vulpe CD, Walker AJ, Wang X, Witzmann FA, Wu N, Xie Y, Zink JI, Nel A, Holian A.

Environ Health Perspect. 2013 Jun;121(6):683-90. doi: 10.1289/ehp.1306561. Epub 2013 May 6.


Proteomic profiling of halloysite clay nanotube exposure in intestinal cell co-culture.

Lai X, Agarwal M, Lvov YM, Pachpande C, Varahramyan K, Witzmann FA.

J Appl Toxicol. 2013 Nov;33(11):1316-29. doi: 10.1002/jat.2858. Epub 2013 Apr 22.


Issues and applications in label-free quantitative mass spectrometry.

Lai X, Wang L, Witzmann FA.

Int J Proteomics. 2013;2013:756039. doi: 10.1155/2013/756039. Epub 2013 Jan 16.


Comparison of nanotube-protein corona composition in cell culture media.

Shannahan JH, Brown JM, Chen R, Ke PC, Lai X, Mitra S, Witzmann FA.

Small. 2013 Jun 24;9(12):2171-81. doi: 10.1002/smll.201202243. Epub 2013 Jan 16.


Developmental analysis and influence of genetic background on the Lhx3 W227ter mouse model of combined pituitary hormone deficiency disease.

Prince KL, Colvin SC, Park S, Lai X, Witzmann FA, Rhodes SJ.

Endocrinology. 2013 Feb;154(2):738-48. doi: 10.1210/en.2012-1790. Epub 2013 Jan 3.


Multi-walled carbon nanotube directed gene and protein expression in cultured human aortic endothelial cells is influenced by suspension medium.

Vidanapathirana AK, Lai X, Hilderbrand SC, Pitzer JE, Podila R, Sumner SJ, Fennell TR, Wingard CJ, Witzmann FA, Brown JM.

Toxicology. 2012 Dec 16;302(2-3):114-22. doi: 10.1016/j.tox.2012.09.008. Epub 2012 Sep 28.


Size dependent aqueous dispersibility of carboxylated multiwall carbon nanotubes.

Ntim SA, Sae-Khow O, Desai C, Witzmann FA, Mitra S.

J Environ Monit. 2012 Oct 26;14(10):2772-9. Epub 2012 Sep 13.


Ethanol exposure alters protein expression in a mouse model of fetal alcohol spectrum disorders.

Mason S, Anthony B, Lai X, Ringham HN, Wang M, Witzmann FA, You JS, Zhou FC.

Int J Proteomics. 2012;2012:867141. doi: 10.1155/2012/867141. Epub 2012 Jun 14.


Proteomic study of low-temperature responses in strawberry cultivars (Fragaria x ananassa) that differ in cold tolerance.

Koehler G, Wilson RC, Goodpaster JV, Sønsteby A, Lai X, Witzmann FA, You JS, Rohloff J, Randall SK, Alsheikh M.

Plant Physiol. 2012 Aug;159(4):1787-805. doi: 10.1104/pp.112.198267. Epub 2012 Jun 11.


Functional effects of nanoparticle exposure on Calu-3 airway epithelial cells.

Banga A, Witzmann FA, Petrache HI, Blazer-Yost BL.

Cell Physiol Biochem. 2012;29(1-2):197-212. doi: 10.1159/000337601. Epub 2012 Mar 1.


Identification of proteins secreted into the medium by human lymphocytes irradiated in vitro with or without adaptive environments.

Rithidech KN, Lai X, Honikel L, Reungpatthanaphong P, Witzmann FA.

Health Phys. 2012 Jan;102(1):39-53. doi: 10.1097/HP.0b013e31822833af.


A novel alignment method and multiple filters for exclusion of unqualified peptides to enhance label-free quantification using peptide intensity in LC-MS/MS.

Lai X, Wang L, Tang H, Witzmann FA.

J Proteome Res. 2011 Oct 7;10(10):4799-812. doi: 10.1021/pr2005633. Epub 2011 Sep 21.


Ethanol-induced changes in the expression of proteins related to neurotransmission and metabolism in different regions of the rat brain.

Zahr NM, Bell RL, Ringham HN, Sullivan EV, Witzmann FA, Pfefferbaum A.

Pharmacol Biochem Behav. 2011 Sep;99(3):428-36. doi: 10.1016/j.pbb.2011.03.002. Epub 2011 Mar 23.


Effects of polymer wrapping and covalent functionalization on the stability of MWCNT in aqueous dispersions.

Ntim SA, Sae-Khow O, Witzmann FA, Mitra S.

J Colloid Interface Sci. 2011 Mar 15;355(2):383-8. doi: 10.1016/j.jcis.2010.12.052. Epub 2010 Dec 22.


Venous and arterial endothelial proteomics: mining for markers and mechanisms of endothelial diversity.

Richardson MR, Lai X, Witzmann FA, Yoder MC.

Expert Rev Proteomics. 2010 Dec;7(6):823-31. doi: 10.1586/epr.10.92. Review.


Alterations in the aqueous humor proteome in patients with Fuchs endothelial corneal dystrophy.

Richardson MR, Segu ZM, Price MO, Lai X, Witzmann FA, Mechref Y, Yoder MC, Price FW.

Mol Vis. 2010 Nov 11;16:2376-83.


Effect of carbon nanoparticles on renal epithelial cell structure, barrier function, and protein expression.

Blazer-Yost BL, Banga A, Amos A, Chernoff E, Lai X, Li C, Mitra S, Witzmann FA.

Nanotoxicology. 2011 Sep;5(3):354-71. doi: 10.3109/17435390.2010.514076. Epub 2010 Nov 10.


Differential expression of renal proteins in a rodent model of Meckel syndrome.

Mason SB, Lai X, Ringham HN, Bacallao RL, Harris PC, Witzmann FA, Gattone VH 2nd.

Nephron Exp Nephrol. 2011;117(2):e31-8. doi: 10.1159/000319722. Epub 2010 Aug 6.


Protein changes in macrophages induced by plasma from rats exposed to 35 GHz millimeter waves.

Sypniewska RK, Millenbaugh NJ, Kiel JL, Blystone RV, Ringham HN, Mason PA, Witzmann FA.

Bioelectromagnetics. 2010 Dec;31(8):656-63. doi: 10.1002/bem.20598.


The biomarker enriched proteome of autosomal dominant polycystic kidney disease cyst fluid.

Mason SB, Lai X, Bacallao RL, Blazer-Yost BL, Gattone VH, Wang KC, Witzmann FA.

Proteomics Clin Appl. 2009 Jun 24;3(10):1247-1250.


Serum Proteomic Profiles In Subjects with Heavy Alcohol Abuse.

Liangpunsakul S, Lai X, Ringham HN, Crabb DW, Witzmann FA.

J Proteomics Bioinform. 2009 May 20;2:236-243.


Protein composition of liver cyst fluid from the BALB/c-cpk/+ mouse model of autosomal recessive polycystic kidney disease.

Lai X, Blazer-Yost BL, Gattone VH 2nd, Muchatuta MN, Witzmann FA.

Proteomics. 2009 Jul;9(14):3775-82. doi: 10.1002/pmic.200800379.


A proteomic workflow for discovery of serum carrier protein-bound biomarker candidates of alcohol abuse using LC-MS/MS.

Lai X, Liangpunsakul S, Crabb DW, Ringham HN, Witzmann FA.

Electrophoresis. 2009 Jun;30(12):2207-14. doi: 10.1002/elps.200800775.


A pilot study of proteomic profiles of human hepatocellular carcinoma in the United States.

Matos JM, Witzmann FA, Cummings OW, Schmidt CM.

J Surg Res. 2009 Aug;155(2):237-43. doi: 10.1016/j.jss.2008.06.008. Epub 2008 Jul 16.


Diabetic dyslipidemia and exercise alter the plasma low-density lipoproteome in Yucatan pigs.

Richardson MR, Lai X, Dixon JL, Sturek M, Witzmann FA.

Proteomics. 2009 May;9(9):2468-83. doi: 10.1002/pmic.200800613.


The role of toxicoproteomics in assessing organ specific toxicity.

Merrick BA, Witzmann FA.

EXS. 2009;99:367-400. Review.


Structural and functional analyses of liver cysts from the BALB/c-cpk mouse model of polycystic kidney disease.

Muchatuta MN, Gattone VH 2nd, Witzmann FA, Blazer-Yost BL.

Exp Biol Med (Maywood). 2009 Jan;234(1):17-27. doi: 10.3181/0807-RM-215. Epub 2008 Nov 7.


Differential protein expression during aging in ventricular myocardium of Fischer 344 x Brown Norway hybrid rats.

Richardson MR, Lai X, Mason SB, Miller SJ, Witzmann FA.

Exp Gerontol. 2008 Oct;43(10):909-18. doi: 10.1016/j.exger.2008.07.003. Epub 2008 Jul 15.

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